JP2016204396A5 - - Google Patents
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- Publication number
- JP2016204396A5 JP2016204396A5 JP2016179732A JP2016179732A JP2016204396A5 JP 2016204396 A5 JP2016204396 A5 JP 2016204396A5 JP 2016179732 A JP2016179732 A JP 2016179732A JP 2016179732 A JP2016179732 A JP 2016179732A JP 2016204396 A5 JP2016204396 A5 JP 2016204396A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- units
- collagenase
- src
- purified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 36
- 102000029816 Collagenase Human genes 0.000 claims 23
- 108060005980 Collagenase Proteins 0.000 claims 23
- 229960002424 collagenase Drugs 0.000 claims 23
- 230000000694 effects Effects 0.000 claims 9
- 208000035484 Cellulite Diseases 0.000 claims 7
- 206010049752 Peau d'orange Diseases 0.000 claims 7
- 230000036232 cellulite Effects 0.000 claims 7
- YRQNKMKHABXEJZ-UVQQGXFZSA-N chembl176323 Chemical compound C1C[C@]2(C)[C@@]3(C)CC(N=C4C[C@]5(C)CCC6[C@]7(C)CC[C@@H]([C@]7(CC[C@]6(C)[C@@]5(C)CC4=N4)C)CCCCCCCC)=C4C[C@]3(C)CCC2[C@]2(C)CC[C@H](CCCCCCCC)[C@]21C YRQNKMKHABXEJZ-UVQQGXFZSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 241000193159 Hathewaya histolytica Species 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 229960001334 corticosteroids Drugs 0.000 claims 2
- 238000001802 infusion Methods 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 claims 2
- 229960005294 triamcinolone Drugs 0.000 claims 2
- 230000000007 visual effect Effects 0.000 claims 2
- 241000193403 Clostridium Species 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77569006P | 2006-02-22 | 2006-02-22 | |
| US60/775,690 | 2006-02-22 | ||
| US11/703,269 | 2007-02-07 | ||
| US11/703,269 US20070224184A1 (en) | 2006-02-22 | 2007-02-07 | Method for treating cellulite |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015095704A Division JP2015134840A (ja) | 2006-02-22 | 2015-05-08 | セルライト処置用コラゲナーゼ |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018182242A Division JP6649449B2 (ja) | 2006-02-22 | 2018-09-27 | セルライト処置用コラゲナーゼ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016204396A JP2016204396A (ja) | 2016-12-08 |
| JP2016204396A5 true JP2016204396A5 (https=) | 2017-03-30 |
| JP6498167B2 JP6498167B2 (ja) | 2019-04-10 |
Family
ID=38325147
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008556445A Active JP5775658B2 (ja) | 2006-02-22 | 2007-02-22 | セルライト処置用コラゲナーゼ |
| JP2015095704A Pending JP2015134840A (ja) | 2006-02-22 | 2015-05-08 | セルライト処置用コラゲナーゼ |
| JP2016179732A Active JP6498167B2 (ja) | 2006-02-22 | 2016-09-14 | セルライト処置用コラゲナーゼ |
| JP2018182242A Active JP6649449B2 (ja) | 2006-02-22 | 2018-09-27 | セルライト処置用コラゲナーゼ |
| JP2019200656A Active JP6853331B2 (ja) | 2006-02-22 | 2019-11-05 | セルライト処置用コラゲナーゼ |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008556445A Active JP5775658B2 (ja) | 2006-02-22 | 2007-02-22 | セルライト処置用コラゲナーゼ |
| JP2015095704A Pending JP2015134840A (ja) | 2006-02-22 | 2015-05-08 | セルライト処置用コラゲナーゼ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018182242A Active JP6649449B2 (ja) | 2006-02-22 | 2018-09-27 | セルライト処置用コラゲナーゼ |
| JP2019200656A Active JP6853331B2 (ja) | 2006-02-22 | 2019-11-05 | セルライト処置用コラゲナーゼ |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US20070224184A1 (https=) |
| EP (1) | EP1991258B1 (https=) |
| JP (5) | JP5775658B2 (https=) |
| KR (2) | KR20120006063A (https=) |
| AU (1) | AU2007221225B2 (https=) |
| BR (1) | BRPI0708186A2 (https=) |
| CA (1) | CA2643171C (https=) |
| DK (1) | DK1991258T3 (https=) |
| ES (1) | ES2553184T3 (https=) |
| HR (1) | HRP20151182T1 (https=) |
| HU (1) | HUE025918T2 (https=) |
| IL (1) | IL193639A (https=) |
| MX (1) | MX2008010767A (https=) |
| NZ (1) | NZ570642A (https=) |
| PL (1) | PL1991258T3 (https=) |
| PT (1) | PT1991258E (https=) |
| RS (1) | RS54372B1 (https=) |
| SI (1) | SI1991258T1 (https=) |
