JP2016502872A - セメント形成組成物、モネタイトセメント、移植片及び骨欠損を修復する方法 - Google Patents
セメント形成組成物、モネタイトセメント、移植片及び骨欠損を修復する方法 Download PDFInfo
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- JP2016502872A JP2016502872A JP2015547258A JP2015547258A JP2016502872A JP 2016502872 A JP2016502872 A JP 2016502872A JP 2015547258 A JP2015547258 A JP 2015547258A JP 2015547258 A JP2015547258 A JP 2015547258A JP 2016502872 A JP2016502872 A JP 2016502872A
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- 239000000203 mixture Substances 0.000 title claims abstract description 92
- 239000004568 cement Substances 0.000 title claims abstract description 69
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 35
- 230000007547 defect Effects 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 title claims abstract description 20
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims abstract description 57
- 229910000393 dicalcium diphosphate Inorganic materials 0.000 claims abstract description 57
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims abstract description 56
- 239000000843 powder Substances 0.000 claims abstract description 53
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 42
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 38
- 239000007943 implant Substances 0.000 claims abstract description 29
- 239000002994 raw material Substances 0.000 claims abstract description 20
- 229910000389 calcium phosphate Inorganic materials 0.000 claims abstract description 18
- 235000011010 calcium phosphates Nutrition 0.000 claims abstract description 17
- 238000001727 in vivo Methods 0.000 claims abstract description 15
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000011575 calcium Substances 0.000 claims abstract description 11
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 11
- 230000006698 induction Effects 0.000 claims abstract description 5
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 claims description 25
- 235000019691 monocalcium phosphate Nutrition 0.000 claims description 25
- 239000007788 liquid Substances 0.000 claims description 24
- 229910000150 monocalcium phosphate Inorganic materials 0.000 claims description 24
- 229940043256 calcium pyrophosphate Drugs 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 238000011282 treatment Methods 0.000 claims description 9
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 5
- 239000010936 titanium Substances 0.000 claims description 5
- 229910052719 titanium Inorganic materials 0.000 claims description 4
- 238000009472 formulation Methods 0.000 description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 18
- ZBZJARSYCHAEND-UHFFFAOYSA-L calcium;dihydrogen phosphate;hydrate Chemical compound O.[Ca+2].OP(O)([O-])=O.OP(O)([O-])=O ZBZJARSYCHAEND-UHFFFAOYSA-L 0.000 description 12
- 238000000338 in vitro Methods 0.000 description 9
- 239000008187 granular material Substances 0.000 description 8
- 239000000919 ceramic Substances 0.000 description 7
- 239000000463 material Substances 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 230000011164 ossification Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 230000002378 acidificating effect Effects 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 229910052586 apatite Inorganic materials 0.000 description 3
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 235000013312 flour Nutrition 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 210000003625 skull Anatomy 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000002441 X-ray diffraction Methods 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000003462 bioceramic Substances 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 230000002138 osteoinductive effect Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 230000004580 weight loss Effects 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- RSEBUVRVKCANEP-UHFFFAOYSA-N 2-pyrroline Chemical compound C1CC=CN1 RSEBUVRVKCANEP-UHFFFAOYSA-N 0.000 description 1
- ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical compound O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 description 1
- 208000006386 Bone Resorption Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000002051 biphasic effect Effects 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 230000024279 bone resorption Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000004068 calcium phosphate ceramic Substances 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- -1 citric acid Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 235000019820 disodium diphosphate Nutrition 0.000 description 1
- GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 1
