JP2016506761A5 - - Google Patents
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- JP2016506761A5 JP2016506761A5 JP2015558224A JP2015558224A JP2016506761A5 JP 2016506761 A5 JP2016506761 A5 JP 2016506761A5 JP 2015558224 A JP2015558224 A JP 2015558224A JP 2015558224 A JP2015558224 A JP 2015558224A JP 2016506761 A5 JP2016506761 A5 JP 2016506761A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- polypeptide
- mouse
- mhc
- chimeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 121
- 229920001184 polypeptide Polymers 0.000 claims description 117
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 117
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims description 39
- 239000002773 nucleotide Substances 0.000 claims description 37
- 125000003729 nucleotide group Chemical group 0.000 claims description 37
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims description 31
- 241001465754 Metazoa Species 0.000 claims description 19
- 230000001086 cytosolic effect Effects 0.000 claims description 19
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 claims description 17
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 13
- 230000001105 regulatory effect Effects 0.000 claims description 8
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 241000283984 Rodentia Species 0.000 claims description 3
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims description 3
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims description 3
- 210000004602 germ cell Anatomy 0.000 claims description 3
- 150000007523 nucleic acids Chemical group 0.000 claims 12
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 11
- 241001529936 Murinae Species 0.000 claims 2
- 108700039855 mouse a Proteins 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 70
- 241000699670 Mus sp. Species 0.000 description 4
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 3
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 description 1
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361766762P | 2013-02-20 | 2013-02-20 | |
| US61/766,762 | 2013-02-20 | ||
| US201361890915P | 2013-10-15 | 2013-10-15 | |
| US61/890,915 | 2013-10-15 | ||
| PCT/US2014/017395 WO2014130671A1 (en) | 2013-02-20 | 2014-02-20 | Mice expressing humanized t-cell co-receptors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018100545A Division JP6752842B2 (ja) | 2013-02-20 | 2018-05-25 | ヒト化ｔ細胞補助受容体を発現するマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016506761A JP2016506761A (ja) | 2016-03-07 |
| JP2016506761A5 true JP2016506761A5 (enExample) | 2017-03-23 |
| JP6444895B2 JP6444895B2 (ja) | 2018-12-26 |
Family
ID=50236327
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015558224A Active JP6444895B2 (ja) | 2013-02-20 | 2014-02-20 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2018100545A Active JP6752842B2 (ja) | 2013-02-20 | 2018-05-25 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2020138641A Active JP7261772B2 (ja) | 2013-02-20 | 2020-08-19 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2022094953A Pending JP2022121465A (ja) | 2013-02-20 | 2022-06-13 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2023191033A Pending JP2023184695A (ja) | 2013-02-20 | 2023-11-08 | ヒト化ｔ細胞補助受容体を発現するマウス |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018100545A Active JP6752842B2 (ja) | 2013-02-20 | 2018-05-25 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2020138641A Active JP7261772B2 (ja) | 2013-02-20 | 2020-08-19 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2022094953A Pending JP2022121465A (ja) | 2013-02-20 | 2022-06-13 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2023191033A Pending JP2023184695A (ja) | 2013-02-20 | 2023-11-08 | ヒト化ｔ細胞補助受容体を発現するマウス |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9848587B2 (enExample) |
| EP (3) | EP2958938B1 (enExample) |
| JP (5) | JP6444895B2 (enExample) |
| KR (5) | KR102714111B1 (enExample) |
| CN (2) | CN105164153B (enExample) |
| AU (4) | AU2014218897C1 (enExample) |
| CA (1) | CA2900832A1 (enExample) |
| CY (1) | CY1121979T1 (enExample) |
| DK (1) | DK2958938T3 (enExample) |
| ES (2) | ES2987445T3 (enExample) |
| HR (1) | HRP20191280T1 (enExample) |
| HU (1) | HUE045478T2 (enExample) |
| LT (1) | LT2958938T (enExample) |
| PL (1) | PL2958938T3 (enExample) |
| PT (1) | PT2958938T (enExample) |
| RS (1) | RS58962B1 (enExample) |
| SI (1) | SI2958938T1 (enExample) |
| SM (1) | SMT201900429T1 (enExample) |
| WO (1) | WO2014130671A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| US9043996B2 (en) | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| SG10201510056SA (en) | 2011-10-28 | 2016-01-28 | Regeneron Pharma | Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules |
