CN104955447A - 用于减轻口干燥症状和用于治疗口溃疡的局部口腔组合物 - Google Patents

用于减轻口干燥症状和用于治疗口溃疡的局部口腔组合物 Download PDF

Info

Publication number
CN104955447A
CN104955447A CN201380065761.9A CN201380065761A CN104955447A CN 104955447 A CN104955447 A CN 104955447A CN 201380065761 A CN201380065761 A CN 201380065761A CN 104955447 A CN104955447 A CN 104955447A
Authority
CN
China
Prior art keywords
oral compositions
topical oral
topical
sodium
fluoride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201380065761.9A
Other languages
English (en)
Other versions
CN104955447B (zh
Inventor
森茂树
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sunstar Americas Inc
Original Assignee
Sunstar Americas Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunstar Americas Inc filed Critical Sunstar Americas Inc
Publication of CN104955447A publication Critical patent/CN104955447A/zh
Application granted granted Critical
Publication of CN104955447B publication Critical patent/CN104955447B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/16—Fluorine compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Confectionery (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及含牛磺酸、丙二醇和木糖醇的局部口腔组合物，及其用于减轻或消除口干燥的症状和/或预防或治疗口溃疡的用途。

Description

用于减轻口干燥症状和用于治疗口溃疡的局部口腔组合物
发明领域
本发明涉及含牛磺酸、丙二醇和木糖醇的局部口腔组合物，及其用于减轻或消除口干燥的症状和/或预防或治疗口溃疡的用途。
技术背景
口干燥(Dry mouth)或口干燥症(xerostomia)是由唾腺的活性下降引起的。唾液流量的下降通过引起口腔pH值下降和细菌生长的增加，能导致不适，影响讲话和吞咽，使得戴假牙困难，引起口臭，并损害口腔卫生。长期口干燥能导致严重的龋齿和口腔念珠菌病。在老年人中口干燥是常见的不适，影响约20％的老年人。
口干燥的原因各不相同，且涉及许多因素诸如应力、唾腺感染或药物诸如抗胆碱药、抗震颤麻痹药、抗肿瘤药的使用、头颈的辐射(用于癌症治疗)或其还可与某些疾病相关、诸如干燥综合征和HIV/AIDS、不受控的糖尿病和其他障碍。
目前使用口腔清洗剂治疗口干燥，通常是局部应用，还有唾液替代物或唾液刺激剂、诸如无糖糖果和口香糖。一些唾液刺激剂可商购获得。目前的治疗聚焦于缓解症状和预防牙龋洞。人工唾液产品经常是口干燥症患者的治疗选择。
口干燥能使口软组织、诸如口粘膜、龈组织和舌上的味蕾更易遭受物理、物理化学和生物学损伤。然而现有的治疗/产品没有解决软组织困扰的问题。本发明组合物通过保护和修复促进口软组织的效应来解决该问题。
口溃疡和口腔病损是发生在口腔黏膜上的具有类似于烧伤和损伤的红斑性病损的炎症形式，该疼痛的溃疡使得咀嚼和吞咽困难，损害患者的生活质量。它们令人疼痛是由于口腔黏膜层被除去露出了下面的神经末梢。
有多种原因，包括配合不良的支架和假牙、物理或化学创伤、口干燥、服用免疫抑制药物、烧伤、变态反应、微生物或病毒感染。一旦形成，溃疡可由于炎症和/或继发感染而持续存在。两种常见的口腔溃疡类型是口疮性溃疡(口疮)和感冒疮。感冒疮可以由单纯性疱疹病毒引起。
口溃疡使用局部冲洗剂、局部凝胶剂和液体、行为改进、镇痛药和预防措施来控制。
发明描述
根据本发明已经发现了局部应用于口腔粘膜的含牛磺酸、木糖醇和丙-1,3-二醇的组合物对口干燥产生有益的作用，并促进口腔粘膜再生。
本发明提供了包含牛磺酸或其盐、木糖醇和丙-1,3-二醇的局部口腔组合物。
牛磺酸(2-氨基乙磺酸)是广泛分布在动物组织中的有机酸。哺乳动物血浆和细胞中存在高浓度的牛磺酸，并在多种生物进程中起重要作用。已显示牛磺酸具有调节渗透、抗氧化、抗细胞凋亡(antiapoptopic)、抗炎和降脂活性。
木糖醇被归类为多元醇，且其被认为是“无糖”甜味剂。已知木糖醇降低龋齿风险。
丙-1,3-二醇以的商标销售，且已知其是润滑剂、湿润剂、手感改良剂或溶剂。
本发明的组合物能保护口软组织并促进它们的修复以减轻口软组织的炎症，预防味觉障碍(由于对味蕾的保护)和防止干燥损伤(由于润滑功能)。
牛磺酸在组合物中的浓度范围以重量计为0.01至5.0％，优选浓度以重量计为0.1至1.0％。
木糖醇在组合物中的浓度范围以重量计为0.1至10.0％，优选浓度以重量计为0.5至5.0％。
丙-1,3-二醇在组合物中的浓度范围以重量计为0.1至30.0％，优选浓度以重量计为2.0至20.0％。
组合物还可包含透明质酸钠。
透明质酸钠以重量计以0.01至1.0％的浓度存在，优选浓度以重量计为0.05至0.3％。透明质酸钠优选具有1.0-1.5x 106的分子量(MW)。
本发明的组合物还可包含组分诸如再矿化剂(remineralizing agent)、渗透保护剂、润滑剂、用于刺激唾液流的化合物。
再矿化剂优选选自氟阴离子、磷酸根阴离子、钠阳离子和钾阳离子，诸如氟化钾、氟化钠、单氟磷酸钠、氟化锡、胺氟化物(鲸蜡基胺氢氟酸盐、双-(羟乙基)氨基丙基-N-羟乙基-十八胺二氢氟酸盐、N-N',N'-三(聚氧乙烯)-N-鲸蜡基-丙二胺亚胺二氢氟酸盐或十八烯胺氢氟酸盐)、磷酸钾、焦磷酸钾、柠檬酸三钾、乳酸钙、泛酸钙和碳酸钙。
优选的再矿化剂为单氟磷酸钠，以重量计其优选以0.10至1.14％的浓度存在。
渗透保护剂优选为甜菜碱，以重量计其优选以0.5至5.0％的浓度存在。
优选的润滑剂是聚乙烯吡咯烷酮，以重量计其优选以0.01至5.0％的浓度存在。
用于刺激唾液流的化合物可以是柠檬酸盐或柠檬酸。优选的用于刺激唾液流的化合物是柠檬酸钠/柠檬酸，以重量计其优选以0.5至5.0％的浓度存在。本发明的组合物在各个情况下可以包括本领域技术人员已知的所有需要的成分以得到所需的感官和流变性质。
依据权利要求的局部口腔组合物可以为凝胶剂、喷雾、牙膏、漱口剂、口腔贴剂、口香糖和片剂形式。
实施例
实施例1
实施例2
实施例3
实施例4

