JP2015525099A5 - - Google Patents
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- Publication number
- JP2015525099A5 JP2015525099A5 JP2015516668A JP2015516668A JP2015525099A5 JP 2015525099 A5 JP2015525099 A5 JP 2015525099A5 JP 2015516668 A JP2015516668 A JP 2015516668A JP 2015516668 A JP2015516668 A JP 2015516668A JP 2015525099 A5 JP2015525099 A5 JP 2015525099A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- composition
- sucrose octasulfate
- hyaluronic acid
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 27
- WEPNHBQBLCNOBB-FZJVNAOYSA-N sucrose octasulfate Chemical compound OS(=O)(=O)O[C@@H]1[C@H](OS(O)(=O)=O)[C@H](COS(=O)(=O)O)O[C@]1(COS(O)(=O)=O)O[C@@H]1[C@H](OS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@@H](COS(O)(=O)=O)O1 WEPNHBQBLCNOBB-FZJVNAOYSA-N 0.000 claims 11
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 9
- 229920002674 hyaluronan Polymers 0.000 claims 9
- 229960003160 hyaluronic acid Drugs 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 7
- 238000009472 formulation Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 239000000017 hydrogel Substances 0.000 claims 2
- 239000003589 local anesthetic agent Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 claims 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 1
- 238000005160 1H NMR spectroscopy Methods 0.000 claims 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
- 206010013774 Dry eye Diseases 0.000 claims 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 229960003150 bupivacaine Drugs 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 229960004194 lidocaine Drugs 0.000 claims 1
- 229960005015 local anesthetics Drugs 0.000 claims 1
- 229960002409 mepivacaine Drugs 0.000 claims 1
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000006069 physical mixture Substances 0.000 claims 1
- 229920005862 polyol Polymers 0.000 claims 1
- 150000003077 polyols Chemical class 0.000 claims 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 229960004919 procaine Drugs 0.000 claims 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims 1
- 229960001549 ropivacaine Drugs 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261659140P | 2012-06-13 | 2012-06-13 | |
| FR1255543 | 2012-06-13 | ||
| FR1255543A FR2991876B1 (fr) | 2012-06-13 | 2012-06-13 | Composition, en milieu aqueux, comprenant au moins un acide hyaluronique et au moins un sel hydrosoluble de sucrose octasulfate |
| US61/659,140 | 2012-06-13 | ||
| PCT/FR2013/051380 WO2013186493A2 (fr) | 2012-06-13 | 2013-06-13 | Composition, en milieux aqueux, comprenant au moins un acide hyaluronique et au moins un sel hydrosoluble de sucrose octasulfate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015525099A JP2015525099A (ja) | 2015-09-03 |
| JP2015525099A5 true JP2015525099A5 (enExample) | 2016-05-12 |
| JP6178414B2 JP6178414B2 (ja) | 2017-08-09 |
Family
ID=46785648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516668A Active JP6178414B2 (ja) | 2012-06-13 | 2013-06-13 | 少なくとも１種のヒアルロン酸及び少なくとも１種のショ糖オクタ硫酸水溶性塩を含有する水性媒体組成物 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9314530B2 (enExample) |
| EP (1) | EP2861301B1 (enExample) |
| JP (1) | JP6178414B2 (enExample) |
| KR (1) | KR20150023468A (enExample) |
| CN (1) | CN104394934B (enExample) |
| AU (1) | AU2013276343B2 (enExample) |
| BR (1) | BR112014029510A2 (enExample) |
| CA (1) | CA2876057A1 (enExample) |
| EA (1) | EA201492208A1 (enExample) |
| ES (1) | ES2728686T3 (enExample) |
| FR (1) | FR2991876B1 (enExample) |
| IL (1) | IL235776A0 (enExample) |
| MX (1) | MX354544B (enExample) |
| PL (1) | PL2861301T3 (enExample) |
| SG (1) | SG11201407857SA (enExample) |
| TR (1) | TR201907427T4 (enExample) |
| WO (1) | WO2013186493A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3613423T (pt) | 2013-07-10 | 2022-12-07 | Matrix Biology Inst | Composições de hialuronano de elevada elasticidade e suas utilizações |
