JP2016501262A - リン酸亜鉛含有組成物 - Google Patents
リン酸亜鉛含有組成物 Download PDFInfo
- Publication number
- JP2016501262A JP2016501262A JP2015546430A JP2015546430A JP2016501262A JP 2016501262 A JP2016501262 A JP 2016501262A JP 2015546430 A JP2015546430 A JP 2015546430A JP 2015546430 A JP2015546430 A JP 2015546430A JP 2016501262 A JP2016501262 A JP 2016501262A
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- JP
- Japan
- Prior art keywords
- dentifrice
- phosphate
- zinc
- mouthwash
- zinc phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 152
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 title claims abstract description 64
- 229910000165 zinc phosphate Inorganic materials 0.000 title claims abstract description 64
- 239000000551 dentifrice Substances 0.000 claims abstract description 54
- 239000002324 mouth wash Substances 0.000 claims abstract description 32
- 229940051866 mouthwash Drugs 0.000 claims abstract description 28
- 150000003839 salts Chemical class 0.000 claims abstract description 26
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 60
- 210000003298 dental enamel Anatomy 0.000 claims description 51
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 33
- 229910019142 PO4 Inorganic materials 0.000 claims description 33
- 235000021317 phosphate Nutrition 0.000 claims description 33
- 239000000377 silicon dioxide Substances 0.000 claims description 29
- 239000010452 phosphate Substances 0.000 claims description 24
- 150000001413 amino acids Chemical class 0.000 claims description 23
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 23
- 239000004475 Arginine Substances 0.000 claims description 20
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 20
- 239000003795 chemical substances by application Substances 0.000 claims description 17
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 239000004094 surface-active agent Substances 0.000 claims description 14
- 210000000214 mouth Anatomy 0.000 claims description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 11
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 11
- 239000002585 base Substances 0.000 claims description 10
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 10
- 230000002378 acidificating effect Effects 0.000 claims description 9
- 239000003513 alkali Substances 0.000 claims description 9
- 239000000080 wetting agent Substances 0.000 claims description 9
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 235000019832 sodium triphosphate Nutrition 0.000 claims description 8
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims description 7
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 7
- 229940043256 calcium pyrophosphate Drugs 0.000 claims description 7
- 229940061607 dibasic sodium phosphate Drugs 0.000 claims description 7
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 7
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 claims description 7
- 235000011187 glycerol Nutrition 0.000 claims description 6
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 5
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 5
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- 229940111685 dibasic potassium phosphate Drugs 0.000 claims description 4
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 4
- 201000005581 enamel erosion Diseases 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- 235000010356 sorbitol Nutrition 0.000 claims description 4
- 230000002087 whitening effect Effects 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 3
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 3
- 235000003599 food sweetener Nutrition 0.000 claims description 3
- 239000003765 sweetening agent Substances 0.000 claims description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims 2
- 239000002994 raw material Substances 0.000 claims 1
- 239000011701 zinc Substances 0.000 description 49
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 41
- 229910052725 zinc Inorganic materials 0.000 description 41
- -1 fluoride ions Chemical class 0.000 description 28
- 238000009472 formulation Methods 0.000 description 25
- 229940091249 fluoride supplement Drugs 0.000 description 24
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 23
- 239000011746 zinc citrate Substances 0.000 description 23
- 235000006076 zinc citrate Nutrition 0.000 description 23