Claims (17)

1.局部口腔组合物，其包含牛磺酸或其盐、木糖醇和丙-1,3-二醇。
2.权利要求1的局部口腔组合物，其中牛磺酸或其盐的浓度以重量计为0.01至5.0％。
3.权利要求1或2的局部口腔组合物，其中木糖醇的浓度以重量计为0.1至10.0％。
4.根据权利要求1-3中任意一项的局部口腔组合物，其中丙-1,3-二醇的浓度以重量计为0.1至30.0％。
5.根据权利要求1-4中任意一项的局部口腔组合物，其还包含透明质酸钠。
6.根据权利要求1-5中任意一项的局部口腔组合物，其还包含再矿化剂。
7.权利要求6的局部口腔组合物，其中再矿化剂选自氟阴离子、磷酸根阴离子、钠阳离子和钾阳离子，诸如氟化钾、氟化钠、单氟磷酸钠、氟化锡、胺氟化物(鲸蜡基胺氢氟酸盐、双-(羟乙基)氨基丙基-N-羟乙基-十八胺二氢氟酸盐、N-N',N'-三(聚氧乙烯)-N-鲸蜡基-丙二胺亚胺二氢氟酸盐或十八烯胺氢氟酸盐)、磷酸钾、焦磷酸钾、柠檬酸三钾、乳酸钙、泛酸钙和碳酸钙。
8.权利要求7的局部口腔组合物，其中再矿化剂为单氟磷酸钠或氟化钠。
9.根据权利要求1-8中任意一项的局部口腔组合物，其还包含渗透保护剂。
10.权利要求9的局部口腔组合物，其中渗透保护剂为甜菜碱。
11.根据权利要求1-10中任意一项的局部口腔组合物，其还包含润滑剂。
12.根据权利要求11的局部口腔组合物，其中润滑剂为聚乙烯吡咯烷酮。
13.权利要求1-12的局部口腔组合物，其还包含用于刺激唾液流的化合物。
14.权利要求13的局部口腔组合物，其中用于刺激唾液流的化合物是柠檬酸盐或柠檬酸。
15.凝胶剂、喷雾、牙膏、漱口剂、口腔贴剂、口香糖和片剂形式的根据权利要求1-14中任意一项的局部口腔组合物。
16.用于减轻或消除口干燥的症状的根据权利要求1-15中任意一项的局部口腔组合物。
17.用于预防或治疗口腔溃疡的根据权利要求1-15中任意一项的局部口腔组合物。
CN201380065761.9A 2012-12-18 2013-12-10 用于减轻口干燥症状和用于治疗口溃疡的局部口腔组合物 Active CN104955447B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12197696.3 2012-12-18
EP12197696.3A EP2745836B1 (en) 2012-12-18 2012-12-18 Topical oral composition for alleviating dry mouth symptoms and for treating mouth ulcers
PCT/EP2013/076080 WO2014095489A1 (en) 2012-12-18 2013-12-10 Topical oral composition for alleviating dry mouth symptoms and for treating mouth ulcers

