JP2016052583A - 極微針パッチアプリケータ - Google Patents
極微針パッチアプリケータ Download PDFInfo
- Publication number
- JP2016052583A JP2016052583A JP2015237187A JP2015237187A JP2016052583A JP 2016052583 A JP2016052583 A JP 2016052583A JP 2015237187 A JP2015237187 A JP 2015237187A JP 2015237187 A JP2015237187 A JP 2015237187A JP 2016052583 A JP2016052583 A JP 2016052583A
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- Prior art keywords
- microneedle patch
- applicator
- support
- microneedle
- patch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 229940086526 renin-inhibitors Drugs 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- IOVGROKTTNBUGK-SJCJKPOMSA-N ritodrine Chemical compound N([C@@H](C)[C@H](O)C=1C=CC(O)=CC=1)CCC1=CC=C(O)C=C1 IOVGROKTTNBUGK-SJCJKPOMSA-N 0.000 description 1
- 229960001634 ritodrine Drugs 0.000 description 1
- OVVGHDNPYGTYIT-BNXXONSGSA-N rutinose Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)O1 OVVGHDNPYGTYIT-BNXXONSGSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
- 229960000553 somatostatin Drugs 0.000 description 1
- HIWPGCMGAMJNRG-RTPHMHGBSA-N sophorose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HIWPGCMGAMJNRG-RTPHMHGBSA-N 0.000 description 1
- 229950006451 sorbitan laurate Drugs 0.000 description 1
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- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229960005202 streptokinase Drugs 0.000 description 1
- GGCSSNBKKAUURC-UHFFFAOYSA-N sufentanil Chemical compound C1CN(CCC=2SC=CC=2)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 GGCSSNBKKAUURC-UHFFFAOYSA-N 0.000 description 1
- 229960004739 sufentanil Drugs 0.000 description 1
- 229940097346 sulfobutylether-beta-cyclodextrin Drugs 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960000195 terbutaline Drugs 0.000 description 1
- OGBMKVWORPGQRR-UMXFMPSGSA-N teriparatide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CNC=N1 OGBMKVWORPGQRR-UMXFMPSGSA-N 0.000 description 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960000103 thrombolytic agent Drugs 0.000 description 1
- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 description 1
- 229960004231 thymalfasin Drugs 0.000 description 1
- 229960000187 tissue plasminogen activator Drugs 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
- 229960004824 triptorelin Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- RULSWEULPANCDV-PIXUTMIVSA-N turanose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](C(=O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RULSWEULPANCDV-PIXUTMIVSA-N 0.000 description 1
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- 229960005486 vaccine Drugs 0.000 description 1
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- 239000003071 vasodilator agent Substances 0.000 description 1