| KR102295746B1 (ko) | 2011-10-28 | 2021-09-01 | 리제너론 파아마슈티컬스, 인크. | 유전자 변형된 주요 조직적합성 복합체 마우스 |
| CA2900832A1 (en) * | 2013-02-20 | 2014-08-28 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized t-cell co-receptors |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| JP6444321B2 (ja) | 2013-02-22 | 2018-12-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
| SMT202500280T1 (it) | 2013-09-23 | 2025-09-12 | Regeneron Pharma | Animali non umani aventi un gene umanizzato della proteina regolatrice del segnale |
| EP3071024B1 (en) | 2013-11-19 | 2018-09-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| SMT202000332T1 (it) | 2014-04-08 | 2020-07-08 | Regeneron Pharma | Animali non umani aventi recettori fc-gamma umanizzati |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| DK3157956T3 (da) | 2014-06-19 | 2020-04-27 | Regeneron Pharma | Ikke-humane dyr med et humaniseret gen med programmeret celledød 1 |
| KR20170083534A (ko) | 2014-09-19 | 2017-07-18 | 리제너론 파마슈티칼스 인코포레이티드 | 키메라 항원 수용체 |
| BR112017010793A2 (pt) * | 2014-11-24 | 2017-12-26 | Regeneron Pharma | animal não humano geneticamente modificado, camundongo, métodos para produzir um animal não humano geneticamente modificado e de triagem de candidatos a fármaco direcionados a um antígeno de interesse, e, modelo de camundongo. |
| ES2969389T3 (es) | 2014-12-05 | 2024-05-17 | Regeneron Pharma | Animales no humanos que tienen un gen del grupo de diferenciación 47 humanizado |
| EP4399969A3 (en) * | 2014-12-09 | 2024-10-30 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 274 gene |
| AU2016246698B2 (en) * | 2015-04-06 | 2022-06-02 | Regeneron Pharmaceuticals, Inc. | Humanized T cell mediated immune responses in non-human animals |
| MA44907A (fr) * | 2015-09-11 | 2018-07-18 | Agenus Inc | Cellules hôtes génétiquement modifiées et leurs procédés d'utilisation |
| PT3376857T (pt) | 2015-11-20 | 2021-05-27 | Regeneron Pharma | Animais não humanos com um gene humanizado 3 de ativação de linfócitos |
| CA3014645C (en) | 2016-02-29 | 2022-10-25 | Regeneron Pharmaceuticals, Inc. | Rodents having a humanized tmprss gene |
| WO2017150763A1 (ko) * | 2016-02-29 | 2017-09-08 | (주)메디톡스 | 인간 cd3 발현 동물모델 및 이의 용도 |
| IL263160B2 (en) | 2016-06-03 | 2024-01-01 | Regeneron Pharma | Non-human animals expressing exogenous terminal deoxynucleotidyltransferase |
| JP7361031B2 (ja) | 2017-11-30 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
| KR20250121150A (ko) | 2018-03-26 | 2025-08-11 | 리제너론 파마슈티칼스 인코포레이티드 | 치료제를 시험하기 위한 인간화된 설치류 |
| JP7529265B2 (ja) * | 2018-04-19 | 2024-08-06 | ベイラー カレッジ オブ メディスン | ＣＤ８ａｂおよびクラス１制限Ｔ細胞受容体の強制発現による細胞傷害性ＣＤ８細胞へのＣＤ４ Ｔ細胞の再プログラミング |
| HUE067361T2 (hu) | 2018-07-16 | 2024-10-28 | Regeneron Pharma | Ditra betegség rágcsáló modelljei és alkalmazásaik |
| US12234473B2 (en) | 2020-12-31 | 2025-02-25 | Immatics US, Inc. | CD8 polypeptides, compositions, and methods of using thereof |
| IL307238A (en) | 2021-03-31 | 2023-11-01 | Regeneron Pharma | Transgenic mice containing human components of the cellular immune system with an enhanced diversity of the TCRB repertoire |
| EP4590120A1 (en) | 2022-09-22 | 2025-07-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice expressing components of human cellular immune system |
| TW202520975A (zh) | 2023-08-09 | 2025-06-01 | 英商劍橋企業有限公司 | 基因改造之囓齒動物及囓齒動物細胞以及其等用途 |
| GB202405657D0 (en) | 2024-04-22 | 2024-06-05 | T Therapeutics Ltd | T cell receptor identification and provision |
| GB2640828A (en) | 2024-04-22 | 2025-11-12 | T Therapeutics Ltd | Methods and products for the generation and identification of T cells and TCRs |
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| US5958678A (en) * | 1986-08-21 | 1999-09-28 | The Trustees Of Columbia University In The City Of New York | DNA encoding the T cell surface protein T4 and use of fragments of T4 in the treatment of AIDS |
| US5574205A (en) | 1989-07-25 | 1996-11-12 | Cell Genesys | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| DE69033493D1 (de) | 1989-07-25 | 2004-08-12 | Cell Genesys Inc | Homologe rekombination für universelle donorzellen und chimerische säugetierzellen |
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| LT2346994T (lt) * | 2008-09-30 | 2022-03-10 | Ablexis, Llc | Knock-in pelė, skirta chimerinių antikūnų gamybai |
| US9277999B2 (en) * | 2009-02-27 | 2016-03-08 | University of Pittsburgh—of the Commonwealth System of Higher Education | Joint bioscaffolds |
