JP2015532654A5 - - Google Patents
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- JP2015532654A5 JP2015532654A5 JP2015530154A JP2015530154A JP2015532654A5 JP 2015532654 A5 JP2015532654 A5 JP 2015532654A5 JP 2015530154 A JP2015530154 A JP 2015530154A JP 2015530154 A JP2015530154 A JP 2015530154A JP 2015532654 A5 JP2015532654 A5 JP 2015532654A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- ntd
- muteins
- tale
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 239000012636 effector Substances 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 230000002103 transcriptional effect Effects 0.000 claims 3
- 102000018120 Recombinases Human genes 0.000 claims 2
- 108010091086 Recombinases Proteins 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 238000005215 recombination Methods 0.000 claims 2
- 230000006798 recombination Effects 0.000 claims 2
- 101710163270 Nuclease Proteins 0.000 claims 1
- 241000232299 Ralstonia Species 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261696689P | 2012-09-04 | 2012-09-04 | |
| US61/696,689 | 2012-09-04 | ||
| US201361753763P | 2013-01-17 | 2013-01-17 | |
| US61/753,763 | 2013-01-17 | ||
| US201361818364P | 2013-05-01 | 2013-05-01 | |
| US61/818,364 | 2013-05-01 | ||
| PCT/US2013/058100 WO2014039585A2 (en) | 2012-09-04 | 2013-09-04 | Chimeric polypeptides having targeted binding specificity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018146232A Division JP6728283B2 (ja) | 2012-09-04 | 2018-08-02 | 標的結合特異性を有するキメラポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015532654A JP2015532654A (ja) | 2015-11-12 |
| JP2015532654A5 true JP2015532654A5 (https=) | 2016-10-13 |
| JP6442406B2 JP6442406B2 (ja) | 2018-12-19 |
Family
ID=50237752
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530154A Active JP6442406B2 (ja) | 2012-09-04 | 2013-09-04 | 標的結合特異性を有するキメラポリペプチド |
| JP2018146232A Active JP6728283B2 (ja) | 2012-09-04 | 2018-08-02 | 標的結合特異性を有するキメラポリペプチド |
| JP2020114229A Active JP7100681B2 (ja) | 2012-09-04 | 2020-07-01 | 標的結合特異性を有するキメラポリペプチド |
| JP2022106801A Active JP7459174B2 (ja) | 2012-09-04 | 2022-07-01 | 標的結合特異性を有するキメラポリペプチド |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018146232A Active JP6728283B2 (ja) | 2012-09-04 | 2018-08-02 | 標的結合特異性を有するキメラポリペプチド |
| JP2020114229A Active JP7100681B2 (ja) | 2012-09-04 | 2020-07-01 | 標的結合特異性を有するキメラポリペプチド |
| JP2022106801A Active JP7459174B2 (ja) | 2012-09-04 | 2022-07-01 | 標的結合特異性を有するキメラポリペプチド |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US9902962B2 (https=) |
| EP (3) | EP2893022B1 (https=) |
| JP (4) | JP6442406B2 (https=) |
| KR (3) | KR102596125B1 (https=) |
| CN (2) | CN109517068B (https=) |
| AU (3) | AU2013312801B2 (https=) |
| BR (1) | BR112015004696B1 (https=) |
| CA (1) | CA2883511C (https=) |
| DK (1) | DK2893022T3 (https=) |
| IL (1) | IL237442B (https=) |
| SG (2) | SG10201701675PA (https=) |
| WO (1) | WO2014039585A2 (https=) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2342336B1 (en) | 2008-09-05 | 2016-12-14 | President and Fellows of Harvard College | Continuous directed evolution of proteins and nucleic acids |
| EP3202903B1 (en) | 2010-12-22 | 2020-02-12 | President and Fellows of Harvard College | Continuous directed evolution |
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| DK2893022T3 (da) * | 2012-09-04 | 2020-07-27 | Scripps Research Inst | Kimæriske polypeptider med målrettet bindingsspecificitet |
| US9708589B2 (en) * | 2012-12-18 | 2017-07-18 | Monsanto Technology Llc | Compositions and methods for custom site-specific DNA recombinases |
| US10793867B2 (en) | 2013-03-15 | 2020-10-06 | Monsanto Technology, Llc | Methods for targeted transgene-integration using custom site-specific DNA recombinases |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| US10179911B2 (en) | 2014-01-20 | 2019-01-15 | President And Fellows Of Harvard College | Negative selection and stringency modulation in continuous evolution systems |
| WO2015153889A2 (en) | 2014-04-02 | 2015-10-08 | University Of Florida Research Foundation, Incorporated | Materials and methods for the treatment of latent viral infection |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| DK3194583T3 (da) * | 2014-07-30 | 2021-12-20 | Zumutor Biologics Inc | Ikke-fucosyleret protein og fremgangsmåder dermed |
