JP2016500106A5 - - Google Patents
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- JP2016500106A5 JP2016500106A5 JP2015544110A JP2015544110A JP2016500106A5 JP 2016500106 A5 JP2016500106 A5 JP 2016500106A5 JP 2015544110 A JP2015544110 A JP 2015544110A JP 2015544110 A JP2015544110 A JP 2015544110A JP 2016500106 A5 JP2016500106 A5 JP 2016500106A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- solid
- water
- aqueous base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261729022P | 2012-11-21 | 2012-11-21 | |
| US61/729,022 | 2012-11-21 | ||
| PCT/US2013/070959 WO2014081800A1 (en) | 2012-11-21 | 2013-11-20 | Synthesis of spirocyclic isoxazoline derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016500106A JP2016500106A (ja) | 2016-01-07 |
| JP2016500106A5 true JP2016500106A5 (https=) | 2016-10-06 |
| JP6234471B2 JP6234471B2 (ja) | 2017-11-22 |
Family
ID=49753486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015544110A Active JP6234471B2 (ja) | 2012-11-21 | 2013-11-20 | スピロ環状イソキサゾリン誘導体の合成 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9593126B2 (https=) |
| EP (2) | EP2922854B1 (https=) |
| JP (1) | JP6234471B2 (https=) |
| CN (1) | CN104918944B (https=) |
| AU (1) | AU2013348091B2 (https=) |
| BR (1) | BR112015011740B1 (https=) |
| CA (1) | CA2892344C (https=) |
| ES (1) | ES2916805T3 (https=) |
| MX (1) | MX368078B (https=) |
| PL (1) | PL2922854T3 (https=) |
| WO (1) | WO2014081800A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1210472A1 (en) * | 2012-09-07 | 2016-04-22 | Zoetis Services Llc | Spirocyclic derivatives as antiparasitic agents |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| EP3426660A1 (en) | 2016-03-09 | 2019-01-16 | Basf Se | Spirocyclic derivatives |
| ES2903286T3 (es) | 2016-04-06 | 2022-03-31 | Boehringer Ingelheim Animal Health Usa Inc | Proceso de preparación de compuestos de isoxazolina enriquecidos enantioméricamente y de solvato de tolueno cristalino de (S)-afoxolaner |
| US10556909B2 (en) | 2016-05-20 | 2020-02-11 | Avista Pharma Solutions, Inc. | Synthetic process and intermediates |
| WO2018071535A1 (en) | 2016-10-14 | 2018-04-19 | Merial, Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
| WO2018162312A1 (en) * | 2017-03-10 | 2018-09-13 | Basf Se | Spirocyclic derivatives |
| BR112020003217A2 (pt) | 2017-08-14 | 2020-10-06 | Boehringer Ingelheim Animal Health USA Inc. | compostos pesticidas e parasiticidas de pirazolisoxazolina |
| CA3118033A1 (en) * | 2018-11-06 | 2020-05-14 | Basf Se | Process for preparation of optically enriched isoxazolines |
| KR20230043904A (ko) | 2020-07-24 | 2023-03-31 | 엘랑코 유에스 인코포레이티드 | 이속사졸린 화합물 및 이의 중간체의 제조 공정 |
| CN116744917A (zh) | 2020-09-04 | 2023-09-12 | 礼蓝美国公司 | 适口调配物 |
| CN113548989A (zh) * | 2021-07-14 | 2021-10-26 | 浙江倍合德制药有限公司 | 一种4-硝基苯基-2-甲磺酰基乙酸酯的制备工艺及其生产线 |
| EP4384514A1 (en) | 2021-08-11 | 2024-06-19 | Elanco Us Inc. | Process for making diaryl isoxazoline derivative |
| WO2026043852A1 (en) | 2024-08-20 | 2026-02-26 | Zoetis Services Llc | Process for preparing optically enriched isoxazolines |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091432A (en) * | 1990-03-28 | 1992-02-25 | Glasky Alvin J | 9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use |
| EP1641804A1 (en) * | 2003-06-20 | 2006-04-05 | Celltech R & D Limited | Thienopyridone derivatives as kinase inhibitors |
| CN103270036B (zh) * | 2010-08-05 | 2015-11-25 | 佐蒂斯有限责任公司 | 作为抗寄生物剂的异噁唑啉衍生物 |
| US9167013B2 (en) * | 2011-03-10 | 2015-10-20 | Telefonaktiebolaget L M Ericsson (Publ) | Method and apparatus for prioritizing media within an electronic conference according to utilization settings at respective conference participants |
| ME02412B (me) * | 2011-03-10 | 2016-09-20 | Zoetis Services Llc | Spirociklični derivati izoksazolina kao antiparazitska sredstva |
| AR086113A1 (es) * | 2011-04-30 | 2013-11-20 | Abbott Lab | Isoxazolinas como agentes terapeuticos |
| TWM424868U (en) | 2011-09-02 | 2012-03-21 | yi-zhen Huang | Baby walker |
-
2013
- 2013-11-20 US US14/439,091 patent/US9593126B2/en active Active
- 2013-11-20 MX MX2015006458A patent/MX368078B/es active IP Right Grant
- 2013-11-20 CA CA2892344A patent/CA2892344C/en active Active
- 2013-11-20 WO PCT/US2013/070959 patent/WO2014081800A1/en not_active Ceased
- 2013-11-20 AU AU2013348091A patent/AU2013348091B2/en active Active
- 2013-11-20 JP JP2015544110A patent/JP6234471B2/ja active Active
- 2013-11-20 BR BR112015011740A patent/BR112015011740B1/pt active IP Right Grant
- 2013-11-20 CN CN201380060755.4A patent/CN104918944B/zh active Active
- 2013-11-20 PL PL13802788.3T patent/PL2922854T3/pl unknown
- 2013-11-20 ES ES13802788T patent/ES2916805T3/es active Active
- 2013-11-20 EP EP13802788.3A patent/EP2922854B1/en active Active
- 2013-11-20 EP EP22170224.4A patent/EP4056572A1/en not_active Withdrawn
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