JP2018188427A - 口腔用組成物 - Google Patents
口腔用組成物 Download PDFInfo
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- JP2018188427A JP2018188427A JP2018084320A JP2018084320A JP2018188427A JP 2018188427 A JP2018188427 A JP 2018188427A JP 2018084320 A JP2018084320 A JP 2018084320A JP 2018084320 A JP2018084320 A JP 2018084320A JP 2018188427 A JP2018188427 A JP 2018188427A
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- oral cavity
- acid
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Abstract
Description
象牙質に発症する根面う蝕(象牙質う蝕)の発症機序としては、まず、象牙質表面に付着したプラーク中の細菌によって糖の代謝がおこり、酸が産生される。産生された酸により象牙質のミネラル成分が溶出(脱灰)し、有機質(コラーゲン)層が露出する。そして露出したコラーゲン層は、物理的・化学的に破壊され、歯の根元に実質的な欠損が生じ、根面う蝕となる。
特許文献2には、象牙質細管の封鎖、象牙質耐酸性及び硬さの向上、フッ素の安定化を目的として、乳清及び/又はラクトフェリン、フッ素化合物、並びに、硝酸、りん酸、塩酸、及び硫酸から選ばれる酸の、K塩又はNa塩を含む口腔用組成物が開示されている。
特許文献3には、象牙質細管封鎖、象牙質脱灰の抑制、フッ素の安定化及び製剤安定化を目的として、リュウガン種子抽出物、フッ素化合物及び糖アルコールを含む口腔用組成物が開示されている。
特許文献5には、象牙質のミネラル溶出を抑制することを目的として、加水分解シルクと、一次粒子の平均粒子径が0.04〜0.5μmの範囲にある軽質炭酸カルシウムと、を成分として有する口腔用組成物が開示されている。
特許文献6には、再石灰化の促進を目的とし、水酸基を有するモノマーと、この水酸基を有するモノマーに対する配合量が5〜200重量%のリン原子含有酸性基を有するモノマーと、を成分として有する歯質再石灰化促進剤が開示されている。
特許文献8には、象牙質知覚過敏症の抑制、歯根面及び象牙質う蝕の抑制を目的とし、水溶性アルミニウム化合物、フッ化物及び水溶性カルシウム化合物を含有する口腔用組成物が開示されている。
特許文献9には、象牙質知覚過敏症の抑制及び良好な使用感を目的とし、水溶性アルミニウム化合物及びフッ化物を含有する口腔用組成物が開示されている。
特許文献10には、象牙質う蝕の抑制及び良好な使用感を目的とし、ピロリドンカルボン酸、6−オキソ−2−ピペリジンカルボン酸、3−(2−オキソ−1−アゼパニル)プロパン酸、及びそれらの塩からなる群より選ばれる1種以上のラクタム化合物と、水溶性2価金属塩と、水溶性フッ素化合物と、を含有する口腔用組成物が開示されている。
即ち、本発明者らは、下記の〔1〕〜〔7〕を提供する。
〔1〕(A)成分:ピロリドンカルボン酸及びそのアルカリ金属塩の少なくともいずれか(以下、「(A)成分」ともいう)と、(B)成分:塩基性アミノ酸及びその塩の少なくともいずれか(以下、「(B)成分」ともいう)と、(C)成分:水溶性フッ素化合物(以下、「(C)成分」ともいう)と、(D)成分:ピロリドンカルボン酸亜鉛(以下、「(D)成分」ともいう)と、を含有する口腔用組成物。