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| SMT201900372T1 (it) * | 2010-02-08 | 2019-09-09 | Regeneron Pharma | Topo con catena leggera comune |
| US9185889B2 (en) * | 2010-02-15 | 2015-11-17 | Indiana University Research And Technology Corporation | CD4 T-cells and CD8zeta cells involved in mammalian host response to epithelial cell infections and uses thereof |
| CN105218674A (zh) | 2010-03-11 | 2016-01-06 | 瑞纳神经科学公司 | 呈pH依赖性抗原结合的抗体 |
| WO2012039779A1 (en) | 2010-09-24 | 2012-03-29 | The United States Of America As Represented By The Secretary Of The Navy | Humanized transgenic mouse model |
| SG10201510056SA (en) | 2011-10-28 | 2016-01-28 | Regeneron Pharma | Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules |
| US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| US9043996B2 (en) | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| KR102295746B1 (ko) | 2011-10-28 | 2021-09-01 | 리제너론 파아마슈티컬스, 인크. | 유전자 변형된 주요 조직적합성 복합체 마우스 |
| RU2751240C2 (ru) | 2011-10-28 | 2021-07-12 | Регенерон Фармасьютикалс, Инк. | Гуманизированные il-6 и рецептор il-6 |
| ES2748662T3 (es) | 2012-11-05 | 2020-03-17 | Institute For Res In Biomedicine Irb | Roedores inmunodeficientes modificados genéticamente y métodos de uso de los mismos |
| CA2900832A1 (en) * | 2013-02-20 | 2014-08-28 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized t-cell co-receptors |
| JP6444321B2 (ja) | 2013-02-22 | 2018-12-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| WO2014164640A1 (en) | 2013-03-11 | 2014-10-09 | Regeneron Pharmaceuticals, Inc. | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class i molecules |
| AU2014249148B2 (en) | 2013-03-11 | 2020-04-02 | Regeneron Pharmaceuticals, Inc. | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules |
| AU2016246698B2 (en) | 2015-04-06 | 2022-06-02 | Regeneron Pharmaceuticals, Inc. | Humanized T cell mediated immune responses in non-human animals |
| JP7172900B2 (ja) * | 2019-07-26 | 2022-11-16 | 株式会社デンソー | 走行中給電システム |
-
2014
- 2014-02-20 CA CA2900832A patent/CA2900832A1/en active Pending
- 2014-02-20 EP EP14708430.5A patent/EP2958938B1/en active Active
- 2014-02-20 SM SM20190429T patent/SMT201900429T1/it unknown
- 2014-02-20 KR KR1020237031201A patent/KR102714111B1/ko active Active
- 2014-02-20 KR KR1020227006387A patent/KR102579405B1/ko active Active
- 2014-02-20 CN CN201480021698.3A patent/CN105164153B/zh active Active
- 2014-02-20 JP JP2015558224A patent/JP6444895B2/ja active Active
- 2014-02-20 PT PT14708430T patent/PT2958938T/pt unknown
- 2014-02-20 DK DK14708430.5T patent/DK2958938T3/da active
- 2014-02-20 KR KR1020157025675A patent/KR102313047B1/ko active Active
- 2014-02-20 LT LTEP14708430.5T patent/LT2958938T/lt unknown
- 2014-02-20 CN CN202010208901.5A patent/CN111484999B/zh active Active
- 2014-02-20 KR KR1020247032785A patent/KR20240147707A/ko active Pending
- 2014-02-20 HR HRP20191280TT patent/HRP20191280T1/hr unknown
- 2014-02-20 HU HUE14708430A patent/HUE045478T2/hu unknown
- 2014-02-20 AU AU2014218897A patent/AU2014218897C1/en active Active
- 2014-02-20 ES ES19159217T patent/ES2987445T3/es active Active
- 2014-02-20 SI SI201431279T patent/SI2958938T1/sl unknown
- 2014-02-20 KR KR1020217032326A patent/KR102369454B1/ko active Active
- 2014-02-20 US US14/185,301 patent/US9848587B2/en active Active
- 2014-02-20 WO PCT/US2014/017395 patent/WO2014130671A1/en not_active Ceased
- 2014-02-20 PL PL14708430T patent/PL2958938T3/pl unknown
- 2014-02-20 ES ES14708430T patent/ES2736052T3/es active Active
- 2014-02-20 EP EP19159217.9A patent/EP3543253B1/en active Active
- 2014-02-20 RS RS20190870A patent/RS58962B1/sr unknown
- 2014-02-20 EP EP24155637.2A patent/EP4374690A3/en active Pending
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2017
- 2017-10-06 US US15/727,057 patent/US10820581B2/en active Active
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2018
- 2018-05-25 JP JP2018100545A patent/JP6752842B2/ja active Active
- 2018-11-30 AU AU2018271383A patent/AU2018271383B2/en active Active
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2019
- 2019-07-12 CY CY20191100749T patent/CY1121979T1/el unknown
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2020
- 2020-08-19 JP JP2020138641A patent/JP7261772B2/ja active Active
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2021
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2022
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2023
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2024
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2025
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