- 229940038485 disodium pyrophosphate Drugs 0.000 description 1
- 230000003176 fibrotic effect Effects 0.000 description 1
- 238000010230 functional analysis Methods 0.000 description 1
- 239000011396 hydraulic cement Substances 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 230000004819 osteoinduction Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- ZVJHJDDKYZXRJI-UHFFFAOYSA-N pyrroline Natural products C1CC=NC1 ZVJHJDDKYZXRJI-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0073—Quadric-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Composite Materials (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
Description
図1に大まかに示したモザイク型移植片を上記の製造方法を用い、チタン(Ti)の針金の上で前もって混合した酸性リン酸カルシウムセメントを鋳造することによって製造した。モザイク型移植片を大きな頭蓋損傷の修復についての実験的臨床試験に用いた。移植片を形成するために、針金を鋳型の中に入れ、次いでこれに前もって混合した酸性リン酸カルシウムセメント形成組成物で満たして、組成物を少なくとも48時間水中で硬化させてモネタイトセメントを形成した。
この実施例はモネタイトセメントのインビトロでの溶解特性を検討した。2つのリン酸カルシウムセメント調合物を製造した。調合物1は約85重量%のモネタイト、8重量%のベータ−リン酸三カルシウム、及び7重量%のベータ−ピロリン酸カルシウムを含んでいた。調合物2は100重量%のモネタイトを含んでいた。〜300−400mgの初期重量を有する各調合物の六角形のサンプルを、37℃でpHが7.4である、リン酸緩衝生理食塩水(PBS)に入れた。サンプルを月に1度乾燥及び秤量して溶解による重量損失を観察した。PBSは月に1度交換した。
この実施例もインビトロでの溶解特性を検討した。表1に記載の異なったモネタイト、ベータ−リン酸三カルシウム(ベータ−TCP)及びベータ−ピロリン酸カルシウム(ベータ−CPP)内容物を用いてモネタイトセメント調合物を製造した。〜300−400mgの初期重量を有する各調合物の六角形のサンプルをトリス(ヒドロキシメチル)アミノメタン−HCl緩衝溶液(37℃で、pH7.4)に入れた。サンプルを1週間に1度乾燥及び秤量して、溶液を置き換えた。2週間における重量減少を表1に示す。
Claims (15)
- リン酸一カルシウム及びβ−リン酸三カルシウム、並びに原料粉の重量に基づいて、3〜30重量%のピロリン酸二カルシウム粉末を含んでいるモネタイト形成カルシウム系原料粉を含有してなる、リン酸カルシウムセメント形成組成物。
- 非水性水溶性液体をさらに含んでいて、組成物中の液体に対する粉末の比が約1〜7である、請求項1に記載のリン酸カルシウムセメント組成物。
- モネタイト形成カルシウム系原料粉が、約40:60〜60:40の重量比でリン酸一カルシウムとβ−リン酸三カルシウムを含んでいる、請求項1又は2に記載のリン酸カルシウムセメント組成物。
- 請求項1〜3の何れか一項に記載のリン酸カルシウム組成物及び、任意に、水から形成される、モネタイトセメント。
- 3〜30重量%のピロリン酸二カルシウムを含有してなる、モネタイトセメント。
- ピロリン酸二カルシウムがβ−ピロリン酸二カルシウムである、請求項1〜4の何れか1項に記載の組成物又はセメント。
- 請求項4〜6の何れか1項に記載のモネタイトセメントを含有してなる、移植片。
- セメントタイルが請求項4〜6の何れか一項に記載のモネタイトセメントで形成されている、チタンの針金又は網、及び針金又は網の上に形成された1つ又は複数のセメントタイルを含有してなる、移植片。
- モネタイトセメントが80重量%以上のモネタイト、1〜15重量%のβ−リン酸三カルシウム、及び3〜15重量%のβ−ピロリン酸二カルシウム粉末を含んでいる、請求項8に記載の移植片。
- 移植片が3〜30重量%のピロリン酸二カルシウムを含んでいるモネタイト組成物で形成されている、患者の骨欠損の治療において移植片吸収を遅らせるための移植片。
- 移植片が3〜30重量%のピロリン酸二カルシウムを含んでいるモネタイト組成物で形成されている、患者の骨欠損の治療においてインビボ骨誘導を改善するための移植片。
- ピロリン酸二カルシウムがβ−ピロリン酸二カルシウムである、請求項7〜11の何れか一項に記載の移植片。
- 方法が、3〜30重量%のピロリン酸二カルシウムを含んでいるモネタイト組成物で形成される移植片を患者に装入することを含んでなる、患者の骨欠損の治療においてインビボでの移植片吸収を遅らせることによって骨欠損を修復する方法。
- 方法が、3〜30重量%のピロリン酸二カルシウムを含んでいるモネタイト組成物で形成される移植片を患者に装入することを含んでなる、患者の骨欠損の治療においてインビボでの改善された骨誘導を提供することによって患者の骨欠損を修復する方法。
- ピロリン酸カルシウムがβ−ピロリン酸二カルシウムである、請求項13又は14に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261737355P | 2012-12-14 | 2012-12-14 | |
US61/737,355 | 2012-12-14 | ||
PCT/IB2013/061002 WO2014091469A1 (en) | 2012-12-14 | 2013-12-16 | Cement-forming compositions, monetite cements, implants and methods for correcting bone defects |
Publications (2)
Publication Number | Publication Date |
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JP2016502872A true JP2016502872A (ja) | 2016-02-01 |
JP6270870B2 JP6270870B2 (ja) | 2018-01-31 |
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JP2015547258A Active JP6270870B2 (ja) | 2012-12-14 | 2013-12-16 | セメント形成組成物、モネタイトセメント、移植片及び骨欠損を修復する方法 |
Country Status (11)
Country | Link |
---|---|
US (1) | US9913931B2 (ja) |
EP (1) | EP2931325B1 (ja) |
JP (1) | JP6270870B2 (ja) |
KR (1) | KR102242323B1 (ja) |
CN (1) | CN104853783B (ja) |
AU (1) | AU2013358613B9 (ja) |
BR (1) | BR112015013539B1 (ja) |
ES (1) | ES2784859T3 (ja) |
HK (1) | HK1216085A1 (ja) |
WO (1) | WO2014091469A1 (ja) |
ZA (1) | ZA201504572B (ja) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2014125381A2 (en) | 2013-02-12 | 2014-08-21 | Ossdsign Ab | Mosaic implants, kits and methods for correcting bone defects |
US9220597B2 (en) | 2013-02-12 | 2015-12-29 | Ossdsign Ab | Mosaic implants, kits and methods for correcting bone defects |
KR20170043110A (ko) * | 2014-08-14 | 2017-04-20 | 오에스에스디자인 아베 | 뼈 결함 교정을 위한 뼈 이식 |
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JP6270870B2 (ja) | 2018-01-31 |
KR102242323B1 (ko) | 2021-04-19 |
KR20150095789A (ko) | 2015-08-21 |
AU2013358613A1 (en) | 2015-07-02 |
US20150328368A1 (en) | 2015-11-19 |
ES2784859T3 (es) | 2020-10-01 |
AU2013358613B9 (en) | 2017-11-02 |
CN104853783A (zh) | 2015-08-19 |
HK1216085A1 (zh) | 2016-10-14 |
US9913931B2 (en) | 2018-03-13 |
ZA201504572B (en) | 2020-11-25 |
CN104853783B (zh) | 2018-03-02 |
BR112015013539A2 (pt) | 2017-07-11 |
AU2013358613B2 (en) | 2017-08-24 |
EP2931325A1 (en) | 2015-10-21 |
WO2014091469A1 (en) | 2014-06-19 |
EP2931325B1 (en) | 2020-02-19 |
BR112015013539B1 (pt) | 2020-01-07 |
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