| US9421198B2 (en) | 2013-07-30 | 2016-08-23 | Teoxane | Composition comprising hyaluronic acid and mepivacaine |
| FR3015290B1 (fr) * | 2013-12-23 | 2017-01-13 | Lab Vivacy | Compositions d'acide hyaluronique compreant de la mepivacaine |
| CN106659663A (zh) * | 2014-06-30 | 2017-05-10 | 纽璀克斯技术公司 | 控制影响角化细胞和/或成纤维细胞和真皮的皮肤失调和皮肤老化的组合产品和美容组合物 |
| FR3032617B1 (fr) * | 2015-02-16 | 2018-03-16 | Kylane Laboratoires Sa | Procede de preparation d un hydrogel injectable; hydrogel obtenu; utilisation de l hydrogel obtenu |
| US10004824B2 (en) | 2015-05-11 | 2018-06-26 | Laboratoires Vivacy | Compositions comprising at least one polyol and at least one anesthetic |
| FR3036035B1 (fr) | 2015-05-11 | 2018-10-05 | Laboratoires Vivacy | Compositions comprenant au moins un polyol et au moins un anesthesique |
| CN104926889A (zh) * | 2015-05-24 | 2015-09-23 | 广西师范学院 | 蔗糖硫酸酯铜银类化合物及其制作方法和用途 |
| PT3352766T (pt) * | 2015-09-24 | 2022-03-22 | Matrix Biology Inst | Composições de hialuronano de elevada elasticidade e processos para o seu uso |
| FR3044557B1 (fr) * | 2015-12-07 | 2017-12-01 | Benedicte Vincente Gavard Molliard Tauzin | Nouvelle composition injectable; procede de preparation de ladite composition; utilisation de ladite composition |
| WO2017102001A1 (fr) | 2015-12-16 | 2017-06-22 | Vplus International Sa | Composition d'acide hyaluronique pour injections peniennes |
| FR3047666A1 (fr) * | 2016-02-15 | 2017-08-18 | Benedicte Vincente Gavard Molliard Tauzin | Composition injectable; procede de preparation de ladite composition; utilisation de ladite composition |
| FR3058064B1 (fr) | 2016-10-28 | 2020-08-07 | Lab Vivacy | Composition a base d'acide hyaluronique comprenant de la mepivacaine |
| US20200093852A1 (en) * | 2016-12-13 | 2020-03-26 | Keats NELMS | Methods of Treating Ocular Disorders |
| US11787783B2 (en) | 2016-12-13 | 2023-10-17 | Beta Therapeutics Pty Ltd | Heparanase inhibitors and use thereof |
| MX2019006863A (es) | 2016-12-13 | 2019-09-13 | Beta Therapeutics Pty Ltd | Inhibidores de heparanasa y uso de los mismos. |
| FR3109153B1 (fr) | 2020-04-10 | 2022-07-15 | Teoxane SA | Compositions à base d’au moins deux glycosaminoglycanes |
| KR102664134B1 (ko) * | 2023-11-23 | 2024-05-10 | 한국콜마주식회사 | 히알루론산 및 이의 유도체를 포함하는 화장료 조성물 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2715091A (en) | 1949-11-28 | 1955-08-09 | Nat Res Dev | Dextran sulfate as anticoagulant, process of preparing same, and sterile solution thereof |
| AU607690B2 (en) | 1985-12-24 | 1991-03-14 | Marion Laboratories, Inc. | Use of synthetic sulfated saccharides to enhance wound healing |
| DK505488D0 (da) * | 1987-12-21 | 1988-09-09 | Bar Shalom Daniel | Middel og anvendelse af samme |
| US5916880A (en) | 1987-12-21 | 1999-06-29 | Bukh Meditec A/S | Reduction of skin wrinkling using sulphated sugars |
| DK86492D0 (da) | 1992-06-30 | 1992-06-30 | Bukh Meditec | Laegemiddel |
| AU4941297A (en) | 1996-11-15 | 1998-06-10 | Dumex-Alpharma A/S | A method for promoting tissue repair |
| JP2000178196A (ja) * | 1998-12-11 | 2000-06-27 | Seikagaku Kogyo Co Ltd | 新規ヒアルロニダーゼ阻害剤及び外用剤 |
| GB9902412D0 (en) | 1999-02-03 | 1999-03-24 | Fermentech Med Ltd | Process |
| EP1423081A4 (en) * | 2001-06-25 | 2005-05-25 | Depuy Int Ltd | COMPOSITION WITH GLYCOSAMINOGYCANES AND HYALURONIDASE INHIBITORS FOR THE TREATMENT OF ARTHRITIC JOINTS |
| US20050187150A1 (en) * | 2001-10-31 | 2005-08-25 | New York University | Structure-based design and synthesis of FGF inhibitors and FGF modulator compounds |
| MXPA01011542A (es) | 2001-11-13 | 2003-05-22 | Alcon Inc | Regeneracion del cartilago articular da°ado por la osteoartritis de grado i y ii, mediante la aplicacion intra-articular de una mezcla de hialuronato de sodio y de condroitin sulfato en un vehiculo de gel. |