- 239000003038 vasopressin antagonist Substances 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
- A61B50/30—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/06—Packaging for specific medical equipment
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Surgical Instruments (AREA)
Abstract
Description
本願は、同時係属の米国仮特許出願第61/426,199号(2010年12月22日出願)の両出願に共通の全ての対象事項に対する優先権および利益を主張する。この出願の開示内容は、その全体が参照することによって本明細書に援用される。
本発明は、極微針パッチを保護し、極微針パッチを皮膚表面に適用するために好適なシステムに関し、より具体的には、滅菌パッケージングの中での極微針パッチの保管と、薬剤の送達のための皮膚表面へのパッチの移送および配備を可能にするシステムに関する。
極微針パッチ技術は、皮膚の表皮および/または真皮層中への薬物の送達を可能にする。この技術は、異なるタイプ、サイズ、構造、または電荷の薬物の送達を可能にする。極微針パッチは、その皮膚特性にかかわらず、患者に適用することができる。パッチは、皮膚の浅層を貫通し、疼痛受容体を回避し、その薬物負荷量を送達するように最適化される。
(項目1)
極微針パッチアプリケータであって、
該アプリケータは、
筐体と、
摺動可能に配置されたアプリケータプレートであって、該アプリケータプレートは、後退位置と配備位置との間を往復する態様で移動可能であり、および係合表面を有する、アプリケータプレートと、
圧縮バネであって、該圧縮バネは、該アプリケータプレートが該後退位置にあるとき、バネ力を該アプリケータプレートに付与するように搭載されている、圧縮バネと、
極微針パッチドッキング機構であって、該ドッキング機構は、該アプリケータプレートが該後退位置にある間、該極微針パッチを該アプリケータプレートの該係合表面の近位の位置に捕捉および保持するように構成される、極微針パッチドッキング機構と、
ラッチ機構であって、該ラッチ機構は、ラッチされると、該アプリケータプレートを適所に保持し、ラッチ解除されると、該アプリケータプレートを移動可能にする、ラッチ機構と
を備え、該アプリケータプレートは、該極微針パッチを該係合表面の近位に保持する該ドッキング機構を用いて該後退位置に定置され、および該アプリケータプレートは、該ラッチ機構がラッチ解除されると、該圧縮バネによって該配備位置まで推進される、極微針パッチアプリケータ。
(項目2)
トリガ機構をさらに備え、該トリガ機構は、トリガの起動が前記ラッチ機構をラッチ解除させるように構成される、項目1に記載の極微針パッチアプリケータ。
(項目3)
前記アプリケータプレートは、前記ラッチ機構がラッチ解除位置にあるとき、前記極微針パッチアプリケータに印加された力に応答して、前記後退位置まで後退することが可能である、項目1に記載の極微針パッチアプリケータ。
(項目4)
前記アプリケータプレートが前記後退位置にあるときの前記ラッチ機構のラッチ解除は、該アプリケータプレートを解放し、約0.1lbf * inから約10lbf * inまでの間、好ましくは、約1lb * inから約2lbf * inまでの間の運動エネルギーによって、該後退位置から前記配備位置までの移動を可能にする、項目1に記載の極微針パッチアプリケータ。
(項目5)
前記圧縮バネは、約0.1lbf/inから約50lbf/inまでの間、好ましくは、約2.4から約8.5lbf/inまでの間のバネ定数を有する、項目1に記載の極微針パッチアプリケータ。
(項目6)
前記極微針パッチアプリケータは、前記極微針パッチの上に配置された複数の極微針を用いて該極微針パッチを皮膚表面に係留するために十分な力によって、該極微針パッチを配備させる、項目1に記載の極微針パッチアプリケータ。
(項目7)
前記極微針パッチアプリケータは、使用に先立って、滅菌パッケージングの中に保管されている、項目1に記載の極微針パッチアプリケータ。
(項目8)
極微針パッチ支持体であって、
該極微針パッチ支持体は、
内部領域を画定する周縁を有する筐体と、
該内部領域内に配置される隆起ハブと
を備え、
該極微針パッチ支持体は、極微針パッチが該隆起ハブ上に静止し、該極微針パッチから延在する針が該極微針パッチ支持体と接触しないよう、該極微針パッチを支持するようにサイズおよび寸法決定される、極微針パッチ支持体。
(項目9)
前記内部領域を画定する前記周縁は、形状が実質的に円形である、項目8に記載の極微針パッチ支持体。
(項目10)
前記隆起ハブは、前記内部領域の実質的に中心点にある場所に配置される、項目8に記載の極微針パッチ支持体。
(項目11)
前記隆起ハブは、実質的にメサ形状を備え、該メサ形状は、該隆起ハブの上部の実質的に平坦な部分に中空中心を有する、項目8に記載の極微針パッチ支持体。
(項目12)
前記隆起ハブは、中空中心を有する、項目8に記載の極微針パッチ支持体。
(項目13)
極微針パッチアプリケータシステムであって、
該システムは、
アプリケータであって、該アプリケータは、
筐体と、
摺動可能に配置されたアプリケータプレートであって、該アプリケータプレートは、後退位置と配備位置との間を往復する態様で移動可能であり、および係合表面を有する、アプリケータプレートと、
圧縮バネであって、該圧縮バネは、該アプリケータプレートが該後退位置にあるとき、バネ力を該アプリケータプレートに付与するように搭載されている、圧縮バネと、
極微針パッチドッキング機構であって、該ドッキング機構は、該アプリケータプレートが該後退位置にある間、極微針パッチを該アプリケータプレートの該係合表面の近位の位置に捕捉および保持するように構成される、極微針パッチドッキング機構と、
ラッチ機構であって、該ラッチ機構は、ラッチされると、該アプリケータプレートを適所に保持し、ラッチ解除されると、該アプリケータプレートを移動可能にする、ラッチ機構と
を備える、アプリケータと、
支持体に配置された該極微針パッチと