Publications (2)

Publication Number Publication Date
CN104955447A true CN104955447A (zh) 2015-09-30
CN104955447B CN104955447B (zh) 2019-02-22

Family

ID=47427251

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380065761.9A Active CN104955447B (zh) 2012-12-18 2013-12-10 用于减轻口干燥症状和用于治疗口溃疡的局部口腔组合物

Country Status (7)

Country Link
US (1) US9895326B2 (zh)
EP (1) EP2745836B1 (zh)
JP (1) JP6461002B2 (zh)
CN (1) CN104955447B (zh)
CA (1) CA2895249C (zh)
ES (1) ES2593618T3 (zh)
WO (1) WO2014095489A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105833278A (zh) * 2016-04-25 2016-08-10 北京凯莱天成医药科技有限公司 用于治疗口腔干燥和口腔疾病的组合物

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016106071A1 (en) * 2014-12-23 2016-06-30 Colgate-Palmolive Company Oral care composition
JPWO2016153015A1 (ja) * 2015-03-25 2018-05-10 株式会社ファルマクリエ神戸 高分子薬効成分を含有した口腔内施用物および口腔内への高分子薬効成分の投与方法
JP7455317B2 (ja) * 2017-06-30 2024-03-26 小林製薬株式会社 口腔用組成物
US10245236B1 (en) * 2018-01-12 2019-04-02 Lisa Carroll Method and product for treating mouth-related disorders
EP4200025A1 (en) * 2021-01-25 2023-06-28 Colgate-Palmolive Company Solid oral care compositions comprising pvp and hec as binder system

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101141999A (zh) * 2004-12-22 2008-03-12 高露洁-棕榄公司 含有类黄酮和黄烷的口腔护理组合物
US20100028318A1 (en) * 2007-01-31 2010-02-04 Ichiro Saito Agent for relief or prevention of xerostomia
CN101810336A (zh) * 2010-04-30 2010-08-25 广东仙乐制药有限公司 一种咀嚼性软胶囊及其制备方法
JP2012097034A (ja) * 2010-11-02 2012-05-24 Kao Corp オートインデューサー−２阻害剤、並びに齲蝕病の予防及び／又は治療剤
JP2012153677A (ja) * 2011-01-28 2012-08-16 Nippon Zettoc Co Ltd 口腔用組成物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63132820A (ja) * 1986-11-22 1988-06-04 Minoru Nakano 口腔用組成物
US4997654A (en) * 1989-08-14 1991-03-05 Warner-Lambert Company Method for increasing salivation for xerostomia patients
EP0817606A1 (en) * 1995-03-28 1998-01-14 Novo Nordisk A/S Oral care compositions
JP2000506490A (ja) * 1995-08-18 2000-05-30 ノボ ノルディスク アクティーゼルスカブ 歯の漂白
JPH11130644A (ja) * 1997-10-29 1999-05-18 Lion Corp 口腔用組成物
AU3327000A (en) * 1999-03-24 2000-10-09 Seikagaku Corporation Artificial saliva
CA2395610A1 (en) * 1999-12-30 2001-07-12 University Of Louisville Research Foundation, Inc. Methods and compositions for inhibiting adhesion by microorganisms
FI114538B (fi) * 2001-01-12 2004-11-15 Finnfeeds Finland Ltd Glysiinibetaiinin käyttö verenpainetta alentavan tuotteen valmistukseen
ES2186569B1 (es) * 2001-09-28 2004-09-16 Lacer, S.A. Composiciones para el alivio de la xerostomia y el tratamiento de los trastornos asociados con la misma.
US8168161B2 (en) * 2004-12-22 2012-05-01 Hill's Pet Nutrition, Inc. Method to promote oral health in companion animals
US20060140881A1 (en) * 2004-12-22 2006-06-29 Guofeng Xu Oral care compositions containing flavonoids and flavans
KR101421749B1 (ko) * 2006-05-17 2014-07-22 이 아이 듀폰 디 네모아 앤드 캄파니 개인용 케어 조성물
ES2304103B1 (es) * 2007-02-22 2009-08-07 Biocosmetics S.L. Composicion para tratamiento de la xerostomia o boca seca.
US20090104128A1 (en) * 2007-10-17 2009-04-23 Orahealth Corporation Denture adhesive compositions with anti-ucler agents
US20100022471A1 (en) * 2008-07-23 2010-01-28 Sage Products Inc. Oral Moisturizer for Alleviating Dry Mouth
US20120245080A1 (en) * 2009-04-15 2012-09-27 Bmg Pharma Llc Mineral salt-sulfonic acid compositions and methods of use
EP3111924B1 (en) * 2011-05-16 2019-07-10 Colgate-Palmolive Company Oral care compositions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101141999A (zh) * 2004-12-22 2008-03-12 高露洁-棕榄公司 含有类黄酮和黄烷的口腔护理组合物
US20100028318A1 (en) * 2007-01-31 2010-02-04 Ichiro Saito Agent for relief or prevention of xerostomia
CN101810336A (zh) * 2010-04-30 2010-08-25 广东仙乐制药有限公司 一种咀嚼性软胶囊及其制备方法
JP2012097034A (ja) * 2010-11-02 2012-05-24 Kao Corp オートインデューサー−２阻害剤、並びに齲蝕病の予防及び／又は治療剤
JP2012153677A (ja) * 2011-01-28 2012-08-16 Nippon Zettoc Co Ltd 口腔用組成物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105833278A (zh) * 2016-04-25 2016-08-10 北京凯莱天成医药科技有限公司 用于治疗口腔干燥和口腔疾病的组合物

