JP2016505623A5 - - Google Patents
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- JP2016505623A5 JP2016505623A5 JP2015551855A JP2015551855A JP2016505623A5 JP 2016505623 A5 JP2016505623 A5 JP 2016505623A5 JP 2015551855 A JP2015551855 A JP 2015551855A JP 2015551855 A JP2015551855 A JP 2015551855A JP 2016505623 A5 JP2016505623 A5 JP 2016505623A5
- Authority
- JP
- Japan
- Prior art keywords
- msc
- pharmaceutical composition
- prostacyclin
- composition according
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361750458P | 2013-01-09 | 2013-01-09 | |
| US61/750,458 | 2013-01-09 | ||
| PCT/US2014/010623 WO2014110094A1 (en) | 2013-01-09 | 2014-01-08 | Treatment of vasculopathy with prostacyclin and mesenchymal stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018207899A Division JP6709834B2 (ja) | 2013-01-09 | 2018-11-05 | プロスタサイクリンおよび間葉系幹細胞による脈管障害の処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505623A JP2016505623A (ja) | 2016-02-25 |
| JP2016505623A5 true JP2016505623A5 (https=) | 2017-02-09 |
| JP6431850B2 JP6431850B2 (ja) | 2018-11-28 |
Family
ID=51061108
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015551855A Active JP6431850B2 (ja) | 2013-01-09 | 2014-01-08 | プロスタサイクリンおよび間葉系幹細胞による脈管障害の処置 |
| JP2018207899A Active JP6709834B2 (ja) | 2013-01-09 | 2018-11-05 | プロスタサイクリンおよび間葉系幹細胞による脈管障害の処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018207899A Active JP6709834B2 (ja) | 2013-01-09 | 2018-11-05 | プロスタサイクリンおよび間葉系幹細胞による脈管障害の処置 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10080730B2 (https=) |
| EP (3) | EP2943069B1 (https=) |
| JP (2) | JP6431850B2 (https=) |
| KR (2) | KR102466885B1 (https=) |
| CN (1) | CN105025720B (https=) |
| AU (3) | AU2014205557B2 (https=) |
| CA (1) | CA2897805C (https=) |
| ES (3) | ES2963968T3 (https=) |
| IL (2) | IL239603A (https=) |
| WO (1) | WO2014110094A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2713988T3 (es) * | 2012-08-01 | 2019-05-24 | United Therapeutics Corp | Tratamiento de hipertensión arterial pulmonar con células progenitoras endoteliales tratadas con prostaciclina |
| EP2879682B1 (en) | 2012-08-01 | 2018-03-21 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension with mesenchymal stem cells |
| CN105358163B (zh) * | 2012-12-12 | 2020-09-11 | 麦瑟布莱斯特公司 | 内皮功能障碍和炎症的疾病的治疗 |
| EP2943069B1 (en) | 2013-01-09 | 2018-08-15 | United Therapeutics Corporation | Treatment of vasculopathy with prostacyclin and mesenchymal stem cells |
| EP3712142B1 (en) | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| ES2860975T3 (es) | 2013-10-25 | 2021-10-05 | Insmed Inc | Compuestos de prostaciclina |
| AU2015349969B2 (en) | 2014-11-18 | 2020-02-06 | Insmed Incorporated | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| EP3328413B1 (en) * | 2015-07-29 | 2024-09-04 | Indiana University Research and Technology Corporation | Materials and methods for treating and evaluating ischemic and/or reperfusion-injured tissue and/or tissue susceptible to same |
| EP3534917B1 (en) * | 2016-10-24 | 2022-08-24 | United Therapeutics Corporation | Enhancement of msc immunomodulatory properties by treprostinil |
| JP2020502078A (ja) * | 2016-11-30 | 2020-01-23 | パイアン・バイオテクノロジー・インコーポレイテッドＰａｅａｎ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｉｎｃ． | ミトコンドリアを含む医薬組成物 |
| CN107602690B (zh) * | 2017-11-03 | 2020-10-20 | 中国医学科学院阜外医院 | 肺动脉高压相关的ptgis基因突变及其应用 |
| US12233092B2 (en) | 2018-04-10 | 2025-02-25 | Brainstorm Cell Therapeutics Ltd. | MSC-NTF specific exosomes and use thereof |
| ES2976468T3 (es) | 2018-09-18 | 2024-08-01 | Lilly Co Eli | Sal de treprostinil erbumina |
| MX2021003866A (es) | 2018-10-05 | 2021-09-08 | Xenotherapeutics Inc | Productos y metodos de xenotransplante. |
