JP2015524813A - タカサゴサンシチソウの肝炎を治療する薬物又は保健用食品の製造への応用 - Google Patents
タカサゴサンシチソウの肝炎を治療する薬物又は保健用食品の製造への応用 Download PDFInfo
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- JP2015524813A JP2015524813A JP2015524634A JP2015524634A JP2015524813A JP 2015524813 A JP2015524813 A JP 2015524813A JP 2015524634 A JP2015524634 A JP 2015524634A JP 2015524634 A JP2015524634 A JP 2015524634A JP 2015524813 A JP2015524813 A JP 2015524813A
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- takasago
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- A—HUMAN NECESSITIES
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- Nutrition Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
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CN201310179552.9A CN103222995B (zh) | 2013-05-15 | 2013-05-15 | 白子菜在制备护肝药物或保健食品中的应用 |
CN201310179552.9 | 2013-05-15 | ||
PCT/CN2014/076376 WO2014183551A1 (zh) | 2013-05-15 | 2014-04-28 | 白子菜在制备治疗肝炎的药物或保健食品中的应用 |
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JP (1) | JP2015524813A (zh) |
KR (1) | KR20150036538A (zh) |
CN (1) | CN103222995B (zh) |
GB (1) | GB2522146B (zh) |
HK (1) | HK1212589A1 (zh) |
SG (1) | SG11201501648SA (zh) |
WO (1) | WO2014183551A1 (zh) |
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CN103222995B (zh) * | 2013-05-15 | 2014-09-03 | 李伟权 | 白子菜在制备护肝药物或保健食品中的应用 |
CN103230444B (zh) * | 2013-05-15 | 2014-03-19 | 李伟权 | 一种降脂护肝中药组合物及其制备方法和应用 |
CN110368411B (zh) * | 2019-08-02 | 2021-08-06 | 龙岩学院 | 一种白背天葵多酚的提取工艺及其分离纯化方法 |
CN112655601A (zh) * | 2020-12-02 | 2021-04-16 | 中国水产科学研究院淡水渔业研究中心 | 一种四氯化碳诱导淡水鱼急性肝肠联合损伤模型的建立及其应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10251154A (ja) * | 1997-03-13 | 1998-09-22 | Suntory Ltd | 肝炎抑制組成物 |
JP2007519715A (ja) * | 2004-01-31 | 2007-07-19 | キョン キム | ケンボナシ抽出物、ダンコウバイ抽出物、またはその混合生薬抽出物を有効成分として含む組成物 |
JP2008074807A (ja) * | 2006-09-25 | 2008-04-03 | Oriza Yuka Kk | 肝保護剤 |
CN101485706A (zh) * | 2008-01-19 | 2009-07-22 | 郑乐建 | 抗氧化自由基祛面斑作用的白背三七及其软胶囊制剂 |
JP2010155789A (ja) * | 2008-12-26 | 2010-07-15 | Yakult Honsha Co Ltd | 肝機能障害改善剤 |
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CN102631391A (zh) * | 2012-05-15 | 2012-08-15 | 李伟权 | 白子菜在制备降脂药物或保健食品中的应用 |
CN103222995B (zh) * | 2013-05-15 | 2014-09-03 | 李伟权 | 白子菜在制备护肝药物或保健食品中的应用 |
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2013
- 2013-05-15 CN CN201310179552.9A patent/CN103222995B/zh active Active
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2014
- 2014-04-28 KR KR1020157003623A patent/KR20150036538A/ko not_active Application Discontinuation
- 2014-04-28 SG SG11201501648SA patent/SG11201501648SA/en unknown
- 2014-04-28 GB GB1507323.2A patent/GB2522146B/en active Active
- 2014-04-28 WO PCT/CN2014/076376 patent/WO2014183551A1/zh active Application Filing
- 2014-04-28 JP JP2015524634A patent/JP2015524813A/ja active Pending
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10251154A (ja) * | 1997-03-13 | 1998-09-22 | Suntory Ltd | 肝炎抑制組成物 |
JP2007519715A (ja) * | 2004-01-31 | 2007-07-19 | キョン キム | ケンボナシ抽出物、ダンコウバイ抽出物、またはその混合生薬抽出物を有効成分として含む組成物 |
JP2008074807A (ja) * | 2006-09-25 | 2008-04-03 | Oriza Yuka Kk | 肝保護剤 |
CN101485706A (zh) * | 2008-01-19 | 2009-07-22 | 郑乐建 | 抗氧化自由基祛面斑作用的白背三七及其软胶囊制剂 |
JP2010155789A (ja) * | 2008-12-26 | 2010-07-15 | Yakult Honsha Co Ltd | 肝機能障害改善剤 |
Non-Patent Citations (1)
Title |
---|
JPN6015048065; Pharmacogn Mag. Vol.7, No.25, 2011, p.40-45 * |
Also Published As
Publication number | Publication date |
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GB2522146A (en) | 2015-07-15 |
GB201507323D0 (en) | 2015-06-10 |
HK1212589A1 (zh) | 2016-06-17 |
WO2014183551A1 (zh) | 2014-11-20 |
CN103222995A (zh) | 2013-07-31 |
GB2522146B (en) | 2016-02-10 |
KR20150036538A (ko) | 2015-04-07 |
SG11201501648SA (en) | 2016-01-28 |
CN103222995B (zh) | 2014-09-03 |
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