JP2016136963A5 - - Google Patents

Info

Publication number

JP2016136963A5

JP2016136963A5 JP2016037442A JP2016037442A JP2016136963A5 JP 2016136963 A5 JP2016136963 A5 JP 2016136963A5 JP 2016037442 A JP2016037442 A JP 2016037442A JP 2016037442 A JP2016037442 A JP 2016037442A JP 2016136963 A5 JP2016136963 A5 JP 2016136963A5

Authority

JP

Japan

Prior art keywords

amino acid

seq

hvr

group

biomarker

Prior art date

2016-02-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 238000000034 method Methods 0.000 claims description 19
• 210000004698 lymphocyte Anatomy 0.000 claims description 15
• 230000000968 intestinal effect Effects 0.000 claims description 9
• 210000005259 peripheral blood Anatomy 0.000 claims description 2
• 239000011886 peripheral blood Substances 0.000 claims description 2
• 150000001413 amino acids Chemical class 0.000 claims 27
• 239000000090 biomarker Substances 0.000 claims 12
• 239000005557 antagonist Substances 0.000 claims 9
• 229910052740 iodine Inorganic materials 0.000 claims 8
• 102100033016 Integrin beta-7 Human genes 0.000 claims 7
• 125000003275 alpha amino acid group Chemical group 0.000 claims 7
• 108010021315 integrin beta7 Proteins 0.000 claims 7
• 229910052757 nitrogen Inorganic materials 0.000 claims 6
• 229910052698 phosphorus Inorganic materials 0.000 claims 6
• 229910052739 hydrogen Inorganic materials 0.000 claims 4
• 102000006495 integrins Human genes 0.000 claims 4
• 108010044426 integrins Proteins 0.000 claims 4
• 229910052700 potassium Inorganic materials 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 208000011231 Crohn disease Diseases 0.000 claims 3
• 208000017189 Gastrointestinal inflammatory disease Diseases 0.000 claims 3
• 206010009900 Colitis ulcerative Diseases 0.000 claims 2
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
• 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 2
• 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 230000004043 responsiveness Effects 0.000 claims 2
• GGZZISOUXJHYOY-UHFFFAOYSA-N 8-amino-4-hydroxynaphthalene-2-sulfonic acid Chemical compound C1=C(S(O)(=O)=O)C=C2C(N)=CC=CC2=C1O GGZZISOUXJHYOY-UHFFFAOYSA-N 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 229910052805 deuterium Inorganic materials 0.000 claims 1
• 230000007160 gastrointestinal dysfunction Effects 0.000 claims 1
• 210000004027 cell Anatomy 0.000 description 3
• 210000001165 lymph node Anatomy 0.000 description 3
• 210000001519 tissue Anatomy 0.000 description 3
• 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 1
• 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 1
• 238000007822 cytometric assay Methods 0.000 description 1
• 230000002093 peripheral effect Effects 0.000 description 1