JP2016164156A5 - - Google Patents
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- JP2016164156A5 JP2016164156A5 JP2016039991A JP2016039991A JP2016164156A5 JP 2016164156 A5 JP2016164156 A5 JP 2016164156A5 JP 2016039991 A JP2016039991 A JP 2016039991A JP 2016039991 A JP2016039991 A JP 2016039991A JP 2016164156 A5 JP2016164156 A5 JP 2016164156A5
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- immunogen
- immunogenic
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- immunogenic composition
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- 230000002163 immunogen Effects 0.000 claims 29
- 239000000203 mixture Substances 0.000 claims 11
- 230000000890 antigenic Effects 0.000 claims 9
- 239000000969 carrier Substances 0.000 claims 8
- 230000000240 adjuvant Effects 0.000 claims 7
- 239000002671 adjuvant Substances 0.000 claims 7
- 208000006673 Asthma Diseases 0.000 claims 3
- 201000008937 atopic dermatitis Diseases 0.000 claims 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 3
- 229920000272 Oligonucleotide Polymers 0.000 claims 2
- 101710043203 P23p89 Proteins 0.000 claims 2
- 230000000172 allergic Effects 0.000 claims 2
- 229940037003 alum Drugs 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010002198 Anaphylactic reaction Diseases 0.000 claims 1
- 208000003455 Anaphylaxis Diseases 0.000 claims 1
- 206010006473 Bronchopulmonary aspergillosis Diseases 0.000 claims 1
- 206010010741 Conjunctivitis Diseases 0.000 claims 1
- 208000010247 Contact Dermatitis Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 208000005679 Eczema Diseases 0.000 claims 1
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
- 206010016946 Food allergy Diseases 0.000 claims 1
- 208000008665 Gastrointestinal Disease Diseases 0.000 claims 1
- 201000004331 Henoch-Schoenlein purpura Diseases 0.000 claims 1
- 206010019617 Henoch-Schonlein purpura Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010021972 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000004430 Pulmonary Aspergillosis Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 208000005511 Schoenlein-Henoch Purpura Diseases 0.000 claims 1
- 206010046736 Urticarias Diseases 0.000 claims 1
- 201000009961 allergic asthma Diseases 0.000 claims 1
- 201000005794 allergic hypersensitivity disease Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000002052 anaphylactic Effects 0.000 claims 1
- 230000036783 anaphylactic response Effects 0.000 claims 1
- 201000004624 dermatitis Diseases 0.000 claims 1
- 231100000080 dermatitis contact Toxicity 0.000 claims 1
- 231100001003 eczema Toxicity 0.000 claims 1
- 235000020932 food allergy Nutrition 0.000 claims 1
- 201000002146 gastrointestinal system disease Diseases 0.000 claims 1
- 230000009610 hypersensitivity Effects 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 201000004681 psoriasis Diseases 0.000 claims 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 1
- 150000007949 saponins Chemical class 0.000 claims 1
- 201000010874 syndrome Diseases 0.000 claims 1
- 150000003568 thioethers Chemical class 0.000 claims 1
Claims (17)