| WO (1) | WO2007100675A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6958150B2 (en) | 1994-12-15 | 2005-10-25 | Advance Biofactures Of Curacao, N.V. | Reduction of adipose tissue |
| CN101107006B (zh) * | 2005-01-21 | 2013-09-11 | 纽约州立大学研究基金会 | 治疗黏连性关节囊炎的方法 |
| US20070224184A1 (en) * | 2006-02-22 | 2007-09-27 | The Research Foundation Of The State University Of New York | Method for treating cellulite |
| WO2008008468A2 (en) * | 2006-07-14 | 2008-01-17 | Duncan Diane I | Compositions and methods for fat reduction |
| US10071143B1 (en) | 2007-05-03 | 2018-09-11 | The Research Foundation For The State University Of New York | Methods for non-surgical treatment of carpal tunnel syndrome |
| TWI395593B (zh) | 2008-03-06 | 2013-05-11 | Halozyme Inc | 可活化的基質降解酵素之活體內暫時性控制 |
| EP2403523A1 (en) * | 2009-03-06 | 2012-01-11 | Halozyme, Inc. | Temperature sensitive mutants of matrix metalloprotease 1 und uses thereof |
| JP5284239B2 (ja) * | 2009-10-07 | 2013-09-11 | 株式会社メタコ | スクリーン装置 |
| FR2966734B1 (fr) | 2010-10-29 | 2014-07-18 | Max Rombi | Composition comprenant au moins une enzyme proteolytique pour son utilisation pour empecher la synthese des triglycerides |
| JP2014530873A (ja) * | 2011-10-21 | 2014-11-20 | オーキシリウム インターナショナル ホールディングス，インコーポレイテッド | Ｅｆｐの治療または低減方法 |
| PT2802652T (pt) | 2012-01-12 | 2019-09-10 | Endo Global Ventures | Enzimas de clostridium histolyticum |
| US9636385B2 (en) | 2012-10-24 | 2017-05-02 | The Research Foundation For The State University Of New York | Use of collagenase to treat glaucoma |
| US20150196625A9 (en) | 2013-01-07 | 2015-07-16 | Rudolph D. Paladini | Metal Sensitive Mutants of Matrix Metalloproteases and uses thereof |
| EP3834840B8 (en) | 2013-03-15 | 2025-09-17 | Endo Biologics Limited | Treatment method and product for uterine fibroids using purified collagenase |
| US10117892B2 (en) | 2013-08-29 | 2018-11-06 | Allergan, Inc. | Devices and methods for reducing the appearance of cellulite |
| CN103751102A (zh) | 2014-01-15 | 2014-04-30 | 上海交通大学 | 一种胶原酶温敏水凝胶及其制备方法和应用 |
| EP4591945A3 (en) * | 2017-03-01 | 2026-04-15 | Endo Operations Limited | Apparatus and method for assessing and treating cellulite |
| JP7227918B2 (ja) | 2017-03-28 | 2023-02-22 | エンド ベンチャーズ リミテッド | コラゲナーゼ産生の改良された方法 |
| WO2020021332A2 (en) * | 2018-07-12 | 2020-01-30 | Endo Global Aesthetics Limited | Injection techniques for the treatment of cellulite |
| WO2020021330A2 (en) * | 2018-07-12 | 2020-01-30 | Endo Global Aesthetics Limited | Injection techniques for the treatment of cellulite |
| US20240277595A1 (en) * | 2018-09-18 | 2024-08-22 | Endo Global Aesthetics Limited | Compositions and methods for treating cellulite |
| US20220305094A1 (en) * | 2019-01-06 | 2022-09-29 | Endo Global Aesthetics Limited | Collagenase formulations and methods of producing the same |
| US11872267B2 (en) | 2019-10-15 | 2024-01-16 | The Johns Hopkins University | Treatment of uterine fibroids using purified collagenase |
| WO2021108751A1 (en) * | 2019-11-26 | 2021-06-03 | Standard Of Care Corporation | Hyaluronidase compositions and methods of using same to treat cellulite |
| CA3252851A1 (en) * | 2022-05-10 | 2023-11-16 | Endo Global Aesthetics Limited | Collagenase-mediated methods for reducing bruising in a subject with cellulite |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4338300A (en) * | 1981-02-05 | 1982-07-06 | The Regents Of The University Of California | Use of purified clostridial collangenase in the treatment of Peyronie's disease |
| US4524065A (en) * | 1983-08-04 | 1985-06-18 | Bio-Specifics N.V. | Method for the prevention and treatment of scars with enzymes |
| US4645668A (en) * | 1983-08-04 | 1987-02-24 | Biospecifics, Nv | Method for the prevention and treatment of scars with enzymes |
| US5393792A (en) * | 1991-11-20 | 1995-02-28 | Advance Biofactures Of Curacao, N.V. | High dosage topical forms of collagenase |
