JP2015534804A - チューインガム - Google Patents
チューインガム Download PDFInfo
- Publication number
- JP2015534804A JP2015534804A JP2015536274A JP2015536274A JP2015534804A JP 2015534804 A JP2015534804 A JP 2015534804A JP 2015536274 A JP2015536274 A JP 2015536274A JP 2015536274 A JP2015536274 A JP 2015536274A JP 2015534804 A JP2015534804 A JP 2015534804A
- Authority
- JP
- Japan
- Prior art keywords
- zinc
- chewing gum
- region
- extract
- chewing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000015218 chewing gum Nutrition 0.000 title claims abstract description 88
- 229940112822 chewing gum Drugs 0.000 title claims abstract description 85
- 239000011701 zinc Substances 0.000 claims abstract description 62
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 60
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 59
- 206010006326 Breath odour Diseases 0.000 claims abstract description 27
- 239000000419 plant extract Substances 0.000 claims abstract description 21
- 208000024891 symptom Diseases 0.000 claims abstract description 10
- 239000011885 synergistic combination Substances 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims description 41
- 239000000284 extract Substances 0.000 claims description 36
- 230000001055 chewing effect Effects 0.000 claims description 18
- 150000003751 zinc Chemical class 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 14
- -1 glucopyranosyl mannitol Chemical compound 0.000 claims description 12
- VVOAZFWZEDHOOU-UHFFFAOYSA-N magnolol Chemical compound OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 claims description 12
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 12
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 11
- 239000000600 sorbitol Substances 0.000 claims description 11
- 235000010356 sorbitol Nutrition 0.000 claims description 11
- 150000005846 sugar alcohols Polymers 0.000 claims description 11
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims description 9
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims description 9
- 239000003205 fragrance Substances 0.000 claims description 9
- 235000020688 green tea extract Nutrition 0.000 claims description 9
- 239000011576 zinc lactate Substances 0.000 claims description 9
- 235000000193 zinc lactate Nutrition 0.000 claims description 9
- 229940050168 zinc lactate Drugs 0.000 claims description 9
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 8
- 238000011049 filling Methods 0.000 claims description 8
- 239000004246 zinc acetate Substances 0.000 claims description 8
- 235000013904 zinc acetate Nutrition 0.000 claims description 8
- 229930195725 Mannitol Natural products 0.000 claims description 7
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 7
- 239000003086 colorant Substances 0.000 claims description 7
- 235000003599 food sweetener Nutrition 0.000 claims description 7
- 229940094952 green tea extract Drugs 0.000 claims description 7
- 239000000845 maltitol Substances 0.000 claims description 7
- 235000010449 maltitol Nutrition 0.000 claims description 7
