JP2015529457A5 - - Google Patents
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- Publication number
- JP2015529457A5 JP2015529457A5 JP2015525519A JP2015525519A JP2015529457A5 JP 2015529457 A5 JP2015529457 A5 JP 2015529457A5 JP 2015525519 A JP2015525519 A JP 2015525519A JP 2015525519 A JP2015525519 A JP 2015525519A JP 2015529457 A5 JP2015529457 A5 JP 2015529457A5
- Authority
- JP
- Japan
- Prior art keywords
- genetically modified
- hla
- cell
- nucleic acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261677739P | 2012-07-31 | 2012-07-31 | |
| US61/677,739 | 2012-07-31 | ||
| PCT/US2013/052767 WO2014022423A2 (en) | 2012-07-31 | 2013-07-30 | Hla g-modified cells and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018028816A Division JP6502544B2 (ja) | 2012-07-31 | 2018-02-21 | Ｈｌａ ｇ改変された細胞および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015529457A JP2015529457A (ja) | 2015-10-08 |
| JP2015529457A5 true JP2015529457A5 (https=) | 2016-09-15 |
| JP6297559B2 JP6297559B2 (ja) | 2018-03-20 |
Family
ID=50028654
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015525519A Active JP6297559B2 (ja) | 2012-07-31 | 2013-07-30 | Ｈｌａｇ改変された細胞および方法 |
| JP2018028816A Active JP6502544B2 (ja) | 2012-07-31 | 2018-02-21 | Ｈｌａ ｇ改変された細胞および方法 |
| JP2019052699A Active JP7294838B2 (ja) | 2012-07-31 | 2019-03-20 | Ｈｌａ ｇ改変された細胞および方法 |
| JP2021068195A Active JP7379410B2 (ja) | 2012-07-31 | 2021-04-14 | Ｈｌａ ｇ改変された細胞および方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018028816A Active JP6502544B2 (ja) | 2012-07-31 | 2018-02-21 | Ｈｌａ ｇ改変された細胞および方法 |
| JP2019052699A Active JP7294838B2 (ja) | 2012-07-31 | 2019-03-20 | Ｈｌａ ｇ改変された細胞および方法 |
| JP2021068195A Active JP7379410B2 (ja) | 2012-07-31 | 2021-04-14 | Ｈｌａ ｇ改変された細胞および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9714280B2 (https=) |
| EP (4) | EP3483178B1 (https=) |
| JP (4) | JP6297559B2 (https=) |
| KR (4) | KR102366081B1 (https=) |
| CN (2) | CN113151179A (https=) |
| AU (2) | AU2013296564C1 (https=) |
| CA (1) | CA2882028C (https=) |
| ES (2) | ES2716577T3 (https=) |
| SG (1) | SG11201500799YA (https=) |
| WO (1) | WO2014022423A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012145384A1 (en) | 2011-04-20 | 2012-10-26 | University Of Washington Through Its Center For Commercialization | Beta-2 microglobulin-deficient cells |
| KR102366081B1 (ko) * | 2012-07-31 | 2022-02-23 | 에이지엑스 쎄라퓨틱스, 인크. | Hla g-변형된 세포 및 방법 |
| US10927384B2 (en) | 2014-04-09 | 2021-02-23 | Dna Twopointo Inc. | DNA vectors, transposons and transposases for eukaryotic genome modification |
| US9534234B2 (en) | 2014-04-09 | 2017-01-03 | Dna2.0, Inc. | Enhanced nucleic acid constructs for eukaryotic gene expression |
| SG10202009095VA (en) * | 2014-11-26 | 2020-10-29 | Accelerated Biosciences Corp | Induced hepatocytes and uses thereof |
| AU2015360502A1 (en) | 2014-12-10 | 2017-06-29 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
| US20220241345A1 (en) * | 2015-10-02 | 2022-08-04 | The Regents Of The University Of California | Induced pluripotent stem cell derived glial enriched progenitor cells for the treatment of white matter stroke |
| EP3355898B1 (en) | 2015-10-02 | 2020-11-25 | The Regents of the University of California | Induced pluripotent stem cell derived glial enriched progenitor cells for the treatment of white matter stroke |
| CA3001312A1 (en) | 2015-10-08 | 2017-04-13 | Dna2.0, Inc. | Dna vectors, transposons and transposases for eukaryotic genome modification |
| AU2017285224B2 (en) * | 2016-06-14 | 2023-05-18 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
| RU2019103384A (ru) | 2016-07-26 | 2020-08-26 | Дзе Юниверсити Оф Норт Каролина Эт Чепел Хилл | Опосредуемая вектором иммунологическая толерантность глаз |
| JP7717439B2 (ja) | 2017-01-10 | 2025-08-04 | ザ ジェネラル ホスピタル コーポレイション | 修飾されたｔ細胞及びその使用方法 |
| CN120041380A (zh) * | 2017-06-12 | 2025-05-27 | 西奈卫生系统公司 | 无需全身性免疫遏制的同种异体移植物耐受 |
