JP2016509842A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016509842A5 JP2016509842A5 JP2015560302A JP2015560302A JP2016509842A5 JP 2016509842 A5 JP2016509842 A5 JP 2016509842A5 JP 2015560302 A JP2015560302 A JP 2015560302A JP 2015560302 A JP2015560302 A JP 2015560302A JP 2016509842 A5 JP2016509842 A5 JP 2016509842A5
- Authority
- JP
- Japan
- Prior art keywords
- synthase
- acid
- thca
- cbda
- cbca
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 23
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 18
- 101000712615 Cannabis sativa Tetrahydrocannabinolic acid synthase Proteins 0.000 claims 12
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 12
- 239000011541 reaction mixture Substances 0.000 claims 11
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 9
- WVOLTBSCXRRQFR-DLBZAZTESA-N cannabidiolic acid Chemical compound OC1=C(C(O)=O)C(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 WVOLTBSCXRRQFR-DLBZAZTESA-N 0.000 claims 9
- 229930003827 cannabinoid Natural products 0.000 claims 9
- 239000003557 cannabinoid Substances 0.000 claims 9
- 108010075293 Cannabidiolic acid synthase Proteins 0.000 claims 8
- UCONUSSAWGCZMV-HZPDHXFCSA-N Delta(9)-tetrahydrocannabinolic acid Chemical compound C([C@H]1C(C)(C)O2)CC(C)=C[C@H]1C1=C2C=C(CCCCC)C(C(O)=O)=C1O UCONUSSAWGCZMV-HZPDHXFCSA-N 0.000 claims 7
- HRHJHXJQMNWQTF-UHFFFAOYSA-N cannabichromenic acid Chemical compound O1C(C)(CCC=C(C)C)C=CC2=C1C=C(CCCCC)C(C(O)=O)=C2O HRHJHXJQMNWQTF-UHFFFAOYSA-N 0.000 claims 7
- 239000002253 acid Substances 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- WVOLTBSCXRRQFR-SJORKVTESA-N Cannabidiolic acid Natural products OC1=C(C(O)=O)C(CCCCC)=CC(O)=C1[C@@H]1[C@@H](C(C)=C)CCC(C)=C1 WVOLTBSCXRRQFR-SJORKVTESA-N 0.000 claims 3
- 229920000858 Cyclodextrin Polymers 0.000 claims 3
- 241000588724 Escherichia coli Species 0.000 claims 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 3
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- QXACEHWTBCFNSA-SFQUDFHCSA-N cannabigerol Chemical compound CCCCCC1=CC(O)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1 QXACEHWTBCFNSA-SFQUDFHCSA-N 0.000 claims 2
- QXACEHWTBCFNSA-UHFFFAOYSA-N cannabigerol Natural products CCCCCC1=CC(O)=C(CC=C(C)CCC=C(C)C)C(O)=C1 QXACEHWTBCFNSA-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- KTPDAZGMXXWSMU-UHFFFAOYSA-N Cannabichromen Natural products CCCCc1cc(O)c2C=CC(C)(CCC=C(C)C)Oc2c1 KTPDAZGMXXWSMU-UHFFFAOYSA-N 0.000 claims 1
- UVOLYTDXHDXWJU-NRFANRHFSA-N Cannabichromene Natural products C1=C[C@](C)(CCC=C(C)C)OC2=CC(CCCCC)=CC(O)=C21 UVOLYTDXHDXWJU-NRFANRHFSA-N 0.000 claims 1
- CYQFCXCEBYINGO-UHFFFAOYSA-N THC Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-UHFFFAOYSA-N 0.000 claims 1
- 108030003705 Tetrahydrocannabinolic acid synthases Proteins 0.000 claims 1
- QHMBSVQNZZTUGM-UHFFFAOYSA-N Trans-Cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-UHFFFAOYSA-N 0.000 claims 1
- QHMBSVQNZZTUGM-ZWKOTPCHSA-N cannabidiol Chemical compound OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-ZWKOTPCHSA-N 0.000 claims 1
- 229950011318 cannabidiol Drugs 0.000 claims 1
- ZTGXAWYVTLUPDT-UHFFFAOYSA-N cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CC=C(C)C1 ZTGXAWYVTLUPDT-UHFFFAOYSA-N 0.000 claims 1
