JP2015523330A5 - - Google Patents
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- Publication number
- JP2015523330A5 JP2015523330A5 JP2015511734A JP2015511734A JP2015523330A5 JP 2015523330 A5 JP2015523330 A5 JP 2015523330A5 JP 2015511734 A JP2015511734 A JP 2015511734A JP 2015511734 A JP2015511734 A JP 2015511734A JP 2015523330 A5 JP2015523330 A5 JP 2015523330A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- composition according
- pharmaceutical composition
- bacterial biofilm
- ulcer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims description 76
- 230000001580 bacterial effect Effects 0.000 claims description 25
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- 108010038346 Seaprose S Proteins 0.000 claims description 13
- 239000004599 antimicrobial Substances 0.000 claims description 12
- 241000191967 Staphylococcus aureus Species 0.000 claims description 10
- 206010052428 Wound Diseases 0.000 claims description 10
- 208000027418 Wounds and injury Diseases 0.000 claims description 10
- 241000191940 Staphylococcus Species 0.000 claims description 9
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 241000894006 Bacteria Species 0.000 claims description 6
- 206010040943 Skin Ulcer Diseases 0.000 claims description 6
- 230000001338 necrotic effect Effects 0.000 claims description 6
- 210000001519 tissue Anatomy 0.000 claims description 6
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims description 5
- 239000003242 anti bacterial agent Substances 0.000 claims description 5
- 239000003429 antifungal agent Substances 0.000 claims description 5
- 229940121375 antifungal agent Drugs 0.000 claims description 5
- 230000003115 biocidal effect Effects 0.000 claims description 5
- 239000012459 cleaning agent Substances 0.000 claims description 5
- 239000006071 cream Substances 0.000 claims description 5
- 229960003085 meticillin Drugs 0.000 claims description 5
- 239000002674 ointment Substances 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- 230000002335 preservative effect Effects 0.000 claims description 5
- 206010011985 Decubitus ulcer Diseases 0.000 claims description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 4
- 208000005230 Leg Ulcer Diseases 0.000 claims description 4
- 239000004264 Petrolatum Substances 0.000 claims description 4
- 208000004210 Pressure Ulcer Diseases 0.000 claims description 4
- 230000000843 anti-fungal effect Effects 0.000 claims description 4
- 230000001684 chronic effect Effects 0.000 claims description 4
- 239000008387 emulsifying waxe Substances 0.000 claims description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 4
- 239000007943 implant Substances 0.000 claims description 4
- 229940066842 petrolatum Drugs 0.000 claims description 4
- 235000019271 petrolatum Nutrition 0.000 claims description 4
- 229920000058 polyacrylate Polymers 0.000 claims description 4
- 239000000243 solution Substances 0.000 claims description 3
- 230000000699 topical effect Effects 0.000 claims description 3
- 208000008960 Diabetic foot Diseases 0.000 claims description 2
- 208000025865 Ulcer Diseases 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 claims description 2
- 230000001079 digestive effect Effects 0.000 claims description 2
- 210000000959 ear middle Anatomy 0.000 claims description 2
- 210000004392 genitalia Anatomy 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 210000000214 mouth Anatomy 0.000 claims description 2
- 210000002307 prostate Anatomy 0.000 claims description 2
- 230000000241 respiratory effect Effects 0.000 claims description 2
- 231100000075 skin burn Toxicity 0.000 claims description 2
- 231100000019 skin ulcer Toxicity 0.000 claims description 2
- 231100000397 ulcer Toxicity 0.000 claims description 2
- 230000002485 urinary effect Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 238000000034 method Methods 0.000 description 31