| US20210061914A1 (en) * | 2017-12-28 | 2021-03-04 | Gritstone Oncology, Inc. | Antigen-Binding Proteins Targeting Shared Antigens |
| WO2020028656A1 (en) | 2018-08-01 | 2020-02-06 | Nantkwest, Inc. | A quadricistronic system comprising a homing receptor or a cytokine, and chimeric antigen receptor for genetic modification of immunotherapies |
| US10883084B2 (en) | 2018-10-05 | 2021-01-05 | Xenotherapeutics, Inc. | Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same |
| TW202035682A (zh) | 2018-12-14 | 2020-10-01 | 比利時商普羅米修亞生物科技股份有限公司 | 表現hla-g之肝先驅細胞及取得包含該等細胞之此等細胞組成物之方法與其用途 |
| BR112021011273A2 (pt) * | 2018-12-14 | 2021-09-28 | Promethera Therapeutics Sa | Composição celular que compreende células progenitoras do fígado que expressam hla-e |
| US11230699B2 (en) | 2020-01-28 | 2022-01-25 | Immunitybio, Inc. | Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors |
| CN115151636A (zh) * | 2020-02-10 | 2022-10-04 | 鲁比厄斯治疗法股份有限公司 | 包含hla-g多肽的经工程改造的红系细胞及其使用方法 |
| EP4159846A4 (en) * | 2020-05-26 | 2024-08-14 | Healios K.K. | HYPOIMMUNOGENIC CELLS |
| EP4200023A4 (en) * | 2020-08-23 | 2024-10-30 | Applied StemCell, Inc. | Hla-f-modified cells and methods |
| US11591381B2 (en) | 2020-11-30 | 2023-02-28 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| WO2022144632A1 (en) | 2020-12-30 | 2022-07-07 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into nk cells |
| CN113234664B (zh) * | 2021-05-11 | 2024-05-10 | 澳门大学 | 一种胰腺祖细胞的制备方法及其应用 |
| IL311786A (en) * | 2021-10-21 | 2024-05-01 | Vertex Pharma | hypoimmune cells |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1339354C (en) | 1988-09-01 | 1997-08-26 | The Whitehead Institute For Biomedical Research | Recombinant retroviruses with amphotropic and ecotropic host ranges |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| US5534423A (en) | 1993-10-08 | 1996-07-09 | Regents Of The University Of Michigan | Methods of increasing rates of infection by directing motion of vectors |
| US6686198B1 (en) | 1993-10-14 | 2004-02-03 | President And Fellows Of Harvard College | Method of inducing and maintaining neuronal cells |
| US6013517A (en) | 1994-05-09 | 2000-01-11 | Chiron Corporation | Crossless retroviral vectors |
| US5650135A (en) | 1994-07-01 | 1997-07-22 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive localization of a light-emitting conjugate in a mammal |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5741657A (en) | 1995-03-20 | 1998-04-21 | The Regents Of The University Of California | Fluorogenic substrates for β-lactamase and methods of use |
| US5744320A (en) | 1995-06-07 | 1998-04-28 | Promega Corporation | Quenching reagents and assays for enzyme-mediated luminescence |
| US6982431B2 (en) | 1998-08-31 | 2006-01-03 | Molecular Devices Corporation | Sample analysis systems |
| US6031094A (en) | 1998-07-23 | 2000-02-29 | The Regents Of The University Of California | Beta-lactam substrates and uses thereof |
| US7005252B1 (en) | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
| IL158514A0 (en) | 2001-04-23 | 2004-05-12 | Amaxa Gmbh | Buffer solution for electroporation and a method comprising the use of the same |
| WO2004098490A2 (en) | 2002-05-17 | 2004-11-18 | Mount Sinai School Of Medicine Of New York University | Mesoderm and definitive endoderm cell populations |
| EP1594962B1 (en) | 2003-01-31 | 2014-08-27 | Promega Corporation | Covalent tethering of functional groups to proteins |
| US7960166B2 (en) | 2003-05-21 | 2011-06-14 | The General Hospital Corporation | Microfabricated compositions and processes for engineering tissues containing multiple cell types |
| PL1675956T3 (pl) * | 2003-10-21 | 2011-06-30 | Merck Serono Sa | Minimalna sekwencja DNA działająca jako insulator chromatyny i jej zastosowanie do wyrażania białek |
| US8673634B2 (en) | 2003-11-13 | 2014-03-18 | Massachusetts Eye & Ear Infirmary | Method for the treatment of hearing loss |
| EP1809750B1 (en) | 2004-11-08 | 2012-03-21 | ChromaGenics B.V. | Selection of host cells expressing protein at high levels |
