JP2018183180A5 - - Google Patents
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- JP2018183180A5 JP2018183180A5 JP2018146232A JP2018146232A JP2018183180A5 JP 2018183180 A5 JP2018183180 A5 JP 2018183180A5 JP 2018146232 A JP2018146232 A JP 2018146232A JP 2018146232 A JP2018146232 A JP 2018146232A JP 2018183180 A5 JP2018183180 A5 JP 2018183180A5
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- 102000018120 Recombinases Human genes 0.000 claims description 77
- 108010091086 Recombinases Proteins 0.000 claims description 77
- 108090000623 proteins and genes Proteins 0.000 claims description 63
- 102000004169 proteins and genes Human genes 0.000 claims description 59
- 108020004707 nucleic acids Proteins 0.000 claims description 37
- 102000039446 nucleic acids Human genes 0.000 claims description 37
- 150000007523 nucleic acids Chemical class 0.000 claims description 37
- 102000037865 fusion proteins Human genes 0.000 claims description 36
- 108020001507 fusion proteins Proteins 0.000 claims description 36
- 229920001184 polypeptide Polymers 0.000 claims description 36
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 36
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 29
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 20
- 230000014509 gene expression Effects 0.000 claims description 14
- 239000012636 effector Substances 0.000 claims description 11
- 230000002103 transcriptional effect Effects 0.000 claims description 11
- 210000004899 c-terminal region Anatomy 0.000 claims description 10
- 230000006798 recombination Effects 0.000 claims description 10
- 238000005215 recombination Methods 0.000 claims description 10
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 9
- 230000035772 mutation Effects 0.000 claims description 9
- 101710163270 Nuclease Proteins 0.000 claims description 7
- 125000000539 amino acid group Chemical group 0.000 claims description 7
- 210000004027 cell Anatomy 0.000 claims description 7
- 241000232299 Ralstonia Species 0.000 claims description 4
- 230000010354 integration Effects 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 108091023040 Transcription factor Proteins 0.000 claims description 2
- 102000040945 Transcription factor Human genes 0.000 claims description 2
- 102000008300 Mutant Proteins Human genes 0.000 claims 8
- 108010021466 Mutant Proteins Proteins 0.000 claims 8
- 108010073062 Transcription Activator-Like Effectors Proteins 0.000 claims 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 54
- 241000187432 Streptomyces coelicolor Species 0.000 description 21
- 210000000349 chromosome Anatomy 0.000 description 20
- 230000003197 catalytic effect Effects 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 7
- 241000187747 Streptomyces Species 0.000 description 6
- 201000008827 tuberculosis Diseases 0.000 description 6
- 239000003937 drug carrier Substances 0.000 description 4
- 239000002773 nucleotide Substances 0.000 description 4
- 125000003729 nucleotide group Chemical group 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 241000193830 Bacillus <bacterium> Species 0.000 description 3
- 241000701950 Bacillus phage phi105 Species 0.000 description 3
- 241000935762 Bacillus virus SPbeta Species 0.000 description 3
- 101100004560 Bacteroides fragilis ccrA gene Proteins 0.000 description 3
- 101100114777 Brucella suis biovar 1 (strain 1330) crcB2 gene Proteins 0.000 description 3
- 241001493117 Lactococcus phage TP901-1 Species 0.000 description 3
- 241000186781 Listeria Species 0.000 description 3
- 241000123765 Listeria phage A118 Species 0.000 description 3
- 241000193996 Streptococcus pyogenes Species 0.000 description 3
- 241001263399 Streptococcus pyogenes phage Species 0.000 description 3
- 241000701955 Streptomyces virus phiC31 Species 0.000 description 3
- 238000001415 gene therapy Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 230000002759 chromosomal effect Effects 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 230000009261 transgenic effect Effects 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000002708 random mutagenesis Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261696689P | 2012-09-04 | 2012-09-04 | |
| US61/696,689 | 2012-09-04 | ||