- WVOLTBSCXRRQFR-DLBZAZTESA-M cannabidiolate Chemical compound OC1=C(C([O-])=O)C(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 WVOLTBSCXRRQFR-DLBZAZTESA-M 0.000 claims 1
- SEEZIOZEUUMJME-FOWTUZBSSA-N cannabigerolic acid Chemical compound CCCCCC1=CC(O)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1C(O)=O SEEZIOZEUUMJME-FOWTUZBSSA-N 0.000 claims 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 1
- PCXRACLQFPRCBB-ZWKOTPCHSA-N dihydrocannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)C)CCC(C)=C1 PCXRACLQFPRCBB-ZWKOTPCHSA-N 0.000 claims 1
- 229960004242 dronabinol Drugs 0.000 claims 1
- 230000003100 immobilizing effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361770766P | 2013-02-28 | 2013-02-28 | |
| US61/770,766 | 2013-02-28 | ||
| PCT/US2014/018944 WO2014134281A1 (en) | 2013-02-28 | 2014-02-27 | Biosynthesis of cannabinoids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018025851A Division JP6724052B2 (ja) | 2013-02-28 | 2018-02-16 | カンナビノイドの生合成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016509842A JP2016509842A (ja) | 2016-04-04 |
| JP2016509842A5 true JP2016509842A5 (https=) | 2017-02-16 |
| JP6581509B2 JP6581509B2 (ja) | 2019-09-25 |
Family
ID=51428796
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015560302A Expired - Fee Related JP6581509B2 (ja) | 2013-02-28 | 2014-02-27 | 化合物を合成する化学工学プロセス及び装置 |
| JP2018025851A Expired - Fee Related JP6724052B2 (ja) | 2013-02-28 | 2018-02-16 | カンナビノイドの生合成 |
| JP2019205366A Pending JP2020022507A (ja) | 2013-02-28 | 2019-11-13 | カンナビノイドの生合成 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018025851A Expired - Fee Related JP6724052B2 (ja) | 2013-02-28 | 2018-02-16 | カンナビノイドの生合成 |
| JP2019205366A Pending JP2020022507A (ja) | 2013-02-28 | 2019-11-13 | カンナビノイドの生合成 |
Country Status (9)
| Country | Link |
|---|---|
| US (8) | US9359625B2 (https=) |
| EP (1) | EP2961402B1 (https=) |
| JP (3) | JP6581509B2 (https=) |
| CN (1) | CN105555265A (https=) |
| AU (2) | AU2014223458A1 (https=) |
| BR (1) | BR112015020332A2 (https=) |
| CA (2) | CA3012383C (https=) |
| IL (1) | IL240830B (https=) |
| WO (1) | WO2014134281A1 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3012383C (en) | 2013-02-28 | 2021-03-02 | Teewinot Technologies Limited | Biosynthesis of cannabinoids |
| CA2990071C (en) | 2014-07-14 | 2023-01-24 | Librede Inc. | Production of cannabigerolic acid |
| US11293038B2 (en) | 2014-07-14 | 2022-04-05 | Librede Inc. | Production of cannabinoids in yeast |
| CN109593651A (zh) * | 2014-08-25 | 2019-04-09 | 蒂威诺特科技有限公司 | 用于大麻素化合物的同时生产的设备和方法 |
| BR122021018502B1 (pt) | 2014-10-21 | 2022-05-03 | United Cannabis Corp | Formulação de canabinoide líquida |
| MX395015B (es) | 2014-12-12 | 2025-03-24 | Ojai Energetics Pbc | Composiciones microencapsuladas de cannabinoides |
| US10350165B2 (en) | 2014-12-12 | 2019-07-16 | Ojai Energetics Pbc | Methods and systems for forming stable droplets |
| WO2017175064A1 (en) * | 2016-04-04 | 2017-10-12 | Full Spectrum Laboratories Ltd | Bioenzymatic synthesis of tetrahydrocannabivarin (thc-v), cannabinol (cbn), and cannabivarin (cbv) and their use as therapeutic agents |
| AU2017250303B2 (en) * | 2016-04-15 | 2019-09-26 | Teewinot Technologies Limited | Biosynthesis of cannabinoid prodrugs |
