JP2015533817A5 - - Google Patents
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- JP2015533817A5 JP2015533817A5 JP2015533387A JP2015533387A JP2015533817A5 JP 2015533817 A5 JP2015533817 A5 JP 2015533817A5 JP 2015533387 A JP2015533387 A JP 2015533387A JP 2015533387 A JP2015533387 A JP 2015533387A JP 2015533817 A5 JP2015533817 A5 JP 2015533817A5
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- JP
- Japan
- Prior art keywords
- peptide
- protein
- composition
- target protein
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261706506P | 2012-09-27 | 2012-09-27 | |
| US61/706,506 | 2012-09-27 | ||
| PCT/CA2013/050741 WO2014047741A1 (en) | 2012-09-27 | 2013-09-27 | Peptide directed protein knockdown |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533817A JP2015533817A (ja) | 2015-11-26 |
| JP2015533817A5 true JP2015533817A5 (https=) | 2016-11-04 |
| JP6550333B2 JP6550333B2 (ja) | 2019-07-24 |
Family
ID=50386747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015533387A Expired - Fee Related JP6550333B2 (ja) | 2012-09-27 | 2013-09-27 | ペプチドに誘導されたタンパク質ノックダウン |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10287333B2 (https=) |
| EP (1) | EP2900697B1 (https=) |
| JP (1) | JP6550333B2 (https=) |
| CN (2) | CN104797603B (https=) |
| AU (1) | AU2013323101C1 (https=) |
| CA (1) | CA2885894C (https=) |
| WO (1) | WO2014047741A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108779167A (zh) * | 2015-10-28 | 2018-11-09 | 宾夕法尼亚州大学信托人 | 鞘内施用腺伴随病毒载体用于基因治疗 |
| WO2017079723A1 (en) * | 2015-11-07 | 2017-05-11 | Board Of Regents, The University Of Texas System | Targeting proteins for degradation |
| CN116082457A (zh) | 2016-02-01 | 2023-05-09 | 堪培拉大学 | 蛋白化合物及其用途 |
| EA037848B1 (ru) * | 2016-07-14 | 2021-05-27 | Общество С Ограниченной Ответственностью "Биохимический Агент" | Гибридный белок, полинуклеотид, генетическая конструкция, продуцент, препарат для регенерации хряща (варианты) |
| WO2018103038A1 (zh) * | 2016-12-08 | 2018-06-14 | 拜西欧斯（北京）生物技术有限公司 | 一种缀合物及其应用 |
| US10906949B2 (en) * | 2017-06-28 | 2021-02-02 | The Cleveland Clinic Foundation | Methods of treating spinal cord injury using a chondroitin sulfate proteoglycan (CSPG) reduction peptide (CRP) comprising a cell membrane penetrating domain, a CSPG binding domain, and a lysosome targeting domain |
| CN109553685B (zh) * | 2017-09-25 | 2021-07-27 | 华中科技大学 | 一种小分子多肽及其在制备防治缺血性脑卒中药物中的应用 |
| WO2019090390A1 (en) | 2017-11-08 | 2019-05-16 | University Of Canberra | Immunogenic compositions and uses therefor |
| CN108358999A (zh) * | 2018-01-17 | 2018-08-03 | 南京师范大学 | 一种雌激素受体靶向肽及其制备和应用 |
| CN112654702B (zh) * | 2018-09-07 | 2025-05-13 | 阿斯利康(瑞典)有限公司 | 改进的核酸酶的组合物和方法 |
| CN111363014A (zh) * | 2018-12-26 | 2020-07-03 | 苏州格兰科医药科技有限公司 | 用于治疗创伤性脑损伤的多肽及其用途和制备方法 |
| US20220170930A1 (en) * | 2019-03-11 | 2022-06-02 | Fudan University | Method for screening compound for treating or preventing polyq-related neurodegenerative diseases |
| CN110013542B (zh) * | 2019-03-20 | 2022-09-20 | 南通大学 | 一种预防/治疗突触核蛋白病的药物及多肽类似物 |
| WO2021223026A1 (en) * | 2020-05-06 | 2021-11-11 | University Of British Columbia | Ezh1/2 knockdown peptides, methods and uses thereof |
| CN112142856B (zh) * | 2020-09-30 | 2022-05-03 | 中国人民解放军空军军医大学 | 一种用于改善脑卒中兴奋性毒性损伤的特异性降解ndrg2靶向肽及其应用 |
| US20260027179A1 (en) * | 2021-02-08 | 2026-01-29 | University Of British Columbia | Anti-synucleinopathy peptide and methods to treat neurodegenerative diseases |
| CN115215939B (zh) * | 2021-04-14 | 2025-09-23 | 中山大学 | 一种融合蛋白及其制备方法与应用 |
| CN116102657A (zh) * | 2021-11-09 | 2023-05-12 | 四川大学华西医院 | 一种基于多肽Pep42构建的嵌合抗原受体免疫细胞制备及其应用 |
