JP2015529686A5 - - Google Patents
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- Publication number
- JP2015529686A5 JP2015529686A5 JP2015532149A JP2015532149A JP2015529686A5 JP 2015529686 A5 JP2015529686 A5 JP 2015529686A5 JP 2015532149 A JP2015532149 A JP 2015532149A JP 2015532149 A JP2015532149 A JP 2015532149A JP 2015529686 A5 JP2015529686 A5 JP 2015529686A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- poly
- compound according
- item
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 50
- 125000003545 alkoxy group Chemical group 0.000 claims description 20
- 125000003282 alkyl amino group Chemical group 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 18
- 125000001475 halogen functional group Chemical group 0.000 claims description 18
- 229910052739 hydrogen Inorganic materials 0.000 claims description 18
- 239000001257 hydrogen Substances 0.000 claims description 18
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 18
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 7
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 6
- 239000000178 monomer Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- -1 ether compound Chemical group 0.000 claims description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical group NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical group NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000004202 carbamide Chemical group 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 20
- 125000006850 spacer group Chemical group 0.000 description 5
- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 description 2
- 229960004503 metoclopramide Drugs 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 1
- 150000003936 benzamides Chemical class 0.000 description 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- REQCZEXYDRLIBE-UHFFFAOYSA-N procainamide Chemical compound CCN(CC)CCNC(=O)C1=CC=C(N)C=C1 REQCZEXYDRLIBE-UHFFFAOYSA-N 0.000 description 1
- 229960000244 procainamide Drugs 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261702088P | 2012-09-17 | 2012-09-17 | |
| US61/702,088 | 2012-09-17 | ||
| PCT/US2013/060179 WO2014043707A1 (en) | 2012-09-17 | 2013-09-17 | Oligomer-containing benzamide-based compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015529686A JP2015529686A (ja) | 2015-10-08 |
| JP2015529686A5 true JP2015529686A5 (enExample) | 2016-10-27 |
| JP6265998B2 JP6265998B2 (ja) | 2018-01-24 |
Family
ID=49263466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532149A Active JP6265998B2 (ja) | 2012-09-17 | 2013-09-17 | オリゴマー含有ベンズアミド系化合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US9375486B2 (enExample) |
| EP (1) | EP2895457B1 (enExample) |
| JP (1) | JP6265998B2 (enExample) |
| WO (1) | WO2014043707A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8796248B2 (en) * | 2007-10-05 | 2014-08-05 | Nektar Therapeutics | Oligomer-corticosteroid conjugates |
| EP2895457B1 (en) | 2012-09-17 | 2020-05-20 | Nektar Therapeutics | Oligomer-containing benzamide-based compounds |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL281394A (enExample) | 1961-07-25 | |||
| FR2313935A1 (fr) | 1975-06-10 | 1977-01-07 | Ile De France | Nouveaux benzamides substitues, leurs derives et leur procede de preparation |
| GB1451770A (en) | 1972-08-25 | 1976-10-06 | Delmar Chem | Processes for making n-dialkyl-aminoalkyl-2-alkoxy-4-amino-5-halo benzamide compounds |
| JPS49135941A (enExample) * | 1973-04-16 | 1974-12-27 | ||
| JPS6058224B2 (ja) | 1978-07-31 | 1985-12-19 | 旭化成株式会社 | メトクロプラミドの製造方法 |
| JPS5533416A (en) | 1978-08-31 | 1980-03-08 | Sogo Yatsukou Kk | Production of hexamethyene bis-dicyandiamide |
| US4992540A (en) | 1984-11-28 | 1991-02-12 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US4810646A (en) | 1984-11-28 | 1989-03-07 | Massachusetts Institute Of Technology | Glucan compositions and process for preparation thereof |
| US5028703A (en) | 1988-03-11 | 1991-07-02 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US5227397A (en) * | 1989-04-28 | 1993-07-13 | Pfizer Inc. | Polyamines and polypeptides useful as antagonists of excitatory amino acid neuro-transmitters and/or as blockers of calcium channels |
| US5032401A (en) | 1989-06-15 | 1991-07-16 | Alpha Beta Technology | Glucan drug delivery system and adjuvant |
| US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
| DK1694363T3 (en) | 2003-12-16 | 2014-03-24 | Nektar Therapeutics | Monodisperse PEGylated Naloxole Compositions |
| NZ588373A (en) | 2004-05-19 | 2012-01-12 | Emisphere Tech Inc | Topical cromolyn formulations |
| US7740861B2 (en) | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
| WO2007008963A1 (en) * | 2005-07-13 | 2007-01-18 | Jenrin Discovery | Mao-b inhibitors useful for treating obesity |
| US20080044438A1 (en) | 2006-03-17 | 2008-02-21 | Ostroff Gary R | Yeast Cell Particles As Oral Delivery Vehicles For Antigens |
| EP2121031B1 (en) | 2007-03-12 | 2013-10-16 | Nektar Therapeutics | Oligomer-antihistamine conjugates |
| US8389759B2 (en) | 2007-03-12 | 2013-03-05 | Nektar Therapeutics | Oligomer-anticholinergic agent conjugates |
| AU2009292631A1 (en) | 2008-09-16 | 2010-03-25 | Nektar Therapeutics | Pegylated opioids with low potential for abuse |
| WO2010088340A1 (en) | 2009-01-28 | 2010-08-05 | Nektar Therapeutics | Oligomer-phenothiazine conjugates |
| WO2010120387A1 (en) * | 2009-04-17 | 2010-10-21 | Nektar Therapeutics | Oligomer-protein tyrosine kinase inhibitor conjugates |
| GB201101209D0 (en) | 2011-01-24 | 2011-03-09 | Syngenta Ltd | Formulation component |
| EP2895457B1 (en) | 2012-09-17 | 2020-05-20 | Nektar Therapeutics | Oligomer-containing benzamide-based compounds |
-
2013
- 2013-09-17 EP EP13770766.7A patent/EP2895457B1/en active Active
- 2013-09-17 US US14/428,816 patent/US9375486B2/en active Active
- 2013-09-17 JP JP2015532149A patent/JP6265998B2/ja active Active
- 2013-09-17 WO PCT/US2013/060179 patent/WO2014043707A1/en not_active Ceased
-
2016
- 2016-05-25 US US15/164,607 patent/US9937266B2/en active Active
-
2018
- 2018-02-28 US US15/908,286 patent/US10434181B2/en active Active
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