| BR112018071518A2 (pt) | 2016-04-22 | 2019-02-19 | Receptor Life Sciences, Inc. | compostos medicinais à base de planta de ação rápida e suplementos nutricionais |
| NZ749229A (en) * | 2016-06-15 | 2026-01-30 | Ojai Energetics Pbc | Methods and compositions for reducing oxidative stress |
| WO2018091551A1 (en) * | 2016-11-15 | 2018-05-24 | Full Spectrum Laboratories Ltd | Bio-stable cannabinoid compounds and methods for enhancing their physiological concentration |
| EA201892396A1 (ru) | 2016-12-02 | 2019-04-30 | Ресептор Лайф Сайенсиз, Инк. | Быстродействующие растительные лекарственные соединения и биологически активные добавки |
| US10239808B1 (en) | 2016-12-07 | 2019-03-26 | Canopy Holdings, LLC | Cannabis extracts |
| SG11201907504PA (en) | 2017-02-17 | 2019-09-27 | Hyasynth Biologicals Inc | Method and cell line for production of phytocannabinoids and phytocannabinoid analogues in yeast |
| BR112019019966A2 (pt) | 2017-03-24 | 2020-04-28 | Trait Biosciences Inc | biossíntese in vivo de alto nível e isolamento de canabinoides solúveis em água em sistemas de plantas |
| AU2018260710B2 (en) * | 2017-04-26 | 2022-07-21 | Teewinot Technologies Limited | Apparatus, methods and composition for synthesis of cannabinoid compounds |
| CN110914416B (zh) | 2017-04-27 | 2023-07-21 | 加州大学董事会 | 产生大麻素和大麻素衍生物的微生物和方法 |
| CN111465700A (zh) * | 2017-07-11 | 2020-07-28 | 特征生物科学公司 | 在酵母和植物细胞悬浮培养物中产生水溶性大麻素化合物和材料组合物 |
| US11946059B2 (en) | 2017-07-11 | 2024-04-02 | Trait Biosciences, Inc. | In vivo generation of water-soluble cannabinoids in plant cell suspension cultures |
| US11905543B2 (en) | 2017-07-11 | 2024-02-20 | Trait Biosceinces, Inc. | In vivo generation of water-soluble acetylated cannabinoid glycoside compounds in plant cell suspension cultures |
| CN110892075A (zh) | 2017-07-12 | 2020-03-17 | 生物医学股份有限公司 | 在酵母中生产大麻素 |
| KR20200070237A (ko) | 2017-09-05 | 2020-06-17 | 인메드 파마슈티컬스 인코포레이티드 | 칸나비노이드 생성물의 생합성을 위한 대장균의 대사 조작 |
| EP3691442A4 (en) | 2017-10-03 | 2021-07-07 | The Regents of the University of Colorado | PROCESS FOR DIFFERENTIATING CANNABIS PLANT CULTIVARS BASED ON CANNABINOID SYNTHASE PARALOGUES |
| CN114703347A (zh) | 2017-10-20 | 2022-07-05 | 杰富意钢铁株式会社 | 高强度钢板及其制造方法 |
| CA3089994A1 (en) | 2018-01-31 | 2019-08-08 | Canopy Holdings, LLC | Hemp powder |
| CA3098351A1 (en) | 2018-04-23 | 2019-10-31 | Renew Biopharma, Inc. | Variant cannbinoid synthases and methods and uses thereof |
| US10801049B2 (en) | 2018-06-14 | 2020-10-13 | Syntiva Therapeutics, Inc. | Genetically engineered microorganisms and processes for the production of cannabinoids from a carbon source precursor |
| WO2020077153A1 (en) * | 2018-10-10 | 2020-04-16 | Canopy Holdings, LLC | Synthesis of cannabigerol |
| US11993563B2 (en) | 2018-10-31 | 2024-05-28 | Enantia S.L. | Solid compositions of cocrystals of cannabinoids |
| EP3883595A4 (en) | 2018-11-19 | 2022-12-14 | Receptor Holdings, Inc. | N-ACYLATED FATTY AMINO ACIDS TO REDUCE ABSORPTION VARIABILITY IN CANNABINOID-BASED COMPOSITIONS |
| CN109734591A (zh) * | 2018-12-26 | 2019-05-10 | 江苏暨明医药科技有限公司 | 一种大麻二酚中间体及其制备方法与及应用 |
| EP3931330A4 (en) | 2019-02-25 | 2023-03-15 | Ginkgo Bioworks, Inc. | BIOSYNTHESIS OF CANNABINOIDS AND CANNABINOID PRECURSORS |
| EP3934641A4 (en) | 2019-03-07 | 2022-12-21 | Ilera Therapeutics LLC | FORMULATIONS FOR THE TREATMENT OF SYMPTOMS ACCOMPLISHED WITH AUTISM |