- 免疫原性担体に連結された抗原性ＩｇＥペプチドを含む免疫原であって、前記抗原性ＩｇＥペプチドが、配列番号２２２−２２４、２３５、２４７、２５８、２５９および２６８−２７０からなる群から選択されるアミノ酸配列からなり、前記抗原性ＩｇＥペプチドが、アミノ酸リンカーを介して前記免疫原性担体に連結し、前記アミノ酸リンカーは
（ａ）前記抗原性ＩｇＥペプチドのＣ末端に結合し、式（Ｇ）ｎＣ［式中、ｎは、０、１、２、３、４、５、６、７、８、９、および１０からなる群から選択される整数であり、（ｎが０である場合には、前記式はシステインを表す）］を有するか、または、
（ｂ）前記抗原性ＩｇＥペプチドのＮ末端に結合し、式Ｃ（Ｇ）ｎ［式中、ｎは、０、１、２、３、４、５、６、７、８、９、および１０からなる群から選択される整数であり、（ｎが０である場合には、前記式はシステインを表す）］を有する、
免疫原。 - 前記式（Ｇ）ｎＣまたはＣ（Ｇ）ｎ中のｎが０、１および２からなる群から選択される整数である、請求項１に記載の免疫原。
- 前記免疫原性担体が、ＨＢｃＡｇ、ＨＢｓＡｇおよびＱｂｅｔａ ＶＬＰからなる群から選択されるウイルス様粒子である、請求項１に記載の免疫原。
- 前記抗原性ＩｇＥペプチドが、前記抗原性ＩｇＥペプチドのシステイン残基および前記免疫原性担体のリシン残基間のチオエーテル連結を介して前記免疫原性担体に連結している、請求項１に記載の免疫原。
- 前記免疫原性担体がＱｂｅｔａ ＶＬＰである、請求項４に記載の免疫原。
- 請求項１〜５のいずれか一項に記載の免疫原を含む、免疫原性組成物。
- 免疫原性担体に連結された抗原性ＩｇＥペプチドを含む第２の免疫原をさらに含む、請求項６に記載の免疫原性組成物。
- 前記第２の免疫原の前記免疫原性担体が、ＨＢｃＡｇ ＶＬＰ、ＨＢｓＡｇ ＶＬＰおよびＱｂｅｔａ ＶＬＰからなる群から選択されるウイルス様粒子である、請求項７に記載の免疫原性組成物。
- 前記第２の免疫原の前記抗原性ＩｇＥペプチドが配列番号３１２のアミノ酸配列からなる、請求項８に記載の免疫原性組成物。
- さらにアジュバントを含む、請求項６に記載の免疫原性組成物。
- 前記アジュバントがミョウバン、ＣｐＧ含有オリゴヌクレオチドおよびサポニン系アジュバントからなる群から選択される、請求項１０に記載の免疫原性組成物。
- 前記アジュバントがＣｐＧ７９０９（配列番号４３３）、ＣｐＧ１０１０３（配列番号４３２）およびＣｐＧ２４５５５（配列番号４３１）から選択されるＣｐＧ含有オリゴヌクレオチドである、請求項１１に記載の免疫原性組成物。
- 前記アジュバントがミョウバンである、請求項１１に記載の免疫原性組成物。
- さらに第２のアジュバントを含む、請求項１３に記載の免疫原性組成物。
- 前記第２のアジュバントがＣｐＧ２４５５５（配列番号４３１）である、請求項１４に記載の免疫原性組成物。
- 喘息、アレルギー性喘息、アレルギー性鼻炎、結膜炎、湿疹、じん麻疹、アトピー性皮膚炎、食品アレルギー、アナフィラキシー、接触性皮膚炎、アレルギー性胃腸病、アレルギー性肺アスペルギルス症、アレルギー性紫斑、過剰ＩｇＥ症候群、アナフィラキシー性過敏症、ＩｇＥ骨髄腫、炎症性腸疾患、および乾癬からなる群から選択される疾患を治療、または予防するための医薬組成物であって、請求項１に記載の免疫原および薬学的に許容できる賦形剤を含む組成物。
- 疾患が喘息である、請求項１６に記載の医薬組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12098908P | 2008-12-09 | 2008-12-09 | |
| US61/120,989 | 2008-12-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013167494A Division JP5964280B2 (ja) | 2008-12-09 | 2013-08-12 | ＩｇＥＣＨ３ペプチドワクチン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016164156A JP2016164156A (ja) | 2016-09-08 |
| JP2016164156A5 true JP2016164156A5 (ja) | 2016-10-20 |
Family
ID=42035836
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540292A Expired - Fee Related JP5209800B2 (ja) | 2008-12-09 | 2009-12-04 | ＩｇＥＣＨ３ペプチドワクチン |
| JP2012175784A Expired - Fee Related JP5367137B2 (ja) | 2008-12-09 | 2012-08-08 | ＩｇＥＣＨ３ペプチドワクチン |
| JP2013167494A Expired - Fee Related JP5964280B2 (ja) | 2008-12-09 | 2013-08-12 | ＩｇＥＣＨ３ペプチドワクチン |
| JP2016039991A Pending JP2016164156A (ja) | 2008-12-09 | 2016-03-02 | ＩｇＥＣＨ３ペプチドワクチン |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540292A Expired - Fee Related JP5209800B2 (ja) | 2008-12-09 | 2009-12-04 | ＩｇＥＣＨ３ペプチドワクチン |
| JP2012175784A Expired - Fee Related JP5367137B2 (ja) | 2008-12-09 | 2012-08-08 | ＩｇＥＣＨ３ペプチドワクチン |
| JP2013167494A Expired - Fee Related JP5964280B2 (ja) | 2008-12-09 | 2013-08-12 | ＩｇＥＣＨ３ペプチドワクチン |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US8298547B2 (ja) |
| EP (2) | EP2865389A1 (ja) |
| JP (4) | JP5209800B2 (ja) |
| KR (3) | KR101634058B1 (ja) |
| CN (1) | CN102245198B (ja) |
| AR (1) | AR074505A1 (ja) |
| AU (1) | AU2009325950B2 (ja) |
| BR (1) | BRPI0922561A2 (ja) |
| CA (1) | CA2744754A1 (ja) |
| CO (1) | CO6561830A2 (ja) |
| DK (1) | DK2376108T3 (ja) |
| ES (1) | ES2622562T3 (ja) |
| HK (1) | HK1163511A1 (ja) |
| IL (1) | IL213029A0 (ja) |
| MX (2) | MX337723B (ja) |
| NZ (2) | NZ592977A (ja) |