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 7
- 229940035436 maltitol Drugs 0.000 claims description 7
- 239000000594 mannitol Substances 0.000 claims description 7
- 235000010355 mannitol Nutrition 0.000 claims description 7
- 150000003464 sulfur compounds Chemical class 0.000 claims description 7
- 239000003765 sweetening agent Substances 0.000 claims description 7
- 229960000314 zinc acetate Drugs 0.000 claims description 7
- 239000011670 zinc gluconate Substances 0.000 claims description 7
- 235000011478 zinc gluconate Nutrition 0.000 claims description 7
- 229960000306 zinc gluconate Drugs 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000002304 perfume Substances 0.000 claims description 6
- 239000011592 zinc chloride Substances 0.000 claims description 6
- 235000005074 zinc chloride Nutrition 0.000 claims description 6
- 229960001939 zinc chloride Drugs 0.000 claims description 6
- BYTORXDZJWWIKR-UHFFFAOYSA-N Hinokiol Natural products CC(C)c1cc2CCC3C(C)(CO)C(O)CCC3(C)c2cc1O BYTORXDZJWWIKR-UHFFFAOYSA-N 0.000 claims description 4
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 4
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 4
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 4
- 239000002535 acidifier Substances 0.000 claims description 4
- 239000003995 emulsifying agent Substances 0.000 claims description 4
- 239000000945 filler Substances 0.000 claims description 4
- FVYXIJYOAGAUQK-UHFFFAOYSA-N honokiol Chemical compound C1=C(CC=C)C(O)=CC=C1C1=CC(CC=C)=CC=C1O FVYXIJYOAGAUQK-UHFFFAOYSA-N 0.000 claims description 4
- 238000011282 treatment Methods 0.000 claims description 4
- 235000013343 vitamin Nutrition 0.000 claims description 4
- 239000011782 vitamin Substances 0.000 claims description 4
- 229940088594 vitamin Drugs 0.000 claims description 4
- 229930003231 vitamin Natural products 0.000 claims description 4
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000000416 hydrocolloid Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- CLWNPUARORRDFD-UHFFFAOYSA-N 2-hydroxybutanedioic acid;zinc Chemical compound [Zn].OC(=O)C(O)CC(O)=O CLWNPUARORRDFD-UHFFFAOYSA-N 0.000 claims description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 2
- 241001517403 Spiranthes Species 0.000 claims description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims description 2
- MFGZXPGKKJMZIY-UHFFFAOYSA-N ethyl 5-amino-1-(4-sulfamoylphenyl)pyrazole-4-carboxylate Chemical compound NC1=C(C(=O)OCC)C=NN1C1=CC=C(S(N)(=O)=O)C=C1 MFGZXPGKKJMZIY-UHFFFAOYSA-N 0.000 claims description 2
- 229940041616 menthol Drugs 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 239000011593 sulfur Substances 0.000 claims description 2
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 2
- BIKXLKXABVUSMH-UHFFFAOYSA-N trizinc;diborate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]B([O-])[O-].[O-]B([O-])[O-] BIKXLKXABVUSMH-UHFFFAOYSA-N 0.000 claims description 2
- 229940056904 zinc ascorbate Drugs 0.000 claims description 2