- 229940068475 zinc citrate Drugs 0.000 description 23
- 239000002253 acid Substances 0.000 description 22
- 229940024606 amino acid Drugs 0.000 description 21
- 235000001014 amino acid Nutrition 0.000 description 21
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 18
- 235000009697 arginine Nutrition 0.000 description 18
- 229960003121 arginine Drugs 0.000 description 18
- 239000011575 calcium Substances 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 239000006072 paste Substances 0.000 description 15
- 239000011734 sodium Substances 0.000 description 15
- 229920000642 polymer Polymers 0.000 description 11
- 239000000606 toothpaste Substances 0.000 description 11
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 10
- 239000003945 anionic surfactant Substances 0.000 description 10
- 230000003628 erosive effect Effects 0.000 description 10
- 239000000463 material Substances 0.000 description 10
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 10
- 238000004833 X-ray photoelectron spectroscopy Methods 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 9
- 229910052708 sodium Inorganic materials 0.000 description 9
- 229940034610 toothpaste Drugs 0.000 description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 8
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 8
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 8
- 150000002500 ions Chemical class 0.000 description 8
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 229940083542 sodium Drugs 0.000 description 8
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 208000002925 dental caries Diseases 0.000 description 7
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 239000002562 thickening agent Substances 0.000 description 7
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 6
- 229920001577 copolymer Polymers 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 5
- 239000003082 abrasive agent Substances 0.000 description 5
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 5
- 125000000129 anionic group Chemical group 0.000 description 5
- 229920006318 anionic polymer Polymers 0.000 description 5
- 229910052791 calcium Inorganic materials 0.000 description 5
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 239000011775 sodium fluoride Substances 0.000 description 5
- 235000013024 sodium fluoride Nutrition 0.000 description 5
- 229960000414 sodium fluoride Drugs 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 229960003500 triclosan Drugs 0.000 description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 4
- 239000004472 Lysine Substances 0.000 description 4
- INVGWHRKADIJHF-UHFFFAOYSA-N Sanguinarin Chemical compound C1=C2OCOC2=CC2=C3[N+](C)=CC4=C(OCO5)C5=CC=C4C3=CC=C21 INVGWHRKADIJHF-UHFFFAOYSA-N 0.000 description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 4
- 230000001680 brushing effect Effects 0.000 description 4
- 239000001506 calcium phosphate Substances 0.000 description 4
- 159000000007 calcium salts Chemical class 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 235000011180 diphosphates Nutrition 0.000 description 4
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 239000006260 foam Substances 0.000 description 4
- 239000004088 foaming agent Substances 0.000 description 4
- 239000003205 fragrance Substances 0.000 description 4
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 235000018977 lysine Nutrition 0.000 description 4
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 4
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- 229910052700 potassium Inorganic materials 0.000 description 4
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 4
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
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- 210000003296 saliva Anatomy 0.000 description 4
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- 150000003751 zinc Chemical class 0.000 description 4
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 3
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 3
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- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
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- 238000005211 surface analysis Methods 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- MSLRPWGRFCKNIZ-UHFFFAOYSA-J tetrasodium;hydrogen peroxide;dicarbonate Chemical compound [Na+].[Na+].[Na+].[Na+].OO.OO.OO.[O-]C([O-])=O.[O-]C([O-])=O MSLRPWGRFCKNIZ-UHFFFAOYSA-J 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical class [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 description 1