| PE (2) | PE20142330A1 (ja) |
| RU (1) | RU2495049C2 (ja) |
| SG (2) | SG186611A1 (ja) |
| TW (1) | TWI387463B (ja) |
| WO (1) | WO2010067286A2 (ja) |
| ZA (1) | ZA201104072B (ja) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0614366A2 (pt) * | 2005-08-11 | 2009-10-06 | Arpi Matossian Rogers | peptìdeo, anticorpo ou fragmento de anticorpo, anticorpo ou ligante funcionalmente equivalente, molécula de ácido nucleico, vetor, célula hospedeira, métodos para expressar um peptìdeo, um anticorpo ou fragmento de anticorpo, um anticorpo ou ligante equivalente e para tratar uma doença em um paciente, composição farmacêutica, composição de vacina, métodos de vacinação de um indivìduo contra uma doença ou um distúrbio e de diagnose de um indivìduo para a presença de anticorpos autoimunes, e, arranjo de peptìdeos |
| MY160201A (en) | 2008-12-09 | 2017-02-28 | Coley Pharm Group Inc | Immunostimulatory oligonucleotides |
| US8552165B2 (en) * | 2008-12-09 | 2013-10-08 | Heather Davis | Immunostimulatory oligonucleotides |
| EP2942061A3 (en) * | 2010-06-07 | 2016-01-13 | Pfizer Vaccines LLC | Ige ch3 peptide vaccine |
| EP2471926A3 (en) | 2010-12-30 | 2012-07-11 | Intervet International BV | Immunostimulatory oligodeoxynucleotides |
| JP5872684B2 (ja) * | 2011-05-26 | 2016-03-01 | インターベット インターナショナル ベー． フェー． | 免疫刺激性オリゴデオキシヌクレオチド |
| BR112013029966A2 (pt) | 2011-05-26 | 2017-01-31 | Intervet Int Bv | oligodesoxinucleotídeo imunoestimulatório não metilado, vetor, e, vacina para prevenir ou combater uma doença infecciosa |
| US9956276B2 (en) | 2012-01-19 | 2018-05-01 | Duke University | Vaccines against antigens involved in therapy resistance and methods of using same |
| US9187553B2 (en) * | 2012-01-25 | 2015-11-17 | Swey-Shen Chen | Displaying native human IgE neutralizing FcepsilonRIa-contacting IgE B-cell epitopes by constraining super beta(b)-strands and cystine knots on thermostable protein scaffold |
| JP5918851B2 (ja) * | 2012-06-18 | 2016-05-18 | 日本全薬工業株式会社 | ＩｇＥペプチドワクチン |
| US20170196952A1 (en) | 2014-07-07 | 2017-07-13 | Duke University | Vaccines against an oncogenic isoform of esr1 and methods of using the same |
| WO2016007499A1 (en) | 2014-07-07 | 2016-01-14 | Duke University | Vaccines against an oncogenic isoform of her2 (erbb2) and methods of using the same |
| WO2016005545A1 (en) | 2014-07-10 | 2016-01-14 | Affiris Ag | Substances and methods for the use in prevention and/or treatment in huntington's disease |
| KR102230325B1 (ko) * | 2015-09-30 | 2021-03-19 | 시오노기 앤드 컴파니, 리미티드 | 면역 부활 활성을 갖는 핵산 유도체 |
| KR101876620B1 (ko) * | 2015-10-27 | 2018-07-09 | 대구한의대학교산학협력단 | 펩타이드 기반 분자결합자를 이용한 노로바이러스 검출칩 및 그 제작방법 |
| CN108697779B (zh) | 2016-01-07 | 2023-09-19 | 杜克大学 | 癌症疫苗和递送方法 |
| US11224665B2 (en) | 2016-10-05 | 2022-01-18 | Duke University | Mitochondrial antiviral signaling (MAVS) protein compositions and methods of using the same |
| US10487143B2 (en) | 2016-10-05 | 2019-11-26 | Duke University | Vaccines against HER3 antigens and methods of using the same |
| MY186779A (en) * | 2017-03-29 | 2021-08-19 | Shionogi & Co | Nucleic acid derivative having immunostimulatory activity |