| US201361753763P | 2013-01-17 | 2013-01-17 | |
| US61/753,763 | 2013-01-17 | ||
| US201361818364P | 2013-05-01 | 2013-05-01 | |
| US61/818,364 | 2013-05-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530154A Division JP6442406B2 (ja) | 2012-09-04 | 2013-09-04 | 標的結合特異性を有するキメラポリペプチド |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020114229A Division JP7100681B2 (ja) | 2012-09-04 | 2020-07-01 | 標的結合特異性を有するキメラポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018183180A JP2018183180A (ja) | 2018-11-22 |
| JP2018183180A5 true JP2018183180A5 (https=) | 2019-02-21 |
| JP6728283B2 JP6728283B2 (ja) | 2020-07-22 |
Family
ID=50237752
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530154A Active JP6442406B2 (ja) | 2012-09-04 | 2013-09-04 | 標的結合特異性を有するキメラポリペプチド |
| JP2018146232A Active JP6728283B2 (ja) | 2012-09-04 | 2018-08-02 | 標的結合特異性を有するキメラポリペプチド |
| JP2020114229A Active JP7100681B2 (ja) | 2012-09-04 | 2020-07-01 | 標的結合特異性を有するキメラポリペプチド |
| JP2022106801A Active JP7459174B2 (ja) | 2012-09-04 | 2022-07-01 | 標的結合特異性を有するキメラポリペプチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530154A Active JP6442406B2 (ja) | 2012-09-04 | 2013-09-04 | 標的結合特異性を有するキメラポリペプチド |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020114229A Active JP7100681B2 (ja) | 2012-09-04 | 2020-07-01 | 標的結合特異性を有するキメラポリペプチド |
| JP2022106801A Active JP7459174B2 (ja) | 2012-09-04 | 2022-07-01 | 標的結合特異性を有するキメラポリペプチド |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US9902962B2 (https=) |
| EP (3) | EP4148134A1 (https=) |
| JP (4) | JP6442406B2 (https=) |
| KR (3) | KR102357105B1 (https=) |
| CN (2) | CN104781404B (https=) |
| AU (3) | AU2013312801B2 (https=) |
| BR (1) | BR112015004696B1 (https=) |
| CA (1) | CA2883511C (https=) |
| DK (1) | DK2893022T3 (https=) |
| IL (1) | IL237442B (https=) |
| SG (2) | SG10201701675PA (https=) |
| WO (1) | WO2014039585A2 (https=) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010028347A2 (en) | 2008-09-05 | 2010-03-11 | President & Fellows Of Harvard College | Continuous directed evolution of proteins and nucleic acids |
| CA2825370A1 (en) | 2010-12-22 | 2012-06-28 | President And Fellows Of Harvard College | Continuous directed evolution |
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| KR102357105B1 (ko) * | 2012-09-04 | 2022-02-08 | 더 스크립스 리서치 인스티튜트 | 표적화된 바인딩 특이도를 갖는 키메라 폴리펩타이드들 |
| US9708589B2 (en) * | 2012-12-18 | 2017-07-18 | Monsanto Technology Llc | Compositions and methods for custom site-specific DNA recombinases |
| US10793867B2 (en) | 2013-03-15 | 2020-10-06 | Monsanto Technology, Llc | Methods for targeted transgene-integration using custom site-specific DNA recombinases |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| WO2015134121A2 (en) | 2014-01-20 | 2015-09-11 | President And Fellows Of Harvard College | Negative selection and stringency modulation in continuous evolution systems |
| WO2015153889A2 (en) | 2014-04-02 | 2015-10-08 | University Of Florida Research Foundation, Incorporated | Materials and methods for the treatment of latent viral infection |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| EP3194583B1 (en) * | 2014-07-30 | 2021-09-15 | Zumutor Biologics, Inc. | Non-fucosylated protein and methods thereof |
| WO2016077052A2 (en) | 2014-10-22 | 2016-05-19 | President And Fellows Of Harvard College | Evolution of proteases |
| WO2016168631A1 (en) | 2015-04-17 | 2016-10-20 | President And Fellows Of Harvard College | Vector-based mutagenesis system |
| WO2017015545A1 (en) | 2015-07-22 | 2017-01-26 | President And Fellows Of Harvard College | Evolution of site-specific recombinases |
| US11524983B2 (en) | 2015-07-23 | 2022-12-13 | President And Fellows Of Harvard College | Evolution of Bt toxins |
| WO2017019895A1 (en) | 2015-07-30 | 2017-02-02 | President And Fellows Of Harvard College | Evolution of talens |
