JP2016507470A5 - - Google Patents
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- Publication number
- JP2016507470A5 JP2016507470A5 JP2015540879A JP2015540879A JP2016507470A5 JP 2016507470 A5 JP2016507470 A5 JP 2016507470A5 JP 2015540879 A JP2015540879 A JP 2015540879A JP 2015540879 A JP2015540879 A JP 2015540879A JP 2016507470 A5 JP2016507470 A5 JP 2016507470A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- antigen
- seq
- binding fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 26
- 239000000427 antigen Substances 0.000 claims 24
- 102000036639 antigens Human genes 0.000 claims 24
- 108091007433 antigens Proteins 0.000 claims 24
- 239000012634 fragment Substances 0.000 claims 18
- 125000000539 amino acid group Chemical group 0.000 claims 15
- 230000035772 mutation Effects 0.000 claims 15
- 101710092462 Alpha-hemolysin Proteins 0.000 claims 5
- 101710197219 Alpha-toxin Proteins 0.000 claims 5
- 101710124951 Phospholipase C Proteins 0.000 claims 5
- 239000002776 alpha toxin Substances 0.000 claims 5
- 208000015181 infectious disease Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 230000009424 thromboembolic effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261723137P | 2012-11-06 | 2012-11-06 | |
| US61/723,137 | 2012-11-06 | ||
| US201361782405P | 2013-03-14 | 2013-03-14 | |
| US61/782,405 | 2013-03-14 | ||
| PCT/US2013/068624 WO2014074540A2 (en) | 2012-11-06 | 2013-11-06 | Antibodies to s. aureus surface determinants |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019011283A Division JP2019089801A (ja) | 2012-11-06 | 2019-01-25 | Ｓ．アウレウス（Ｓ．ａｕｒｅｕｓ）表面決定基に対する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016507470A JP2016507470A (ja) | 2016-03-10 |
| JP2016507470A5 true JP2016507470A5 (show.php) | 2016-12-22 |
| JP6694269B2 JP6694269B2 (ja) | 2020-05-13 |
Family
ID=50685304
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540879A Active JP6694269B2 (ja) | 2012-11-06 | 2013-11-06 | Ｓ．アウレウス（Ｓ．ａｕｒｅｕｓ）表面決定基に対する抗体 |
| JP2019011283A Withdrawn JP2019089801A (ja) | 2012-11-06 | 2019-01-25 | Ｓ．アウレウス（Ｓ．ａｕｒｅｕｓ）表面決定基に対する抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019011283A Withdrawn JP2019089801A (ja) | 2012-11-06 | 2019-01-25 | Ｓ．アウレウス（Ｓ．ａｕｒｅｕｓ）表面決定基に対する抗体 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US9879070B2 (show.php) |
| EP (2) | EP3640338A1 (show.php) |
| JP (2) | JP6694269B2 (show.php) |
| KR (1) | KR102288394B1 (show.php) |
| CN (2) | CN109553681A (show.php) |
| AU (2) | AU2013341361A1 (show.php) |
| BR (1) | BR112015010125A2 (show.php) |
| CA (1) | CA2890427C (show.php) |
| DK (1) | DK2917360T3 (show.php) |
| ES (1) | ES2776179T3 (show.php) |
| HU (1) | HUE049012T2 (show.php) |
| MX (2) | MX375324B (show.php) |
| PL (1) | PL2917360T3 (show.php) |
| RU (1) | RU2698131C2 (show.php) |
| SG (2) | SG11201503232TA (show.php) |
| WO (1) | WO2014074540A2 (show.php) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2826566C (en) * | 2011-02-08 | 2022-09-13 | Medimmune, Llc | Antibodies that specifically bind staphylococcus aureus alpha toxin and methods of use |
| JP6058645B2 (ja) | 2011-06-10 | 2017-01-11 | メディミューン，エルエルシー | 抗シュードモナス属（Ｐｓｅｕｄｏｍｏｎａｓ）Ｐｓｌ結合分子およびその使用 |
| CA3161431A1 (en) | 2011-11-07 | 2013-05-16 | Medimmune Limited | Combination therapies using anti-pseudomonas psl and pcrv binding molecules |
| US9988439B2 (en) | 2011-12-23 | 2018-06-05 | Nicholas B. Lydon | Immunoglobulins and variants directed against pathogenic microbes |
| WO2013096948A1 (en) | 2011-12-23 | 2013-06-27 | Lydon Nicholas B | Immunoglobulins and variants directed against pathogenic microbes |
| CN109553681A (zh) * | 2012-11-06 | 2019-04-02 | 米迪缪尼有限公司 | 金黄色葡萄球菌表面决定簇的抗体 |