| WO2022058571A1 (en) | 2020-09-17 | 2022-03-24 | Neovacs | IMMUNOGENIC PRODUCT COMPRISING AN IgE FRAGMENT FOR TREATING IgE-MEDIATED INFLAMMATORY DISORDERS |
| WO2023192203A2 (en) * | 2022-03-28 | 2023-10-05 | The Regents Of The University Of California | Novel plant virus and bacteriophage vaccines |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1980000727A1 (en) | 1978-09-29 | 1980-04-17 | Secretary Energy Brit | Improvements in and relating to electrical power transmission in fluid wells |
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US5023243A (en) | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
| JP2547714B2 (ja) | 1981-10-23 | 1996-10-23 | モルキユラ− バイオシステムズ インコ−ポレテツド | オリゴヌクレオチド治療剤及びその製法 |
| US4722840A (en) | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
| US5374426A (en) | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
| JPS63225397A (ja) * | 1986-10-03 | 1988-09-20 | Dainippon Pharmaceut Co Ltd | 抗アレルギー作用を有する新規ペプチド |
| GB8815795D0 (en) | 1988-07-02 | 1988-08-10 | Bkl Extrusions Ltd | Glazing bead |
| NZ230747A (en) | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| CA2017507C (en) | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant formulation comprising a submicron oil droplet emulsion |
| NZ235315A (en) | 1989-09-19 | 1991-09-25 | Wellcome Found | Chimaeric hepadnavirus core antigen proteins and their construction |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| US5258289A (en) * | 1990-09-05 | 1993-11-02 | Davis Claude G | Method for the selecting of genes encoding catalytic antibodies |
| WO1992011291A1 (en) | 1990-12-20 | 1992-07-09 | Smithkline Beecham Biologicals (S.A.) | Vaccines based on hepatitis b surface antigen |
| SE9102808L (sv) | 1991-09-26 | 1993-03-27 | Lars T Hellman Inst F Immunolo | Vaccin, foer humant bruk, vars avsedda effekt aer att lindra symptomen eller foerhindra uppkomsten av ige-medierade allergiska reaktioner |
| ATE188613T1 (de) | 1992-06-25 | 2000-01-15 | Smithkline Beecham Biolog | Adjuvantien enthaltende impfstoffzusammensetzung |
| HU219056B (hu) | 1993-03-23 | 2001-02-28 | Smithkline Beecham Biologicals Sa | 3-O-Dezacilezett monofoszforil-lipid A-t tartalmazó vakcinakészítmény |
| DE4321946A1 (de) | 1993-07-01 | 1995-01-12 | Hoechst Ag | Methylphosphonsäureester, Verfahren zu deren Herstellung und deren Verwendung |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| US5658738A (en) | 1994-05-31 | 1997-08-19 | Becton Dickinson And Company | Bi-directional oligonucleotides that bind thrombin |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| ATE420171T1 (de) | 1994-07-15 | 2009-01-15 | Univ Iowa Res Found | Immunomodulatorische oligonukleotide |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| WO1996030523A2 (en) | 1995-03-31 | 1996-10-03 | Hans Wolf | Antigen presentation system based on retrovirus-like particles |
| GB9513261D0 (en) | 1995-06-29 | 1995-09-06 | Smithkline Beecham Biolog | Vaccines |
| HUP9901109A3 (en) | 1996-03-01 | 1999-11-29 | Novartis Ag | Peptide immunogens for vaccination against and treatment of allergy |
| ID18046A (id) | 1996-08-20 | 1998-02-19 | Takeda Chemical Industries Ltd | Senyawa siklik campuran, pembuatan dan penngunaannya. |