〔2〕前記(A)成分の含有量が、0.1〜10質量%である上記〔1〕に記載の口腔用組成物。
〔3〕前記(B)成分の含有量が、0.05〜20質量%である上記〔1〕又は〔2〕に記載の口腔用組成物。
〔4〕前記(C)成分の含有量が、フッ素原子換算で、0.01〜0.5質量%である上記〔1〕〜〔3〕のいずれかに記載の口腔用組成物。
〔5〕前記(D)成分の含有量が、0.1〜10質量%である上記〔1〕〜〔4〕のいずれかに記載の口腔用組成物。
〔6〕前記(B)成分が、アルギニン、リジン、及びそれらの塩からなる群から選択される少なくとも1種である上記〔1〕〜〔5〕のいずれかに記載の口腔用組成物。
〔7〕前記(C)成分が、フッ化ナトリウム又はモノフルオロリン酸ナトリウムである上記〔1〕〜〔6〕のいずれかに記載の口腔用組成物。
(A)成分は、ピロリドンカルボン酸及びそのアルカリ金属塩の少なくともいずれかである。ピロリドンカルボン酸の構造式を下記式(1)に示す。
(A)成分の含有量は、口腔用組成物全体に対して0.1〜10質量%が好ましく、0.5〜10質量%がより好ましく、0.5〜5質量%がさらに好ましい。
(B)成分は、塩基性アミノ酸である。塩基性アミノ酸としては、例えば、アルギニン、リジン、オルニチン、ヒスチジンが挙げられる。中でも、アルギニン及びリジンが好ましい。なお、塩基性アミノ酸はL−体であってもよく、D−体であってもよく、両方の光学異性体を任意の比率で混合したものであってもよい。
(B)成分は、塩基性アミノ酸の塩であってもよい。アルギニンの塩としては、例えば、L−アルギニンL−グルタミン酸塩、L−アルギニンL−アスパラギン酸塩、L−アルギニン塩酸塩が挙げられる。中でも、L−アルギニンL−グルタミン酸塩が好ましい。また、リジンの塩としては、L−リジンL−グルタミン酸塩、L−リジンL−アスパラギン酸塩、L−リジン塩酸塩が挙げられる。中でも、L−リジン塩酸塩が好ましい。
(B)成分としては、アルギニン、リジン、及びそれらの塩からなる群から選択される少なくとも1種であることが好ましい。
(B)成分の含有量は、口腔用組成物全体に対して0.05〜20質量%が好ましく、0.1〜20質量%がより好ましく、0.2〜20質量%がさらに好ましい。
なお、(B)成分を2種以上使用する際の(B)成分の含有量は、合計の含有量である。
(C)成分は、水溶性フッ素化合物である。水溶性フッ素化合物としては、例えば、フッ化ナトリウム、フッ化カリウム、フッ化アンモニウム、フッ化スズ、アミンフッ化物、モノフルオロリン酸ナトリウム、モノフルオロリン酸カリウム、フッ化ケイ素ナトリウム、フッ化ケイ素カルシウムが挙げられる。中でも、フッ化ナトリウム、モノフルオロリン酸ナトリウムが好ましい。
(C)成分の含有量は、口腔用組成物全体に対して0.01〜0.5質量%(100〜5000ppm)が好ましく、0.05〜0.4質量%(500〜4000ppm)がより好ましい。
(D)成分は、ピロリドンカルボン酸亜鉛である。上記した通り、ピロリドンカルボン酸は、通常、海草・小麦粉、サトウキビから抽出されたグルタミン酸を脱水することで生成され、これに、亜鉛イオンを結合させたものをピロリドンカルボン酸亜鉛(以下、「PCA亜鉛」ともいう)という。
(D)成分の含有量は、口腔用組成物全体に対して、0.1〜10質量%が好ましく、0.5〜10質量%がより好ましく、0.5〜5質量%がさらに好ましい。
本発明の口腔用組成物における(A)〜(D)成分の構成比率としては、次のことがいえる。
