JP2016502522A5 - - Google Patents
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- Publication number
- JP2016502522A5 JP2016502522A5 JP2015542135A JP2015542135A JP2016502522A5 JP 2016502522 A5 JP2016502522 A5 JP 2016502522A5 JP 2015542135 A JP2015542135 A JP 2015542135A JP 2015542135 A JP2015542135 A JP 2015542135A JP 2016502522 A5 JP2016502522 A5 JP 2016502522A5
- Authority
- JP
- Japan
- Prior art keywords
- ethyl
- purin
- pyrrolidin
- methylpyrimidin
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261727392P | 2012-11-16 | 2012-11-16 | |
| US61/727,392 | 2012-11-16 | ||
| PCT/CN2013/001395 WO2014075393A1 (en) | 2012-11-16 | 2013-11-15 | Purine inhibitors of human phosphatidylinositol 3-kinase delta |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016502522A JP2016502522A (ja) | 2016-01-28 |
| JP2016502522A5 true JP2016502522A5 (enExample) | 2016-12-22 |
| JP6322200B2 JP6322200B2 (ja) | 2018-05-09 |
Family
ID=50730542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015542135A Active JP6322200B2 (ja) | 2012-11-16 | 2013-11-15 | ヒトホスファチジルイノシトール３−キナーゼデルタのプリン阻害剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9938281B2 (enExample) |
| EP (1) | EP2920172B1 (enExample) |
| JP (1) | JP6322200B2 (enExample) |
| KR (1) | KR20150084992A (enExample) |
| CN (1) | CN104918940B (enExample) |
| AU (1) | AU2013347539B2 (enExample) |
| BR (1) | BR112015011147A8 (enExample) |
| CA (1) | CA2891013A1 (enExample) |
| MX (1) | MX2015006192A (enExample) |
| RU (1) | RU2661896C2 (enExample) |
| WO (1) | WO2014075393A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0906473A8 (pt) | 2008-01-04 | 2016-02-10 | Intellikine Inc | Certas entidades químicas, composições e métodos |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| EP3238722B1 (en) | 2011-01-10 | 2019-03-13 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinones |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| RU2702908C2 (ru) | 2012-11-01 | 2019-10-14 | Инфинити Фармасьютикалз, Инк. | Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы |
| WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| EP3145512B1 (en) * | 2014-05-19 | 2019-07-17 | Jiangsu Hengrui Medicine Co., Ltd. | Substituted ethynyl heterobicyclic compounds as tyrosine kinase inhibitors |
| WO2015188369A1 (en) * | 2014-06-13 | 2015-12-17 | Merck Sharp & Dohme Corp. | Purine inhibitors of human phosphatidylinositol 3-kinase delta |
| KR101710127B1 (ko) * | 2014-08-29 | 2017-02-27 | 한화제약주식회사 | 야누스인산화효소 억제제로서의 치환된 N-(피롤리딘-3-일)-7H-피롤로[2,3-d]피리미딘-4-아민 |
| WO2017000125A1 (en) * | 2015-06-29 | 2017-01-05 | Merck Sharp & Dohme Corp. | Purine inhibitors of human phosphatidylinositol 3-kinase delta |
| WO2017166104A1 (en) * | 2016-03-30 | 2017-10-05 | Merck Sharp & Dohme Corp. | Purine inhibitors of human phosphatidylinositol 3-kinase delta |
| EP3474856B1 (en) | 2016-06-24 | 2022-09-14 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| CN110300590A (zh) | 2016-10-21 | 2019-10-01 | 林伯士拉克许米公司 | Tyk2抑制剂及其用途 |
| CN108892635A (zh) * | 2018-09-07 | 2018-11-27 | 江苏工程职业技术学院 | 一种西沙必利关键中间体的制备方法 |
| CA3126224A1 (en) * | 2019-01-08 | 2020-07-16 | Corxel Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| PH12022551379A1 (en) | 2019-12-06 | 2023-05-03 | Vertex Pharma | Substituted tetrahydrofurans as modulators of sodium channels |
| SI4347031T1 (sl) | 2021-06-04 | 2026-01-30 | Vertex Pharmaceuticals Incorporated | N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov |
| WO2024083237A1 (en) * | 2022-10-20 | 2024-04-25 | Impact Therapeutics (Shanghai) , Inc | Substituted heteroaryl bicyclic compounds as usp1 inhibitors and the use thereof |
| AR131380A1 (es) | 2022-12-16 | 2025-03-12 | Astrazeneca Ab | Purinas 2,6,9-trisustituidas |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US5117830A (en) | 1990-11-08 | 1992-06-02 | Whitby Research, Inc. | Method of determining viability of tissue |