| GB9621091D0 (en) | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| ATE292980T1 (de) | 1996-10-11 | 2005-04-15 | Univ California | Immunostimulierende oligonucleotidekonjugate |
| AUPO517897A0 (en) * | 1997-02-19 | 1997-04-11 | Csl Limited | Chelating immunostimulating complexes |
| WO1998037919A1 (en) | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS |
| DK1005368T3 (da) | 1997-03-10 | 2010-01-04 | Ottawa Hospital Res Inst | Anvendelse af nukleinsyrer, der indeholder ikke-metyleret CpG dinukleotid i kombination med alun som hjælpestoffer |
| EP1003531B1 (en) | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Processes for preparing nucleic acid constructs |
| JP4101888B2 (ja) | 1997-06-06 | 2008-06-18 | ダイナバックス テクノロジーズ コーポレイション | 免疫刺激オリゴヌクレオチド、その組成物およびその使用方法 |
| GB9712347D0 (en) | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
| GB9717953D0 (en) | 1997-08-22 | 1997-10-29 | Smithkline Beecham Biolog | Vaccine |
| DE69838992T2 (de) | 1997-09-05 | 2008-12-24 | Glaxosmithkline Biologicals S.A., Rixensart | Öl-in-Wasser Emulsionen mit Saponinen |
| CA2320488C (en) | 1998-02-12 | 2007-03-06 | Immune Complex, Corporation | Strategically modified hepatitis b core proteins and their derivatives |
| US6303114B1 (en) | 1998-03-05 | 2001-10-16 | The Medical College Of Ohio | IL-12 enhancement of immune responses to T-independent antigens |
| AU760549B2 (en) | 1998-04-03 | 2003-05-15 | University Of Iowa Research Foundation, The | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
| PL354714A1 (en) | 1998-04-09 | 2004-02-09 | Smithkline Beecham Biologicals S.A. | Adjuvant compositions |
| US7393529B2 (en) * | 1998-04-09 | 2008-07-01 | Idexx Laboratories, Inc. | Methods and compositions for inhibiting binding of IgE to a high affinity receptor |
| US6734287B1 (en) * | 1998-04-09 | 2004-05-11 | Idexx Laboratories, Inc. | Specific binding proteins for treating canine allergy |
| EP0957111B1 (en) * | 1998-04-09 | 2004-12-29 | Idexx Laboratories, Inc. | Specific binding proteins for treating canine allergy |
| TWI227241B (en) * | 1998-06-20 | 2005-02-01 | United Biomedical Inc | IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate |
| GB9817052D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
| ES2327839T3 (es) | 1998-09-03 | 2009-11-04 | Novartis Vaccines And Diagnostics, Inc. | Monodosis de fgf-2 eficaz angiogenicamente y metodo de uso. |
| EP1114024B1 (de) | 1998-09-18 | 2002-11-27 | Pentapharm A.G. | Urokinase-inhibitoren |
| DE69935606T9 (de) | 1998-10-16 | 2021-03-11 | Glaxosmithkline Biologicals S.A. | Adjuvanzsysteme und impfstoffe |
| WO2000023955A1 (en) | 1998-10-21 | 2000-04-27 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Virus-like particles for the induction of autoantibodies |
| US6913749B2 (en) | 1998-11-02 | 2005-07-05 | Resistentia Pharmaceuticals Ab | Immunogenic polypeptides for inducing anti-self IgE responses |
| ATE315658T1 (de) | 1998-11-05 | 2006-02-15 | Powderject Vaccines Inc | Genkonstrukte für genimmunisierung |
