JP2016060725A - コアシェル構造体及びそれを含有するs/o型サスペンション - Google Patents
コアシェル構造体及びそれを含有するs/o型サスペンション Download PDFInfo
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- JP2016060725A JP2016060725A JP2014191274A JP2014191274A JP2016060725A JP 2016060725 A JP2016060725 A JP 2016060725A JP 2014191274 A JP2014191274 A JP 2014191274A JP 2014191274 A JP2014191274 A JP 2014191274A JP 2016060725 A JP2016060725 A JP 2016060725A
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- Prior art keywords
- core
- shell structure
- acid
- shell
- sucrose
- Prior art date
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- 235000010378 sodium ascorbate Nutrition 0.000 description 1
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Abstract
Description
項1.
コア部及びシェル部を含むコアシェル構造体であって、
コア部が、親水性基及び疎水性基を有する化合物を、かつ
シェル部が、融点30℃以上の界面活性剤を
それぞれ含有するコアシェル構造体。
項2.
前記界面活性剤が、ショ糖脂肪酸エステルである、項1に記載のコアシェル構造体。
項3.
前記ショ糖脂肪酸エステルが、ショ糖と、炭素数8〜30の飽和又は不飽和の一価の脂肪酸とのエステルである、項2に記載のコアシェル構造体。
項4.
前記ショ糖脂肪酸エステルが、ショ糖パルミチン酸エステル、ショ糖オレイン酸エステル及びショ糖ベヘニン酸エステルからなる群より選択される少なくとも一種のショ糖脂肪酸エステルである、項2に記載のコアシェル構造体。
項5.
項1〜4のいずれか一項に記載のコアシェル構造体、及び
基剤相を含有し、
前記基剤相が前記コアシェル構造体を含有する、
S/O型サスペンション。
本発明のコアシェル構造体は、コア部が、親水性基及び疎水性基を有する化合物を、かつシェル部が、融点30℃以上の界面活性剤をそれぞれ含有する。
1.1 コア部
親水性基及び疎水性基を有する化合物は、特に限定されない。
(1)分子量が、100〜10000である。
(2)水溶解度が、1%〜100%である。
(3)HLB値が、0〜7又は10〜20である。
シェル部は、融点30℃以上の界面活性剤を含有する。
本発明のS/O型サスペンションは、基剤相を含有し、
該基剤相が前記コアシェル構造体を含有する、
S/O型サスペンションである。
基剤相とは、基剤を含有する相であり、該S/O型サスペンションにおいて、前記コアシェル構造体は、前記基剤相中に分散又は溶解している。
本発明のS/O型サスペンションは、その剤形や使用目的等に応じて、その他の添加成分を含有していてもよい。
本発明のコアシェル構造及び本発明のS/O型サスペンションは、特に限定されないが、例えば以下のようにして製造することができる。
本発明のS/O型サスペンションは、特に限定されないが、例えば、外用剤、接着剤、塗料、化粧料及び香料等の用途に使用できる。
モンテルカストナトリウム0.1gを40gの純水に溶解し、これに、ショ糖エルカ酸エステル(三菱化学フーズ社製、ER−290、融点4.0℃、HLB2、主成分はジエステル及びトリエステル)1.0g及びショ糖ステアリン酸エステル(三菱化学フーズ社製、S−070、融点61.5℃、HLB1以下、主成分はジエステル及びトリエステル)1.0gをシクロヘキサン80gに溶解した溶液を加え、ホモジナイザー(ポリトロン社製、PT3100型)を用いて25℃でホモジナイザー攪拌(10000rpm、2分)した。この後に凍結乾燥装置(東京理化器械社製、FDU1100型)で2日間凍結乾燥することによって、コアシェル構造体を調製した。当該生成物3.0gを17.0gのミリスチン酸イソプロピルに加え、サスペンションを得た。
ショ糖エルカ酸エステルの量を2.0gにしたこと以外は実施例1と同様にして、サスペンションを得た。
ショ糖エルカ酸エステルの量を2.5gに、ショ糖ステアリン酸エステルの量を0.5gにしたこと以外は実施例1と同様にして、サスペンションを得た。
ショ糖エルカ酸エステルの量を2.75gに、ショ糖ステアリン酸エステルの量を0.25gにしたこと以外は実施例1と同様にして、サスペンションを得た。
ショ糖エルカ酸エステルの量を2.9gに、ショ糖ステアリン酸エステルの量を0.1gにしたこと以外は実施例1と同様にして、サスペンションを得た。
ショ糖ステアリン酸エステルをS−170(三菱化学フーズ社製、融点65.2℃、HLB1、主成分はジエステル及びトリエステル)にしたこと以外は実施例5を同様にして、サスペンションを得た。
モンテルカストナトリウム0.1gを40gの純水に溶解し、これに、ショ糖エルカ酸エステル(三菱化学フーズ社製、ER−290、融点4.0℃、HLB2、主成分はジエステル及びトリエステル)3.0gをシクロヘキサン80gに溶解した溶液を加え、ホモジナイザー(ポリトロン社製、PT3100型)を用いて25℃でホモジナイザー攪拌(10000rpm、2分)した。この後に凍結乾燥装置(東京理化器械社製、FDU1100型)で凍結乾燥した。当該生成物3.0gを17.0gのミリスチン酸イソプロピルに加えたが、生成物は溶解し、サスペンションは得られなかった。
ショ糖エルカ酸エステルをショ糖ラウリン酸エステル(三菱化学フーズ社製、L−195、融点23.9℃、HLB2、主成分はジエステル及びトリエステル)5.0gにしたこと以外は比較例1と同様にして、同様の結果を得た。
Claims (5)
- コア部及びシェル部を含むコアシェル構造体であって、
コア部が、親水性基及び疎水性基を有する化合物を、かつ
シェル部が、融点30℃以上の界面活性剤を
それぞれ含有するコアシェル構造体。 - 前記界面活性剤が、ショ糖脂肪酸エステルである、請求項1に記載のコアシェル構造体。
- 前記ショ糖脂肪酸エステルが、ショ糖と、炭素数8〜30の飽和又は不飽和の一価の脂肪酸とのエステルである、請求項2に記載のコアシェル構造体。
- 前記ショ糖脂肪酸エステルが、ショ糖パルミチン酸エステル、ショ糖オレイン酸エステル及びショ糖ベヘニン酸エステルからなる群より選択される少なくとも一種のショ糖脂肪酸エステルである、請求項2に記載のコアシェル構造体。
- 請求項1〜4のいずれか一項に記載のコアシェル構造体、及び
基剤相を含有し、
前記基剤相が前記コアシェル構造体を含有する、
S/O型サスペンション。
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