HRP20151182T1 - Kolagenaza za tretiranje celulita - Google Patents
Kolagenaza za tretiranje celulita Download PDFInfo
- Publication number
- HRP20151182T1 HRP20151182T1 HRP20151182TT HRP20151182T HRP20151182T1 HR P20151182 T1 HRP20151182 T1 HR P20151182T1 HR P20151182T T HRP20151182T T HR P20151182TT HR P20151182 T HRP20151182 T HR P20151182T HR P20151182 T1 HRP20151182 T1 HR P20151182T1
- Authority
- HR
- Croatia
- Prior art keywords
- collagenase
- purified
- purified collagenase
- injected
- administered
- Prior art date
Links
- 102000029816 Collagenase Human genes 0.000 title claims 18
- 108060005980 Collagenase Proteins 0.000 title claims 18
- 229960002424 collagenase Drugs 0.000 title claims 18
- 208000035484 Cellulite Diseases 0.000 title claims 2
- 206010049752 Peau d'orange Diseases 0.000 title claims 2
- 230000036232 cellulite Effects 0.000 title claims 2
- YRQNKMKHABXEJZ-UVQQGXFZSA-N chembl176323 Chemical compound C1C[C@]2(C)[C@@]3(C)CC(N=C4C[C@]5(C)CCC6[C@]7(C)CC[C@@H]([C@]7(CC[C@]6(C)[C@@]5(C)CC4=N4)C)CCCCCCCC)=C4C[C@]3(C)CCC2[C@]2(C)CC[C@H](CCCCCCCC)[C@]21C YRQNKMKHABXEJZ-UVQQGXFZSA-N 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 241000193159 Hathewaya histolytica Species 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 claims 1
- 229960005294 triamcinolone Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
Claims (7)
1. Pročišćena kolagenaza za primjenu u terapiji celulita kod ljudi, administriranjem u potkožnu kolagenu mrežu, naznačena time što je kolagenza u biti pročišćena od drugih enzima, pri čemu se pročišćena kolagenaza ubrizgava u dozi od najmanje 1 000 ABC jedinica, primjenjenoj u vidu jedne ili više injekcija i naznačena time što je kolagenaza pročišćena iz bakterije Clostridium histolyticum.
2. Pročišćena kolagenaza za primjenu kao u zahtjevu 1, naznačena time što se pročišćena kolagenaza primjenjuje bez triamcinolona ili nekog drugog kortikosteroida.
3. Pročišćena kolagenaza za primjenu kao u zahtjevu 1, naznačena time što se pročišćena kolagenaza ubrizgava u volumenu od 1.0 ml.
4. Pročišćena kolagenaza za primjenu kao u zahtjevu 1, naznačena time što se pročišćena kolagenaza ubrizgava na različitim mjestima.
5. Pročišćena kolagenaza za primjenu kao u zahtjevu 1, naznačena time što se pročišćena kolagenaza sastoji od od kolagenaze I i kolagenaze II.
6. Pročišćena kolagenaza kao u zahtjevu 1, naznačena time što se tretman ponavlja nakon četiri do šest mjeseci.
7. Pročišćena kolagenaza za primjenu kao u zahtjevu 5, naznačena time što se pročišćena kolagenaza administrira u farmaceutski prihvatljivom tekućem nosaču i sastoji se od kolagenaze I i kolagenaze II u odnosu masa 1 prema 1.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77569006P | 2006-02-22 | 2006-02-22 | |
| US11/703,269 US20070224184A1 (en) | 2006-02-22 | 2007-02-07 | Method for treating cellulite |
| PCT/US2007/004752 WO2007100675A2 (en) | 2006-02-22 | 2007-02-22 | Collagenase for treating cellulite |
| EP07751508.8A EP1991258B1 (en) | 2006-02-22 | 2007-02-22 | Collagenase for treating cellulite |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20151182T1 true HRP20151182T1 (hr) | 2016-01-01 |
Family
ID=38325147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20151182TT HRP20151182T1 (hr) | 2006-02-22 | 2015-11-04 | Kolagenaza za tretiranje celulita |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US20070224184A1 (hr) |
| EP (1) | EP1991258B1 (hr) |
| JP (5) | JP5775658B2 (hr) |
| KR (2) | KR20080108996A (hr) |
| AU (1) | AU2007221225B2 (hr) |
| BR (1) | BRPI0708186A2 (hr) |
| CA (1) | CA2643171C (hr) |
| DK (1) | DK1991258T3 (hr) |
| ES (1) | ES2553184T3 (hr) |
| HR (1) | HRP20151182T1 (hr) |
| HU (1) | HUE025918T2 (hr) |
| IL (1) | IL193639A (hr) |
| MX (1) | MX2008010767A (hr) |
| NZ (1) | NZ570642A (hr) |
| PL (1) | PL1991258T3 (hr) |
| PT (1) | PT1991258E (hr) |
