JP2015529194A - ＰＩ３Ｋインヒビターとｃ−Ｍｅｔインヒビターの組み合わせ - Google Patents

ＰＩ３Ｋインヒビターとｃ−Ｍｅｔインヒビターの組み合わせ Download PDF

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JP2015529194A
JP2015529194A JP2015527558A JP2015527558A JP2015529194A JP 2015529194 A JP2015529194 A JP 2015529194A JP 2015527558 A JP2015527558 A JP 2015527558A JP 2015527558 A JP2015527558 A JP 2015527558A JP 2015529194 A JP2015529194 A JP 2015529194A
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substituted
unsubstituted
compound
group
methyl
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JP2015529194A5 (OSRAM
Inventor
キャポニグロ，ジョルダーノ
ヒュアン，シジョン
レハール，ジョゼフ
ワン，フイ−キン
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ノバルティス アーゲー
ノバルティス アーゲー
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Publication of JP2015529194A publication Critical patent/JP2015529194A/ja
Publication of JP2015529194A5 publication Critical patent/JP2015529194A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015527558A 2012-08-16 2013-08-14 ＰＩ３Ｋインヒビターとｃ−Ｍｅｔインヒビターの組み合わせ Withdrawn JP2015529194A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261683790P 2012-08-16 2012-08-16
US61/683,790 2012-08-16
PCT/US2013/054848 WO2014028566A1 (en) 2012-08-16 2013-08-14 Combination of pi3k inhibitor and c-met inhibitor

Related Child Applications (1)

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JP2017201774A Division JP6644042B2 (ja) 2012-08-16 2017-10-18 ＰＩ３Ｋインヒビターとｃ−Ｍｅｔインヒビターの組み合わせ

Publications (2)

Publication Number Publication Date
JP2015529194A true JP2015529194A (ja) 2015-10-05
JP2015529194A5 JP2015529194A5 (OSRAM) 2016-09-29

Family

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Family Applications (3)

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JP2015527558A Withdrawn JP2015529194A (ja) 2012-08-16 2013-08-14 ＰＩ３Ｋインヒビターとｃ−Ｍｅｔインヒビターの組み合わせ
JP2017201774A Expired - Fee Related JP6644042B2 (ja) 2012-08-16 2017-10-18 ＰＩ３Ｋインヒビターとｃ−Ｍｅｔインヒビターの組み合わせ
JP2020000928A Expired - Fee Related JP6970217B2 (ja) 2012-08-16 2020-01-07 ＰＩ３Ｋインヒビターとｃ−Ｍｅｔインヒビターの組み合わせ

Family Applications After (2)

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JP2017201774A Expired - Fee Related JP6644042B2 (ja) 2012-08-16 2017-10-18 ＰＩ３Ｋインヒビターとｃ−Ｍｅｔインヒビターの組み合わせ
JP2020000928A Expired - Fee Related JP6970217B2 (ja) 2012-08-16 2020-01-07 ＰＩ３Ｋインヒビターとｃ−Ｍｅｔインヒビターの組み合わせ

Country Status (14)

Country Link
US (5) US20150216870A1 (OSRAM)
EP (1) EP2885003B1 (OSRAM)
JP (3) JP2015529194A (OSRAM)
KR (2) KR20210049187A (OSRAM)
CN (1) CN105050623B (OSRAM)
AU (4) AU2013302702A1 (OSRAM)
BR (1) BR112015002528A2 (OSRAM)
CA (1) CA2879704A1 (OSRAM)
ES (1) ES2901712T3 (OSRAM)
HK (1) HK1211476A1 (OSRAM)
IN (1) IN2015DN00528A (OSRAM)
MX (1) MX369518B (OSRAM)
RU (1) RU2705095C2 (OSRAM)
WO (1) WO2014028566A1 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103958506B (zh) 2011-09-27 2017-02-22 诺华股份有限公司 用作突变idh抑制剂的3‑嘧啶‑4‑基‑噁唑烷‑2‑酮化合物
UY34632A (es) 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
RU2660354C2 (ru) 2012-04-03 2018-07-05 Новартис Аг Комбинированные продукты, содержащие ингибиторы тирозинкиназ, и их применение
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
AP2015008707A0 (en) 2013-03-14 2015-09-30 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
CA2914310A1 (en) * 2013-06-18 2014-12-24 Novartis Ag Pharmaceutical combinations
AU2014296887A1 (en) 2013-08-02 2016-01-28 Aduro Biotech Holdings, Europe B.V. Combining CD27 agonists and immune checkpoint inhibition for immune stimulation
EA202191301A1 (ru) 2014-07-25 2021-11-30 Новартис Аг СОСТАВ ТАБЛЕТОК 2-ФТОР-N-МЕТИЛ-4-[7-(ХИНОЛИН-6-ИЛМЕТИЛ)ИМИДАЗО[1,2-b][1,2,4]ТРИАЗИН-2-ИЛ]БЕНЗАМИДА
CN108367003B (zh) 2014-12-12 2022-01-21 麻省总医院 乳腺癌脑转移的治疗
GB201516504D0 (en) 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
JP2023508331A (ja) * 2019-12-20 2023-03-02 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー 組み合わせ