| US11339408B2 (en) | 2015-08-20 | 2022-05-24 | Applied Stemcell, Inc. | Nuclease with enhanced efficiency of genome editing |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| WO2018187796A1 (en) * | 2017-04-07 | 2018-10-11 | Donald Danforth Plant Science Center | Methods for increasing resistance to cotton bacterial blight and plants produced thereby |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| US11447809B2 (en) | 2017-07-06 | 2022-09-20 | President And Fellows Of Harvard College | Evolution of tRNA synthetases |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| US12060553B2 (en) | 2017-08-25 | 2024-08-13 | President And Fellows Of Harvard College | Evolution of BoNT peptidases |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| WO2019056002A1 (en) | 2017-09-18 | 2019-03-21 | President And Fellows Of Harvard College | CONTINUOUS EVOLUTION FOR STABILIZED PROTEINS |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US12312383B2 (en) | 2018-04-18 | 2025-05-27 | Altius Institute For Biomedical Sciences | Animal pathogen-derived polypeptides and uses thereof for genetic engineering |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| WO2019241649A1 (en) | 2018-06-14 | 2019-12-19 | President And Fellows Of Harvard College | Evolution of cytidine deaminases |
| US12264181B2 (en) | 2018-06-27 | 2025-04-01 | Altius Institute For Biomedical Sciences | Nucleic acid binding domains and methods of use thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| CN109771403A (zh) * | 2019-01-24 | 2019-05-21 | 广州医科大学附属第一医院 | 一种大鼠造影剂肾病模型的构建方法 |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| US20210130828A1 (en) * | 2019-11-01 | 2021-05-06 | Sangamo Therapeutics, Inc. | Gin recombinase variants |
| US12012433B1 (en) * | 2020-02-27 | 2024-06-18 | Integrated Dna Technologies Inc. | Expression and purification of Cas enzymes |
| CN116096878A (zh) | 2020-05-01 | 2023-05-09 | 合成Dna技术公司 | 在非经典tttt前间区序列邻近基序处具有增强的切割活性的毛螺菌科菌种cas12a突变体 |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| US20230313154A1 (en) * | 2020-07-17 | 2023-10-05 | Cb Therapeutics, Inc. | Prenyltransferase enzymes |
| KR102265501B1 (ko) * | 2020-12-17 | 2021-06-15 | 국립해양생물자원관 | 다중구리 산화효소 펩타이드를 포함하는 구리대사 관련 신경계 질환의 예방 또는 치료용 조성물 |
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| US9499592B2 (en) * | 2011-01-26 | 2016-11-22 | President And Fellows Of Harvard College | Transcription activator-like effectors |
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| KR102357105B1 (ko) * | 2012-09-04 | 2022-02-08 | 더 스크립스 리서치 인스티튜트 | 표적화된 바인딩 특이도를 갖는 키메라 폴리펩타이드들 |
-
2013
- 2013-09-04 KR KR1020217000390A patent/KR102357105B1/ko active Active
- 2013-09-04 BR BR112015004696-7A patent/BR112015004696B1/pt active IP Right Grant
- 2013-09-04 JP JP2015530154A patent/JP6442406B2/ja active Active
- 2013-09-04 KR KR1020157008001A patent/KR102201867B1/ko active Active
- 2013-09-04 CN CN201380057657.5A patent/CN104781404B/zh active Active
- 2013-09-04 DK DK13834893.3T patent/DK2893022T3/da active
- 2013-09-04 EP EP22181257.1A patent/EP4148134A1/en active Pending
- 2013-09-04 SG SG10201701675PA patent/SG10201701675PA/en unknown
- 2013-09-04 CN CN201811108126.5A patent/CN109517068B/zh active Active
- 2013-09-04 AU AU2013312801A patent/AU2013312801B2/en not_active Revoked
- 2013-09-04 SG SG11201501525QA patent/SG11201501525QA/en unknown
- 2013-09-04 KR KR1020227002477A patent/KR102596125B1/ko active Active
- 2013-09-04 WO PCT/US2013/058100 patent/WO2014039585A2/en not_active Ceased
- 2013-09-04 EP EP13834893.3A patent/EP2893022B1/en active Active
- 2013-09-04 US US14/425,944 patent/US9902962B2/en active Active
- 2013-09-04 EP EP20167774.7A patent/EP3750999B1/en active Active
- 2013-09-04 CA CA2883511A patent/CA2883511C/en active Active
-
2015
- 2015-02-26 IL IL23744215A patent/IL237442B/en active IP Right Grant
-
2018
- 2018-01-23 US US15/878,043 patent/US10829766B2/en active Active
- 2018-08-02 JP JP2018146232A patent/JP6728283B2/ja active Active
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2019
- 2019-02-08 AU AU2019200922A patent/AU2019200922B2/en active Active
-
2020
- 2020-07-01 JP JP2020114229A patent/JP7100681B2/ja active Active
- 2020-09-24 US US17/031,149 patent/US11466277B2/en active Active
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2021
- 2021-09-30 AU AU2021240252A patent/AU2021240252B2/en active Active
-
2022
- 2022-07-01 JP JP2022106801A patent/JP7459174B2/ja active Active
- 2022-09-23 US US17/951,849 patent/US20230304022A1/en active Pending
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