JP2015536964A - Ｂ−ｒａｆ阻害剤とヒストン脱アセチル化酵素阻害剤を含む医薬組合せおよび増殖性疾患の治療におけるそれらの使用 - Google Patents
Ｂ−ｒａｆ阻害剤とヒストン脱アセチル化酵素阻害剤を含む医薬組合せおよび増殖性疾患の治療におけるそれらの使用 Download PDFInfo
- Publication number
- JP2015536964A JP2015536964A JP2015541167A JP2015541167A JP2015536964A JP 2015536964 A JP2015536964 A JP 2015536964A JP 2015541167 A JP2015541167 A JP 2015541167A JP 2015541167 A JP2015541167 A JP 2015541167A JP 2015536964 A JP2015536964 A JP 2015536964A
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- raf
- histone deacetylase
- inhibitor
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(C)[n](cc1-c2ccnc(*C=C(C)NC(OC)=O)n2)nc1-c1c(*s(C)([n]2)=O)c2cc(*)c1 Chemical compound CC(C)[n](cc1-c2ccnc(*C=C(C)NC(OC)=O)n2)nc1-c1c(*s(C)([n]2)=O)c2cc(*)c1 0.000 description 1
- QJQLZJSVUBZTRT-AWEZNQCLSA-N CC(C)[n](cc1-c2nc(NC[C@H](C)NC(OC)=O)ncc2C)nc1-c1cc(Cl)cc(NS(C)(=O)=O)c1F Chemical compound CC(C)[n](cc1-c2nc(NC[C@H](C)NC(OC)=O)ncc2C)nc1-c1cc(Cl)cc(NS(C)(=O)=O)c1F QJQLZJSVUBZTRT-AWEZNQCLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261723925P | 2012-11-08 | 2012-11-08 | |
| US61/723,925 | 2012-11-08 | ||
| PCT/EP2013/073452 WO2014072493A1 (en) | 2012-11-08 | 2013-11-08 | Pharmaceutical combination comprising a b-raf inhibitor and a histone deacetylase inhibitor and their use in the treatment of proliferative diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015536964A true JP2015536964A (ja) | 2015-12-24 |
| JP2015536964A5 JP2015536964A5 (enExample) | 2016-12-15 |
Family
ID=49552384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015541167A Pending JP2015536964A (ja) | 2012-11-08 | 2013-11-08 | Ｂ−ｒａｆ阻害剤とヒストン脱アセチル化酵素阻害剤を含む医薬組合せおよび増殖性疾患の治療におけるそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20150283136A1 (enExample) |
| EP (1) | EP2916834A1 (enExample) |
| JP (1) | JP2015536964A (enExample) |
| CN (1) | CN104994850A (enExample) |
| AU (1) | AU2013343425A1 (enExample) |
| BR (1) | BR112015010477A2 (enExample) |
| CA (1) | CA2890663A1 (enExample) |
| HK (1) | HK1214765A1 (enExample) |
| RU (1) | RU2015121367A (enExample) |
| UA (1) | UA115151C2 (enExample) |
| WO (1) | WO2014072493A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3002B1 (ar) | 2009-08-28 | 2016-09-05 | Irm Llc | مركبات و تركيبات كمثبطات كيناز بروتين |
| WO2013070996A1 (en) | 2011-11-11 | 2013-05-16 | Novartis Ag | Method of treating a proliferative disease |
| EP2782557B1 (en) | 2011-11-23 | 2018-09-12 | Array Biopharma, Inc. | Pharmaceutical formulations |
| EP3757130A1 (en) | 2013-09-26 | 2020-12-30 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| ME03558B (me) | 2014-03-14 | 2020-07-20 | Novartis Ag | Molekuli anti-lag-3 antiтela i njihove upotrebe |
| KR20170060042A (ko) | 2014-09-13 | 2017-05-31 | 노파르티스 아게 | Alk 억제제의 조합 요법 |
| EA201790737A1 (ru) | 2014-10-03 | 2017-08-31 | Новартис Аг | Комбинированная терапия |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| MX389663B (es) | 2014-10-14 | 2025-03-20 | Novartis Ag | Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas. |