- XROWMBWRMNHXMF-UHFFFAOYSA-J titanium tetrafluoride Chemical compound [F-].[F-].[F-].[F-].[Ti+4] XROWMBWRMNHXMF-UHFFFAOYSA-J 0.000 description 1
- 230000036347 tooth sensitivity Effects 0.000 description 1
- GTZCVFVGUGFEME-UHFFFAOYSA-N trans-aconitic acid Natural products OC(=O)CC(C(O)=O)=CC(O)=O GTZCVFVGUGFEME-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 229940085658 zinc citrate trihydrate Drugs 0.000 description 1
- 239000011576 zinc lactate Substances 0.000 description 1
- 235000000193 zinc lactate Nutrition 0.000 description 1
- 229940050168 zinc lactate Drugs 0.000 description 1
- XSMMCTCMFDWXIX-UHFFFAOYSA-N zinc silicate Chemical compound [Zn+2].[O-][Si]([O-])=O XSMMCTCMFDWXIX-UHFFFAOYSA-N 0.000 description 1
- 235000019352 zinc silicate Nutrition 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- RNWHGQJWIACOKP-UHFFFAOYSA-N zinc;oxygen(2-) Chemical compound [O-2].[Zn+2] RNWHGQJWIACOKP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/591—Mixtures of compounds not provided for by any of the codes A61K2800/592 - A61K2800/596
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2012/068000 WO2014088573A1 (en) | 2012-12-05 | 2012-12-05 | Zinc phosphate containing compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2016501262A true JP2016501262A (ja) | 2016-01-18 |
Family
ID=47356314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015546430A Pending JP2016501262A (ja) | 2012-12-05 | 2012-12-05 | リン酸亜鉛含有組成物 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20150305993A1 (esLanguage) |
| EP (2) | EP2928439B1 (esLanguage) |
| JP (1) | JP2016501262A (esLanguage) |
| KR (1) | KR20150092759A (esLanguage) |
| CN (2) | CN104822361B (esLanguage) |
| AR (1) | AR093794A1 (esLanguage) |
| AU (1) | AU2012396295B2 (esLanguage) |
| BR (1) | BR112015012921B1 (esLanguage) |
| CA (1) | CA2890684C (esLanguage) |
| HK (1) | HK1215158A1 (esLanguage) |
| IL (1) | IL238844B (esLanguage) |
| IN (1) | IN2015DN03992A (esLanguage) |
| MX (1) | MX360491B (esLanguage) |
| PH (1) | PH12015501069A1 (esLanguage) |
| RU (1) | RU2650609C2 (esLanguage) |
| TW (4) | TWI605853B (esLanguage) |
| WO (1) | WO2014088573A1 (esLanguage) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018188427A (ja) * | 2017-04-27 | 2018-11-29 | ライオン株式会社 | 口腔用組成物 |
| JP2023508547A (ja) * | 2019-12-31 | 2023-03-02 | スリーエム イノベイティブ プロパティズ カンパニー | フッ化物を含む水性亜鉛口腔ケア組成物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112315834A (zh) * | 2013-12-19 | 2021-02-05 | 高露洁-棕榄公司 | 抗恶臭口腔护理组合物 |
| BR112017001925A2 (pt) | 2014-08-08 | 2018-07-17 | Colgate-Palmolive Company | remoção e prevenção de manchas dentárias |
| EP3217951B1 (en) * | 2014-12-23 | 2019-04-03 | Colgate-Palmolive Company | Oral care composition |
| AU2014415216B2 (en) | 2014-12-26 | 2018-11-29 | Colgate-Palmolive Company | Zinc phosphate complex |
| RU2681525C2 (ru) | 2014-12-26 | 2019-03-07 | Колгейт-Палмолив Компани | Композиции для личной гигиены с фосфатом цинка в качестве активного вещества |
| BR112017012805B1 (pt) | 2014-12-26 | 2020-11-17 | Colgate-Palmolive Company | complexo de polifosfato de zinco solúvel e método de produção de polifosfato de zinco |
| MX374671B (es) | 2014-12-26 | 2025-03-06 | Colgate Palmolive Co | Complejo de zinc fosfato para el cuidado bucal. |
| RU2704312C2 (ru) | 2015-05-01 | 2019-10-28 | Колгейт-Палмолив Компани | Композиции в виде средства для чистки зубов с низким содержанием воды |
| MY182744A (en) * | 2015-07-01 | 2021-02-04 | Colgate Palmolive Co | Oral care compositions and methods of use |
| AU2015411328B2 (en) * | 2015-10-08 | 2019-05-02 | Colgate-Palmolive Company | Oral care compositions and methods of using the compositions |
| MY186941A (en) * | 2015-10-08 | 2021-08-26 | Colgate Palmolive Co | Oral care compositions and methods of using the compositions |
| CN118267304A (zh) * | 2015-11-13 | 2024-07-02 | 宝洁公司 | 具有改善的氟化物摄取的洁齿剂组合物 |
| EP3462900A4 (en) * | 2016-05-31 | 2020-01-22 | Wm. Wrigley Jr. Company | STAIN PROTECTION FORMULATIONS |
| EP3344217B1 (en) | 2016-06-24 | 2023-05-24 | Colgate-Palmolive Company | Oral care compositions |
| CN114557899A (zh) * | 2016-06-24 | 2022-05-31 | 高露洁-棕榄公司 | 口腔护理组合物 |
