CA2892344C - Synthesis of spirocyclic isoxazoline derivatives - Google Patents
Synthesis of spirocyclic isoxazoline derivatives Download PDFInfo
- Publication number
- CA2892344C CA2892344C CA2892344A CA2892344A CA2892344C CA 2892344 C CA2892344 C CA 2892344C CA 2892344 A CA2892344 A CA 2892344A CA 2892344 A CA2892344 A CA 2892344A CA 2892344 C CA2892344 C CA 2892344C
- Authority
- CA
- Canada
- Prior art keywords
- formula
- compound
- aqueous base
- organics
- nitro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261729022P | 2012-11-21 | 2012-11-21 | |
| US61/729,022 | 2012-11-21 | ||
| PCT/US2013/070959 WO2014081800A1 (en) | 2012-11-21 | 2013-11-20 | Synthesis of spirocyclic isoxazoline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2892344A1 CA2892344A1 (en) | 2014-05-30 |
| CA2892344C true CA2892344C (en) | 2017-06-06 |
Family
ID=49753486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2892344A Active CA2892344C (en) | 2012-11-21 | 2013-11-20 | Synthesis of spirocyclic isoxazoline derivatives |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9593126B2 (https=) |
| EP (2) | EP2922854B1 (https=) |
| JP (1) | JP6234471B2 (https=) |
| CN (1) | CN104918944B (https=) |
| AU (1) | AU2013348091B2 (https=) |
| BR (1) | BR112015011740B1 (https=) |
| CA (1) | CA2892344C (https=) |
| ES (1) | ES2916805T3 (https=) |
| MX (1) | MX368078B (https=) |
| PL (1) | PL2922854T3 (https=) |
| WO (1) | WO2014081800A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1210472A1 (en) * | 2012-09-07 | 2016-04-22 | Zoetis Services Llc | Spirocyclic derivatives as antiparasitic agents |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| EP3426660A1 (en) | 2016-03-09 | 2019-01-16 | Basf Se | Spirocyclic derivatives |
| ES2903286T3 (es) | 2016-04-06 | 2022-03-31 | Boehringer Ingelheim Animal Health Usa Inc | Proceso de preparación de compuestos de isoxazolina enriquecidos enantioméricamente y de solvato de tolueno cristalino de (S)-afoxolaner |
| US10556909B2 (en) | 2016-05-20 | 2020-02-11 | Avista Pharma Solutions, Inc. | Synthetic process and intermediates |
| WO2018071535A1 (en) | 2016-10-14 | 2018-04-19 | Merial, Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
| WO2018162312A1 (en) * | 2017-03-10 | 2018-09-13 | Basf Se | Spirocyclic derivatives |
| BR112020003217A2 (pt) | 2017-08-14 | 2020-10-06 | Boehringer Ingelheim Animal Health USA Inc. | compostos pesticidas e parasiticidas de pirazolisoxazolina |
| CA3118033A1 (en) * | 2018-11-06 | 2020-05-14 | Basf Se | Process for preparation of optically enriched isoxazolines |
| KR20230043904A (ko) | 2020-07-24 | 2023-03-31 | 엘랑코 유에스 인코포레이티드 | 이속사졸린 화합물 및 이의 중간체의 제조 공정 |
| CN116744917A (zh) | 2020-09-04 | 2023-09-12 | 礼蓝美国公司 | 适口调配物 |
| CN113548989A (zh) * | 2021-07-14 | 2021-10-26 | 浙江倍合德制药有限公司 | 一种4-硝基苯基-2-甲磺酰基乙酸酯的制备工艺及其生产线 |
| EP4384514A1 (en) | 2021-08-11 | 2024-06-19 | Elanco Us Inc. | Process for making diaryl isoxazoline derivative |
| WO2026043852A1 (en) | 2024-08-20 | 2026-02-26 | Zoetis Services Llc | Process for preparing optically enriched isoxazolines |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091432A (en) * | 1990-03-28 | 1992-02-25 | Glasky Alvin J | 9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use |
| EP1641804A1 (en) * | 2003-06-20 | 2006-04-05 | Celltech R & D Limited | Thienopyridone derivatives as kinase inhibitors |
| CN103270036B (zh) * | 2010-08-05 | 2015-11-25 | 佐蒂斯有限责任公司 | 作为抗寄生物剂的异噁唑啉衍生物 |
| US9167013B2 (en) * | 2011-03-10 | 2015-10-20 | Telefonaktiebolaget L M Ericsson (Publ) | Method and apparatus for prioritizing media within an electronic conference according to utilization settings at respective conference participants |
| ME02412B (me) * | 2011-03-10 | 2016-09-20 | Zoetis Services Llc | Spirociklični derivati izoksazolina kao antiparazitska sredstva |
| AR086113A1 (es) * | 2011-04-30 | 2013-11-20 | Abbott Lab | Isoxazolinas como agentes terapeuticos |
| TWM424868U (en) | 2011-09-02 | 2012-03-21 | yi-zhen Huang | Baby walker |
-
2013
- 2013-11-20 US US14/439,091 patent/US9593126B2/en active Active
- 2013-11-20 MX MX2015006458A patent/MX368078B/es active IP Right Grant
- 2013-11-20 CA CA2892344A patent/CA2892344C/en active Active
- 2013-11-20 WO PCT/US2013/070959 patent/WO2014081800A1/en not_active Ceased
- 2013-11-20 AU AU2013348091A patent/AU2013348091B2/en active Active
- 2013-11-20 JP JP2015544110A patent/JP6234471B2/ja active Active
- 2013-11-20 BR BR112015011740A patent/BR112015011740B1/pt active IP Right Grant
- 2013-11-20 CN CN201380060755.4A patent/CN104918944B/zh active Active
- 2013-11-20 PL PL13802788.3T patent/PL2922854T3/pl unknown
- 2013-11-20 ES ES13802788T patent/ES2916805T3/es active Active
- 2013-11-20 EP EP13802788.3A patent/EP2922854B1/en active Active
- 2013-11-20 EP EP22170224.4A patent/EP4056572A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP2922854B1 (en) | 2022-05-04 |
| AU2013348091A1 (en) | 2015-06-04 |
| EP2922854A1 (en) | 2015-09-30 |
| JP2016500106A (ja) | 2016-01-07 |
| EP4056572A1 (en) | 2022-09-14 |
| PL2922854T3 (pl) | 2022-07-18 |
| JP6234471B2 (ja) | 2017-11-22 |
| CN104918944A (zh) | 2015-09-16 |
| WO2014081800A1 (en) | 2014-05-30 |
| MX368078B (es) | 2019-09-17 |
| CN104918944B (zh) | 2017-05-10 |
| BR112015011740B1 (pt) | 2020-04-14 |
| US20150291612A1 (en) | 2015-10-15 |
| BR112015011740A2 (pt) | 2017-07-11 |
| AU2013348091B2 (en) | 2017-04-13 |
| CA2892344A1 (en) | 2014-05-30 |
| US9593126B2 (en) | 2017-03-14 |
| AU2013348091A8 (en) | 2015-07-09 |
| MX2015006458A (es) | 2015-08-14 |
| ES2916805T3 (es) | 2022-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20150521 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 11TH ANNIV.) - STANDARD Year of fee payment: 11 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20241010 |
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20241010 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 12TH ANNIV.) - STANDARD Year of fee payment: 12 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20251013 |
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20251013 |