| ATE412434T1 (de) | 1998-11-30 | 2008-11-15 | Cytos Biotechnology Ag | Molekulare anordnung von allergenen, verfahren zur deren herstellung und deren verwendung |
| AUPP807399A0 (en) | 1999-01-08 | 1999-02-04 | Csl Limited | Improved immunogenic lhrh composition and methods relating thereto |
| US7776343B1 (en) | 1999-02-17 | 2010-08-17 | Csl Limited | Immunogenic complexes and methods relating thereto |
| US20030170229A1 (en) * | 1999-02-25 | 2003-09-11 | Smithkline Beecham Biologicals S.A. | Vaccine |
| MXPA01008612A (es) * | 1999-02-25 | 2003-06-24 | Smithkline Beecham Biolog | Epitopos o mimotopos derivados de los dominos c-epsilon-3 o c-epsilon-4 de ige, antagonistas de los mismos y sus usos terapeuticos. |
| CZ303653B6 (cs) | 1999-03-19 | 2013-01-30 | Smithkline Beecham Biologicals S. A. | Imunogenní prostredek |
| AU757334B2 (en) * | 1999-03-30 | 2003-02-13 | Idexx Laboratories, Inc. | Specific binding proteins for treating canine allergy |
| WO2000062800A2 (en) | 1999-04-19 | 2000-10-26 | Smithkline Beecham Biologicals Sa | Adjuvant composition comprising saponin and an immunostimulatory oligonucleotide |
| JP2003509452A (ja) | 1999-09-24 | 2003-03-11 | スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム | ポリオキシエチレンアルキルエーテル又はエステル及び少なくとも一つのノニオン界面活性剤を含有するアジュバント |
| EP1221971A2 (en) | 1999-09-24 | 2002-07-17 | SmithKline Beecham Biologics SA | Use of the combination of polyoxyethylene sorbitan ester and octoxynol as adjuvant and its use in vaccines |
| AU783118B2 (en) | 1999-09-27 | 2005-09-29 | Coley Pharmaceutical Gmbh | Methods related to immunostimulatory nucleic acid-induced interferon |
| ATE336502T1 (de) | 2000-04-07 | 2006-09-15 | Univ Leeds | Hepatitis b kernprotein fusionsproteine |
| CA2407897A1 (en) | 2000-05-05 | 2001-11-15 | Cytos Biotechnology Ag | Molecular antigen arrays and vaccines |
| CA2413546C (en) | 2000-06-22 | 2011-06-14 | Celltech Pharmaceuticals Limited | Modification of hepatitis b core antigen |
| EP1304947A1 (en) | 2000-07-15 | 2003-05-02 | Lighthouse Display International Limited | Shelf edge display fittings |
| AUPQ912000A0 (en) | 2000-07-31 | 2000-08-24 | Crown In The Right Of The Queensland Department Of Health, The | Improved virus like particles |
| US20030138769A1 (en) | 2000-08-16 | 2003-07-24 | Birkett Ashley J. | Immunogenic HBc chimer particles having enhanced stability |
| US6887472B2 (en) | 2000-08-30 | 2005-05-03 | Pfizer Inc. | Anti-IgE vaccines |
| GB0026334D0 (en) | 2000-10-27 | 2000-12-13 | Smithkline Beecham Biolog | Vaccine |
| US7320793B2 (en) | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
| WO2003102165A2 (en) | 2002-02-21 | 2003-12-11 | Apovia, Inc. | IMMUNOGENIC HBc CHIMER PARTICLES STABILIZED WITH AN N-TERMINAL CYSTEINE |
| CN1599623B (zh) * | 2001-09-14 | 2011-05-11 | 赛托斯生物技术公司 | 免疫刺激物向病毒样颗粒内的包装:制备方法与用途 |
| WO2003024480A2 (en) | 2001-09-14 | 2003-03-27 | Cytos Biotechnology Ag | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| US8088388B2 (en) | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| US20040176283A1 (en) * | 2002-04-01 | 2004-09-09 | Robinson John A. | Methods and compositions for the design of synthetic vaccines |
| GB0209878D0 (en) | 2002-04-30 | 2002-06-05 | Glaxosmithkline Biolog Sa | Vaccine |