を備え、該極微針パッチおよび該支持体上への該アプリケータの定置に応じて、該アプリケータへの力の印加は、該後退位置への該アプリケータプレートの後退および該ドッキング機構による該極微針パッチの捕捉を生じさせる、極微針パッチアプリケータシステム。
(項目14)
前記アプリケータは、トリガ機構をさらに備え、該トリガ機構は、該トリガの起動が該ラッチ機構をラッチ解除させるように構成される、項目13に記載の極微針パッチアプリケータシステム。
(項目15)
前記アプリケータプレートは、前記ラッチ機構がラッチ解除位置にあるとき、該アプリケータに印加される力に応答して該後退位置まで後退可能である、項目13に記載の極微針パッチアプリケータシステム。
(項目16)
前記アプリケータプレートが前記後退位置にあるときの前記ラッチ機構のラッチ解除は、該アプリケータプレートを解放し、約0.1lbf * inから約10lbf * inまでの間、好ましくは、約1lbf * inから約2lbf * inまでの間の運動エネルギーを用いて、該後退位置から前記配備位置までの移動を可能にする、項目13に記載の極微針パッチアプリケータシステム。
(項目17)
前記アプリケータは、前記極微針パッチの上に配置された複数の極微針を用いて皮膚表面に該極微針パッチを係留するために十分な力によって該極微針パッチを配備させる、項目13に記載の極微針パッチアプリケータシステム。
(項目18)
前記極微針パッチは、複数の極微針を備え、該複数の極微針は、該極微針パッチを皮膚表面に係留するように構成される、項目13に記載の極微針パッチアプリケータシステム。
(項目19)
極微針パッチは、複数の極微針を備え、該複数の極微針は、生物活性剤を含有し、皮膚表面への取着に応じて、それを送達するように構成される、項目13に記載の極微針パッチアプリケータシステム。
(項目20)
前記極微針パッチは、前記アプリケータでの使用に先立って、滅菌パッケージングの中に保管される、項目13に記載の極微針パッチアプリケータシステム。
(項目21)
前記極微針パッチは、前記アプリケータにおける該極微針パッチの使用に先立って、滅菌パッケージングの中に前記支持体と一緒に保管される、項目13に記載の極微針パッチアプリケータシステム。
(項目22)
前記極微針パッチは、該極微針パッチの上に配置された1つ以上の生物活性剤を含有する、項目13に記載の極微針パッチアプリケータシステム。
(項目23)
前記支持体は、内部領域を画定する周縁を備える、項目13に記載の極微針パッチアプリケータシステム。
(項目24)
隆起ハブは、前記内部領域の実質的に中心点にある場所に配置される、項目23に記載の極微針パッチアプリケータシステム。
(項目25)
前記隆起ハブは、実質的にメサ形状を備え、該メサ形状は、該隆起ハブの上部の実質的に平坦な部分に中空中心を有する、項目24に記載の極微針パッチアプリケータシステム。
(項目26)
前記隆起ハブは、中空中心を有する、項目24に記載の極微針パッチアプリケータシステム。
Claims (8)
- 極微針パッチ支持体であって、
該極微針パッチ支持体は、
内部領域を画定する周縁壁を有する筐体と、
上部を有し、該内部領域内に配置される隆起ハブと
を備え、
該極微針パッチ支持体は、極微針パッチが該隆起ハブ上に静止し、該極微針パッチから延在する針が該極微針パッチ支持体と接触しないよう、該極微針パッチを支持するようにサイズおよび寸法決定され、
該隆起ハブは、該内部領域の実質的に中心点にある場所に配置される、極微針パッチ支持体。 - 前記内部領域を画定する前記周縁壁は、形状が実質的に円形である、請求項1に記載の極微針パッチ支持体。
- 前記隆起ハブは、実質的にメサ形状を備え、該メサ形状は、該隆起ハブの上部の実質的に平坦な部分に中空中心を有する、請求項1に記載の極微針パッチ支持体。
- 前記隆起ハブは、中空中心を有する、請求項1に記載の極微針パッチ支持体。
- 前記筐体を横切って延びて、前記内部領域が閉じられるように密封する、除去可能に取り付けられた密閉カバーをさらに備える、請求項1に記載の極微針パッチ支持体。
- 前記密閉カバーは、化学接着剤または加熱密閉を用いて前記支持体の筐体に接着される、請求項5に記載の極微針パッチ支持体。
- 前記内部領域は、滅菌されている、請求項1に記載の極微針パッチ支持体。
- 前記支持体は、該支持体の保管または取扱いの間、該支持体が極微針パッチを不注意な接触から保護するように構成される、請求項1に記載の極微針パッチ支持体。
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US201061426199P | 2010-12-22 | 2010-12-22 | |
US61/426,199 | 2010-12-22 |
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Family
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JP2013546336A Expired - Fee Related JP6082697B2 (ja) | 2010-12-22 | 2011-12-20 | 極微針パッチアプリケータ |
JP2015237187A Ceased JP2016052583A (ja) | 2010-12-22 | 2015-12-04 | 極微針パッチアプリケータ |
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US (4) | US8540672B2 (ja) |
EP (1) | EP2654582B1 (ja) |
JP (2) | JP6082697B2 (ja) |
AU (1) | AU2011349277A1 (ja) |
CA (1) | CA2822428A1 (ja) |
WO (1) | WO2012088154A1 (ja) |
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Also Published As
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US9415198B2 (en) | 2016-08-16 |
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