| WO2020210810A1 (en) | 2019-04-12 | 2020-10-15 | Renew Biopharma, Inc. | Compositions and methods for using genetically modified enzymes |
| WO2020236789A1 (en) * | 2019-05-22 | 2020-11-26 | Demetrix, Inc. | Optimized cannabinoid synthase polypeptides |
| EP3983367B1 (en) | 2019-06-11 | 2025-07-30 | Symrise AG | Synthesis and purification of cannabigerol and its application |
| US10717056B1 (en) | 2019-09-09 | 2020-07-21 | Michael Cem Gokay | Method and apparatus for purification of cannabinoid extracts |
| JP2022551476A (ja) * | 2019-10-08 | 2022-12-09 | ベッソール ファルマ、エルエルシー | カンナビノイド及びカンナビノイド酸の製造プロセス |
| US12497636B2 (en) | 2019-10-11 | 2025-12-16 | National University Of Singapore | Recombinant Saccharomyces cerevisiae cells for cannabinoid production |
| CN119753051A (zh) | 2019-10-11 | 2025-04-04 | 新加坡国立大学 | 使用大麻素合成酶由大麻萜酚酸生物合成大麻素 |
| WO2021211611A1 (en) | 2020-04-14 | 2021-10-21 | Genomatica, Inc. | Cannabinoid synthase variants and methods for their use |
| EP4149916A4 (en) | 2020-05-12 | 2024-06-19 | Canopy Growth Corporation | Methods of synthesizing cannabigergol, cannabigerolic acid, and analogs thereof |
| WO2021226711A1 (en) * | 2020-05-12 | 2021-11-18 | Canopy Growth Corporation | Methods of synthesizing cannabigergol, cannabigerolic acid, and analogs thereof |
| AU2021411968A1 (en) | 2020-12-31 | 2023-07-13 | Cookies Creative Consulting & Promotions, Inc. | Compositions comprising cannabis and mushroom extracts, and uses thereof |
| US20220298533A1 (en) * | 2021-03-22 | 2022-09-22 | Cb Therapeutics, Inc. | Biosynthetic methods for the modification of cannabinoids |
| EP4347854A4 (en) * | 2021-06-04 | 2025-10-01 | Amyris Inc | CANNABINOID PURIFICATION PROCESSES |
| US20250027127A1 (en) * | 2021-09-15 | 2025-01-23 | The Regents Of The University Of California | Cannabinoid production in bacteria |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5086646A (en) | 1989-09-12 | 1992-02-11 | Jamison Dale E | Apparatus and method for analyzing well fluid sag |
| US5290701A (en) * | 1991-08-28 | 1994-03-01 | Wilkins Judd R | Microbial detection system and process |
| US5302525A (en) * | 1992-11-23 | 1994-04-12 | National Research Council Of Canada | Methylobacterium extorquwns microorganism useful for the preparation of poly-β-hydroxybutyric acid polymers |
| US7530461B2 (en) * | 1995-03-10 | 2009-05-12 | Photocure Asa | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| US6113940A (en) | 1997-03-03 | 2000-09-05 | Brooke; Lawrence L. | Cannabinoid patch and method for cannabis transdermal delivery |
| JP2000078979A (ja) | 1998-09-04 | 2000-03-21 | Taisho Pharmaceut Co Ltd | テトラヒドロカンナビノール酸シンターゼ遺伝子 |
| AR022383A1 (es) * | 1998-09-18 | 2002-09-04 | Univ Kentucky Res Found | Sintasas |
| US6403126B1 (en) | 1999-05-26 | 2002-06-11 | Websar Innovations Inc. | Cannabinoid extraction method |
| US6949582B1 (en) | 1999-05-27 | 2005-09-27 | Wallace Walter H | Method of relieving analgesia and reducing inflamation using a cannabinoid delivery topical liniment |
| JP2001029082A (ja) * | 1999-07-22 | 2001-02-06 | Yukihiro Masayama | カンナビジオール酸シンターゼをコードするｄｎａ |
| US6730330B2 (en) | 2001-02-14 | 2004-05-04 | Gw Pharma Limited | Pharmaceutical formulations |
