JP2016506966A5 - - Google Patents
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- Publication number
- JP2016506966A5 JP2016506966A5 JP2015556155A JP2015556155A JP2016506966A5 JP 2016506966 A5 JP2016506966 A5 JP 2016506966A5 JP 2015556155 A JP2015556155 A JP 2015556155A JP 2015556155 A JP2015556155 A JP 2015556155A JP 2016506966 A5 JP2016506966 A5 JP 2016506966A5
- Authority
- JP
- Japan
- Prior art keywords
- ophthalmic solution
- solution according
- improvement
- patient
- ophthalmic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002997 ophthalmic solution Substances 0.000 claims 93
- 229940054534 ophthalmic solution Drugs 0.000 claims 93
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 18
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 18
- -1 polyol compound Chemical class 0.000 claims 17
- 229920005862 polyol Polymers 0.000 claims 13
- 210000001747 pupil Anatomy 0.000 claims 11
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 10
- 229930195725 Mannitol Natural products 0.000 claims 10
- 239000000594 mannitol Substances 0.000 claims 10
- 235000010355 mannitol Nutrition 0.000 claims 10
- PPWLAQVKIFDULF-UHFFFAOYSA-N 2-phenyl-1h-pyrrolo[2,3-b]pyridine Chemical compound N1C2=NC=CC=C2C=C1C1=CC=CC=C1 PPWLAQVKIFDULF-UHFFFAOYSA-N 0.000 claims 9
- 229960003056 phentolamine mesylate Drugs 0.000 claims 9
- 230000004382 visual function Effects 0.000 claims 9
- 239000002738 chelating agent Substances 0.000 claims 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 7
- 229960001999 phentolamine Drugs 0.000 claims 6
- MRBDMNSDAVCSSF-UHFFFAOYSA-N phentolamine Chemical compound C1=CC(C)=CC=C1N(C=1C=C(O)C=CC=1)CC1=NCCN1 MRBDMNSDAVCSSF-UHFFFAOYSA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims 5
- 229910052783 alkali metal Inorganic materials 0.000 claims 5
- 239000001913 cellulose Substances 0.000 claims 5
- 229920002678 cellulose Polymers 0.000 claims 5
- 235000010980 cellulose Nutrition 0.000 claims 5
- 239000001632 sodium acetate Substances 0.000 claims 5
- 235000017281 sodium acetate Nutrition 0.000 claims 5
- 230000004304 visual acuity Effects 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 239000006172 buffering agent Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 230000035945 sensitivity Effects 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 229920002307 Dextran Polymers 0.000 claims 3
- 239000000872 buffer Substances 0.000 claims 2
- 230000004300 dark adaptation Effects 0.000 claims 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 241000220317 Rosa Species 0.000 claims 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 229940012356 eye drops Drugs 0.000 claims 1
- 230000004438 eyesight Effects 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 1
- 239000003961 penetration enhancing agent Substances 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000008181 tonicity modifier Substances 0.000 claims 1
- 239000004034 viscosity adjusting agent Substances 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
- 229960002675 xylitol Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361759530P | 2013-02-01 | 2013-02-01 | |
| US61/759,530 | 2013-02-01 | ||
| PCT/US2014/014067 WO2014121027A1 (en) | 2013-02-01 | 2014-01-31 | Aqueous ophthalmic solutions of phentolamine and medical uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016506966A JP2016506966A (ja) | 2016-03-07 |
| JP2016506966A5 true JP2016506966A5 (enExample) | 2017-03-02 |
| JP6335927B2 JP6335927B2 (ja) | 2018-05-30 |
Family
ID=51259735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556155A Active JP6335927B2 (ja) | 2013-02-01 | 2014-01-31 | フェントラミンの水性点眼液およびそれらの医学的用途 |
Country Status (9)
| Country | Link |
|---|---|
| US (9) | US9795560B2 (enExample) |
| EP (1) | EP2950648B1 (enExample) |
| JP (1) | JP6335927B2 (enExample) |
| AU (2) | AU2014212274A1 (enExample) |
| CA (1) | CA2899339C (enExample) |
| DK (1) | DK2950648T3 (enExample) |
| ES (1) | ES2762153T3 (enExample) |
| PT (1) | PT2950648T (enExample) |
| WO (1) | WO2014121027A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2950800B1 (en) * | 2013-02-01 | 2020-09-09 | Ocuphire Pharma, Inc. | Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance |
| CA2899339C (en) | 2013-02-01 | 2021-07-06 | Ocularis Pharma, Llc | Aqueous ophthalmic solutions of phentolamine and medical uses thereof |
| KR102478553B1 (ko) * | 2018-02-28 | 2022-12-16 | 한림제약(주) | 벤조피란 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 용액 형태의 점안제 |
| KR20210005134A (ko) | 2018-04-24 | 2021-01-13 | 알러간, 인코포레이티드 | 안구 증상의 치료를 위한 필로카르핀 염산염의 용도 |
| CN113164451A (zh) | 2018-10-15 | 2021-07-23 | 奥库菲尔制药股份有限公司 | 治疗青光眼的方法和组合物及相关病症 |
| EP3870170A4 (en) | 2018-10-26 | 2022-07-20 | Ocuphire Pharma, Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PRESBYOPIA, MYDRIASIS AND OTHER EYE DISEASES |
| CN115368310B (zh) | 2021-05-18 | 2025-06-27 | 奥库菲尔医药公司 | 合成甲磺酸酚妥拉明的方法 |
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| EP2950800B1 (en) | 2013-02-01 | 2020-09-09 | Ocuphire Pharma, Inc. | Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance |
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-
2014
- 2014-01-31 CA CA2899339A patent/CA2899339C/en active Active
- 2014-01-31 AU AU2014212274A patent/AU2014212274A1/en not_active Abandoned
- 2014-01-31 WO PCT/US2014/014067 patent/WO2014121027A1/en not_active Ceased
- 2014-01-31 DK DK14746208T patent/DK2950648T3/da active
- 2014-01-31 US US14/169,339 patent/US9795560B2/en active Active
- 2014-01-31 PT PT147462089T patent/PT2950648T/pt unknown
- 2014-01-31 EP EP14746208.9A patent/EP2950648B1/en active Active
- 2014-01-31 ES ES14746208T patent/ES2762153T3/es active Active
- 2014-01-31 JP JP2015556155A patent/JP6335927B2/ja active Active
-
2017
- 2017-10-13 US US15/783,160 patent/US10278918B2/en active Active
-
2018
- 2018-01-24 AU AU2018200566A patent/AU2018200566B9/en active Active
-
2019
- 2019-04-30 US US16/398,536 patent/US11090261B2/en active Active
- 2019-04-30 US US16/398,687 patent/US10772829B2/en active Active
-
2021
- 2021-08-13 US US17/401,604 patent/US11844858B2/en active Active
-
2023
- 2023-12-13 US US18/538,502 patent/US12350366B2/en active Active
-
2025
- 2025-04-25 US US19/190,263 patent/US20250248931A1/en active Pending
- 2025-04-25 US US19/190,199 patent/US20250248930A1/en active Pending
- 2025-04-25 US US19/190,234 patent/US20250262149A1/en active Pending
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