| RS (1) | RS54372B1 (hr) |
| SI (1) | SI1991258T1 (hr) |
| WO (1) | WO2007100675A2 (hr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6958150B2 (en) | 1994-12-15 | 2005-10-25 | Advance Biofactures Of Curacao, N.V. | Reduction of adipose tissue |
| KR100989267B1 (ko) * | 2005-01-21 | 2010-10-20 | 더 리서치 파운데이션 오브 스테이트 유니버시티 오브 뉴욕 | 유착 관절낭염을 치료하는 방법 |
| US20070224184A1 (en) * | 2006-02-22 | 2007-09-27 | The Research Foundation Of The State University Of New York | Method for treating cellulite |
| US20090233885A1 (en) * | 2006-07-14 | 2009-09-17 | Duncan Diane I | Compositions and Methods for Fat Reduction |
| US10071143B1 (en) | 2007-05-03 | 2018-09-11 | The Research Foundation For The State University Of New York | Methods for non-surgical treatment of carpal tunnel syndrome |
| TWI395593B (zh) | 2008-03-06 | 2013-05-11 | Halozyme Inc | 可活化的基質降解酵素之活體內暫時性控制 |
| US20110229451A2 (en) * | 2009-03-06 | 2011-09-22 | Halozyme, Inc. | Temperature sensitive mutants of matrix metalloproteases and uses thereof |
| JP5284239B2 (ja) * | 2009-10-07 | 2013-09-11 | 株式会社メタコ | スクリーン装置 |
| FR2966734B1 (fr) * | 2010-10-29 | 2014-07-18 | Max Rombi | Composition comprenant au moins une enzyme proteolytique pour son utilisation pour empecher la synthese des triglycerides |
| ES2953560T3 (es) * | 2011-10-21 | 2023-11-14 | Endo Global Ventures | Procedimiento para el tratamiento o reducción de paniculopatía fibrosclerótica edematosa |
| NZ766918A (en) | 2012-01-12 | 2023-03-31 | Auxilium Int Holdings Inc | Clostridium histolyticum enzymes and methods for the use thereof |
| US9636385B2 (en) | 2012-10-24 | 2017-05-02 | The Research Foundation For The State University Of New York | Use of collagenase to treat glaucoma |
| WO2014107745A1 (en) | 2013-01-07 | 2014-07-10 | Halozyme, Inc. | Metal sensitive mutants of matrix metalloproteases and uses thereof |
| EP3834840A1 (en) | 2013-03-15 | 2021-06-16 | BioSpecifics Technologies Corporation | Treatment method and product for uterine fibroids using purified collagenase |
| US10117892B2 (en) | 2013-08-29 | 2018-11-06 | Allergan, Inc. | Devices and methods for reducing the appearance of cellulite |
| CN103751102A (zh) | 2014-01-15 | 2014-04-30 | 上海交通大学 | 一种胶原酶温敏水凝胶及其制备方法和应用 |
| US11123280B2 (en) | 2017-03-01 | 2021-09-21 | Endo Ventures Limited | Method of assessing and treating cellulite |
| US11473074B2 (en) | 2017-03-28 | 2022-10-18 | Endo Global Aesthetics Limited | Method of producing collagenase |
| WO2020021332A2 (en) * | 2018-07-12 | 2020-01-30 | Endo Global Aesthetics Limited | Injection techniques for the treatment of cellulite |
| WO2020021330A2 (en) * | 2018-07-12 | 2020-01-30 | Endo Global Aesthetics Limited | Injection techniques for the treatment of cellulite |
| CN113015514A (zh) * | 2018-09-18 | 2021-06-22 | 恩多全球美学有限公司 | 用于治疗皮下脂肪团的组合物和方法 |
| CN113382714A (zh) * | 2019-01-06 | 2021-09-10 | 恩多全球美学有限公司 | 胶原酶制剂及其制备方法 |
| CA3157517A1 (en) | 2019-10-15 | 2021-04-22 | The Johns Hopkins University | Treatment of uterine fibroids using purified collagenase |
| BR112022010042A2 (pt) * | 2019-11-26 | 2022-08-16 | Standard Of Care Corp | Composições de hialuronidase e métodos de uso da mesma para tratar celulite |
| WO2023218384A1 (en) * | 2022-05-10 | 2023-11-16 | Endo Global Aesthetics Limited | Methods of reducing collagenase-mediated bruising in a subject having cellulite |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4338300A (en) * | 1981-02-05 | 1982-07-06 | The Regents Of The University Of California | Use of purified clostridial collangenase in the treatment of Peyronie's disease |
| US4645668A (en) * | 1983-08-04 | 1987-02-24 | Biospecifics, Nv | Method for the prevention and treatment of scars with enzymes |
| US4524065A (en) * | 1983-08-04 | 1985-06-18 | Bio-Specifics N.V. | Method for the prevention and treatment of scars with enzymes |