| US6946150B2 (en) | 2002-08-14 | 2005-09-20 | Gw Pharma Limited | Pharmaceutical formulation |
| WO2004016254A2 (en) | 2002-08-16 | 2004-02-26 | Immugen Pharmaceuticals, Inc. | Contraceptive methods and formulations |
| GB0222077D0 (en) | 2002-09-23 | 2002-10-30 | Gw Pharma Ltd | Methods of preparing cannabinoids from plant material |
| DE10335130A1 (de) * | 2003-07-31 | 2005-02-24 | Blue Membranes Gmbh | Immobilisierung von Katalysatoren auf porösen Körpern auf Kohlenstoffbasis |
| GB2418612A (en) | 2004-10-01 | 2006-04-05 | Gw Pharma Ltd | Inhibition of tumour cell migration with cannabinoids |
| KR20070101359A (ko) * | 2005-01-28 | 2007-10-16 | 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 신규한 방향족 프레닐트랜스퍼라제, 이것을 코드화한 핵산및 그의 용도 |
| EP1868698A1 (de) | 2005-04-01 | 2007-12-26 | Basf Aktiengesellschaft | Verwendung von proteinen als demulgatoren |
| EP1885865A4 (en) * | 2005-05-12 | 2010-12-22 | Univ North Carolina | ENZYMATIC SYNTHESIS OF SULFATED POLYSACCHARIDES |
| JP2007020466A (ja) | 2005-07-15 | 2007-02-01 | Institute Of Physical & Chemical Research | 大麻ＣａｎｎａｂｉｓｓａｔｉｖａＬ．の識別方法 |
| US9265724B2 (en) | 2005-11-07 | 2016-02-23 | Ram B. Murty | Oral dosage form of tetrahydrocannabinol and a method of avoiding and/or suppressing hepatic first pass metabolism via targeted chylomicron/lipoprotein delivery |
| US20070104741A1 (en) | 2005-11-07 | 2007-05-10 | Murty Pharmaceuticals, Inc. | Delivery of tetrahydrocannabinol |
| GB2434312B (en) | 2006-01-18 | 2011-06-29 | Gw Pharma Ltd | Cannabinoid-containing plant extracts as neuroprotective agents |
| GB2450493A (en) * | 2007-06-25 | 2008-12-31 | Gw Pharma Ltd | Cannabigerol for use in treatment of diseases benefiting from agonism of CB1 and CB2 cannabinoid receptors |
| WO2009102466A1 (en) | 2008-02-14 | 2009-08-20 | The General Hospital Corporation | Well-based flow system for cell culture |
| GB2459125B (en) | 2008-04-10 | 2013-01-02 | Gw Pharma Ltd | Method if extracting cannabichromene and its acid from Cannabis sativa plant material |
| US9921576B2 (en) * | 2008-05-05 | 2018-03-20 | Finesse Solutions, Inc. | Virtual transmitter for bioreactor automation system |
| SI2285387T1 (sl) * | 2008-06-13 | 2016-02-29 | N.V. Nutricia | Prehrana za preprečevanje infekcij |
| WO2010118240A1 (en) | 2009-04-08 | 2010-10-14 | Bristol-Myers Squibb Company | A genetically stable plasmid expressing pdh and fdh enzymes |
| DE102009019322A1 (de) * | 2009-04-30 | 2010-11-11 | The Health Concept Gmbh | Verfahren zur Herstellung von Synthetischen Cannabinoiden |
| US20120117686A1 (en) | 2009-05-04 | 2012-05-10 | The Regentsof The University Of California | Stress-tolerant plants expressing mannosylglycerate-producing enzymes |
| US20110003703A1 (en) * | 2009-07-01 | 2011-01-06 | Charles Ma | Nucleic Acid Hybridization and Detection Using Enzymatic Reactions on a Microarray |
| WO2011017798A1 (en) | 2009-08-12 | 2011-02-17 | National Research Council Of Canada | Aromatic prenyltransferase from cannabis |
| RU2711869C3 (ru) * | 2009-12-01 | 2022-02-02 | Эббви Инк. | Имидазопирролопиразиновые производные, полезные для лечения заболеваний, вызванных аномальной активностью протеинкиназ Jak1, Jak3 или Syk |
| GB2478595B (en) | 2010-03-12 | 2018-04-04 | Gw Pharma Ltd | Phytocannabinoids in the treatment of glioma |