| US10617620B2 (en) * | 2016-06-24 | 2020-04-14 | Colgate-Palmolive Company | Oral care compositions and methods of use |
| CN108601715A (zh) * | 2016-06-24 | 2018-09-28 | 高露洁-棕榄公司 | 口腔护理组合物和使用该组合物的方法 |
| BR112019002366B1 (pt) * | 2016-08-11 | 2022-11-29 | Colgate-Palmolive Company | Composição para higiene bucal, método para fabricar a referida e método para tratar e/ou inibir mancha química, erosão dental, doença gengival, halitose e/ou formação de biofilme |
| CA3045783A1 (en) | 2016-12-21 | 2018-06-28 | Colgate-Palmolive Company | Oral care compositions comprising salicylamide |
| WO2018118161A1 (en) * | 2016-12-21 | 2018-06-28 | Colgate-Palmolive Company | Oral care compositions and methods of use |
| EP3541350B1 (en) | 2016-12-21 | 2023-05-24 | Colgate-Palmolive Company | Oral care compositions |
| CA3044403A1 (en) | 2016-12-21 | 2018-06-28 | Colgate-Palmolive Company | Oral care compositions and methods of use |
| MX2019007186A (es) | 2016-12-21 | 2019-09-05 | Colgate Palmolive Co | Composiciones para el cuidado bucal. |
| BR112019012369B1 (pt) | 2016-12-21 | 2022-03-22 | Colgate-Palmolive Company | Composição para higiene bucal com alto teor de água e uso da mesma |
| CN110099664B (zh) | 2016-12-21 | 2022-05-17 | 高露洁-棕榄公司 | 口腔护理组合物 |
| BR112019012374B1 (pt) | 2016-12-21 | 2022-03-22 | Colgate-Palmolive Company | Composição para higiene bucal e uso desta |
| WO2018125691A1 (en) * | 2016-12-27 | 2018-07-05 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| US11253449B2 (en) | 2018-12-26 | 2022-02-22 | Colgate-Palmolive Company | Oral care compositions |
| EP3697380B1 (en) * | 2019-01-11 | 2020-12-02 | Meda AB | Oral care preparations comprising chlorhexidine and arginine or their salts |
| AU2020253232B2 (en) | 2019-03-29 | 2022-12-08 | Colgate-Palmolive Company | Oral care product |
| MX2021011552A (es) | 2019-03-29 | 2021-10-26 | Colgate Palmolive Co | Producto para el cuidado bucal y metodos para uso y fabricacion de este. |
| US20210059914A1 (en) * | 2019-08-27 | 2021-03-04 | Colgate-Palmolive Company | Zinc Phosphate Containing Compositions |
| EP4056234B1 (en) * | 2021-03-12 | 2024-04-17 | Dr. Kurt Wolff GmbH & Co. KG | Composition for treatment and/or prevention of a corona virus infection |
| WO2025174942A1 (en) | 2024-02-16 | 2025-08-21 | Colgate-Palmolive Company | Methods for mediating an inflammatory response |
| WO2025229087A1 (en) * | 2024-04-30 | 2025-11-06 | DEBx Medical Holding B.V. | Antimicrobial composition comprising zinc and a biguanide or quaternary ammonium cationic surface active agent |
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| US3538230A (en) | 1966-12-05 | 1970-11-03 | Lever Brothers Ltd | Oral compositions containing silica xerogels as cleaning and polishing agents |
| US3678154A (en) | 1968-07-01 | 1972-07-18 | Procter & Gamble | Oral compositions for calculus retardation |
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| US3959458A (en) | 1973-02-09 | 1976-05-25 | The Procter & Gamble Company | Oral compositions for calculus retardation |
| US3937807A (en) | 1973-03-06 | 1976-02-10 | The Procter & Gamble Company | Oral compositions for plaque, caries, and calculus retardation with reduced staining tendencies |
| US3862307A (en) | 1973-04-09 | 1975-01-21 | Procter & Gamble | Dentifrices containing a cationic therapeutic agent and improved silica abrasive |
| US4051234A (en) | 1975-06-06 | 1977-09-27 | The Procter & Gamble Company | Oral compositions for plaque, caries, and calculus retardation with reduced staining tendencies |
| US4340583A (en) | 1979-05-23 | 1982-07-20 | J. M. Huber Corporation | High fluoride compatibility dentifrice abrasives and compositions |
| US4885155A (en) | 1982-06-22 | 1989-12-05 | The Procter & Gamble Company | Anticalculus compositions using pyrophosphate salt |
| GB2179536B (en) * | 1984-06-11 | 1988-12-21 | Godfrey Science & Design Inc | Improvement in the flavour of zinc supplements for oral use |
| US5192531A (en) | 1988-12-29 | 1993-03-09 | Colgate-Palmolive Company | Antibacterial antiplaque oral composition |
| US5188821A (en) | 1987-01-30 | 1993-02-23 | Colgate-Palmolive Company | Antibacterial antiplaque oral composition mouthwash or liquid dentifrice |
| US4866161A (en) | 1987-08-24 | 1989-09-12 | University Of South Alabama | Inhibition of tartar deposition by polyanionic/hydrophobic peptides and derivatives thereof which have a clustered block copolymer structure |