| US5877179A (en) * | 1992-09-29 | 1999-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Xanthines for identifying CFTR--binding compounds useful for activating chloride conductance in animal cells |
| RU2112765C1 (ru) * | 1993-02-09 | 1998-06-10 | Дзе Велкам Фаундейшн Лимитед | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ПРОЯВЛЯЮЩАЯ АКТИВНОСТЬ ПРОТИВ ВИРУСНОЙ ИНФЕКЦИИ И β D-АРАБИНОФУРАНОЗИЛ-2-АМИНО-6-МЕТОКСИ-9Н-ПУРИНЫ |
| US5670501A (en) * | 1994-09-01 | 1997-09-23 | Discovery Therapeutics, Inc. | N-substituted 9-alkyladenines |
| AU4157500A (en) * | 1999-03-26 | 2000-10-16 | Astrazeneca Ab | Novel compounds |
| EP1651229A1 (en) | 2003-05-23 | 2006-05-03 | Chiron Corporation | Guanidino-substituted quinazolinone compounds as mc4-r agonists |
| CA2565037A1 (en) * | 2004-04-28 | 2005-11-10 | Cv Therapeutics, Inc. | Purine derivatives as a1 adenosine receptor antagonists |
| US7977327B2 (en) | 2004-05-13 | 2011-07-12 | Daiichi Sankyo Company, Limited | Substituted pyrrolidine derivative |
| LT2612862T (lt) | 2004-05-13 | 2017-01-25 | Icos Corporation | Chinazolinonai kaip žmogaus fosfatidilinozitol-3-kinazės delta inhibitoriai |
| WO2006099204A1 (en) | 2005-03-11 | 2006-09-21 | Aderis Pharmaceuticals, Inc. | Substituted 9-alkyladenines and the use thereof |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| US7795427B2 (en) * | 2006-02-14 | 2010-09-14 | New York University | Methods for inhibiting osteoclast differentiation, formation, or function and for increasing bone mass |
| WO2011075643A1 (en) * | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted heteroaryl fused derivatives as pi3k inhibitors |
| WO2011075630A1 (en) * | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted fused aryl and heteroaryl derivatives as pi3k inhibitors |
| DE102010011431A1 (de) * | 2009-12-23 | 2011-06-30 | WABCO GmbH, 30453 | Ventileinrichtung für eine Luftfederungsanlage |
| EA201201274A1 (ru) | 2010-03-10 | 2013-04-30 | Инджениум Фармасьютиклз Гмбх | Ингибиторы протеинкиназ |
| US20130096104A1 (en) * | 2010-03-17 | 2013-04-18 | Genentech, Inc. | Imidazopyridine compounds, compositions and methods of use |
| AU2011271462A1 (en) * | 2010-06-30 | 2013-01-10 | Amgen Inc. | Nitrogen containing heterocyclic compounds as PIK3 -delta inhibitors |
| UA112517C2 (uk) | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
| EP2616469B1 (en) | 2010-09-14 | 2016-10-26 | Exelixis, Inc. | 9h-purine compounds as pi3k-delta inhibitors and methods for their manufacture |
| US9273028B2 (en) * | 2010-10-29 | 2016-03-01 | Biogen Ma Inc. | Heterocyclic tyrosine kinase inhibitors |
| EP2518070A1 (en) * | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Pyrrolotriazinone derivatives as PI3K inhibitors |
| CN102838600A (zh) * | 2011-06-24 | 2012-12-26 | 山东亨利医药科技有限责任公司 | 苯基喹唑啉类PI3Kδ抑制剂 |
-
2013
- 2013-11-15 RU RU2015122894A patent/RU2661896C2/ru not_active IP Right Cessation
- 2013-11-15 MX MX2015006192A patent/MX2015006192A/es unknown
- 2013-11-15 CA CA2891013A patent/CA2891013A1/en not_active Abandoned
- 2013-11-15 CN CN201380070631.4A patent/CN104918940B/zh not_active Expired - Fee Related
- 2013-11-15 AU AU2013347539A patent/AU2013347539B2/en not_active Ceased
- 2013-11-15 US US14/443,314 patent/US9938281B2/en active Active
- 2013-11-15 JP JP2015542135A patent/JP6322200B2/ja active Active
- 2013-11-15 WO PCT/CN2013/001395 patent/WO2014075393A1/en not_active Ceased
- 2013-11-15 KR KR1020157015531A patent/KR20150084992A/ko not_active Withdrawn
- 2013-11-15 EP EP13855780.6A patent/EP2920172B1/en active Active
- 2013-11-15 BR BR112015011147A patent/BR112015011147A8/pt not_active Application Discontinuation
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