| US5332503A (en) * | 1993-04-16 | 1994-07-26 | Baxter International Inc. | Process for purifying collagenase |
| CA2189646C (en) * | 1994-06-24 | 1999-05-25 | Francis E. Dwulet | A purified mixture of collagenases and two other proteases obtained from clostridium histolyticum |
| US5589171A (en) * | 1994-08-22 | 1996-12-31 | Advance Biofactures Of Curacao | Treatment of Dupuytren's disease with collagenase |
| CA2158822C (en) * | 1994-09-27 | 2008-12-23 | Kusuki Nishioka | Therapeutic agent for rheumatic disease |
| US6958150B2 (en) * | 1994-12-15 | 2005-10-25 | Advance Biofactures Of Curacao, N.V. | Reduction of adipose tissue |
| US5830741A (en) * | 1996-12-06 | 1998-11-03 | Boehringer Mannheim Corporation | Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease |
| US6086872A (en) * | 1997-03-27 | 2000-07-11 | Advance Biofactures Of Curacao, Nv | Amelioration of dupuytren's disease |
| US6335388B1 (en) * | 1997-10-03 | 2002-01-01 | Lavipharm Laboratories Inc. | Prolamine-plant polar lipid composition, its method of preparation and applications thereof |
| US6022539A (en) * | 1999-06-03 | 2000-02-08 | Advance Biofactures Of Curacao | Amelioration of peyronie's disease |
| US6358539B1 (en) * | 1999-08-20 | 2002-03-19 | Howard Murad | Pharmaceutical compositions for reducing the appearance of cellulite |
| US20070224184A1 (en) * | 2006-02-22 | 2007-09-27 | The Research Foundation Of The State University Of New York | Method for treating cellulite |
| CN101107006B (zh) * | 2005-01-21 | 2013-09-11 | 纽约州立大学研究基金会 | 治疗黏连性关节囊炎的方法 |
| US7811560B2 (en) * | 2006-01-30 | 2010-10-12 | Auxilium Us Holdings, Llc | Compositions and methods for treating collagen-mediated diseases |
| JO3400B1 (ar) * | 2010-09-30 | 2019-10-20 | Ferring Bv | مركب صيدلاني من كاربيتوسين |
| US20210169844A1 (en) * | 2019-12-10 | 2021-06-10 | Tulex Pharmaceuticals Inc. | Compositions and methods for treating epilepsy, seizures and other conditions |
-
2007
- 2007-02-07 US US11/703,269 patent/US20070224184A1/en not_active Abandoned
- 2007-02-22 AU AU2007221225A patent/AU2007221225B2/en active Active
- 2007-02-22 ES ES07751508.8T patent/ES2553184T3/es active Active
- 2007-02-22 SI SI200731702T patent/SI1991258T1/sl unknown
- 2007-02-22 PT PT77515088T patent/PT1991258E/pt unknown
- 2007-02-22 PL PL07751508T patent/PL1991258T3/pl unknown
- 2007-02-22 MX MX2008010767A patent/MX2008010767A/es active IP Right Grant
- 2007-02-22 HU HUE07751508A patent/HUE025918T2/en unknown
- 2007-02-22 EP EP07751508.8A patent/EP1991258B1/en active Active
- 2007-02-22 CA CA2643171A patent/CA2643171C/en active Active
- 2007-02-22 RS RS20150714A patent/RS54372B1/sr unknown
- 2007-02-22 WO PCT/US2007/004752 patent/WO2007100675A2/en not_active Ceased
- 2007-02-22 KR KR1020117028099A patent/KR20120006063A/ko not_active Ceased
- 2007-02-22 NZ NZ570642A patent/NZ570642A/en unknown
- 2007-02-22 HR HRP20151182TT patent/HRP20151182T1/hr unknown
- 2007-02-22 JP JP2008556445A patent/JP5775658B2/ja active Active
- 2007-02-22 DK DK07751508.8T patent/DK1991258T3/en active
- 2007-02-22 KR KR1020087022877A patent/KR20080108996A/ko not_active Ceased
- 2007-02-22 BR BRPI0708186-3A patent/BRPI0708186A2/pt not_active Application Discontinuation
-
2008
- 2008-08-21 IL IL193639A patent/IL193639A/en active IP Right Grant
-
2015
- 2015-05-08 JP JP2015095704A patent/JP2015134840A/ja active Pending
-
2016
- 2016-06-03 US US15/173,092 patent/US10123959B2/en active Active
- 2016-09-14 JP JP2016179732A patent/JP6498167B2/ja active Active
-
2018
- 2018-09-27 JP JP2018182242A patent/JP6649449B2/ja active Active
- 2018-10-19 US US16/165,910 patent/US20190053995A1/en not_active Abandoned
-
2019
- 2019-11-05 JP JP2019200656A patent/JP6853331B2/ja active Active
-
2022
- 2022-04-22 US US17/727,118 patent/US20220249348A1/en active Pending
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