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008540599A (ja) * 2005-05-20 2008-11-20 ノバルティス アクチエンゲゼルシャフト 脂質キナーゼ阻害剤としてのイミダゾキノリン
JP2011527703A (ja) * 2008-07-11 2011-11-04 ノバルティス アーゲー （ａ）ホスホイノシタイド３−キナーゼ阻害剤および（ｂ）Ｒａｓ／Ｒａｆ／Ｍｅｋ経路のモジュレーターの配合物
WO2012047775A1 (en) * 2010-10-04 2012-04-12 Novartis Ag Pharmaceutical combinations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0211649D0 (en) * 2002-05-21 2002-07-03 Novartis Ag Organic compounds
JO2660B1 (en) * 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
EP3034075B1 (en) * 2006-11-22 2018-07-25 Incyte Holdings Corporation Imidazotriazines and imidazopyrimidines as kinase inhibitors
US9370508B2 (en) * 2007-02-20 2016-06-21 Novartis Ag Imidazoquinolines as dual lipid kinase and mTOR inhibitors
PL2259800T3 (pl) * 2008-03-05 2014-09-30 Novartis Ag Zastosowanie 5-(2,6-dimorfolin-4-ylopirymidyn-4-ylo)-4-trifluorometylopirydyn-2-yloaminy do leczenia niedrobnokomórkowego raka płuca wykazującego nabytą oporność wobec modulatorów receptora dla naskórkowego czynnika wzrostu (EGFR)
TWI472529B (zh) * 2008-05-21 2015-02-11 Incyte Corp ２－氟－Ｎ－甲基－４－〔７－（喹啉－６－基－甲基）－咪唑并〔１，２－ｂ〕〔１，２，４〕三－２－基〕苯甲醯胺之鹽類及其相關製備方法
UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
WO2010121175A1 (en) * 2009-04-17 2010-10-21 Rush University Medical Center Combination targeted therapy for lung cancer
EP2637661B1 (en) * 2010-11-08 2017-12-20 Novartis AG Use of (S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)- pyridin-4-yl]-thiazol-2-yl}-amide) in the treatment of EGFR dependent diseases or diseases that have acquired resistance to agents that target EGFR family members

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008540599A (ja) * 2005-05-20 2008-11-20 ノバルティス アクチエンゲゼルシャフト 脂質キナーゼ阻害剤としてのイミダゾキノリン
JP2011527703A (ja) * 2008-07-11 2011-11-04 ノバルティス アーゲー （ａ）ホスホイノシタイド３−キナーゼ阻害剤および（ｂ）Ｒａｓ／Ｒａｆ／Ｍｅｋ経路のモジュレーターの配合物
WO2012047775A1 (en) * 2010-10-04 2012-04-12 Novartis Ag Pharmaceutical combinations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HUA,C.G. ET AL.: ""SIGNATURES OF DRUG SENSITIVITY IN NONSMALL CELL LUNG CANCER"", INT. J. PROTEOMICS, vol. Vol.2011，Article ID 215496, JPN5015009013, 1 January 2011 (2011-01-01), pages 1 - 13, ISSN: 0003540405 *

Also Published As

Publication number Publication date
JP2020079243A (ja) 2020-05-28
RU2015108755A (ru) 2016-10-10
MX2015002005A (es) 2015-10-08
JP6644042B2 (ja) 2020-02-12
MX369518B (es) 2019-11-11
US20200253980A1 (en) 2020-08-13
US20190083500A1 (en) 2019-03-21
AU2018201725A1 (en) 2018-04-05
KR102245985B1 (ko) 2021-04-30
AU2019226212B2 (en) 2020-05-14
CN105050623B (zh) 2018-06-12
EP2885003B1 (en) 2021-09-29
ES2901712T3 (es) 2022-03-23
HK1211476A1 (en) 2016-05-27
RU2705095C2 (ru) 2019-11-05
JP6970217B2 (ja) 2021-11-24
KR20210049187A (ko) 2021-05-04
AU2019226212A1 (en) 2019-09-26
US20190350935A1 (en) 2019-11-21
EP2885003A1 (en) 2015-06-24
AU2016238903A1 (en) 2016-10-27
IN2015DN00528A (OSRAM) 2015-06-26
US20220280523A1 (en) 2022-09-08
WO2014028566A1 (en) 2014-02-20
KR20150043328A (ko) 2015-04-22
AU2013302702A1 (en) 2015-02-19
CA2879704A1 (en) 2014-02-20
JP2018035188A (ja) 2018-03-08
CN105050623A (zh) 2015-11-11
BR112015002528A2 (pt) 2018-05-22
US20150216870A1 (en) 2015-08-06

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