| AUPS052802A0 (en) | 2002-02-15 | 2002-03-07 | Praxis Pharmaceuticals International Pty Ltd | Carbohydrate-based anti-wrinkle and tissue remodelling compounds |
| US20080003258A1 (en) | 2002-10-16 | 2008-01-03 | Marcum Frank D | Composition and Method for Treating Rheumatoid Arthritis |
| PT1560588E (pt) | 2002-10-16 | 2012-01-06 | Arthrodynamic Technologies Animal Health Division Inc | Tratamento para sinovite traumática e lesões na cartilagem |
| FR2861734B1 (fr) | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
| GB0329907D0 (en) | 2003-12-23 | 2004-01-28 | Innomed Ltd | Compositions |
| FR2865737B1 (fr) | 2004-02-03 | 2006-03-31 | Anteis Sa | Gel reticule biocompatible |
| WO2006017752A2 (en) | 2004-08-05 | 2006-02-16 | Ivax Corporation | Sulfated oligosaccharides |
| AU2005272578A1 (en) * | 2004-08-13 | 2006-02-23 | Angiotech International Ag | Compositions and methods using hyaluronic acid and hyluronidase inhibitors |
| WO2008011836A2 (es) | 2006-07-25 | 2008-01-31 | Osmotica Corp. | Soluciones oftálmicas |
| JPWO2008020495A1 (ja) * | 2006-08-15 | 2010-01-07 | 東京化成工業株式会社 | 新規阻害剤 |
| FR2918276B1 (fr) | 2007-07-02 | 2010-01-22 | Anteis Sa | "utilisation d'un gel de polysaccharide(s)naturel(s)pour la preparation d'une formulation injectable de traitement des degenerescences articulaires" |
| ITMI20072237A1 (it) | 2007-11-27 | 2009-05-28 | Sigea Srl | Esteri misti butirrico-formico di polisaccaridi acidi, loro preparazione ed uso come dermocosmetici |
| US8394784B2 (en) * | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having multi-stage bioactive agent delivery |
| FR2924615B1 (fr) | 2007-12-07 | 2010-01-22 | Vivacy Lab | Hydrogel cohesif biodegradable. |
| FR2953522B1 (fr) | 2009-12-07 | 2012-03-09 | Fabre Pierre Dermo Cosmetique | Sucrose octasulfates de zinc, leur preparation et leurs applications pharmaceutiques et cosmetiques |
| US20110171310A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie, Sas | Hydrogel compositions comprising vasoconstricting and anti-hemorrhagic agents for dermatological use |
| FR2956322A1 (fr) | 2010-02-17 | 2011-08-19 | Urgo Lab | Utilisation d'oligosaccharides polysulfates synthetiques comme agents de detersion d'une plaie. |
| CA2805008C (en) * | 2010-07-12 | 2015-05-12 | Shin Poong Pharmaceutical Co., Ltd. | Filler composition for tissue augmentation comprising a hydrogel of hyaluronic acid cross-linked with alkylene diamine |
| FR2983483B1 (fr) | 2011-12-02 | 2014-11-14 | Vivacy Lab | Procede de substitution et reticulation simultanees d'un polysaccharide via ses fonctions hydroxyles |
-
2012
- 2012-06-13 FR FR1255543A patent/FR2991876B1/fr not_active Expired - Fee Related
-
2013
- 2013-06-12 US US13/916,236 patent/US9314530B2/en active Active
- 2013-06-13 CA CA2876057A patent/CA2876057A1/fr not_active Abandoned
- 2013-06-13 TR TR2019/07427T patent/TR201907427T4/tr unknown
- 2013-06-13 AU AU2013276343A patent/AU2013276343B2/en active Active
- 2013-06-13 ES ES13733396T patent/ES2728686T3/es active Active
- 2013-06-13 MX MX2014013949A patent/MX354544B/es active IP Right Grant
- 2013-06-13 PL PL13733396T patent/PL2861301T3/pl unknown
- 2013-06-13 KR KR20147036186A patent/KR20150023468A/ko not_active Withdrawn
- 2013-06-13 SG SG11201407857SA patent/SG11201407857SA/en unknown
- 2013-06-13 BR BR112014029510A patent/BR112014029510A2/pt not_active IP Right Cessation
- 2013-06-13 JP JP2015516668A patent/JP6178414B2/ja active Active
- 2013-06-13 WO PCT/FR2013/051380 patent/WO2013186493A2/fr not_active Ceased
- 2013-06-13 CN CN201380031227.6A patent/CN104394934B/zh active Active
- 2013-06-13 EP EP13733396.9A patent/EP2861301B1/fr active Active
- 2013-06-13 EA EA201492208A patent/EA201492208A1/ru unknown
-
2014
- 2014-11-18 IL IL235776A patent/IL235776A0/en unknown
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