(A)成分に対する(B)成分の比率((B)/(A))は、0.033〜20であることが好ましく、0.067〜6.7であることがより好ましい。
(A)成分に対する(C)成分の比率((C)/(A))は、0.003〜1であることが好ましく、0.010〜0.20であることがより好ましい。
(A)成分〜(C)成分の合計に対する(D)成分の比率((D)/{(A)+(B)+(C)})は、0.020〜1.96であることが好ましく、0.098〜1.96であることがより好ましい。
本発明の口腔用組成物には、上記各成分に加えて、コラーゲン分解抑制や、耐酸性効果の向上等の本発明の効果を損なわない範囲において、組成物に必要な任意成分を配合することができる。任意成分としては、例えば、研磨剤、粘結剤、界面活性剤、粘稠剤、甘味剤、防腐剤、香料、酸味料、滑沢剤、着色剤、光沢剤、流動化剤、結合剤、崩壊剤、薬用成分、pH調整剤、水等の溶剤、賦形剤が挙げられる。以下に任意成分の具体例を示すが、本発明の組成物に配合可能な成分はこれらに制限されるものではない。
なお、吸液量は、以下の方法により測定した値である。即ち、試料1gをガラス板上に量りとり、ビュレットを用いて42.5質量%グリセリン水溶液を滴下しながらヘラで液が均一になるように混合する。試料が1つの塊となり、ヘラでガラス板よりきれいにはがれるようになったときを終点とし、試料1.0gに対して要したグリセリン水溶液量を吸液量(mL/g)として表す。
無機系粘結剤としては、例えば、無水ケイ酸(以下、粘結剤としての無水ケイ酸を「増粘性シリカ」又は「無水ケイ酸(増粘性)」ともいう)、ベントナイトが挙げられる。中でも、無水ケイ酸(増粘性)が好ましい。
また、N−アシルアミノ酸塩としては、例えば、N−アシルタウリン塩が挙げられ、炭素原子数が8〜18、好ましくは12〜16の直鎖又は分岐鎖の飽和若しくは不飽和炭化水素基を有する、ラウロイルメチルタウリン塩、ヤシ油脂肪酸メチルタウリン塩、ミリストイルメチルタウリン塩等のメチルタウリン塩;ラウロイルメチルアラニン塩等のメチルアラニン塩;ラウロイルグルタミン酸塩、ミリストイルグルタミン酸塩等のグルタミン酸塩も使用し得る。
甘味剤は、1種単独で、又は2種以上を組み合わせて使用することができる。甘味剤を用いる場合、含有量は本発明の効果を損なわない範囲で適宜定めることができる。
防腐剤は、1種単独で、又は2種以上を組み合わせて使用することができる。防腐剤を用いる場合、含有量は本発明の効果を損なわない範囲で適宜定めることができる。
口腔用組成物が着色剤を含有する場合、その含有量は、口腔用組成物全体に対して0.00001〜3質量%が好ましい。
口腔用組成物が光沢剤を含有する場合、その含有量は、口腔用組成物全体に対して0.01〜5質量%が好ましい。
口腔用組成物が流動化剤を含有する場合、その含有量は、口腔用組成物全体に対して0.01〜5質量%が好ましい。
結合剤を含有する場合、含有量は製剤により異なり一律に規定することはできない。例えばフィルムの場合には、通常、組成物全体に対し0.01〜90質量%が好ましい。フィルム以外の場合には、通常、組成物全体に対して0.01〜10質量%が好ましい。
薬用成分は、1種単独で、又は2種以上を組み合わせて使用することができる。薬用成分を使用する場合の含有量は、それぞれの薬用成分について薬剤学的に許容できる範囲で使用することができる。
本発明の口腔用組成物の形状、剤形は特に限定されない。例えば、液体系(液体、液状、ペースト状)、固体系(固体、固形状)等の各種形状で調製できる。剤形の例としては、練歯磨剤、液体歯磨剤、液状歯磨剤、粉歯磨剤等の歯磨剤組成物、洗口剤組成物、塗布剤組成物、口腔用パスタ、口中清涼剤組成物、食品形態(チューインガム、錠菓、キャンディ、グミ、フィルム、トローチ等)が挙げられる。
