JP2016504362A - アルブミンおよびパクリタキセルのナノ粒子組成物 - Google Patents

アルブミンおよびパクリタキセルのナノ粒子組成物 Download PDF

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Publication number
JP2016504362A
JP2016504362A JP2015550675A JP2015550675A JP2016504362A JP 2016504362 A JP2016504362 A JP 2016504362A JP 2015550675 A JP2015550675 A JP 2015550675A JP 2015550675 A JP2015550675 A JP 2015550675A JP 2016504362 A JP2016504362 A JP 2016504362A
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Prior art keywords
composition
albumin
paclitaxel
less
nanoparticles
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JP2015550675A
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English (en)
Japanese (ja)
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JP2016504362A5 (enExample
Inventor
ニール ピー． デサイ，
ニール ピー． デサイ，
Original Assignee
アブラクシス バイオサイエンス， エルエルシー
アブラクシス バイオサイエンス， エルエルシー
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Application filed by アブラクシス バイオサイエンス， エルエルシー, アブラクシス バイオサイエンス， エルエルシー filed Critical アブラクシス バイオサイエンス， エルエルシー
Publication of JP2016504362A publication Critical patent/JP2016504362A/ja
Publication of JP2016504362A5 publication Critical patent/JP2016504362A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2015550675A 2012-12-28 2013-12-19 アルブミンおよびパクリタキセルのナノ粒子組成物 Pending JP2016504362A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261747123P 2012-12-28 2012-12-28
US61/747,123 2012-12-28
US13/794,705 US20140186447A1 (en) 2012-12-28 2013-03-11 Nanoparticle compositions of albumin and paclitaxel
US13/794,705 2013-03-11
PCT/US2013/076630 WO2014105644A1 (en) 2012-12-28 2013-12-19 Nanoparticle compositions of albumin and paclitaxel

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018030637A Division JP2018087241A (ja) 2012-12-28 2018-02-23 アルブミンおよびパクリタキセルのナノ粒子組成物

Publications (2)

Publication Number Publication Date
JP2016504362A true JP2016504362A (ja) 2016-02-12
JP2016504362A5 JP2016504362A5 (enExample) 2017-02-02

Family

ID=51017455

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015550675A Pending JP2016504362A (ja) 2012-12-28 2013-12-19 アルブミンおよびパクリタキセルのナノ粒子組成物
JP2018030637A Pending JP2018087241A (ja) 2012-12-28 2018-02-23 アルブミンおよびパクリタキセルのナノ粒子組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018030637A Pending JP2018087241A (ja) 2012-12-28 2018-02-23 アルブミンおよびパクリタキセルのナノ粒子組成物

Country Status (19)

Country Link
US (2) US20140186447A1 (enExample)
EP (1) EP2938340A4 (enExample)
JP (2) JP2016504362A (enExample)
KR (1) KR20150100903A (enExample)
CN (1) CN105007912A (enExample)
AU (1) AU2013370955B2 (enExample)
BR (1) BR112015015319A2 (enExample)
CA (1) CA2896288A1 (enExample)
CR (1) CR20150386A (enExample)
HK (1) HK1216611A1 (enExample)
IL (1) IL239593A0 (enExample)
MX (1) MX2015008361A (enExample)
NI (1) NI201500090A (enExample)
NZ (1) NZ630912A (enExample)
PH (1) PH12015501486B1 (enExample)
RU (1) RU2663687C2 (enExample)
SG (1) SG11201505111TA (enExample)
WO (1) WO2014105644A1 (enExample)
ZA (1) ZA201504762B (enExample)

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JP2020536052A (ja) * 2017-10-03 2020-12-10 クリティテック・インコーポレイテッド 癌の治療のための免疫療法剤の全身送達と組み合わせた抗腫瘍粒子の局所送達
JP2022553426A (ja) * 2019-10-28 2022-12-22 アブラクシス バイオサイエンス， エルエルシー アルブミンおよびラパマイシンの医薬組成物
JP2024540366A (ja) * 2021-11-03 2024-10-31 エスエヌ バイオサイエンス インコーポレイテッド 粒度分布維持安定性が改善されたアルブミン結合タキサンナノ粒子の製造方法