| US10883084B2 (en) | 2018-10-05 | 2021-01-05 | Xenotherapeutics, Inc. | Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same |
| JP2022526820A (ja) * | 2019-04-08 | 2022-05-26 | シンバイオセルテック・エルエルシー | 間葉系幹細胞およびそのエクソソームによる微小血管障害の治療 |
| US10881693B2 (en) * | 2019-04-09 | 2021-01-05 | Combangio, Inc. | Processes for making and using a mesenchymal stem cell derived secretome |
| CN114072136B (zh) | 2019-04-29 | 2024-11-29 | 英斯梅德股份有限公司 | 曲前列素前药的干粉组合物及其使用方法 |
| EP4004191A4 (en) | 2019-07-26 | 2022-10-12 | Brexogen Inc. | Precursor cells of induced pluripotent stem cell-derived mesenchymal stem cells and method for preparing the same |
| WO2021020666A1 (en) * | 2019-07-26 | 2021-02-04 | Brexogen Inc. | Precursor cells of induced pluripotent stem cell-derived mesenchymal stem cells and method for preparing the same |
| WO2021207282A2 (en) | 2020-04-07 | 2021-10-14 | Combangio, Inc. | Lyophilized mesenchymal stem cell derived secretome and uses thereof |
| US20250082781A1 (en) * | 2021-12-29 | 2025-03-13 | Salk Institute For Biological Studies | Methods of lowering blood glucose and treating type 2 diabetes by activation of pde4d3 |
| EP4285915A1 (en) * | 2022-06-03 | 2023-12-06 | Medizinische Hochschule Hannover | Human mesenchymal stem cell-conditioned medium for use in treatment of chronic heart-lung and vascular diseases, in particular, of pulmonary arterial hypertension (pah) |
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| EP2879682B1 (en) * | 2012-08-01 | 2018-03-21 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension with mesenchymal stem cells |
| EP2943069B1 (en) | 2013-01-09 | 2018-08-15 | United Therapeutics Corporation | Treatment of vasculopathy with prostacyclin and mesenchymal stem cells |
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| EP3534917B1 (en) | 2016-10-24 | 2022-08-24 | United Therapeutics Corporation | Enhancement of msc immunomodulatory properties by treprostinil |
-
2014
- 2014-01-08 EP EP14737912.7A patent/EP2943069B1/en active Active
- 2014-01-08 ES ES21170653T patent/ES2963968T3/es active Active
- 2014-01-08 KR KR1020227000014A patent/KR102466885B1/ko active Active
- 2014-01-08 KR KR1020157020740A patent/KR102348611B1/ko active Active
- 2014-01-08 JP JP2015551855A patent/JP6431850B2/ja active Active
- 2014-01-08 CN CN201480008413.2A patent/CN105025720B/zh active Active
- 2014-01-08 AU AU2014205557A patent/AU2014205557B2/en active Active
- 2014-01-08 CA CA2897805A patent/CA2897805C/en active Active
- 2014-01-08 US US14/149,929 patent/US10080730B2/en active Active
- 2014-01-08 EP EP21170653.6A patent/EP3878452B1/en active Active
- 2014-01-08 ES ES14737912T patent/ES2697573T3/es active Active
- 2014-01-08 EP EP18185761.6A patent/EP3415150B1/en active Active
- 2014-01-08 WO PCT/US2014/010623 patent/WO2014110094A1/en not_active Ceased
- 2014-01-08 ES ES18185761T patent/ES2888909T3/es active Active
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2015
- 2015-06-23 IL IL239603A patent/IL239603A/en active IP Right Grant
-
2017
- 2017-11-08 AU AU2017258866A patent/AU2017258866B2/en active Active
- 2017-11-09 IL IL255547A patent/IL255547B/en active IP Right Grant
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2018
- 2018-09-21 US US16/137,629 patent/US11141393B2/en active Active
- 2018-11-05 JP JP2018207899A patent/JP6709834B2/ja active Active
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2019
- 2019-01-25 AU AU2019200504A patent/AU2019200504B2/en active Active
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2021
- 2021-09-08 US US17/469,745 patent/US11839596B2/en active Active
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2023
- 2023-12-11 US US18/535,865 patent/US12274684B2/en active Active
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