| CA3130705A1 (en) * | 2010-04-15 | 2011-10-20 | National Research Council Of Canada | Genes and proteins for aromatic polyketide synthesis |
| JP5751661B2 (ja) | 2010-11-02 | 2015-07-22 | 国立研究開発法人農業・食品産業技術総合研究機構 | デキストラングルカナーゼ |
| JP2012130294A (ja) | 2010-12-22 | 2012-07-12 | Tosoh Corp | 抗体結合タンパク質およびその製造方法 |
| WO2013009928A1 (en) * | 2011-07-11 | 2013-01-17 | Organic Medical Research | Cannabinoid formulations |
| WO2013006953A1 (en) | 2011-07-13 | 2013-01-17 | National Research Council Of Canada | Genes and proteins for alkanoyl-coa synthesis |
| US20140057251A1 (en) | 2011-08-18 | 2014-02-27 | Medicinal Genomics Corporation | Cannabis Genomes and Uses Thereof |
| GB2494461A (en) | 2011-09-12 | 2013-03-13 | Gw Pharma Ltd | Phytocannabinoids for use in the treatment of invasive cancers or metastases |
| GB2514054A (en) | 2011-09-29 | 2014-11-12 | Gw Pharma Ltd | A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD) |
| GB2496688B (en) | 2011-11-21 | 2016-06-29 | Gw Pharma Ltd | Tetrahydrocannabivarin for use in the treatment of intestinal inflammatory diseases |
| AU2013239962B9 (en) | 2012-03-30 | 2017-11-16 | The Scripps Research Institute | Cyclic prodrugs of duocarmycin analogs |
| WO2013165251A1 (en) | 2012-05-03 | 2013-11-07 | Echo Pharmaceuticals B.V. | Cannabis plant isolate comprising /\9-tetrahydrocannabinol and a method for preparing such an isolate |
| CA3012383C (en) | 2013-02-28 | 2021-03-02 | Teewinot Technologies Limited | Biosynthesis of cannabinoids |
| WO2014145490A2 (en) | 2013-03-15 | 2014-09-18 | Biotech Institute, Llc | Breeding, production, processing and use of specialty cannabis |
| ES2525137B1 (es) | 2013-06-13 | 2016-01-18 | Servicio Andaluz De Salud | Agentes para tratar el mieloma múltiple |
| US10214718B2 (en) | 2013-07-01 | 2019-02-26 | University Of Massachusetts | Distributed perfusion bioreactor system for continuous culture of biological cells |
| US9326967B2 (en) | 2013-08-22 | 2016-05-03 | Stephen C. Perry | Vaporizable cannabinoid compositions |
| US9655910B2 (en) | 2014-03-21 | 2017-05-23 | Bodybio Inc. | Compositions and methods for treating addiction |
| EP3171872B1 (en) * | 2014-07-21 | 2020-11-11 | Glia, LLC | Method for treating radiotherapy-and-chemotherapy associated cognitive or emotional impairment with cannabinoids |
| CN109593651A (zh) | 2014-08-25 | 2019-04-09 | 蒂威诺特科技有限公司 | 用于大麻素化合物的同时生产的设备和方法 |
| AU2018260710B2 (en) * | 2017-04-26 | 2022-07-21 | Teewinot Technologies Limited | Apparatus, methods and composition for synthesis of cannabinoid compounds |
-
2014
- 2014-02-27 CA CA3012383A patent/CA3012383C/en active Active
- 2014-02-27 JP JP2015560302A patent/JP6581509B2/ja not_active Expired - Fee Related
- 2014-02-27 IL IL240830A patent/IL240830B/en unknown
- 2014-02-27 AU AU2014223458A patent/AU2014223458A1/en not_active Abandoned
- 2014-02-27 CN CN201480023902.5A patent/CN105555265A/zh active Pending
- 2014-02-27 BR BR112015020332A patent/BR112015020332A2/pt not_active IP Right Cessation
- 2014-02-27 WO PCT/US2014/018944 patent/WO2014134281A1/en not_active Ceased
- 2014-02-27 EP EP14757297.8A patent/EP2961402B1/en active Active
- 2014-02-27 CA CA2902452A patent/CA2902452C/en active Active
-
2015
- 2015-08-26 US US14/836,339 patent/US9359625B2/en active Active
