IL239603A - Composition comprising prostacyclin and mesenchymal stem cells for treatment of vasculopathy - Google Patents

Composition comprising prostacyclin and mesenchymal stem cells for treatment of vasculopathy

Info

Publication number
IL239603A
IL239603A IL239603A IL23960315A IL239603A IL 239603 A IL239603 A IL 239603A IL 239603 A IL239603 A IL 239603A IL 23960315 A IL23960315 A IL 23960315A IL 239603 A IL239603 A IL 239603A
Authority
IL
Israel
Prior art keywords
prostecycline
vasculitis
treatment
stem cells
mesenchymal stem
Prior art date
Application number
IL239603A
Other languages
English (en)
Hebrew (he)
Other versions
IL239603A0 (en
Original Assignee
United Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United Therapeutics Corp filed Critical United Therapeutics Corp
Publication of IL239603A0 publication Critical patent/IL239603A0/en
Publication of IL239603A publication Critical patent/IL239603A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
    • A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/02—Compounds of the arachidonic acid pathway, e.g. prostaglandins, leukotrienes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL239603A 2013-01-09 2015-06-23 Composition comprising prostacyclin and mesenchymal stem cells for treatment of vasculopathy IL239603A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361750458P 2013-01-09 2013-01-09
PCT/US2014/010623 WO2014110094A1 (en) 2013-01-09 2014-01-08 Treatment of vasculopathy with prostacyclin and mesenchymal stem cells

Publications (2)

Publication Number Publication Date
IL239603A0 IL239603A0 (en) 2015-08-31
IL239603A true IL239603A (en) 2017-11-30

Family

ID=51061108

Family Applications (2)

Application Number Title Priority Date Filing Date
IL239603A IL239603A (en) 2013-01-09 2015-06-23 Composition comprising prostacyclin and mesenchymal stem cells for treatment of vasculopathy
IL255547A IL255547B (en) 2013-01-09 2017-11-09 Treatment of vasculopathy with prostacyclin and mesenchymal stem cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL255547A IL255547B (en) 2013-01-09 2017-11-09 Treatment of vasculopathy with prostacyclin and mesenchymal stem cells

Country Status (10)

Country Link
US (4) US10080730B2 (https=)
EP (3) EP2943069B1 (https=)
JP (2) JP6431850B2 (https=)
KR (2) KR102466885B1 (https=)
CN (1) CN105025720B (https=)
AU (3) AU2014205557B2 (https=)
CA (1) CA2897805C (https=)
ES (3) ES2963968T3 (https=)
IL (2) IL239603A (https=)
WO (1) WO2014110094A1 (https=)

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ES2713988T3 (es) * 2012-08-01 2019-05-24 United Therapeutics Corp Tratamiento de hipertensión arterial pulmonar con células progenitoras endoteliales tratadas con prostaciclina
EP2879682B1 (en) 2012-08-01 2018-03-21 United Therapeutics Corporation Treatment of pulmonary arterial hypertension with mesenchymal stem cells
CN105358163B (zh) * 2012-12-12 2020-09-11 麦瑟布莱斯特公司 内皮功能障碍和炎症的疾病的治疗
EP2943069B1 (en) 2013-01-09 2018-08-15 United Therapeutics Corporation Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
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US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
ES2860975T3 (es) 2013-10-25 2021-10-05 Insmed Inc Compuestos de prostaciclina
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WO2021020666A1 (en) * 2019-07-26 2021-02-04 Brexogen Inc. Precursor cells of induced pluripotent stem cell-derived mesenchymal stem cells and method for preparing the same
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EP4285915A1 (en) * 2022-06-03 2023-12-06 Medizinische Hochschule Hannover Human mesenchymal stem cell-conditioned medium for use in treatment of chronic heart-lung and vascular diseases, in particular, of pulmonary arterial hypertension (pah)

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Also Published As

Publication number Publication date
EP2943069B1 (en) 2018-08-15
IL255547B (en) 2018-11-29
EP3878452A1 (en) 2021-09-15
JP6709834B2 (ja) 2020-06-17
CN105025720B (zh) 2019-06-14
US12274684B2 (en) 2025-04-15
KR102348611B1 (ko) 2022-01-06
AU2014205557A1 (en) 2015-07-23
JP2019031566A (ja) 2019-02-28
US11141393B2 (en) 2021-10-12
WO2014110094A1 (en) 2014-07-17
EP3415150B1 (en) 2021-08-18
KR20150103211A (ko) 2015-09-09
KR20220003673A (ko) 2022-01-10
EP2943069A4 (en) 2016-07-27
ES2697573T3 (es) 2019-01-25
CN105025720A (zh) 2015-11-04
AU2019200504A1 (en) 2019-02-14
AU2017258866A1 (en) 2017-11-30
AU2014205557B2 (en) 2017-08-10
KR102466885B1 (ko) 2022-11-11
EP3415150A1 (en) 2018-12-19
US20240100003A1 (en) 2024-03-28
AU2017258866B2 (en) 2018-10-25
EP2943069A1 (en) 2015-11-18
ES2888909T3 (es) 2022-01-10
US11839596B2 (en) 2023-12-12
IL255547A (en) 2018-01-31
IL239603A0 (en) 2015-08-31
US20190160032A1 (en) 2019-05-30
US20140193379A1 (en) 2014-07-10
JP2016505623A (ja) 2016-02-25
EP3878452B1 (en) 2023-09-20
US10080730B2 (en) 2018-09-25
US20220062210A1 (en) 2022-03-03
AU2019200504B2 (en) 2020-12-03
CA2897805C (en) 2023-03-21
ES2963968T3 (es) 2024-04-03
CA2897805A1 (en) 2014-07-17
JP6431850B2 (ja) 2018-11-28

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