| US10449211B2 (en) | 2015-03-10 | 2019-10-22 | Aduro Biotech, Inc. | Compositions and methods for activating “stimulator of interferon gene”—dependent signalling |
| WO2017019664A1 (en) * | 2015-07-28 | 2017-02-02 | University Of Iowa Research Foundation | Compositions and methods of treating cancer |
| US20180222982A1 (en) | 2015-07-29 | 2018-08-09 | Novartis Ag | Combination therapies comprising antibody molecules to pd-1 |
| DK3317301T3 (da) | 2015-07-29 | 2021-06-28 | Immutep Sas | Kombinationsterapier omfattende antistofmolekyler mod lag-3 |
| EP3878465A1 (en) | 2015-07-29 | 2021-09-15 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
| EP3355923B1 (en) * | 2015-10-01 | 2022-02-23 | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis | Histone deacetylase inhibitors for use in the treatment of drug resistant melanoma |
| SI3370768T1 (sl) | 2015-11-03 | 2022-04-29 | Janssen Biotech, Inc. | Protitelesa, ki se specifično vežejo na PD-1, in njihove uporabe |
| EP3389712B1 (en) | 2015-12-17 | 2024-04-10 | Novartis AG | Antibody molecules to pd-1 and uses thereof |
| AU2017281940C1 (en) | 2016-06-24 | 2024-11-07 | University Of Iowa Research Foundation | Compositions and methods of treating melanoma |
| US11098077B2 (en) | 2016-07-05 | 2021-08-24 | Chinook Therapeutics, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
| WO2018134254A1 (en) | 2017-01-17 | 2018-07-26 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
| WO2018237173A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| TWI869346B (zh) | 2018-05-30 | 2025-01-11 | 瑞士商諾華公司 | Ｅｎｔｐｄ２抗體、組合療法、及使用該等抗體和組合療法之方法 |
| US20220348651A1 (en) | 2019-09-18 | 2022-11-03 | Novartis Ag | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
| US11529335B2 (en) | 2020-07-31 | 2022-12-20 | University Of Iowa Research Foundation | Compositions and methods for treating cancer |
| WO2023230554A1 (en) | 2022-05-25 | 2023-11-30 | Pfizer Inc. | Combination of a braf inhibitor, an egfr inhibitor, and a pd-1 antagonist for the treatment of braf v600e-mutant, msi-h/dmmr colorectal cancer |
| WO2025003956A1 (en) | 2023-06-30 | 2025-01-02 | Pfizer Inc. | High drug loading formulations of encorafenib |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| MXPA06003163A (es) * | 2003-09-23 | 2006-06-05 | Novartis Ag | Combinacion de un inhibidor de receptor de vegf con un agente quimioterapeutico. |
| PE20070427A1 (es) | 2005-08-30 | 2007-04-21 | Novartis Ag | Compuestos derivados de benzimidazoles sustituidos como inhibidores de tirosina quinasas |
| JO3002B1 (ar) | 2009-08-28 | 2016-09-05 | Irm Llc | مركبات و تركيبات كمثبطات كيناز بروتين |
| ES2627020T3 (es) * | 2011-03-21 | 2017-07-26 | Valcuria Ab | Composición farmacéutica que comprende un inhibidor de HDAC y un esteroide y el uso de la misma |
| NZ618367A (en) * | 2011-06-14 | 2016-01-29 | Novartis Ag | Combination of panobinostat and ruxolitinib in the treatment of cancer such as a myeloproliferative neoplasm |
-
2013