Also Published As

Publication number Publication date
US9895326B2 (en) 2018-02-20
ES2593618T3 (es) 2016-12-12
EP2745836A1 (en) 2014-06-25
EP2745836B1 (en) 2016-08-31
US20150320701A1 (en) 2015-11-12
CN104955447B (zh) 2019-02-22
CA2895249A1 (en) 2014-06-26
JP6461002B2 (ja) 2019-01-30
WO2014095489A1 (en) 2014-06-26
CA2895249C (en) 2021-06-22
JP2016510308A (ja) 2016-04-07

Similar Documents

Publication Publication Date Title
JP2927850B2 (ja) 歯とその支持組織の症状の治療のための局所用製剤
JP4111916B2 (ja) 口内乾燥症の軽減および関連疾病の治療のための組成物
JP5684454B2 (ja) 口腔ケア用の治療及び予防組成物
US5900230A (en) Dental products to treat and prevent periodontal disease
JP4919957B2 (ja) 口腔乾燥症用新規組成物
JP2794388B2 (ja) 口腔乾燥症状軽減の為の固形調剤形態製造物
CN104955447A (zh) 用于减轻口干燥症状和用于治疗口溃疡的局部口腔组合物
ES2946767T3 (es) Composiciones terapéuticas antimicrobianas hipertónicas
EP3661480A1 (en) Gel comprising chlorhexidine
US8071076B2 (en) Oral lubricating and stain retarding compositions
CN109646452A (zh) 人工唾液
EP0988033B1 (en) Use of dichlorobenzyl alcohol for preparing a preparation for topical treatment of inflammation
KR20160061852A (ko) 금속이온 봉쇄제와 이소프로필메틸페놀을 함유하는 구강 조성물
JP2007269806A (ja) 人工唾液
WO2006133412A1 (en) Methods and compositions for the prevention, suppression and elimination of oral pain
KR20190045623A (ko) 구강용 조성물
KR20220008722A (ko) 카라기난을 포함하는 구강 청결용 조성물
US20100297265A1 (en) Optimal compositions and methods for treating oral disease and pain
DK169606B1 (da) Anvendelse af sulfaterede saccharider til fremstilling af præparater, og præparater indeholdende sulfaterede saccharider
US20210169777A1 (en) Artificial Saliva with Electrolytes for Xerostomia
WO2022136264A1 (en) A mucosal re-epithelialization composition
KR20090079369A (ko) 특정 ｐＨ를 가지는 죽염을 함유하는 치약 조성물
WO2009107098A2 (en) An oral treatment composition
UA32680U (uk) Засіб у формі стоматологічної лікувальної плівки для лікування патології пародонта і слизової оболонки порожнини рота

Legal Events

Date Code Title Description
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant