EA201492208A1 - Композиция в водной среде, включающая по меньшей мере одну гиалуроновую кислоту и по меньшей мере одну водорастворимую соль октасульфата сахарозы - Google Patents
Композиция в водной среде, включающая по меньшей мере одну гиалуроновую кислоту и по меньшей мере одну водорастворимую соль октасульфата сахарозыInfo
- Publication number
- EA201492208A1 EA201492208A1 EA201492208A EA201492208A EA201492208A1 EA 201492208 A1 EA201492208 A1 EA 201492208A1 EA 201492208 A EA201492208 A EA 201492208A EA 201492208 A EA201492208 A EA 201492208A EA 201492208 A1 EA201492208 A1 EA 201492208A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- less
- composition
- hyaluronic acid
- salt
- vodorable
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 8
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 2
- 229920002674 hyaluronan Polymers 0.000 title abstract 2
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- WEPNHBQBLCNOBB-FZJVNAOYSA-N sucrose octasulfate Chemical class OS(=O)(=O)O[C@@H]1[C@H](OS(O)(=O)=O)[C@H](COS(=O)(=O)O)O[C@]1(COS(O)(=O)=O)O[C@@H]1[C@H](OS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@@H](COS(O)(=O)=O)O1 WEPNHBQBLCNOBB-FZJVNAOYSA-N 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000037303 wrinkles Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261659140P | 2012-06-13 | 2012-06-13 | |
| FR1255543A FR2991876B1 (fr) | 2012-06-13 | 2012-06-13 | Composition, en milieu aqueux, comprenant au moins un acide hyaluronique et au moins un sel hydrosoluble de sucrose octasulfate |
| PCT/FR2013/051380 WO2013186493A2 (fr) | 2012-06-13 | 2013-06-13 | Composition, en milieux aqueux, comprenant au moins un acide hyaluronique et au moins un sel hydrosoluble de sucrose octasulfate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201492208A1 true EA201492208A1 (ru) | 2015-04-30 |
Family
ID=46785648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201492208A EA201492208A1 (ru) | 2012-06-13 | 2013-06-13 | Композиция в водной среде, включающая по меньшей мере одну гиалуроновую кислоту и по меньшей мере одну водорастворимую соль октасульфата сахарозы |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9314530B2 (enExample) |
| EP (1) | EP2861301B1 (enExample) |
| JP (1) | JP6178414B2 (enExample) |
| KR (1) | KR20150023468A (enExample) |
| CN (1) | CN104394934B (enExample) |
| AU (1) | AU2013276343B2 (enExample) |
| BR (1) | BR112014029510A2 (enExample) |
| CA (1) | CA2876057A1 (enExample) |
| EA (1) | EA201492208A1 (enExample) |
| ES (1) | ES2728686T3 (enExample) |
| FR (1) | FR2991876B1 (enExample) |
| IL (1) | IL235776A0 (enExample) |
| MX (1) | MX354544B (enExample) |
| PL (1) | PL2861301T3 (enExample) |
| SG (1) | SG11201407857SA (enExample) |
| TR (1) | TR201907427T4 (enExample) |
| WO (1) | WO2013186493A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9492474B2 (en) | 2013-07-10 | 2016-11-15 | Matrix Biology Institute | Compositions of hyaluronan with high elasticity and uses thereof |
| US9421198B2 (en) | 2013-07-30 | 2016-08-23 | Teoxane | Composition comprising hyaluronic acid and mepivacaine |
| FR3015290B1 (fr) * | 2013-12-23 | 2017-01-13 | Lab Vivacy | Compositions d'acide hyaluronique compreant de la mepivacaine |
| ES2898656T3 (es) * | 2014-06-30 | 2022-03-08 | Nutricos Tech | Productos de combinación y composiciones cosméticas para luchar contra los trastornos de la piel y su envejecimiento que afectan a los queratinocitos y/o los fibroblastos y la dermis |
| FR3032617B1 (fr) * | 2015-02-16 | 2018-03-16 | Kylane Laboratoires Sa | Procede de preparation d un hydrogel injectable; hydrogel obtenu; utilisation de l hydrogel obtenu |
| FR3036035B1 (fr) | 2015-05-11 | 2018-10-05 | Laboratoires Vivacy | Compositions comprenant au moins un polyol et au moins un anesthesique |
| US10004824B2 (en) | 2015-05-11 | 2018-06-26 | Laboratoires Vivacy | Compositions comprising at least one polyol and at least one anesthetic |
| CN104926889A (zh) * | 2015-05-24 | 2015-09-23 | 广西师范学院 | 蔗糖硫酸酯铜银类化合物及其制作方法和用途 |
| PT3842047T (pt) * | 2015-09-24 | 2024-09-19 | Matrix Biology Inst | Composições de hialuronano de elevada elasticidade e processos para o seu uso |
| FR3044557B1 (fr) * | 2015-12-07 | 2017-12-01 | Benedicte Vincente Gavard Molliard Tauzin | Nouvelle composition injectable; procede de preparation de ladite composition; utilisation de ladite composition |
| WO2017102001A1 (fr) | 2015-12-16 | 2017-06-22 | Vplus International Sa | Composition d'acide hyaluronique pour injections peniennes |
| FR3047666A1 (fr) * | 2016-02-15 | 2017-08-18 | Benedicte Vincente Gavard Molliard Tauzin | Composition injectable; procede de preparation de ladite composition; utilisation de ladite composition |
| FR3058064B1 (fr) | 2016-10-28 | 2020-08-07 | Lab Vivacy | Composition a base d'acide hyaluronique comprenant de la mepivacaine |
| WO2018107226A1 (en) * | 2016-12-13 | 2018-06-21 | Beta Therapeutics Pty. Ltd. | Methods of treating ocular disorders |
| BR112019012045A2 (pt) | 2016-12-13 | 2020-08-18 | Beta Therapeutics Pty Ltd | inibidores de heparanase e uso dos mesmos |
| US11787783B2 (en) | 2016-12-13 | 2023-10-17 | Beta Therapeutics Pty Ltd | Heparanase inhibitors and use thereof |
| FR3109153B1 (fr) | 2020-04-10 | 2022-07-15 | Teoxane SA | Compositions à base d’au moins deux glycosaminoglycanes |
| KR102664134B1 (ko) * | 2023-11-23 | 2024-05-10 | 한국콜마주식회사 | 히알루론산 및 이의 유도체를 포함하는 화장료 조성물 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2715091A (en) | 1949-11-28 | 1955-08-09 | Nat Res Dev | Dextran sulfate as anticoagulant, process of preparing same, and sterile solution thereof |
| AU607690B2 (en) | 1985-12-24 | 1991-03-14 | Marion Laboratories, Inc. | Use of synthetic sulfated saccharides to enhance wound healing |
| DK505488D0 (da) * | 1987-12-21 | 1988-09-09 | Bar Shalom Daniel | Middel og anvendelse af samme |
| US5916880A (en) | 1987-12-21 | 1999-06-29 | Bukh Meditec A/S | Reduction of skin wrinkling using sulphated sugars |
| DK86492D0 (da) | 1992-06-30 | 1992-06-30 | Bukh Meditec | Laegemiddel |
| WO1998022114A1 (en) | 1996-11-15 | 1998-05-28 | Dumex-Alpharma A/S | A method for promoting tissue repair |
| JP2000178196A (ja) * | 1998-12-11 | 2000-06-27 | Seikagaku Kogyo Co Ltd | 新規ヒアルロニダーゼ阻害剤及び外用剤 |
| GB9902412D0 (en) | 1999-02-03 | 1999-03-24 | Fermentech Med Ltd | Process |
| EP1423081A4 (en) * | 2001-06-25 | 2005-05-25 | Depuy Int Ltd | COMPOSITION WITH GLYCOSAMINOGYCANES AND HYALURONIDASE INHIBITORS FOR THE TREATMENT OF ARTHRITIC JOINTS |
| US20050187150A1 (en) * | 2001-10-31 | 2005-08-25 | New York University | Structure-based design and synthesis of FGF inhibitors and FGF modulator compounds |
| MXPA01011542A (es) | 2001-11-13 | 2003-05-22 | Alcon Inc | Regeneracion del cartilago articular da°ado por la osteoartritis de grado i y ii, mediante la aplicacion intra-articular de una mezcla de hialuronato de sodio y de condroitin sulfato en un vehiculo de gel. |
| AUPS052802A0 (en) | 2002-02-15 | 2002-03-07 | Praxis Pharmaceuticals International Pty Ltd | Carbohydrate-based anti-wrinkle and tissue remodelling compounds |
| US20080003258A1 (en) | 2002-10-16 | 2008-01-03 | Marcum Frank D | Composition and Method for Treating Rheumatoid Arthritis |
| AU2003295347B2 (en) | 2002-10-16 | 2010-02-11 | Arthrodynamic Holdings, Llc | Treatment for traumatic synovitis and damaged articular cartilage |
| FR2861734B1 (fr) | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
| GB0329907D0 (en) | 2003-12-23 | 2004-01-28 | Innomed Ltd | Compositions |
| FR2865737B1 (fr) | 2004-02-03 | 2006-03-31 | Anteis Sa | Gel reticule biocompatible |
| US20090215717A1 (en) | 2004-08-05 | 2009-08-27 | Ivax Drug Research Institute Ltd. | Sulfated oligosaccharides |