| US10920208B2 (en) | 2014-10-22 | 2021-02-16 | President And Fellows Of Harvard College | Evolution of proteases |
| WO2016168631A1 (en) | 2015-04-17 | 2016-10-20 | President And Fellows Of Harvard College | Vector-based mutagenesis system |
| WO2017015545A1 (en) | 2015-07-22 | 2017-01-26 | President And Fellows Of Harvard College | Evolution of site-specific recombinases |
| US11524983B2 (en) | 2015-07-23 | 2022-12-13 | President And Fellows Of Harvard College | Evolution of Bt toxins |
| US10612011B2 (en) | 2015-07-30 | 2020-04-07 | President And Fellows Of Harvard College | Evolution of TALENs |
| US11339408B2 (en) | 2015-08-20 | 2022-05-24 | Applied Stemcell, Inc. | Nuclease with enhanced efficiency of genome editing |
| JP7109784B2 (ja) | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したＣａｓ９蛋白質 |
| KR102547316B1 (ko) | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| EP3526320A1 (en) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| JP2020510038A (ja) | 2017-03-09 | 2020-04-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | がんワクチン |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| WO2018187796A1 (en) * | 2017-04-07 | 2018-10-11 | Donald Danforth Plant Science Center | Methods for increasing resistance to cotton bacterial blight and plants produced thereby |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| US11447809B2 (en) | 2017-07-06 | 2022-09-20 | President And Fellows Of Harvard College | Evolution of tRNA synthetases |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
| AU2018321405A1 (en) | 2017-08-25 | 2020-03-05 | Ipsen Biopharm Ltd. | Evolution of BoNT peptidases |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| US11624130B2 (en) | 2017-09-18 | 2023-04-11 | President And Fellows Of Harvard College | Continuous evolution for stabilized proteins |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| JP2021523733A (ja) | 2018-04-18 | 2021-09-09 | アルティウス インスティテュート フォー バイオメディカル サイエンスィズ | 動物病原体由来ポリペプチドおよびその遺伝子工学的利用 |
| EP3797160A1 (en) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Base editors and uses thereof |
| WO2019241649A1 (en) | 2018-06-14 | 2019-12-19 | President And Fellows Of Harvard College | Evolution of cytidine deaminases |
| US12264181B2 (en) | 2018-06-27 | 2025-04-01 | Altius Institute For Biomedical Sciences | Nucleic acid binding domains and methods of use thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| CN109771403A (zh) * | 2019-01-24 | 2019-05-21 | 广州医科大学附属第一医院 | 一种大鼠造影剂肾病模型的构建方法 |
| JP7657726B2 (ja) | 2019-03-19 | 2025-04-07 | ザ ブロード インスティテュート，インコーポレーテッド | 編集ヌクレオチド配列を編集するための方法および組成物 |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| US20210130828A1 (en) * | 2019-11-01 | 2021-05-06 | Sangamo Therapeutics, Inc. | Gin recombinase variants |
| US12012433B1 (en) * | 2020-02-27 | 2024-06-18 | Integrated Dna Technologies Inc. | Expression and purification of Cas enzymes |
| CN116096878A (zh) | 2020-05-01 | 2023-05-09 | 合成Dna技术公司 | 在非经典tttt前间区序列邻近基序处具有增强的切割活性的毛螺菌科菌种cas12a突变体 |
| DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
| WO2022016118A2 (en) * | 2020-07-17 | 2022-01-20 | Cb Therapeutics, Inc. | Prenyltransferase enzymes |
| KR102265501B1 (ko) * | 2020-12-17 | 2021-06-15 | 국립해양생물자원관 | 다중구리 산화효소 펩타이드를 포함하는 구리대사 관련 신경계 질환의 예방 또는 치료용 조성물 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2137547A1 (en) * | 1992-06-11 | 1993-12-23 | Daniel Meruelo | Chimeric receptor polypeptides, human h13 proteins and uses thereof |
| US20050084885A1 (en) | 1994-01-18 | 2005-04-21 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US6242568B1 (en) | 1994-01-18 | 2001-06-05 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US7277941B2 (en) | 1998-03-11 | 2007-10-02 | Commvault Systems, Inc. | System and method for providing encryption in a storage network by storing a secured encryption key with encrypted archive data in an archive storage device |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US7013219B2 (en) | 1999-01-12 | 2006-03-14 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6794136B1 (en) | 2000-11-20 | 2004-09-21 | Sangamo Biosciences, Inc. | Iterative optimization in the design of binding proteins |
| US7030215B2 (en) | 1999-03-24 | 2006-04-18 | Sangamo Biosciences, Inc. | Position dependent recognition of GNN nucleotide triplets by zinc fingers |
| EP1181359A1 (en) | 1999-05-28 | 2002-02-27 | Sangamo Biosciences Inc. | Gene switches |
| CA2394850C (en) | 1999-12-06 | 2012-02-07 | Sangamo Biosciences, Inc. | Methods of using randomized libraries of zinc finger proteins for the identification of gene function |
| AU2002228841C1 (en) | 2000-12-07 | 2006-11-23 | Sangamo Biosciences, Inc | Regulation of angiogenesis with zinc finger proteins |
| US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| WO2002057294A2 (en) | 2001-01-22 | 2002-07-25 | Sangamo Biosciences, Inc. | Zinc finger proteins for dna binding and gene regulation in plants |
| US7067617B2 (en) | 2001-02-21 | 2006-06-27 | The Scripps Research Institute | Zinc finger binding domains for nucleotide sequence ANN |
| US20040224385A1 (en) | 2001-08-20 | 2004-11-11 | Barbas Carlos F | Zinc finger binding domains for cnn |
| CA2475276A1 (en) | 2002-02-07 | 2003-08-14 | The Scripps Research Institute | Zinc finger libraries |
| US20060211846A1 (en) | 2002-02-13 | 2006-09-21 | Barbas Carlos F Iii | Zinc finger binding domains for nucleotide sequence ANN |
| AU2007269048A1 (en) * | 2006-07-05 | 2008-01-10 | The Scripps Research Institute | Chimeric zinc finger recombinases optimized for catalysis by directed evolution |
| HUE041436T2 (hu) * | 2009-12-10 | 2019-05-28 | Univ Minnesota | Tal-effektor-közvetített DNS-módosítás |
| JP6208580B2 (ja) * | 2010-05-17 | 2017-10-04 | サンガモ セラピューティクス， インコーポレイテッド | 新規のｄｎａ結合タンパク質及びその使用 |
| AU2010360293B2 (en) * | 2010-09-06 | 2016-06-16 | Temasek Life Sciences Laboratory Limited | Molecular interaction between Xa10 and AvrXa10 |
| US9499592B2 (en) * | 2011-01-26 | 2016-11-22 | President And Fellows Of Harvard College | Transcription activator-like effectors |
| AU2012340213B2 (en) * | 2011-11-16 | 2017-12-07 | Sangamo Therapeutics, Inc. | Modified DNA-binding proteins and uses thereof |
| US9688997B2 (en) * | 2011-12-29 | 2017-06-27 | Iowa State University Research Foundation, Inc. | Genetically modified plants with resistance to Xanthomonas and other bacterial plant pathogens |
| DK2893022T3 (da) * | 2012-09-04 | 2020-07-27 | Scripps Research Inst | Kimæriske polypeptider med målrettet bindingsspecificitet |
-
2013
- 2013-09-04 DK DK13834893.3T patent/DK2893022T3/da active
- 2013-09-04 JP JP2015530154A patent/JP6442406B2/ja active Active
- 2013-09-04 EP EP13834893.3A patent/EP2893022B1/en active Active
- 2013-09-04 EP EP22181257.1A patent/EP4148134A1/en active Pending
- 2013-09-04 CA CA2883511A patent/CA2883511C/en active Active
- 2013-09-04 AU AU2013312801A patent/AU2013312801B2/en not_active Revoked
- 2013-09-04 SG SG10201701675PA patent/SG10201701675PA/en unknown
- 2013-09-04 KR KR1020227002477A patent/KR102596125B1/ko active Active
- 2013-09-04 BR BR112015004696-7A patent/BR112015004696B1/pt active IP Right Grant
- 2013-09-04 KR KR1020157008001A patent/KR102201867B1/ko active Active
- 2013-09-04 CN CN201811108126.5A patent/CN109517068B/zh active Active
- 2013-09-04 WO PCT/US2013/058100 patent/WO2014039585A2/en not_active Ceased
- 2013-09-04 KR KR1020217000390A patent/KR102357105B1/ko active Active
- 2013-09-04 SG SG11201501525QA patent/SG11201501525QA/en unknown
- 2013-09-04 EP EP20167774.7A patent/EP3750999B1/en active Active
- 2013-09-04 US US14/425,944 patent/US9902962B2/en active Active
- 2013-09-04 CN CN201380057657.5A patent/CN104781404B/zh active Active
-
2015
- 2015-02-26 IL IL23744215A patent/IL237442B/en active IP Right Grant
-
2018
- 2018-01-23 US US15/878,043 patent/US10829766B2/en active Active
- 2018-08-02 JP JP2018146232A patent/JP6728283B2/ja active Active
-
2019
- 2019-02-08 AU AU2019200922A patent/AU2019200922B2/en active Active
-
2020
- 2020-07-01 JP JP2020114229A patent/JP7100681B2/ja active Active
- 2020-09-24 US US17/031,149 patent/US11466277B2/en active Active
-
2021
- 2021-09-30 AU AU2021240252A patent/AU2021240252B2/en active Active
-
2022
- 2022-07-01 JP JP2022106801A patent/JP7459174B2/ja active Active
- 2022-09-23 US US17/951,849 patent/US20230304022A1/en active Pending
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