ヒト抜去歯の象牙質をマイクロカッターにて厚さ250μmの切片状に切り出した。試験部位として2mm×2mmのウィンドウを残し、それ以外の部分をマニキュア被覆してヒト象牙質サンプルとした。このサンプルを下記に示す歯磨剤組成物調製方法で調製した組成物の3倍水希釈液に3分間、室温で浸漬した(以下、「組成物処置」ともいう)。精製水で洗浄後、再石灰化液(1.5mM CaCl2,5mM KH2PO4,0.1M 酢酸,0.1M NaCl,pH6.5)0.5mlに浸漬し、37℃でインキュベートした。組成物処置を2回/日実施し、それ以外の時間は再石灰化液に浸漬し、これを合計3日間繰り返した。サンプルを脱灰液(2.2mM CaCl2,2.2mM KH2PO4,50mM 酢酸,pH5.0)0.5mlに浸漬し、37℃で6時間インキュベートした。この脱灰液を50μl採取し、原子吸光光度計(日立製作所製:Z−5310)を用いて脱灰液中のカルシウム濃度を測定した。測定は5回実施し、平均値を算出した。下記の式より、測定したカルシウム濃度から溶出カルシウム量を算出し、以下に示す基準で評価した。
なお、コントロール群とは、実施例・比較例に示す組成物で処置をしない群を示しており、同様に5回の平均値で評価した。
A:溶出カルシウム量(μg)が15μg未満
B:溶出カルシウム量(μg)が15μg以上20μg未満
C:溶出カルシウム量(μg)が20μg以上25μg未満
D:溶出カルシウム量(μg)が25μg以上
ウシ抜去歯の象牙質をマイクロカッターにて厚さ300μmの切片状に切り出した。試験部位として2mm×220mmのウィンドウを残し、それ以外の部分をマニキュア被覆してウシ象牙質サンプルとした。このサンプルを脱灰液(2.2mM CaCl2,2.2mM KH2PO4,50mM 酢酸,pH4.0)に浸漬し、37℃で48時間インキュベートした。各サンプルを下記に示す歯磨剤組成物調製方法で調製した組成物の3倍水希釈液に3分間、室温で浸漬した。精製水で洗浄後、Clostridium histolyticum由来collagenase(C9891−500MG,Sigma) 20U/mlを溶解した50mM PIPES緩衝液(0.05M PIPES,0.15M NaCl,0.005M CaCl2,pH6.5)に37℃で6時間浸漬した。象牙質切片をプレパラートに乗せ、顕微鏡用デジタルカメラ(オリンパス製、DP−62)により画像を取り込み、画像解析した。下記の式より平均コラーゲン分解深さを算出し、以下に示す基準で評価した。
A:平均コラーゲン分解深さ(μm)が50μm未満
B:平均コラーゲン分解深さ(μm)が50μm以上55μm未満
C:平均コラーゲン分解深さ(μm)が55μm以上60μm未満
D:平均コラーゲン分解深さ(μm)が60μm以上
10名の被験者が、各組成の歯磨剤組成物をチューブから押し出したときの指圧の程度から、下記3段階の評点で押し出し易さを評点した。10名の被験者の評点から平均値を算出し、以下に示す評価基準で押し出し易さを評価した。
[評点]
3点:わずかな力で簡単に歯磨剤をチューブから出すことができる
2点:やや強い力で歯磨剤をチューブから出すことができる
1点:強く握らないと歯磨剤がチューブから出てこない
A:平均点が2.5点以上3点以下
B:平均点が2点以上2.5点未満
C:平均点が1.5点以上2点未満
D:平均点が1.5点未満