| US5004597A (en) | 1987-09-14 | 1991-04-02 | The Procter & Gamble Company | Oral compositions comprising stannous flouride and stannous gluconate |
| US4842847A (en) | 1987-12-21 | 1989-06-27 | The B. F. Goodrich Company | Dental calculus inhibiting compositions |
| US6221340B1 (en) * | 1999-04-08 | 2001-04-24 | Warner-Lambert Company | Zinc containing dentifrice compositions |
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| US6610639B1 (en) * | 2002-05-13 | 2003-08-26 | Colgate-Palmolive Company | High foaming, grease cutting light duty liquid composition containing zinc chloride |
| JP4929628B2 (ja) * | 2004-07-08 | 2012-05-09 | 大正製薬株式会社 | 亜鉛含有内服液剤 |
| EP1698324A1 (en) * | 2004-11-09 | 2006-09-06 | The Procter & Gamble Company | Zinc-containing dentifrice compositions having an improved taste |
| EP1792544A1 (en) * | 2005-11-30 | 2007-06-06 | Unilever N.V. | Zinc fortified food product and additive |
| KR20080070757A (ko) * | 2005-12-20 | 2008-07-30 | 더 프록터 앤드 갬블 캄파니 | 아연 및 피테이트를 함유하는 구강 케어 조성물 |
| BRPI0620265B8 (pt) * | 2005-12-21 | 2021-05-25 | Colgate Palmolive Co | composição oral anti-placa e dessensibilizante |
| US8628755B2 (en) * | 2007-01-30 | 2014-01-14 | Colgate-Palmolive Company | Dentifrice containing zinc ions and polyphosphate ions |
| WO2009099450A1 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Oral care regimen |
| CN101925346A (zh) * | 2008-02-08 | 2010-12-22 | 高露洁-棕榄公司 | 口腔护理产品及其使用和制造方法 |
| CN104940037A (zh) * | 2008-02-08 | 2015-09-30 | 高露洁-棕榄公司 | 口腔护理制品及其应用与制备方法 |
| EP2341985A1 (en) * | 2008-08-12 | 2011-07-13 | Bardow Consult v/Allan Bardow | Dental formulations for the prevention of dental erosion |
| GB0905863D0 (en) * | 2009-04-03 | 2009-05-20 | Glaxo Group Ltd | Novel composition |
| TWI396554B (zh) * | 2009-05-26 | 2013-05-21 | Colgate Palmolive Co | 增進可溶性鋅的量之口腔保健調配物 |
| TWI442937B (zh) * | 2009-05-26 | 2014-07-01 | Colgate Palmolive Co | 較高含量的含鋅薄膜 |
| MY162655A (en) * | 2010-12-21 | 2017-06-30 | Colgate Palmolive Co | Metal salt compositions |
-
2012
- 2012-12-05 IN IN3992DEN2015 patent/IN2015DN03992A/en unknown
- 2012-12-05 CN CN201280077527.3A patent/CN104822361B/zh active Active
- 2012-12-05 EP EP12799707.0A patent/EP2928439B1/en active Active
- 2012-12-05 WO PCT/US2012/068000 patent/WO2014088573A1/en not_active Ceased
- 2012-12-05 EP EP17174701.7A patent/EP3238695B1/en active Active
- 2012-12-05 JP JP2015546430A patent/JP2016501262A/ja active Pending
- 2012-12-05 US US14/649,221 patent/US20150305993A1/en not_active Abandoned
- 2012-12-05 MX MX2015007013A patent/MX360491B/es active IP Right Grant
- 2012-12-05 KR KR1020157017964A patent/KR20150092759A/ko not_active Withdrawn
- 2012-12-05 RU RU2015126796A patent/RU2650609C2/ru not_active Application Discontinuation
- 2012-12-05 BR BR112015012921-8A patent/BR112015012921B1/pt active IP Right Grant
- 2012-12-05 CA CA2890684A patent/CA2890684C/en active Active
- 2012-12-05 HK HK16103090.5A patent/HK1215158A1/zh unknown
- 2012-12-05 AU AU2012396295A patent/AU2012396295B2/en active Active
- 2012-12-05 CN CN201710581483.2A patent/CN107252395B/zh active Active
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2013
- 2013-11-19 TW TW102141979A patent/TWI605853B/zh not_active IP Right Cessation
- 2013-11-19 TW TW105106616A patent/TW201701923A/zh unknown
- 2013-11-19 TW TW105106619A patent/TWI619512B/zh not_active IP Right Cessation
- 2013-11-19 TW TW106107881A patent/TW201808256A/zh unknown
- 2013-12-04 AR ARP130104491A patent/AR093794A1/es unknown
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2015
- 2015-05-14 PH PH12015501069A patent/PH12015501069A1/en unknown
- 2015-05-14 IL IL238844A patent/IL238844B/en active IP Right Grant
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2021
- 2021-06-23 US US17/356,000 patent/US20210315785A1/en not_active Abandoned
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2023
- 2023-05-08 US US18/313,848 patent/US20230270638A1/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018188427A (ja) * | 2017-04-27 | 2018-11-29 | ライオン株式会社 | 口腔用組成物 |
| JP7064938B2 (ja) | 2017-04-27 | 2022-05-11 | ライオン株式会社 | 口腔用組成物 |
| JP2023508547A (ja) * | 2019-12-31 | 2023-03-02 | スリーエム イノベイティブ プロパティズ カンパニー | フッ化物を含む水性亜鉛口腔ケア組成物 |
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