| AU2013341421A1 (en) | 2012-11-06 | 2015-06-04 | Medimmune, Llc | Methods of treating S. aureus-associated diseases |
| KR20210047355A (ko) * | 2014-06-03 | 2021-04-29 | 엑스바이오테크 인코포레이티드 | 스타필로코커스 아우레우스 감염의 치료 및 예방을 위한 조성물 및 방법 |
| TWI719938B (zh) | 2014-06-19 | 2021-03-01 | 美商麥迪紐有限責任公司 | 多重細菌感染之治療 |
| US20180017559A1 (en) * | 2014-08-12 | 2018-01-18 | Arsanis Biosciences Gmbh | Predicting s. aureus disease |
| WO2016073860A1 (en) * | 2014-11-06 | 2016-05-12 | Medimmune, Llc | Binding molecules specific for staphylococcus protein a and uses thereof |
| FR3033333A1 (fr) * | 2015-03-06 | 2016-09-09 | Commissariat Energie Atomique | Procede et dispositif pour detecter en temps reel un compose secrete et la cible secretrice ainsi que leurs utilisations |
| MX2017012775A (es) * | 2015-04-17 | 2019-04-29 | Arsanis Biosciences Gmbh | Preparacion combinatoria de anticuerpos anti-staphylococcus aureus. |
| WO2017075188A2 (en) * | 2015-10-30 | 2017-05-04 | Medimmune, Llc | Methods of using anti-alpha toxin antibody |
| CN105424930A (zh) * | 2015-11-23 | 2016-03-23 | 天津科技大学 | 一种快速检测金黄色葡萄球菌的方法 |
| MY199789A (en) * | 2017-09-29 | 2023-11-23 | Regeneron Pharma | Bispecific antigen-binding molecules that bind a staphylococcus target antigen and a complement component and uses thereof |
| US11155606B2 (en) | 2018-07-24 | 2021-10-26 | Medimmune, Llc | Antibody directed against S. aureus clumping factor a (ClfA) |
| CA3115633A1 (en) | 2018-10-09 | 2020-04-16 | Medimmune, Llc | Combinations of anti-staphylococcus aureus antibodies |
| MX2021004114A (es) | 2018-10-09 | 2021-07-16 | Medimmune Llc | Anticuerpos dirigidos contra leucotoxinas de staphylococcus aureus. |
| US12459991B2 (en) | 2019-02-12 | 2025-11-04 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for using bispecific antibodies to bind complement and a target antigen |
| EP3938388A1 (en) | 2019-03-13 | 2022-01-19 | MedImmune, LLC | Decreasings staphylococcus aureus infections in colonized patients |
| WO2020210650A1 (en) | 2019-04-12 | 2020-10-15 | Medimmune, Llc | Neutralization of tgf-beta or alpha-v-beta-8 integrin for s. aureus infections |
| CN112538112B (zh) * | 2019-09-20 | 2023-10-27 | 迈威(上海)生物科技股份有限公司 | 抗α-溶血素的抗体及其应用 |
| KR102397684B1 (ko) * | 2019-12-09 | 2022-05-13 | (주)옵토레인 | 항체의 항원 결합 부위에 결합하는 펩티드 및 이를 이용한 분석 방법 |
| KR102504175B1 (ko) * | 2020-06-17 | 2023-02-28 | (주)옵토레인 | 항체의 항원 결합 부위에 결합하는 펩타이드, 이를 이용한 약물 복합체, 바이오센서 및 분석 방법 |
| KR102674098B1 (ko) * | 2021-01-14 | 2024-06-12 | (주)옵토레인 | 스위칭 펩티드 및 이를 이용한 멀티플렉스 면역분석 방법 |
| KR102674109B1 (ko) * | 2021-01-14 | 2024-06-12 | (주)옵토레인 | 스위칭 펩티드, 이를 포함하는 면역분석 장치 및 이를 이용한 면역분석 방법 |
| KR102674120B1 (ko) * | 2021-01-18 | 2024-06-12 | (주)옵토레인 | 스위칭 펩티드 및 이를 이용한 면역분석 방법 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2017198A (en) * | 1931-10-17 | 1935-10-15 | Anglada Motor Corp | Cuff valve engine |
| US20030044772A1 (en) * | 1997-08-04 | 2003-03-06 | Applied Molecular Evolution [Formerly Ixsys] | Methods for identifying ligand specific binding molecules |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7396917B2 (en) * | 2000-12-05 | 2008-07-08 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
| US7214786B2 (en) * | 2000-12-14 | 2007-05-08 | Kovalic David K | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| AT410798B (de) * | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
| ATE524195T1 (de) * | 2001-01-26 | 2011-09-15 | Inhibitex Inc | Monoklonale antikörper gegen das clfa-protein und verfahren zur verwendung bei der behandlung bzw. pr vention von infektionen |
| EP1638514A4 (en) | 2003-06-06 | 2009-11-18 | Medimmune Inc | USE OF EPHA4 AND MODULATOR OR EPHA4 FOR THE DIAGNOSIS, TREATMENT AND PREVENTION OF CANCER |