| US5393792A (en) * | 1991-11-20 | 1995-02-28 | Advance Biofactures Of Curacao, N.V. | High dosage topical forms of collagenase |
| US5332503A (en) * | 1993-04-16 | 1994-07-26 | Baxter International Inc. | Process for purifying collagenase |
| CA2189646C (en) * | 1994-06-24 | 1999-05-25 | Francis E. Dwulet | A purified mixture of collagenases and two other proteases obtained from clostridium histolyticum |
| US5589171A (en) * | 1994-08-22 | 1996-12-31 | Advance Biofactures Of Curacao | Treatment of Dupuytren's disease with collagenase |
| CA2158822C (en) * | 1994-09-27 | 2008-12-23 | Kusuki Nishioka | Therapeutic agent for rheumatic disease |
| US6958150B2 (en) * | 1994-12-15 | 2005-10-25 | Advance Biofactures Of Curacao, N.V. | Reduction of adipose tissue |
| US5830741A (en) * | 1996-12-06 | 1998-11-03 | Boehringer Mannheim Corporation | Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease |
| US6086872A (en) * | 1997-03-27 | 2000-07-11 | Advance Biofactures Of Curacao, Nv | Amelioration of dupuytren's disease |
| WO1999017738A1 (en) * | 1997-10-03 | 1999-04-15 | Lavipharm Laboratories, Inc. | A prolamine-plant polar lipid composition, its method of preparation and applications thereof |
| US6022539A (en) * | 1999-06-03 | 2000-02-08 | Advance Biofactures Of Curacao | Amelioration of peyronie's disease |
| WO2001013865A1 (en) * | 1999-08-20 | 2001-03-01 | Howard Murad | Pharmaceutical compositions and methods for reducing the appearance of cellulite |
| US20070224184A1 (en) * | 2006-02-22 | 2007-09-27 | The Research Foundation Of The State University Of New York | Method for treating cellulite |
| KR100989267B1 (ko) * | 2005-01-21 | 2010-10-20 | 더 리서치 파운데이션 오브 스테이트 유니버시티 오브 뉴욕 | 유착 관절낭염을 치료하는 방법 |
| US7811560B2 (en) * | 2006-01-30 | 2010-10-12 | Auxilium Us Holdings, Llc | Compositions and methods for treating collagen-mediated diseases |
-
2007
- 2007-02-07 US US11/703,269 patent/US20070224184A1/en not_active Abandoned
- 2007-02-22 KR KR1020087022877A patent/KR20080108996A/ko not_active Application Discontinuation
- 2007-02-22 DK DK07751508.8T patent/DK1991258T3/en active
- 2007-02-22 EP EP07751508.8A patent/EP1991258B1/en active Active
- 2007-02-22 CA CA2643171A patent/CA2643171C/en active Active
- 2007-02-22 PT PT77515088T patent/PT1991258E/pt unknown
- 2007-02-22 JP JP2008556445A patent/JP5775658B2/ja active Active
- 2007-02-22 PL PL07751508T patent/PL1991258T3/pl unknown
- 2007-02-22 RS RS20150714A patent/RS54372B1/en unknown
- 2007-02-22 BR BRPI0708186-3A patent/BRPI0708186A2/pt not_active Application Discontinuation
- 2007-02-22 SI SI200731702T patent/SI1991258T1/sl unknown
- 2007-02-22 ES ES07751508.8T patent/ES2553184T3/es active Active
- 2007-02-22 HU HUE07751508A patent/HUE025918T2/en unknown
- 2007-02-22 KR KR1020117028099A patent/KR20120006063A/ko active Search and Examination
- 2007-02-22 MX MX2008010767A patent/MX2008010767A/es active IP Right Grant
- 2007-02-22 NZ NZ570642A patent/NZ570642A/en unknown
- 2007-02-22 AU AU2007221225A patent/AU2007221225B2/en active Active
- 2007-02-22 WO PCT/US2007/004752 patent/WO2007100675A2/en active Application Filing
-
2008
- 2008-08-21 IL IL193639A patent/IL193639A/en active IP Right Grant
-
2015
- 2015-05-08 JP JP2015095704A patent/JP2015134840A/ja active Pending
- 2015-11-04 HR HRP20151182TT patent/HRP20151182T1/hr unknown
-
2016
- 2016-06-03 US US15/173,092 patent/US10123959B2/en active Active
- 2016-09-14 JP JP2016179732A patent/JP6498167B2/ja active Active
-
2018
- 2018-09-27 JP JP2018182242A patent/JP6649449B2/ja active Active
- 2018-10-19 US US16/165,910 patent/US20190053995A1/en not_active Abandoned
-
2019
- 2019-11-05 JP JP2019200656A patent/JP6853331B2/ja active Active
-
2022
- 2022-04-22 US US17/727,118 patent/US20220249348A1/en active Pending
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