JP2016504369A5 - - Google Patents

Info

Publication number

JP2016504369A5

JP2016504369A5 JP2015550818A JP2015550818A JP2016504369A5 JP 2016504369 A5 JP2016504369 A5 JP 2016504369A5 JP 2015550818 A JP2015550818 A JP 2015550818A JP 2015550818 A JP2015550818 A JP 2015550818A JP 2016504369 A5 JP2016504369 A5 JP 2016504369A5

Authority

JP

Japan

Prior art keywords

formulation

hydrophilic polymer

type

polymer chain

peg

Prior art date

2013-12-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 238000009472 formulation Methods 0.000 claims 33
• 229920001477 hydrophilic polymer Polymers 0.000 claims 33
• 239000000203 mixture Substances 0.000 claims 33
• 239000003795 chemical substances by application Substances 0.000 claims 6
• 239000000872 buffer Substances 0.000 claims 5
• 238000004132 cross linking Methods 0.000 claims 5
• 239000003814 drug Substances 0.000 claims 5
• 125000000524 functional group Chemical group 0.000 claims 5
• 108010005716 Interferon beta-1a Proteins 0.000 claims 4
• 230000004913 activation Effects 0.000 claims 4
• -1 amino, hydroxyl Chemical group 0.000 claims 3
• 239000000017 hydrogel Substances 0.000 claims 3
• 229920001223 polyethylene glycol Polymers 0.000 claims 3
• 229920000642 polymer Polymers 0.000 claims 3
• 229940124597 therapeutic agent Drugs 0.000 claims 3
• NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 2
• 239000002202 Polyethylene glycol Substances 0.000 claims 2
• 229960002964 adalimumab Drugs 0.000 claims 2
• 239000007853 buffer solution Substances 0.000 claims 2
• 229920001577 copolymer Polymers 0.000 claims 2
• 230000001186 cumulative effect Effects 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 230000009977 dual effect Effects 0.000 claims 2
• 229960004461 interferon beta-1a Drugs 0.000 claims 2
• 229920001432 poly(L-lactide) Polymers 0.000 claims 2
• 239000002244 precipitate Substances 0.000 claims 2
• 238000001556 precipitation Methods 0.000 claims 2
• 238000002360 preparation method Methods 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 230000002441 reversible effect Effects 0.000 claims 2
• 229960004641 rituximab Drugs 0.000 claims 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
• IQUPABOKLQSFBK-UHFFFAOYSA-N 2-nitrophenol Chemical compound OC1=CC=CC=C1[N+]([O-])=O IQUPABOKLQSFBK-UHFFFAOYSA-N 0.000 claims 1
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
• 102000008186 Collagen Human genes 0.000 claims 1
• 108010035532 Collagen Proteins 0.000 claims 1
• 229920002307 Dextran Polymers 0.000 claims 1
• 108010008165 Etanercept Proteins 0.000 claims 1
• 102000008946 Fibrinogen Human genes 0.000 claims 1
• 108010049003 Fibrinogen Proteins 0.000 claims 1
• JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims 1
• 229920000436 Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide) Polymers 0.000 claims 1
• 229960002833 aflibercept Drugs 0.000 claims 1
• 108010081667 aflibercept Proteins 0.000 claims 1
• 150000001299 aldehydes Chemical class 0.000 claims 1
• 229940072056 alginate Drugs 0.000 claims 1
• 229920000615 alginic acid Polymers 0.000 claims 1
• 235000010443 alginic acid Nutrition 0.000 claims 1
• 229940120638 avastin Drugs 0.000 claims 1
• 229940003504 avonex Drugs 0.000 claims 1
• 229960000397 bevacizumab Drugs 0.000 claims 1
• 229940126587 biotherapeutics Drugs 0.000 claims 1
• 229920001436 collagen Polymers 0.000 claims 1
• 229960005188 collagen Drugs 0.000 claims 1
• 229960002086 dextran Drugs 0.000 claims 1
• AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 229960000403 etanercept Drugs 0.000 claims 1
• 229940012952 fibrinogen Drugs 0.000 claims 1
• 229940022353 herceptin Drugs 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 229960000598 infliximab Drugs 0.000 claims 1
• 229940076783 lucentis Drugs 0.000 claims 1
• 229920001277 pectin Polymers 0.000 claims 1
• 235000010987 pectin Nutrition 0.000 claims 1
• 239000001814 pectin Substances 0.000 claims 1
• 229960000292 pectin Drugs 0.000 claims 1
• HQQSBEDKMRHYME-UHFFFAOYSA-N pefloxacin mesylate Chemical compound [H+].CS([O-])(=O)=O.C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCN(C)CC1 HQQSBEDKMRHYME-UHFFFAOYSA-N 0.000 claims 1
• 229960001373 pegfilgrastim Drugs 0.000 claims 1
• 108010044644 pegfilgrastim Proteins 0.000 claims 1
• 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
• 229960003876 ranibizumab Drugs 0.000 claims 1
• 229940038850 rebif Drugs 0.000 claims 1
• 229940116176 remicade Drugs 0.000 claims 1
• 125000003396 thiol group Chemical class [H]S* 0.000 claims 1
• 229960000575 trastuzumab Drugs 0.000 claims 1
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
• 229920002554 vinyl polymer Polymers 0.000 claims 1