10名の被験者が、歯磨剤組成物を使用した歯みがき直後の口腔内の刺激の無さの程度から、下記4段階の評点で口腔内の刺激の無さを評点した。10名の被験者の評点の平均値を算出し、以下に示す評価基準で口腔内の刺激の無さを評価した。
なお、歯みがきは、各被験者において、約1gの歯磨剤組成物を歯ブラシにつけ、3分間ブラッシングした後、口腔内を水ですすぐことにより実施した。
[評点]
4点:口腔内の刺激を感じない
3点:口腔内の刺激をほとんど感じない
2点:口腔内の刺激を感じた
1点:口腔内の刺激を強く感じた
A:平均点3.5点以上
B:平均点3.0点以上3.5点未満
C:平均点2.0点以上3.0点未満
D:平均点2.0点未満
歯磨剤組成物は、以下のようにして調製した。まず、精製水に(A)成分:ピロリドンカルボン酸Na、(B)成分:塩基性アミノ酸、(C)成分:水溶性フッ素化合物、(D)成分:ピロリドンカルボン酸亜鉛、サッカリンナトリウム、70%ソルビット液、及び無水ケイ酸(増粘性)を溶解してX液を調製した。
別途、プロピレングリコールに、カルボキシメチルセルロースナトリウムを分散させてY液を調製した。
撹拌中のX液に、Y液及び酸化チタンを加えた後、香料、酸化チタン、無水ケイ酸(研磨性)、ラウリル硫酸ナトリウム、ヤシ油脂肪酸アミドプロピルベタイン液、及びポリオキシエチレン硬化ヒマシ油を加え、さらに減圧下で撹拌して歯磨剤組成物を得た。製造には、1.5Lニーダー(石山工作所社製)を用いた。
(A)成分:ピロリドンカルボン酸Na(AJIDEW N−50(味の素社製))
(B)成分:塩異性アミノ酸(L−アルギニン Cグレード(味の素社製)又はリジン塩酸塩(L−リジン塩酸塩(食添)(味の素社製)))
(C)成分:水溶性フッ素化合物(フッ化ナトリウム(精製フッ化ナトリウム(S)RKX−32(ステラケミファ製))又はモノフルオロリン酸ナトリウム(ICL Japan Ltd.))
(D)成分:ピロリドンカルボン酸亜鉛(AJIDEW ZN−100(味の素社製))
その他の成分については医薬部外品原料規格2006に適合したものを用いた。
(A)〜(D)成分を表2〜4に記載した配合量とし、上記歯磨剤組成物調製方法に記載の方法で歯磨剤組成物を調製した。調製した歯磨剤組成物について、各種評価試験を行った。評価結果を表2〜4に併せて記す。
なお、ピロリドンカルボン酸ナトリウム又はピロリドンカルボン酸亜鉛の配合量が10%の場合であると(実施例5、20参照)、押し出し性の評価結果が「B」又は「C」であるが、実用上は問題ない。
Claims (7)
- (A)成分:ピロリドンカルボン酸及びそのアルカリ金属塩の少なくともいずれかと、
(B)成分:塩基性アミノ酸及びその塩の少なくともいずれかと、
(C)成分:水溶性フッ素化合物と、
(D)成分:ピロリドンカルボン酸亜鉛と、を含有する口腔用組成物。 - 前記(A)成分の含有量が、0.1〜10質量%である請求項1に記載の口腔用組成物。
- 前記(B)成分の含有量が、0.05〜20質量%である請求項1又は2に記載の口腔用組成物。
- 前記(C)成分の含有量が、フッ素原子換算で、0.01〜0.5質量%である請求項1〜3のいずれか1項に記載の口腔用組成物。
- 前記(D)成分の含有量が、0.1〜10質量%である請求項1〜4のいずれか1項に記載の口腔用組成物。
- 前記(B)成分が、アルギニン、リジン、及びそれらの塩からなる群から選択される少なくとも1種である請求項1〜5のいずれか1項に記載の口腔用組成物。
- 前記(C)成分が、フッ化ナトリウム又はモノフルオロリン酸ナトリウムである請求項1〜6のいずれか1項に記載の口腔用組成物。
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