JP6335927B2 - フェントラミンの水性点眼液およびそれらの医学的用途 - Google Patents

フェントラミンの水性点眼液およびそれらの医学的用途 Download PDF

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Publication number
JP6335927B2
JP6335927B2 JP2015556155A JP2015556155A JP6335927B2 JP 6335927 B2 JP6335927 B2 JP 6335927B2 JP 2015556155 A JP2015556155 A JP 2015556155A JP 2015556155 A JP2015556155 A JP 2015556155A JP 6335927 B2 JP6335927 B2 JP 6335927B2
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ophthalmic solution
mannitol
solution according
phentolamine
patient
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JP2016506966A (ja
JP2016506966A5 (enExample
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アラン・マイヤー
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Ocularis Pharma LLC
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Ocularis Pharma LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015556155A 2013-02-01 2014-01-31 フェントラミンの水性点眼液およびそれらの医学的用途 Active JP6335927B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361759530P 2013-02-01 2013-02-01
US61/759,530 2013-02-01
PCT/US2014/014067 WO2014121027A1 (en) 2013-02-01 2014-01-31 Aqueous ophthalmic solutions of phentolamine and medical uses thereof

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JP2016506966A JP2016506966A (ja) 2016-03-07
JP2016506966A5 JP2016506966A5 (enExample) 2017-03-02
JP6335927B2 true JP6335927B2 (ja) 2018-05-30

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US (9) US9795560B2 (enExample)
EP (1) EP2950648B1 (enExample)
JP (1) JP6335927B2 (enExample)
AU (2) AU2014212274A1 (enExample)
CA (1) CA2899339C (enExample)
DK (1) DK2950648T3 (enExample)
ES (1) ES2762153T3 (enExample)
PT (1) PT2950648T (enExample)
WO (1) WO2014121027A1 (enExample)

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KR102478553B1 (ko) * 2018-02-28 2022-12-16 한림제약(주) 벤조피란 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 용액 형태의 점안제
KR20210005134A (ko) 2018-04-24 2021-01-13 알러간, 인코포레이티드 안구 증상의 치료를 위한 필로카르핀 염산염의 용도
CN113164451A (zh) 2018-10-15 2021-07-23 奥库菲尔制药股份有限公司 治疗青光眼的方法和组合物及相关病症
EP3870170A4 (en) 2018-10-26 2022-07-20 Ocuphire Pharma, Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF PRESBYOPIA, MYDRIASIS AND OTHER EYE DISEASES
CN115368310B (zh) 2021-05-18 2025-06-27 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法

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Publication number Publication date
AU2018200566A1 (en) 2018-02-15
US20180221274A1 (en) 2018-08-09
US20140221445A1 (en) 2014-08-07
US12350366B2 (en) 2025-07-08
US11844858B2 (en) 2023-12-19
WO2014121027A1 (en) 2014-08-07
DK2950648T3 (da) 2019-12-02
EP2950648B1 (en) 2019-09-18
PT2950648T (pt) 2020-01-06
US9795560B2 (en) 2017-10-24
US10278918B2 (en) 2019-05-07
US20220175668A1 (en) 2022-06-09
AU2018200566B9 (en) 2019-06-20
CA2899339A1 (en) 2014-08-07
US20240285519A1 (en) 2024-08-29
US11090261B2 (en) 2021-08-17
JP2016506966A (ja) 2016-03-07
AU2018200566B2 (en) 2019-06-13
US20250248930A1 (en) 2025-08-07
EP2950648A1 (en) 2015-12-09
CA2899339C (en) 2021-07-06
US10772829B2 (en) 2020-09-15
US20190254963A1 (en) 2019-08-22
US20250262149A1 (en) 2025-08-21
ES2762153T3 (es) 2020-05-22
EP2950648A4 (en) 2016-07-20
AU2014212274A1 (en) 2015-08-13
US20250248931A1 (en) 2025-08-07
US20190358152A1 (en) 2019-11-28

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