| CU22983A1 (es) * | 2002-05-08 | 2004-09-09 | Inst Finlay | Composición vacunal contra las alergias y método para su obtención y empleo en el tratamiento de las mismas |
| JP4726483B2 (ja) | 2002-07-17 | 2011-07-20 | サイトス バイオテクノロジー アーゲー | 分子抗原アレイ |
| ATE546156T1 (de) | 2002-12-10 | 2012-03-15 | Sanofi Pasteur Biologics Co | Stabilisierte immunogene chimäre hbc-partikel |
| KR20050115913A (ko) * | 2003-03-26 | 2005-12-08 | 사이토스 바이오테크놀로지 아게 | Ｍｅｌａｎ―ａ 펩티드 유사체-바이러스-양-입자컨쥬게이트 |
| JP2008507474A (ja) | 2004-02-02 | 2008-03-13 | タノックス インコーポレイテッド | 新規のＩｇＥエピトープの同定 |
| EP1781325A2 (en) | 2004-07-18 | 2007-05-09 | CSL Limited | Immuno stimulating complex and oligonucleotide formulations for inducing enhanced interferon-gamma responses |
| EP1776105A2 (en) | 2004-07-18 | 2007-04-25 | Coley Pharmaceutical Group, Ltd | Methods and compositions for inducing innate immune responses |
| EP1736538A1 (en) | 2005-06-21 | 2006-12-27 | Cytos Biotechnology AG | Process for the preparative purification of virus-like-particles (VLPs) |
| EP1924279A2 (en) * | 2005-09-07 | 2008-05-28 | The Secretary of State for Defence | Adjuvanted vaccine |
| JP5473336B2 (ja) | 2006-02-15 | 2014-04-16 | アディウタイド・ファーマスーティカルズ・ゲーエムベーハー | オリゴヌクレオチドの処方に関する組成物および方法 |
| US20080166785A1 (en) | 2006-08-16 | 2008-07-10 | Monica Sala-Schaeffer | Polynucleotides allowing the expression and secretion of recombinant HBsAg virus-like particles containing a foreign peptide, their production and use |
| AR065921A1 (es) | 2007-04-02 | 2009-07-08 | Amgen Fremont Inc | Anticuerpos anti-ige |
| US20100203083A1 (en) * | 2007-05-31 | 2010-08-12 | Medigene Ag | Mutated structural protein of a parvovirus |
| US9501570B2 (en) | 2014-07-14 | 2016-11-22 | Verizon Patent And Licensing Inc. | Dynamic routing system |
| US9719791B2 (en) | 2014-12-10 | 2017-08-01 | Mapquest, Inc. | Computerized systems and methods for providing travel information and/or content to users |
| ES2893464T3 (es) | 2016-06-23 | 2022-02-09 | Ripples Ltd | Procedimiento y aparato para imprimir en una bebida |
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- 2009-12-04 EP EP20140195370 patent/EP2865389A1/en not_active Withdrawn
- 2009-12-04 CN CN200980149635.5A patent/CN102245198B/zh not_active Expired - Fee Related
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- 2009-12-04 WO PCT/IB2009/055508 patent/WO2010067286A2/en active Application Filing
- 2009-12-04 JP JP2011540292A patent/JP5209800B2/ja not_active Expired - Fee Related
- 2009-12-04 PE PE2014000753A patent/PE20142330A1/es not_active Application Discontinuation
- 2009-12-04 RU RU2011121043/10A patent/RU2495049C2/ru not_active IP Right Cessation
- 2009-12-04 BR BRPI0922561-7A patent/BRPI0922561A2/pt not_active IP Right Cessation
- 2009-12-04 AU AU2009325950A patent/AU2009325950B2/en not_active Ceased
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- 2009-12-04 CA CA2744754A patent/CA2744754A1/en not_active Abandoned
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- 2009-12-04 EP EP09793590.2A patent/EP2376108B1/en not_active Not-in-force
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