-
2016
- 2016-06-02 US US15/171,517 patent/US9526715B1/en not_active Expired - Fee Related
- 2016-08-19 US US15/242,189 patent/US9861609B2/en not_active Expired - Fee Related
-
2017
- 2017-02-10 US US15/430,122 patent/US10081818B2/en active Active
- 2017-02-23 US US15/441,109 patent/US20170159080A1/en not_active Abandoned
- 2017-05-12 US US15/594,348 patent/US10214753B2/en active Active
- 2017-09-22 US US15/713,304 patent/US10472652B2/en active Active
-
2018
- 2018-02-16 JP JP2018025851A patent/JP6724052B2/ja not_active Expired - Fee Related
- 2018-09-10 AU AU2018228329A patent/AU2018228329A1/en not_active Abandoned
-
2019
- 2019-10-15 US US16/601,984 patent/US20200048664A1/en not_active Abandoned
- 2019-11-13 JP JP2019205366A patent/JP2020022507A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016509842A5 (https=) | ||
| ECSP18010065A (es) | Proceso para la producción de cannabidiol y delta-9-tetrahidrocannabinol | |
| JP2019526717A5 (https=) | ||
| HK1252151A1 (zh) | Thca合成酶表达改变的大麻植物 | |
| WO2011101260A3 (en) | Sulfonamide-containing photoresist compositions and methods of use | |
| BR112016013316A8 (pt) | método para a produção de furfural e uso de ácido metanossulfônico | |
| BR112013028764A2 (pt) | suspensão do canal de fluxo frio de um turborreator por pequenas bielas e forquilhas radiais no cárter de escape | |
| BR112018007692A2 (pt) | processo de produção de 5-hidroximetilfurfural na presença de catalisadores da família de ácidos sulfônicos homogêneos na presença de pelo menos um solvente polar aprótico | |
| BR112018000257A2 (pt) | célula hospedeira, método para produzir um haa, uso de uma célula hospedeira, método para produzir uma célula hospedeira, célula, preparação de haa, método para produzir uma composição de ácido graxo e composição de ácido graxo | |
| MX384825B (es) | Metodo para separar ramnolipidos de un caldo de fermentacion. | |
| Jaishree et al. | Antioxidant and hepatoprotective effect of the ethyl acetate extract of Enicostemma axillare (Lam). Raynal against CCL4-induced liver injury in rats. | |
| BR112019000610A2 (pt) | fator vii de coagulação de longa ação e métodos de produção do mesmo | |
| WO2019112352A3 (ko) | 홍합접착단백질의 생산 방법 | |
| ES2584802T3 (es) | Procedimiento de preparación de sílice precipitada que comprende una etapa de desaglomeración en caliente | |
| JP2016525410A5 (https=) | ||
| MX372637B (es) | Proceso para la preparación de diosmina | |
| WO2012051323A3 (en) | Cryptophane derivatives and methods of use thereof | |
| MY180919A (en) | Method for producing photosensitive resin element | |
| RU2014112487A (ru) | Способ получения нанокапсул резвератрола в альгинате натрия | |
| McCormack | Wilde the “Pervert”: Oscar and Transnational (Roman Catholic) Religion | |
| WO2016110869A3 (en) | Dna molecules producing custom designed replicating and non-replicating negative stranded rna viruses and uses there of | |
| RU2015140786A (ru) | Способ получения состава с гербицидной активностью | |
| 최수연 | In vitro digestibility of starch and lipid in cookies as affected by the degree of esterification of pectin | |
| JP2016513158A5 (https=) | ||
| BR112018015481A2 (pt) | processo para preparar um complexo de ciclodextrina e ingrediente farmacêutico ativo |