| US20070036773A1 (en) * | 2005-08-09 | 2007-02-15 | City Of Hope | Generation and application of universal T cells for B-ALL |
| EP1937326B1 (en) * | 2005-10-21 | 2018-09-12 | CellResearch Corporation Pte Ltd | Isolation and cultivation of stem/progenitor cells from the amniotic membrane of umbilical cord and uses of cells differentiated therefrom |
| BRPI0619794B8 (pt) | 2005-12-13 | 2022-06-14 | Univ Kyoto | Uso de um fator de reprogramação, agente para a preparação de uma célula-tronco pluripotente induzida a partir de uma célula somática e métodos para preparar uma célula- tronco pluripotente induzida método e para preparar uma célula somática e uso de células-tronco pluripotentes induzidas |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US20090156532A1 (en) * | 2006-01-24 | 2009-06-18 | The University Of Chicago | SNP BINDING SITE FOR microRNAs IN HLA-G |
| WO2007091078A2 (en) * | 2006-02-10 | 2007-08-16 | Axordia Limited | Polypeptide conjugate comprising hla-g and uses thereof, stem cells transfected with hla-g |
| EP2374875B1 (en) | 2006-10-30 | 2015-09-02 | Promega Corporation | Mutant hydrolase proteins with enhanced kinetics and funcitional expression |
| US8647871B2 (en) * | 2007-03-30 | 2014-02-11 | Escape Therapeutics, Inc. | Endogenous expression of HLA-G and/or HLA-E by mesenchymal cells |
| CN102369288A (zh) * | 2008-11-14 | 2012-03-07 | 生命技术公司 | 用于工程化细胞的组合物和方法 |
| US8592211B2 (en) | 2009-03-20 | 2013-11-26 | The Rockefeller University | Enhanced PiggyBac transposon and methods for transposon mutagenesis |
| US8048675B1 (en) | 2010-05-12 | 2011-11-01 | Ipierian, Inc. | Integration-free human induced pluripotent stem cells from blood |
| KR102366081B1 (ko) | 2012-07-31 | 2022-02-23 | 에이지엑스 쎄라퓨틱스, 인크. | Hla g-변형된 세포 및 방법 |
| CN103333861A (zh) * | 2013-06-03 | 2013-10-02 | 浙江省台州医院 | 特异性表达hla-g1抗原的细胞株k562 |
| CN111808819A (zh) * | 2020-05-26 | 2020-10-23 | 台州恩泽医疗中心(集团) | 表达hla-g3异构体标准蛋白的细胞株及其应用 |
-
2013
- 2013-07-30 KR KR1020207033804A patent/KR102366081B1/ko active Active
- 2013-07-30 CA CA2882028A patent/CA2882028C/en active Active
- 2013-07-30 JP JP2015525519A patent/JP6297559B2/ja active Active
- 2013-07-30 EP EP18211100.5A patent/EP3483178B1/en active Active
- 2013-07-30 AU AU2013296564A patent/AU2013296564C1/en not_active Ceased
- 2013-07-30 KR KR1020197036122A patent/KR102184947B1/ko active Active
- 2013-07-30 EP EP13825511.2A patent/EP2880054B1/en active Active
- 2013-07-30 SG SG11201500799YA patent/SG11201500799YA/en unknown
- 2013-07-30 KR KR1020187034048A patent/KR102055438B1/ko active Active
- 2013-07-30 CN CN202110063720.2A patent/CN113151179A/zh active Pending
- 2013-07-30 ES ES13825511T patent/ES2716577T3/es active Active
- 2013-07-30 EP EP20196775.9A patent/EP3805261A1/en not_active Withdrawn
- 2013-07-30 CN CN201380051169.3A patent/CN105612176B/zh active Active
- 2013-07-30 KR KR1020157005165A patent/KR101923632B1/ko active Active
- 2013-07-30 WO PCT/US2013/052767 patent/WO2014022423A2/en not_active Ceased
- 2013-07-30 ES ES18211100T patent/ES2837487T3/es active Active
- 2013-07-30 EP EP21209423.9A patent/EP4015530A1/en active Pending
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2015
- 2015-01-28 US US14/608,004 patent/US9714280B2/en active Active
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2017
- 2017-06-16 US US15/625,964 patent/US10502738B2/en active Active
-
2018
- 2018-02-21 JP JP2018028816A patent/JP6502544B2/ja active Active
- 2018-08-23 AU AU2018220087A patent/AU2018220087B2/en not_active Ceased
-
2019
- 2019-03-20 JP JP2019052699A patent/JP7294838B2/ja active Active
- 2019-10-22 US US16/659,918 patent/US11977073B2/en active Active
-
2020
- 2020-03-27 US US16/832,321 patent/US20200309776A1/en not_active Abandoned
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2021
- 2021-04-14 JP JP2021068195A patent/JP7379410B2/ja active Active
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