| WO2005019267A2 (en) * | 2003-08-12 | 2005-03-03 | Dyax Corp. | Tie1-binding ligands |
| JP2008515774A (ja) * | 2004-08-03 | 2008-05-15 | ダイアックス コーポレイション | ｈＫ１結合タンパク質 |
| US20080050361A1 (en) | 2004-10-25 | 2008-02-28 | Heinrichs David E | Staphylococcus aureas specific anti-infectives |
| CA2638833A1 (en) * | 2006-03-06 | 2007-09-13 | Symphogen A/S | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
| US7910703B2 (en) * | 2006-03-10 | 2011-03-22 | Zymogenetics, Inc. | Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use |
| EP2719397A1 (en) * | 2006-06-12 | 2014-04-16 | GlaxoSmithKline Biologicals SA | Use of alpha-toxin for treating and preventing staphylococcus infections |
| CA2667788A1 (en) * | 2006-10-30 | 2008-12-18 | The University Of Western Ontario | Staphylococcus aureus specific anti-infectives |
| US9526774B1 (en) * | 2006-11-06 | 2016-12-27 | Microvax, Llc | Methods and compositions for suppressing virulence of methicillin resistant Staphylococcus aureus |
| HRP20161305T1 (hr) * | 2008-01-31 | 2017-01-27 | The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen | Liječenje mikrobnih infekcija |
| WO2009140236A2 (en) * | 2008-05-12 | 2009-11-19 | Strox Biopharmaceuticals, Llc | Staphylococcus aureus-specific antibody preparations |
| WO2010005513A2 (en) * | 2008-06-30 | 2010-01-14 | The Texas A&M University System | Crystal structure of staphylococcus aureus clumping factor a in complex with fibrinogen derived peptide and uses thereof |
| EP2341929B1 (en) * | 2008-10-06 | 2017-01-25 | University Of Chicago | Compositions and methods related to bacterial emp proteins |
| EP2432499A2 (en) * | 2009-05-20 | 2012-03-28 | Schering Corporation | Modulation of pilr receptors to treat microbial infections |
| CN102481352A (zh) * | 2009-06-22 | 2012-05-30 | 惠氏有限责任公司 | 金黄色葡萄球菌抗原的免疫原性组合物 |
| DK2454284T3 (en) * | 2009-07-15 | 2018-07-02 | Aimm Therapeutics Bv | GRAM POSITIVE BACTERIA-SPECIFIC BINDING COMPOUNDS |
| GB0913680D0 (en) * | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| EP2284193A1 (en) * | 2009-08-10 | 2011-02-16 | Kenta Biotech AG | Human monoclonal antibody against S. aureus derived apha-toxin and its use in treating or preventing abscess formation |
| EP2516467A2 (en) * | 2009-12-23 | 2012-10-31 | Emergent Product Development Seattle, LLC | Compositions comprising tnf-alpha and il-6 antagonists and methods of use thereof |
| JP2013523818A (ja) * | 2010-04-05 | 2013-06-17 | ザ・ユニバーシティー・オブ・シカゴ | 免疫反応のエンハンサーとしてのプロテインＡ（ＳｐＡ）抗体に関連する組成物および方法 |
| US9095540B2 (en) * | 2010-09-09 | 2015-08-04 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens |
| US20120202047A1 (en) | 2011-02-07 | 2012-08-09 | Baker Hughes Incorporated | Nano-coatings for articles |
| CA2826566C (en) * | 2011-02-08 | 2022-09-13 | Medimmune, Llc | Antibodies that specifically bind staphylococcus aureus alpha toxin and methods of use |
| US9556281B2 (en) * | 2011-08-15 | 2017-01-31 | The University Of Chicago | Compositions and methods related to antibodies to staphylococcal protein A |
| RS60499B1 (sr) * | 2011-12-20 | 2020-08-31 | Medimmune Llc | Modifikovani polipeptidi za bispecifične skelete antitela |
| PL2844275T3 (pl) * | 2012-04-26 | 2021-03-08 | University Of Chicago | Koagulazy gronkowcowe stanowiące antygeny i sposoby ich zastosowania |
| AU2013341421A1 (en) * | 2012-11-06 | 2015-06-04 | Medimmune, Llc | Methods of treating S. aureus-associated diseases |
| CN109553681A (zh) * | 2012-11-06 | 2019-04-02 | 米迪缪尼有限公司 | 金黄色葡萄球菌表面决定簇的抗体 |
| CA2898472C (en) * | 2013-02-15 | 2023-03-07 | Immunomedics, Inc. | Chimeric and humanized anti-histone antibodies |