- 229940062776 zinc aspartate Drugs 0.000 claims description 2
- 239000011667 zinc carbonate Substances 0.000 claims description 2
- 235000004416 zinc carbonate Nutrition 0.000 claims description 2
- 229910000010 zinc carbonate Inorganic materials 0.000 claims description 2
- 239000011746 zinc citrate Substances 0.000 claims description 2
- 235000006076 zinc citrate Nutrition 0.000 claims description 2
- 229940068475 zinc citrate Drugs 0.000 claims description 2
- SRWMQSFFRFWREA-UHFFFAOYSA-M zinc formate Chemical compound [Zn+2].[O-]C=O SRWMQSFFRFWREA-UHFFFAOYSA-M 0.000 claims description 2
- 239000011787 zinc oxide Substances 0.000 claims description 2
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 claims description 2
- 229910000165 zinc phosphate Inorganic materials 0.000 claims description 2
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims description 2
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 2
- 229960001763 zinc sulfate Drugs 0.000 claims description 2
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 2
- WWRJFSIRMWUMAE-ZZMNMWMASA-L zinc;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2h-furan-4-olate Chemical compound [Zn+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] WWRJFSIRMWUMAE-ZZMNMWMASA-L 0.000 claims description 2
- VRGNUPCISFMPEM-ZVGUSBNCSA-L zinc;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Zn+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O VRGNUPCISFMPEM-ZVGUSBNCSA-L 0.000 claims description 2
- NJNDBGREJCHIFG-MDTVQASCSA-L zinc;(2s)-2,6-diaminohexanoate Chemical compound [Zn+2].NCCCC[C@H](N)C([O-])=O.NCCCC[C@H](N)C([O-])=O NJNDBGREJCHIFG-MDTVQASCSA-L 0.000 claims description 2
- POEVDIARYKIEGF-CEOVSRFSSA-L zinc;(2s)-2-aminobutanedioate;hydron Chemical compound [Zn+2].[O-]C(=O)[C@@H](N)CC(O)=O.[O-]C(=O)[C@@H](N)CC(O)=O POEVDIARYKIEGF-CEOVSRFSSA-L 0.000 claims description 2
- LPEBYPDZMWMCLZ-CVBJKYQLSA-L zinc;(z)-octadec-9-enoate Chemical compound [Zn+2].CCCCCCCC\C=C/CCCCCCCC([O-])=O.CCCCCCCC\C=C/CCCCCCCC([O-])=O LPEBYPDZMWMCLZ-CVBJKYQLSA-L 0.000 claims description 2
- JNPQFTCBVDSMDO-UHFFFAOYSA-L zinc;2,3-dihydroxypropanoate Chemical compound [Zn+2].OCC(O)C([O-])=O.OCC(O)C([O-])=O JNPQFTCBVDSMDO-UHFFFAOYSA-L 0.000 claims description 2
- UOXSXMSTSYWNMH-UHFFFAOYSA-L zinc;2-aminoacetate Chemical compound [Zn+2].NCC([O-])=O.NCC([O-])=O UOXSXMSTSYWNMH-UHFFFAOYSA-L 0.000 claims description 2
- MCOGTQGPHPAUJN-UHFFFAOYSA-L zinc;2-hydroxyacetate Chemical compound [Zn+2].OCC([O-])=O.OCC([O-])=O MCOGTQGPHPAUJN-UHFFFAOYSA-L 0.000 claims description 2
- WDHVIZKSFZNHJB-UHFFFAOYSA-L zinc;butanoate Chemical compound [Zn+2].CCCC([O-])=O.CCCC([O-])=O WDHVIZKSFZNHJB-UHFFFAOYSA-L 0.000 claims description 2
- ZPEJZWGMHAKWNL-UHFFFAOYSA-L zinc;oxalate Chemical compound [Zn+2].[O-]C(=O)C([O-])=O ZPEJZWGMHAKWNL-UHFFFAOYSA-L 0.000 claims description 2
- XDWXRAYGALQIFG-UHFFFAOYSA-L zinc;propanoate Chemical compound [Zn+2].CCC([O-])=O.CCC([O-])=O XDWXRAYGALQIFG-UHFFFAOYSA-L 0.000 claims description 2
- 239000011247 coating layer Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims 1