- 2013-11-08 UA UAA201505166A patent/UA115151C2/uk unknown
- 2013-11-08 RU RU2015121367A patent/RU2015121367A/ru not_active Application Discontinuation
- 2013-11-08 BR BR112015010477A patent/BR112015010477A2/pt not_active IP Right Cessation
- 2013-11-08 CN CN201380063549.9A patent/CN104994850A/zh active Pending
- 2013-11-08 US US14/441,750 patent/US20150283136A1/en active Granted
- 2013-11-08 AU AU2013343425A patent/AU2013343425A1/en not_active Abandoned
- 2013-11-08 CA CA2890663A patent/CA2890663A1/en not_active Abandoned
- 2013-11-08 HK HK16102742.9A patent/HK1214765A1/zh unknown
- 2013-11-08 EP EP13788784.0A patent/EP2916834A1/en not_active Withdrawn
- 2013-11-08 JP JP2015541167A patent/JP2015536964A/ja active Pending
- 2013-11-08 WO PCT/EP2013/073452 patent/WO2014072493A1/en not_active Ceased
Non-Patent Citations (1)
| Title |
|---|
| LAI, FRITZ ET AL.: "Histone Deacytylases(HDACs) as Mediators of Resistance to Apoptosis in Melanoma and as Targets for C", ADVANCES IN PHARMACOLOGY, vol. 65, JPN6017026965, 6 September 2012 (2012-09-06), pages 27 - 43, ISSN: 0003750444 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2916834A1 (en) | 2015-09-16 |
| RU2015121367A (ru) | 2017-01-10 |
| WO2014072493A1 (en) | 2014-05-15 |
| CA2890663A1 (en) | 2014-05-15 |
| US20150283136A1 (en) | 2015-10-08 |
| AU2013343425A1 (en) | 2015-06-11 |
| BR112015010477A2 (pt) | 2017-07-11 |
| HK1214765A1 (zh) | 2016-08-05 |
| CN104994850A (zh) | 2015-10-21 |
| UA115151C2 (uk) | 2017-09-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015536964A (ja) | Ｂ−ｒａｆ阻害剤とヒストン脱アセチル化酵素阻害剤を含む医薬組合せおよび増殖性疾患の治療におけるそれらの使用 | |
| US12036227B2 (en) | Combination therapy | |
| US9700557B2 (en) | Pharmaceutical combinations of a CDK4/6 inhibitor and a B-RAF inhibitor | |
| KR102418765B1 (ko) | 암 치료를 위한 Notch 및 CDK4/6 억제제의 조합 요법 | |
| CN103764144B (zh) | Pi3k抑制剂与mek抑制剂的协同组合 | |
| JP2022544234A (ja) | 胃腸間質腫瘍を治療するためのリプレチニブ | |
| TW202214242A (zh) | 西奧羅尼或其衍生物在製備用於預防和/或治療非霍奇金淋巴瘤的藥物之用途 | |
| US11083722B2 (en) | Combination therapies for the treatment of breast cancer | |
| EP4106756A1 (en) | Therapeutic combinations comprising a raf inhibitor for use in treating braf mutant nsclc | |
| US11406627B2 (en) | Combinations of MDM2 inhibitors with inhibitors of ERK for treating cancers | |
| RU2815400C2 (ru) | Комбинированная терапия | |
| US20230061353A1 (en) | Abt-751 and ionizing radiation | |
| TW202435890A (zh) | Raf抑制劑及kras g12c抑制劑組合療法 | |
| HK40103009A (en) | Combination therapy comprising a raf inhibitor and trametinib | |
| Alimova et al. | ATRT-07. AN EPIGENOME DIRECTED FUNCTIONAL GENOMIC SCREEN IDENTIFIES SIRT2 AS A SYNTHETIC LETHAL TARGET IN SMARCB1 DEFICIENT ATRT | |
| BR112014033118B1 (pt) | Combinações farmacêuticas de um inibidor de cdk4/6 e um inibidor de braf, e seus usos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20161024 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20161024 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170725 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20180306 |