JP2016503411A5 - - Google Patents
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- Publication number
- JP2016503411A5 JP2016503411A5 JP2015541920A JP2015541920A JP2016503411A5 JP 2016503411 A5 JP2016503411 A5 JP 2016503411A5 JP 2015541920 A JP2015541920 A JP 2015541920A JP 2015541920 A JP2015541920 A JP 2015541920A JP 2016503411 A5 JP2016503411 A5 JP 2016503411A5
- Authority
- JP
- Japan
- Prior art keywords
- sodium
- range
- silicate
- composite
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 27
- 239000002245 particle Substances 0.000 claims description 14
- 239000011248 coating agent Substances 0.000 claims description 7
- 238000000576 coating method Methods 0.000 claims description 7
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 6
- 239000002105 nanoparticle Substances 0.000 claims description 5
- 238000005243 fluidization Methods 0.000 claims description 3
- 239000011246 composite particle Substances 0.000 claims 17
- 239000000463 material Substances 0.000 claims 16
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 10
- 239000000725 suspension Substances 0.000 claims 7
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 6
- 239000000377 silicon dioxide Substances 0.000 claims 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 4
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 4
- -1 polyethylene Polymers 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- 239000001856 Ethyl cellulose Substances 0.000 claims 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 229920002678 cellulose Polymers 0.000 claims 3
- 239000001913 cellulose Substances 0.000 claims 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims 3
- 229920001249 ethyl cellulose Polymers 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 2
- CTTJWXVQRJUJQW-UHFFFAOYSA-N 2,2-dioctyl-3-sulfobutanedioic acid Chemical compound CCCCCCCCC(C(O)=O)(C(C(O)=O)S(O)(=O)=O)CCCCCCCC CTTJWXVQRJUJQW-UHFFFAOYSA-N 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 2
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 229910000503 Na-aluminosilicate Inorganic materials 0.000 claims 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 2
- 239000004698 Polyethylene Substances 0.000 claims 2
- 239000004111 Potassium silicate Substances 0.000 claims 2
- 239000004115 Sodium Silicate Substances 0.000 claims 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 2
- 239000000378 calcium silicate Substances 0.000 claims 2
- 229910052918 calcium silicate Inorganic materials 0.000 claims 2
- 235000012241 calcium silicate Nutrition 0.000 claims 2
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 claims 2
- 239000006229 carbon black Substances 0.000 claims 2
- 239000012876 carrier material Substances 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- IQDXNHZDRQHKEF-UHFFFAOYSA-N dialuminum;dicalcium;dioxido(oxo)silane Chemical compound [Al+3].[Al+3].[Ca+2].[Ca+2].[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O IQDXNHZDRQHKEF-UHFFFAOYSA-N 0.000 claims 2
- BCAARMUWIRURQS-UHFFFAOYSA-N dicalcium;oxocalcium;silicate Chemical compound [Ca+2].[Ca+2].[Ca]=O.[O-][Si]([O-])([O-])[O-] BCAARMUWIRURQS-UHFFFAOYSA-N 0.000 claims 2
- 229960000878 docusate sodium Drugs 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 239000008101 lactose Substances 0.000 claims 2
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 claims 2
- 239000000391 magnesium silicate Substances 0.000 claims 2
- 235000019792 magnesium silicate Nutrition 0.000 claims 2
- 229910052919 magnesium silicate Inorganic materials 0.000 claims 2
- 229910044991 metal oxide Inorganic materials 0.000 claims 2
- 150000004706 metal oxides Chemical class 0.000 claims 2
- 229920000573 polyethylene Polymers 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 235000019353 potassium silicate Nutrition 0.000 claims 2
- 229910052913 potassium silicate Inorganic materials 0.000 claims 2
- NNHHDJVEYQHLHG-UHFFFAOYSA-N potassium silicate Chemical compound [K+].[K+].[O-][Si]([O-])=O NNHHDJVEYQHLHG-UHFFFAOYSA-N 0.000 claims 2