- 244000175448 Citrus madurensis Species 0.000 claims 1
- 241001672694 Citrus reticulata Species 0.000 claims 1
- 235000017317 Fortunella Nutrition 0.000 claims 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims 1
- 235000005487 catechin Nutrition 0.000 claims 1
- 229950001002 cianidanol Drugs 0.000 claims 1
- 239000010410 layer Substances 0.000 claims 1
- 229940032991 zinc picolinate Drugs 0.000 claims 1
- NHVUUBRKFZWXRN-UHFFFAOYSA-L zinc;pyridine-2-carboxylate Chemical compound C=1C=CC=NC=1C(=O)O[Zn]OC(=O)C1=CC=CC=N1 NHVUUBRKFZWXRN-UHFFFAOYSA-L 0.000 claims 1
- 150000008442 polyphenolic compounds Chemical class 0.000 abstract 1
- 235000013824 polyphenols Nutrition 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 description 18
- 238000000576 coating method Methods 0.000 description 18
- 230000000694 effects Effects 0.000 description 15
- 238000009472 formulation Methods 0.000 description 12
- 239000004615 ingredient Substances 0.000 description 10
- 244000215068 Acacia senegal Species 0.000 description 9
- 229920000084 Gum arabic Polymers 0.000 description 9
- 239000000205 acacia gum Substances 0.000 description 9
- 235000010489 acacia gum Nutrition 0.000 description 9
- 230000002195 synergetic effect Effects 0.000 description 9
- 239000008188 pellet Substances 0.000 description 8
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 7
- 208000032139 Halitosis Diseases 0.000 description 7
- 241000218378 Magnolia Species 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 230000009467 reduction Effects 0.000 description 7
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 6
- 239000000811 xylitol Substances 0.000 description 6
- 235000010447 xylitol Nutrition 0.000 description 6
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 6
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Abstract
Description
口臭(halitosis)は、患者の社会生活を制限する状態である。人口の15%から40%が中等度の口臭を患っていると推測されている(Rosing CKら、Braz Oral Res 2011;25(5):466〜71)。臭い息(bad breath)は、一般的に、揮発性硫黄化合物(VSC)の存在によって引き起こされる(Kleinberg Iら、Crit Rev Oral Biol.Med.1990;1(4):247〜59)。前記化合物は、口内細菌による、タンパク質の異化により生じる(De Boever EHら、J Am.Dent.Assoc 1995;126(10):1384〜93)。鼻は、非常に低い濃度のVSCを不快臭として認識でき、臨床診療では、吐き出された空気中のVSC、75ppb(パーツ・パー・ビリオン)が、中等度の口臭の分類のための最小閾値であると考えられている(van den Broek AM.ら、J Dent.2007;35:627〜635)。
ガムベースを有する少なくとも1つの第1の領域と、ガムベースを有さない完全に水溶性の第2の領域とからなるチューインガムであって、コウボク抽出物、緑茶抽出物、およびそれらの組合せから選択される有効量の植物抽出物と、完全に水溶性である微小顆粒に少なくとも部分的に含有されている、有効量の亜鉛イオンとの相乗的組合せを含むチューインガムを作製することが可能であることが、今や判明した。
1)少なくとも、
a)微小顆粒により与えられる亜鉛の含有量が、チューインガムの0.0005%から0.05%の範囲であり、前記微小顆粒が、80%超のソルビトール、2%未満のアラビアゴム、および1%超の亜鉛塩(全微小顆粒のうちの割合)を含有する、ガムベースを有する第1の領域;
b)完全に水溶性のコーティングからなる、ガムベースを有さない第2の領域であって、該コーティングが、75%超のマルチトール、グルコピラノシルソルビトールとグルコピラノシルマンニトールとの混合物、またはキシリトールとマンニトールとの混合物を含有し、チューインガムの0.02%から2%の範囲のコウボク抽出物を含有する第2の領域;
からなる1個のチューインガムを、口臭患者の口腔内に入れるステップと、
2)前記1個のチューインガムを10分間噛むステップ。
試験は、OralChromaで、参照ガム(例2)と比較して本発明によるガム(例3)に関して行なわれ、75ppbという最小の口腔内VSC値を有するボランティアの口腔内VSCを測定した。ハーブ抽出物(0.36%の生コーヒー豆、および0.36%のゴボウ)を含む波形の無糖錠剤からなる、市場で入手できる製品を試験した。VSCを測定するのに使用する方法論は、上記の通りである。