| WO2024044493A2 (en) * | 2022-08-22 | 2024-02-29 | The Johns Hopkins University | Treatment of repeat expansion disease |
| CN115957348A (zh) * | 2023-02-23 | 2023-04-14 | 澳门科技大学 | 靶向类风湿性关节炎脂质体递药系统、制备方法及应用 |
| CN116590342B (zh) * | 2023-05-11 | 2026-04-03 | 普递瑞(上海)医药有限公司 | 一种aav载体及其应用 |
| WO2024229777A1 (zh) * | 2023-05-11 | 2024-11-14 | 深圳先进技术研究院 | 一种aav载体及其应用 |
| WO2025113706A1 (zh) * | 2023-12-01 | 2025-06-05 | 苏州格兰科医药科技有限公司 | 一种化学修饰的多肽 |
| WO2025113713A1 (zh) * | 2023-12-01 | 2025-06-05 | 苏州格兰科医药科技有限公司 | 用于治疗新生儿缺氧缺血性脑病的组合物和方法 |
| CN119638819B (zh) * | 2024-12-04 | 2025-12-30 | 厦门大学 | 一种靶向降解tmem59多肽及其应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6225444B1 (en) | 1998-02-10 | 2001-05-01 | Protarga, Inc. | Neuroprotective peptides and uses thereof |
| US7510824B2 (en) * | 1999-06-02 | 2009-03-31 | Nono Inc. | Method of screening peptides useful in treating traumatic injury to the brain or spinal cord |
| WO2001047496A1 (en) * | 1999-12-29 | 2001-07-05 | Mixson A James | Histidine copolymer and methods for using same |
| US6632616B2 (en) | 2000-03-16 | 2003-10-14 | Duke University | Compounds that selectively bind to expanded polyglutamine repeat domains and methods of use thereof |
| JP2003009883A (ja) * | 2001-07-05 | 2003-01-14 | Mitsubishi Pharma Corp | マスト細胞の細胞死誘発剤 |
| AU2002365396A1 (en) * | 2001-11-21 | 2003-06-10 | The Trustees Of The University Of Pennsylvania | Peptides, peptide compositions,and methods of use in binding p 185 |
| US7740839B2 (en) * | 2003-10-31 | 2010-06-22 | Tae-Yoon Kim | EC SOD and cell transducing EC SOD and use thereof |
| US20060014712A1 (en) * | 2004-05-30 | 2006-01-19 | Cemines, Inc. | Controlled delivery of therapeutic compounds |
| CN101374860A (zh) * | 2005-12-23 | 2009-02-25 | 技术转让合伙人公司 | 用作神经递质分泌抑制剂和肌肉松弛诱导物的合成肽 |
| US20070244057A1 (en) | 2006-01-20 | 2007-10-18 | Henry Paulson | Suppressing polyglutamine aggregation and toxicity |
| US7744879B2 (en) | 2006-06-07 | 2010-06-29 | Wisconsin Alumni Research Foundation | Blood-brain barrier targeting antibodies |
| CN101008012A (zh) * | 2006-10-27 | 2007-08-01 | 王尚武 | 一种新型人源神经营养因子bdnf表达结构及其表达 |
| CN101134780A (zh) * | 2007-07-09 | 2008-03-05 | 南京医科大学 | 阻断nr2b信号通路的多肽类似物及其制备方法和药物用途 |
| US20100016221A1 (en) | 2008-07-17 | 2010-01-21 | Riken | Method of degrading protein by chaperone-mediated autophagy |
| HRP20160385T1 (hr) * | 2009-03-09 | 2016-05-06 | Ramot At Tel-Aviv University Ltd. | Pripravci za prevenciju i liječenje neurodegenerativnih bolesti |
| US9746475B2 (en) * | 2011-03-14 | 2017-08-29 | University Of Southern California | Antibody and antibody mimetic for visualization and ablation of endogenous proteins |
| US20130065267A1 (en) * | 2011-09-09 | 2013-03-14 | Emory University | Conjugates and methods for measuring chaperone-mediated autophagy |
-
2013
- 2013-09-27 CA CA2885894A patent/CA2885894C/en active Active
- 2013-09-27 CN CN201380058754.6A patent/CN104797603B/zh active Active
- 2013-09-27 WO PCT/CA2013/050741 patent/WO2014047741A1/en not_active Ceased
- 2013-09-27 JP JP2015533387A patent/JP6550333B2/ja not_active Expired - Fee Related
- 2013-09-27 EP EP13841990.8A patent/EP2900697B1/en active Active
- 2013-09-27 CN CN202011118282.7A patent/CN112225819A/zh active Pending
- 2013-09-27 AU AU2013323101A patent/AU2013323101C1/en active Active
- 2013-09-27 US US14/431,060 patent/US10287333B2/en active Active
-
2019
- 2019-03-27 US US16/366,420 patent/US11186620B2/en active Active
-
2021
- 2021-11-05 US US17/520,015 patent/US12428456B2/en active Active
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