- 235000010413 sodium alginate Nutrition 0.000 claims 2
- 239000000661 sodium alginate Substances 0.000 claims 2
- 229940005550 sodium alginate Drugs 0.000 claims 2
- 239000000429 sodium aluminium silicate Substances 0.000 claims 2
- 235000012217 sodium aluminium silicate Nutrition 0.000 claims 2
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 claims 2
- 229940083575 sodium dodecyl sulfate Drugs 0.000 claims 2
- 229910052911 sodium silicate Inorganic materials 0.000 claims 2
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims 2
- 235000019794 sodium silicate Nutrition 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 239000000600 sorbitol Substances 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- 239000000454 talc Substances 0.000 claims 2
- 229910052623 talc Inorganic materials 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- 235000019976 tricalcium silicate Nutrition 0.000 claims 2
- 229910021534 tricalcium silicate Inorganic materials 0.000 claims 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- 229920000084 Gum arabic Polymers 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- VEUACKUBDLVUAC-UHFFFAOYSA-N [Na].[Ca] Chemical compound [Na].[Ca] VEUACKUBDLVUAC-UHFFFAOYSA-N 0.000 claims 1
- 235000010489 acacia gum Nutrition 0.000 claims 1
- 239000000205 acacia gum Substances 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 229910000323 aluminium silicate Inorganic materials 0.000 claims 1
- IDZYHGDLWGVHQM-UHFFFAOYSA-N aluminum;calcium;sodium;silicate Chemical compound [Na+].[Al+3].[Ca+2].[O-][Si]([O-])([O-])[O-] IDZYHGDLWGVHQM-UHFFFAOYSA-N 0.000 claims 1
- 238000000889 atomisation Methods 0.000 claims 1
- 125000000656 azaniumyl group Chemical group [H][N+]([H])([H])[*] 0.000 claims 1
- 229920003086 cellulose ether Polymers 0.000 claims 1
- 229940082500 cetostearyl alcohol Drugs 0.000 claims 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 claims 1
- 229940043264 dodecyl sulfate Drugs 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims 1
- 235000010445 lecithin Nutrition 0.000 claims 1
- 239000000787 lecithin Substances 0.000 claims 1
- 229940067606 lecithin Drugs 0.000 claims 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 1
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims 1
- 239000011234 nano-particulate material Substances 0.000 claims 1
- 239000006070 nanosuspension Substances 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 229920001993 poloxamer 188 Polymers 0.000 claims 1
- 229940044519 poloxamer 188 Drugs 0.000 claims 1
- 229920001992 poloxamer 407 Polymers 0.000 claims 1
- 229940044476 poloxamer 407 Drugs 0.000 claims 1
- 239000008389 polyethoxylated castor oil Substances 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 229940012831 stearyl alcohol Drugs 0.000 claims 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims 1
- 229960004224 tyloxapol Drugs 0.000 claims 1
- 229920001664 tyloxapol Polymers 0.000 claims 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000000843 powder Substances 0.000 description 8
- 238000005054 agglomeration Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261725301P | 2012-11-12 | 2012-11-12 | |
| US61/725,301 | 2012-11-12 | ||
| PCT/US2013/069128 WO2014074808A1 (en) | 2012-11-12 | 2013-11-08 | Pharmaceutical core-shell composite powder and processes for making the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016503411A JP2016503411A (ja) | 2016-02-04 |
| JP2016503411A5 true JP2016503411A5 (OSRAM) | 2016-12-22 |
| JP6460562B2 JP6460562B2 (ja) | 2019-01-30 |
Family
ID=50685172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015541920A Active JP6460562B2 (ja) | 2012-11-12 | 2013-11-08 | 医薬コアシェル複合粉末、及びそれを作成するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9801820B2 (OSRAM) |
| EP (1) | EP2916824B1 (OSRAM) |
| JP (1) | JP6460562B2 (OSRAM) |
| CN (1) | CN104968332B (OSRAM) |
| AR (1) | AR093449A1 (OSRAM) |
| BR (1) | BR112015010704B8 (OSRAM) |
| DK (1) | DK2916824T3 (OSRAM) |
| ES (1) | ES2745759T3 (OSRAM) |