| CA2952930A1 (en) * | 2013-10-15 | 2015-04-23 | The Texas A&M University System | Compositions and the use of a fibrinogn binding motif presence in efb and coa for vaccine against staphylococcus aureus and drug delivery |
| US20170023569A1 (en) * | 2014-01-10 | 2017-01-26 | University Of Rochester | Diagnostic device and method for detection of staphylococcus infection |
| WO2015112895A2 (en) * | 2014-01-24 | 2015-07-30 | Church William R | Antibody specific to staphylococcus aureus, therapeutic method and detection method using same |
| KR20210047355A (ko) * | 2014-06-03 | 2021-04-29 | 엑스바이오테크 인코포레이티드 | 스타필로코커스 아우레우스 감염의 치료 및 예방을 위한 조성물 및 방법 |
| TWI719938B (zh) * | 2014-06-19 | 2021-03-01 | 美商麥迪紐有限責任公司 | 多重細菌感染之治療 |
| WO2016073860A1 (en) * | 2014-11-06 | 2016-05-12 | Medimmune, Llc | Binding molecules specific for staphylococcus protein a and uses thereof |
| MX2017012775A (es) | 2015-04-17 | 2019-04-29 | Arsanis Biosciences Gmbh | Preparacion combinatoria de anticuerpos anti-staphylococcus aureus. |
| WO2017075188A2 (en) * | 2015-10-30 | 2017-05-04 | Medimmune, Llc | Methods of using anti-alpha toxin antibody |
| WO2017186928A1 (en) * | 2016-04-29 | 2017-11-02 | Curevac Ag | Rna encoding an antibody |
| CA3030154A1 (en) * | 2016-07-08 | 2018-01-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric dengue/zika viruses live-attenuated zika virus vaccines |
| US11155606B2 (en) * | 2018-07-24 | 2021-10-26 | Medimmune, Llc | Antibody directed against S. aureus clumping factor a (ClfA) |
| CA3115633A1 (en) * | 2018-10-09 | 2020-04-16 | Medimmune, Llc | Combinations of anti-staphylococcus aureus antibodies |
| MX2021004114A (es) * | 2018-10-09 | 2021-07-16 | Medimmune Llc | Anticuerpos dirigidos contra leucotoxinas de staphylococcus aureus. |
| EP3938388A1 (en) * | 2019-03-13 | 2022-01-19 | MedImmune, LLC | Decreasings staphylococcus aureus infections in colonized patients |
-
2013
- 2013-11-06 CN CN201811621407.0A patent/CN109553681A/zh active Pending
- 2013-11-06 SG SG11201503232TA patent/SG11201503232TA/en unknown
- 2013-11-06 CN CN201380057603.9A patent/CN104968797B/zh active Active
- 2013-11-06 PL PL13852597T patent/PL2917360T3/pl unknown
- 2013-11-06 WO PCT/US2013/068624 patent/WO2014074540A2/en not_active Ceased
- 2013-11-06 KR KR1020157014912A patent/KR102288394B1/ko active Active
- 2013-11-06 EP EP19211610.1A patent/EP3640338A1/en active Pending
- 2013-11-06 AU AU2013341361A patent/AU2013341361A1/en not_active Abandoned
- 2013-11-06 RU RU2015121624A patent/RU2698131C2/ru active
- 2013-11-06 SG SG10201703678TA patent/SG10201703678TA/en unknown
- 2013-11-06 JP JP2015540879A patent/JP6694269B2/ja active Active
- 2013-11-06 HU HUE13852597A patent/HUE049012T2/hu unknown
- 2013-11-06 BR BR112015010125A patent/BR112015010125A2/pt not_active Application Discontinuation
- 2013-11-06 CA CA2890427A patent/CA2890427C/en active Active
- 2013-11-06 DK DK13852597.7T patent/DK2917360T3/da active
- 2013-11-06 US US14/440,748 patent/US9879070B2/en active Active
- 2013-11-06 ES ES13852597T patent/ES2776179T3/es active Active
- 2013-11-06 MX MX2015005477A patent/MX375324B/es active IP Right Grant
- 2013-11-06 EP EP13852597.7A patent/EP2917360B1/en active Active
-
2015
- 2015-04-29 MX MX2022008079A patent/MX2022008079A/es unknown
-
2018
- 2018-01-25 US US15/880,157 patent/US10730934B2/en active Active
- 2018-10-04 AU AU2018241107A patent/AU2018241107B2/en active Active
-
2019
- 2019-01-25 JP JP2019011283A patent/JP2019089801A/ja not_active Withdrawn
-
2020
- 2020-07-09 US US16/925,129 patent/US11447543B2/en active Active
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