Claims (21)
- ガムベースの少なくとも第1の領域と、ガムベースを有さない完全に水溶性の少なくとも第2の領域とからなるチューインガムであって、前記ガムが、
a)コウボク抽出物、緑茶抽出物、およびそれらの組合せから選択される、有効量の植物抽出物と、
b)完全に水溶性の微小顆粒に少なくとも部分的に含有される、有効量の亜鉛イオンと
の相乗的組合せの存在を特徴とするチューインガム。 - 植物抽出物が、マグノロールおよびホノキオールを、好ましくは該抽出物に対して80重量%を超える濃度で含むコウボク抽出物である、請求項1に記載のチューインガム。
- 植物抽出物が、カテキンを、好ましくは該抽出物に対して40重量%を超える濃度で含む緑茶抽出物である、請求項1に記載のチューインガム。
- 前記植物抽出物が、前記第2の領域に含有される、請求項1から3のいずれかに記載のチューインガム。
- 前記植物抽出物が、前記第1の領域に含有される、請求項1から3のいずれかに記載のチューインガム。
- 亜鉛が、前記第1の領域に含有される、請求項1から5のいずれかに記載のチューインガム。
- 前記水溶性微小顆粒が、1種または複数の多価アルコール、親水コロイド、香料、着色料、甘味料、および他の賦形剤を単独でまたはそれらの混合物で含み、前記微小顆粒が、1000μm未満の平均粒径分布を有する、請求項1から6のいずれかに記載のチューインガム。
- 亜鉛イオンの含有量が、0.0005重量%から0.05重量%の範囲であり、植物抽出物の含有量が、0.02%から2%の範囲である、請求項1から7のいずれか一項に記載のチューインガム。
- 1回分あたり、0.012mgから1.2mgの亜鉛イオン、および0.5mgから50mgのコウボク抽出物を含有する、請求項1から8のいずれか一項に記載のチューインガム。
- 口腔内の空気において75ppbという最小VSC値を有する摂取者により10分間噛まれた1回分のチューインガムが、噛んだ直後、噛む前の値と比較して、口腔内空気中の揮発性硫黄化合物の平均濃度を少なくとも40%減少させることができる、請求項1から9のいずれか一項に記載のチューインガム。
- 口腔内の空気において75ppbという最小VSC値を有する摂取者により10分間噛まれた1回分のチューインガムが、噛み始めてから1時間後、噛む前の値と比較して、口腔内空気中の揮発性硫黄化合物の平均濃度を少なくとも15%減少させることができる、請求項1から10のいずれか一項に記載のチューインガム。
- 亜鉛イオンが、塩化亜鉛、酢酸亜鉛、乳酸亜鉛、グルコン酸亜鉛、酪酸亜鉛、グリセリン酸亜鉛、グリコール酸亜鉛、ギ酸亜鉛、乳酸亜鉛、ピコリン酸亜鉛、プロピオン酸亜鉛、サリチル酸亜鉛、酒石酸亜鉛、硫酸亜鉛、アスコルビン酸亜鉛、ビスグリシン酸亜鉛、リシン酸亜鉛、リンゴ酸亜鉛、モノ−L−メチオニン硫酸亜鉛、ピドロ酸亜鉛、およびそれらの混合物からなる群から選択される塩として存在する、請求項1から11のいずれか一項に記載のチューインガム。
- 追加の亜鉛塩が存在し、オレイン酸亜鉛、ステアリン酸亜鉛、クエン酸亜鉛、リン酸亜鉛、炭酸亜鉛、ホウ酸亜鉛、シュウ酸亜鉛、アスパラギン酸亜鉛、酸化亜鉛、およびそれらの混合物からなる群から選択される、請求項8および9に記載のチューインガム。
- 1回分のチューインガムが、0.1から10mgの亜鉛を与えるような量の前記追加の亜鉛塩を含有する、請求項13に記載のチューインガム。
- ガムベースを有する前記第1の領域がコアを形成し、ガムベースを有さない完全に水溶性の前記第2の領域が、第1の領域を少なくとも部分的にコーティングするコーティング層を形成する、請求項1から14のいずれか一項に記載のチューインガム。
- コーティング層の70乾燥重量%超が、マルチトール、またはグルコピラノシルマンニトールとグルコピラノシルソルビトールとの混合物からなる、請求項15に記載のチューインガム。
- 充填物が、前記第1の領域の内側にも存在する、請求項15または16に記載のチューインガム。
- 前記充填物が、多価アルコール、賦形剤、乳化剤、ビタミン、亜鉛塩を含めた無機塩、緑茶抽出物およびコウボク抽出物、着色料、酸性化剤、ならびに香料のうちの1種または複数を含有する、請求項17に記載のチューインガム。
- 前記第1の領域および前記第2の領域が、重なり合う、交互に重なる層の形態の領域として構成される、請求項1から14のいずれか一項に記載のチューインガム。
- ハッカ属、ミカン属、スピランテス属の種およびメントール、清涼剤および唾液分泌剤として作用する人工および天然香料、ならびにそれらの組合せに由来するものから選択される少なくとも1種の香料を含む、請求項1から19のいずれか一項に記載のチューインガム。
- 口臭の症状の治療に使用するための、請求項1から20に記載のチューインガム。
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ITMI2012A001734 | 2012-10-15 | ||
IT001734A ITMI20121734A1 (it) | 2012-10-15 | 2012-10-15 | Gomme da masticare |
PCT/IB2013/059341 WO2014060929A1 (en) | 2012-10-15 | 2013-10-14 | Chewing gums |
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EP (1) | EP2906046B1 (ja) |
JP (1) | JP6316825B2 (ja) |
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CN106359822A (zh) * | 2015-07-22 | 2017-02-01 | 美佳胜肽科技股份有限公司 | 含多单位活性载体的口香糖 |
CN106880599B (zh) * | 2015-12-15 | 2021-07-06 | 永菳生科股份有限公司 | 含多单位载体的固态软式口溶锭 |
EP3199597A1 (en) | 2016-01-29 | 2017-08-02 | Jotun A/S | Shop primer |
CN106173171A (zh) * | 2016-07-06 | 2016-12-07 | 安徽米乐食品有限公司 | 一种可以清除口臭的抗菌口香糖及其制备方法 |
CN110720542A (zh) * | 2019-11-21 | 2020-01-24 | 福建农林大学 | 一种滑菇子实体多酚糖衣口香糖及其加工方法 |
KR102373361B1 (ko) * | 2021-07-14 | 2022-03-11 | (주)엠엔비물산 | 애완동물용 덴탈껌 제조장치 및 애완동물용 덴탈껌 |
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