| WO (1) | WO2014074808A1 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10149826B2 (en) * | 2015-01-20 | 2018-12-11 | Hyalo Technologies, LLC | Method of preparing microspheres |
| JPWO2017047650A1 (ja) * | 2015-09-14 | 2018-06-28 | 大和製罐株式会社 | 粉末吸入剤、吸入器、及び粉末吸入剤の製造方法 |
| WO2017050528A1 (en) * | 2015-09-24 | 2017-03-30 | Unilever N.V. | Oral care composition |
| US9675609B2 (en) | 2015-11-11 | 2017-06-13 | Cao Pharmaceuticals Inc. | Nano- and micro-sized particles of 20-camptothecin or derivative thereof and pharmaceutical compositions containing same, and treatment of cancers therewith |
| JP6067154B1 (ja) * | 2016-01-25 | 2017-01-25 | 株式会社樋口商会 | コーティング粒子の製造方法 |
| KR101809139B1 (ko) | 2016-11-15 | 2017-12-15 | 주식회사 이코블록 | 무기물 코어에 유기물을 코팅하는 방법 및 그에 따른 용사코팅장치 |
| US11448578B2 (en) * | 2017-08-25 | 2022-09-20 | Fukuda Metal Foil & Powder Co., Ltd. | Lamination shaping powder evaluation method and lamination shaping powder therefor |
| DE102017215328A1 (de) * | 2017-09-01 | 2019-03-07 | Henkel Ag & Co. Kgaa | Treibmittelhaltige kosmetische Zusammensetzungen mit Pigment-haltigen Stärkepartikeln und anionischem Polymer |
| CN107649063B (zh) * | 2017-11-02 | 2023-08-29 | 黑龙江省科学院自动化研究所 | 一种纳米材料超声共振乳化混配装置 |
| WO2020048449A1 (zh) * | 2018-09-03 | 2020-03-12 | 正大天晴药业集团股份有限公司 | 包含1,3,5-三嗪衍生物或其盐的固体药物组合物 |
| CN109046187B (zh) * | 2018-10-09 | 2023-05-23 | 天津西敦津洋环保科技有限公司 | 一种高充气率的气固流化床反应器、实现在流化床中高充气率的方法及其应用 |
| JP7147523B2 (ja) * | 2018-12-06 | 2022-10-05 | 三生医薬株式会社 | 造粒方法 |
| US11549381B2 (en) * | 2019-09-05 | 2023-01-10 | Raytheon Technologies Corporation | Coating fabrication method for producing engineered microstructure of silicate-resistant barrier coating |
| CN114746083A (zh) * | 2019-12-02 | 2022-07-12 | 默克专利股份有限公司 | 活性药物成分的纳米悬浮液在载体上的沉积 |
| JP2023514924A (ja) * | 2019-12-16 | 2023-04-12 | ザ・グッドイヤー・タイヤ・アンド・ラバー・カンパニー | シリカ被覆デンプン |
| WO2021168043A1 (en) * | 2020-02-19 | 2021-08-26 | Nano Pharmasolutions, Inc. | Therapeutic agent nanoparticles and methods of preparation |
| CN112522863B (zh) * | 2020-11-26 | 2021-12-07 | 内蒙古工业大学 | 气流铺覆纤维装置 |
| CN115386208B (zh) * | 2022-08-11 | 2025-06-24 | 长兴电子（苏州）有限公司 | 可降解微珠及其制备方法与应用 |
| TWI859571B (zh) * | 2022-08-29 | 2024-10-21 | 長興材料工業股份有限公司 | 可降解微珠及其製備方法與應用 |
| TWI842445B (zh) * | 2023-03-21 | 2024-05-11 | 國立臺灣海洋大學 | 含有褐藻萃取物的多層顆粒結構及其製造方法 |
| CN119555851B (zh) * | 2025-02-06 | 2025-06-03 | 上海新黄河制药有限公司 | 一种吸入用混悬液的体外溶出曲线测定方法 |
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|---|---|---|---|---|
| GB9515182D0 (en) | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
| US7276249B2 (en) * | 2002-05-24 | 2007-10-02 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
| JP4547888B2 (ja) * | 2003-10-10 | 2010-09-22 | 小野薬品工業株式会社 | 胃内浮遊性固形製剤 |
| US7402175B2 (en) | 2004-05-17 | 2008-07-22 | Massachusetts Eye & Ear Infirmary | Vision prosthesis orientation |
| CA2651716A1 (en) * | 2006-05-22 | 2007-12-06 | Gershon Kolatkar | Duloxetine hydrochloride delayed release formulations |
| US20080050450A1 (en) | 2006-06-26 | 2008-02-28 | Mutual Pharmaceutical Company, Inc. | Active Agent Formulations, Methods of Making, and Methods of Use |
| WO2008022932A2 (en) | 2006-08-25 | 2008-02-28 | Boehringer Ingelheim International Gmbh | Controlled release system and method for manufacturing the same |
| EP2101735A2 (en) * | 2006-11-28 | 2009-09-23 | Marinus Pharmaceuticals, Inc. | Nanoparticulate formulations and methods for the making and use thereof |
| US8993041B2 (en) | 2012-10-15 | 2015-03-31 | New Jersey Institute Of Technology | Taste masked active pharmaceutical powder compositions and processes for making them |
-
2013
- 2013-11-08 US US14/441,970 patent/US9801820B2/en active Active
- 2013-11-08 EP EP13852722.1A patent/EP2916824B1/en active Active
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- 2013-11-08 JP JP2015541920A patent/JP6460562B2/ja active Active
- 2013-11-08 ES ES13852722T patent/ES2745759T3/es active Active
- 2013-11-08 WO PCT/US2013/069128 patent/WO2014074808A1/en not_active Ceased
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