| AU2005272578A1 (en) * | 2004-08-13 | 2006-02-23 | Angiotech International Ag | Compositions and methods using hyaluronic acid and hyluronidase inhibitors |
| MX2009000885A (es) | 2006-07-25 | 2009-02-05 | Osmotica Corp | Soluciones oftalmicas. |
| JPWO2008020495A1 (ja) * | 2006-08-15 | 2010-01-07 | 東京化成工業株式会社 | 新規阻害剤 |
| FR2918276B1 (fr) | 2007-07-02 | 2010-01-22 | Anteis Sa | "utilisation d'un gel de polysaccharide(s)naturel(s)pour la preparation d'une formulation injectable de traitement des degenerescences articulaires" |
| ITMI20072237A1 (it) | 2007-11-27 | 2009-05-28 | Sigea Srl | Esteri misti butirrico-formico di polisaccaridi acidi, loro preparazione ed uso come dermocosmetici |
| US8394784B2 (en) * | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having multi-stage bioactive agent delivery |
| FR2924615B1 (fr) | 2007-12-07 | 2010-01-22 | Vivacy Lab | Hydrogel cohesif biodegradable. |
| FR2953522B1 (fr) | 2009-12-07 | 2012-03-09 | Fabre Pierre Dermo Cosmetique | Sucrose octasulfates de zinc, leur preparation et leurs applications pharmaceutiques et cosmetiques |
| US20110171310A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie, Sas | Hydrogel compositions comprising vasoconstricting and anti-hemorrhagic agents for dermatological use |
| FR2956322A1 (fr) | 2010-02-17 | 2011-08-19 | Urgo Lab | Utilisation d'oligosaccharides polysulfates synthetiques comme agents de detersion d'une plaie. |
| CA2805008C (en) * | 2010-07-12 | 2015-05-12 | Shin Poong Pharmaceutical Co., Ltd. | Filler composition for tissue augmentation comprising a hydrogel of hyaluronic acid cross-linked with alkylene diamine |
| FR2983483B1 (fr) | 2011-12-02 | 2014-11-14 | Vivacy Lab | Procede de substitution et reticulation simultanees d'un polysaccharide via ses fonctions hydroxyles |
-
2012
- 2012-06-13 FR FR1255543A patent/FR2991876B1/fr active Active
-
2013
- 2013-06-12 US US13/916,236 patent/US9314530B2/en active Active
- 2013-06-13 EP EP13733396.9A patent/EP2861301B1/fr active Active
- 2013-06-13 MX MX2014013949A patent/MX354544B/es active IP Right Grant
- 2013-06-13 BR BR112014029510A patent/BR112014029510A2/pt not_active IP Right Cessation
- 2013-06-13 JP JP2015516668A patent/JP6178414B2/ja active Active
- 2013-06-13 TR TR2019/07427T patent/TR201907427T4/tr unknown
- 2013-06-13 WO PCT/FR2013/051380 patent/WO2013186493A2/fr not_active Ceased
- 2013-06-13 KR KR20147036186A patent/KR20150023468A/ko not_active Withdrawn
- 2013-06-13 EA EA201492208A patent/EA201492208A1/ru unknown
- 2013-06-13 ES ES13733396T patent/ES2728686T3/es active Active
- 2013-06-13 PL PL13733396T patent/PL2861301T3/pl unknown
- 2013-06-13 AU AU2013276343A patent/AU2013276343B2/en active Active
- 2013-06-13 CA CA2876057A patent/CA2876057A1/fr not_active Abandoned
- 2013-06-13 CN CN201380031227.6A patent/CN104394934B/zh active Active
- 2013-06-13 SG SG11201407857SA patent/SG11201407857SA/en unknown
-
2014
- 2014-11-18 IL IL235776A patent/IL235776A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN104394934A (zh) | 2015-03-04 |
| JP2015525099A (ja) | 2015-09-03 |
| AU2013276343B2 (en) | 2017-06-15 |
| AU2013276343A1 (en) | 2014-12-04 |
| IL235776A0 (en) | 2015-01-29 |
| KR20150023468A (ko) | 2015-03-05 |
| EP2861301B1 (fr) | 2019-02-20 |
| CN104394934B (zh) | 2018-01-09 |
| PL2861301T3 (pl) | 2020-08-24 |
| FR2991876B1 (fr) | 2014-11-21 |
| TR201907427T4 (tr) | 2019-06-21 |
| MX2014013949A (es) | 2015-05-11 |
| BR112014029510A2 (pt) | 2017-06-27 |
| MX354544B (es) | 2018-03-09 |
| SG11201407857SA (en) | 2015-02-27 |
| WO2013186493A3 (fr) | 2014-05-08 |
| US9314530B2 (en) | 2016-04-19 |
| JP6178414B2 (ja) | 2017-08-09 |
| ES2728686T3 (es) | 2019-10-28 |
| CA2876057A1 (fr) | 2013-12-19 |
| EP2861301A2 (fr) | 2015-04-22 |
| FR2991876A1 (fr) | 2013-12-20 |
| US20140005140A1 (en) | 2014-01-02 |
| WO2013186493A2 (fr) | 2013-12-19 |
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