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BR112012030909A2 (pt) 2010-06-04 2020-08-18 Abraxis Bioscience, Llc métodos de tratamento de câncer pancreático
AU2012249371B2 (en) 2011-04-28 2017-06-08 Abraxis Bioscience, Llc Intravascular delivery of nanoparticle compositions and uses thereof
LT2707030T (lt) 2011-05-09 2020-07-10 Mayo Foundation For Medical Education And Research Vėžio gydymas
RU2705998C2 (ru) 2011-12-14 2019-11-13 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи Применение полимерных эксципиентов для лиофилизации или заморозки частиц
EP2903610B1 (en) 2012-10-01 2021-11-03 Mayo Foundation For Medical Education And Research Cancer treatments
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CN112107558A (zh) 2013-05-30 2020-12-22 库拉迪格姆公司 药物组合物、制备及其用途
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AU2015277494A1 (en) 2014-06-16 2017-01-12 Mayo Foundation For Medical Education And Research Treating myelomas
CN104224750A (zh) * 2014-09-17 2014-12-24 四川大学 一种注射用卡巴他赛白蛋白纳米粒制剂及其制备方法
US9446148B2 (en) 2014-10-06 2016-09-20 Mayo Foundation For Medical Education And Research Carrier-antibody compositions and methods of making and using the same
DK3236934T3 (da) 2014-11-25 2024-08-19 Curadigm Sas Farmaceutisk sammensætning, fremstilling og anvendelser deraf
EP3229843B1 (en) * 2014-11-25 2020-01-01 Curadigm Sas Pharmaceutical composition, preparation and uses thereof
US11304902B2 (en) 2014-11-25 2022-04-19 Curadigm Sas Pharmaceutical compositions, preparation and uses thereof
LT3229776T (lt) 2014-11-25 2023-08-25 Curadigm Sas Farmacinė kompozicija, kurioje derinamos mažiausiai dvi skirtingos nanodalelės ir farmacinis mišinys, jos paruošimas ir vartojimas
US10527604B1 (en) 2015-03-05 2020-01-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel
US10705070B1 (en) 2015-03-05 2020-07-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug
CN118286421A (zh) 2015-05-28 2024-07-05 纳米生物技术公司 用作治疗性疫苗的纳米粒子
KR102606071B1 (ko) 2015-06-29 2023-11-27 아브락시스 바이오사이언스, 엘엘씨 상피양 세포 종양을 치료하는 방법
TW201707725A (zh) 2015-08-18 2017-03-01 美國馬友醫藥教育研究基金會 載體－抗體組合物及其製造及使用方法
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US11571469B2 (en) 2016-01-07 2023-02-07 Mayo Foundation For Medical Education And Research Methods of treating cancer with interferon wherein the cancer cells are HLA negative or have reduced HLA expression
WO2017139698A1 (en) 2016-02-12 2017-08-17 Mayo Foundation For Medical Education And Research Hematologic cancer treatments
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CA3018340A1 (en) 2016-03-21 2017-09-28 Mayo Foundation For Medical Education And Research Methods for improving the therapeutic index for a chemotherapeutic drug
US10618969B2 (en) 2016-04-06 2020-04-14 Mayo Foundation For Medical Education And Research Carrier-binding agent compositions and methods of making and using the same
CA3035377A1 (en) 2016-09-01 2018-03-08 Mayo Foundation For Medical Education And Research Nanoparticle compositions for targeting t-cell cancers
KR20220151022A (ko) 2016-09-01 2022-11-11 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 암 치료용 담체－ｐｄ－ｌ１ 결합제 조성물
EP3509643A1 (en) 2016-09-06 2019-07-17 Mayo Foundation for Medical Education and Research Paclitaxel-albumin-binding agent compositions and methods for using and making the same
US11590098B2 (en) 2016-09-06 2023-02-28 Mayo Foundation For Medical Education And Research Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins
EP3510048A1 (en) 2016-09-06 2019-07-17 Mayo Foundation for Medical Education and Research Methods of treating pd-l1 expressing cancer
CN106420665B (zh) * 2016-10-28 2019-04-16 浙江省林业科学研究院 一种包裹紫杉烷类药物的白蛋白纳米颗粒载体的制备方法
KR102837015B1 (ko) 2018-03-20 2025-07-23 아브락시스 바이오사이언스, 엘엘씨 mTOR 억제제 및 알부민의 나노입자의 투여를 통한 중추 신경계 장애의 치료 방법
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020536052A (ja) * 2017-10-03 2020-12-10 クリティテック・インコーポレイテッド 癌の治療のための免疫療法剤の全身送達と組み合わせた抗腫瘍粒子の局所送達
JP7792750B2 (ja) 2017-10-03 2025-12-26 クリティテック・インコーポレイテッド 癌の治療のための免疫療法剤の全身送達と組み合わせた抗腫瘍粒子の局所送達
JP2022553426A (ja) * 2019-10-28 2022-12-22 アブラクシス バイオサイエンス， エルエルシー アルブミンおよびラパマイシンの医薬組成物
JP2024540366A (ja) * 2021-11-03 2024-10-31 エスエヌ バイオサイエンス インコーポレイテッド 粒度分布維持安定性が改善されたアルブミン結合タキサンナノ粒子の製造方法
JP7786770B2 (ja) 2021-11-03 2025-12-16 エスエヌ バイオサイエンス インコーポレイテッド 粒度分布維持安定性が改善されたアルブミン結合タキサンナノ粒子の製造方法

Also Published As

Publication number Publication date
CA2896288A1 (en) 2014-07-03
BR112015015319A2 (pt) 2017-07-11
AU2013370955A1 (en) 2015-07-16
KR20150100903A (ko) 2015-09-02
PH12015501486B1 (en) 2020-12-16
US20190192477A1 (en) 2019-06-27
NZ630912A (en) 2017-05-26
IL239593A0 (en) 2015-08-31
EP2938340A1 (en) 2015-11-04
PH12015501486A1 (en) 2015-09-21
CN105007912A (zh) 2015-10-28
MX2015008361A (es) 2016-03-11
WO2014105644A1 (en) 2014-07-03
RU2015131141A (ru) 2017-02-03
AU2013370955B2 (en) 2018-12-06
RU2663687C2 (ru) 2018-08-08
NI201500090A (es) 2015-12-22
HK1216611A1 (zh) 2016-11-25
CR20150386A (es) 2015-10-07
SG11201505111TA (en) 2015-07-30
ZA201504762B (en) 2016-10-26
EP2938340A4 (en) 2016-08-03
JP2018087241A (ja) 2018-06-07
US20140186447A1 (en) 2014-07-03

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