- 239000000499 gel Substances 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261645815P | 2012-05-11 | 2012-05-11 | |
| US61/645,815 | 2012-05-11 | ||
| US201361820915P | 2013-05-08 | 2013-05-08 | |
| US61/820,915 | 2013-05-08 | ||
| PCT/US2013/040514 WO2013170128A1 (en) | 2012-05-11 | 2013-05-10 | Use of seaprose to remove bacterial biofilm |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018003062A Division JP2018083830A (ja) | 2012-05-11 | 2018-01-12 | 細菌性バイオフィルムを除去するためのセアプローゼの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015523330A JP2015523330A (ja) | 2015-08-13 |
| JP2015523330A5 true JP2015523330A5 (https=) | 2016-06-30 |
Family
ID=48468851
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511734A Withdrawn JP2015523330A (ja) | 2012-05-11 | 2013-05-10 | 細菌性バイオフィルムを除去するためのセアプローゼの使用 |
| JP2018003062A Pending JP2018083830A (ja) | 2012-05-11 | 2018-01-12 | 細菌性バイオフィルムを除去するためのセアプローゼの使用 |
| JP2019050562A Active JP7118022B2 (ja) | 2012-05-11 | 2019-03-19 | 細菌性バイオフィルムを除去するためのセアプローゼの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018003062A Pending JP2018083830A (ja) | 2012-05-11 | 2018-01-12 | 細菌性バイオフィルムを除去するためのセアプローゼの使用 |
| JP2019050562A Active JP7118022B2 (ja) | 2012-05-11 | 2019-03-19 | 細菌性バイオフィルムを除去するためのセアプローゼの使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US11096992B2 (https=) |
| EP (1) | EP2849777B1 (https=) |
| JP (3) | JP2015523330A (https=) |
| KR (1) | KR20150013280A (https=) |
| CN (1) | CN104602700A (https=) |
| AU (1) | AU2013259360B2 (https=) |
| BR (1) | BR112014027995A2 (https=) |
| CA (1) | CA2872530A1 (https=) |
| CL (1) | CL2014003059A1 (https=) |
| CO (1) | CO7250444A2 (https=) |
| IL (1) | IL235617A0 (https=) |
| IN (1) | IN2014DN09412A (https=) |
| MX (1) | MX2014013745A (https=) |
| NZ (1) | NZ701623A (https=) |
| RU (1) | RU2014145270A (https=) |
| WO (1) | WO2013170128A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5548121B2 (ja) | 2007-05-14 | 2014-07-16 | リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク | バイオフィルム中の細菌細胞における生理学的分散応答の誘導 |
| MX2014013745A (es) | 2012-05-11 | 2016-05-05 | Smith & Nephew Inc | Uso de seaprose para eliminar la pelicula biologica bacteriana. |
| CN109260465A (zh) | 2012-11-14 | 2019-01-25 | 史密夫和内修公司 | 稳定的嗜热菌蛋白酶水凝胶 |
| RU2015137174A (ru) | 2013-03-15 | 2017-04-24 | Смит энд Невью, Инк. | Растворимая образующая гель плёнка и способ очистки раны |
| EP2857025A1 (en) * | 2013-10-02 | 2015-04-08 | Special Water Patents B.V. | Wound treatment composition |
| EP3120866A1 (en) * | 2015-07-24 | 2017-01-25 | Zymetech ehf. | Use of marine serine proteases for removal, prevention and inhibition of formation and growth of biofilms |
| CA3031866A1 (en) | 2016-07-27 | 2018-02-01 | Smith & Nephew, Inc. | Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces |
| WO2018071506A1 (en) * | 2016-10-11 | 2018-04-19 | Sharklet Technologies, Inc | Composition for biofilm disruption, methods of manufacture thereof and articles comprising the same |
| WO2018140707A1 (en) | 2017-01-30 | 2018-08-02 | Smith & Nephew, Inc. | Synergistic combination of thermolysin and an antibacterial agent to reduce eliminate bacterial biofilms from surfaces |
| US20200289552A1 (en) * | 2017-07-04 | 2020-09-17 | Fluchem Ltd | Solid composition comprising iodine agent and sodium chloride having improved water solubility, and antiviral and antimicrobial composition for eye, oral cavity, nasal cavity or inhalation containing aqueous solution thereof |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| WO2022023250A1 (en) * | 2020-07-27 | 2022-02-03 | Unilever Ip Holdings B.V. | Use of an enzyme and surfactant for inhibiting microorganisms |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4197291A (en) | 1974-01-08 | 1980-04-08 | Gerold K. V. Klein | Hydrolytic enzyme material |
| JPS5692217A (en) | 1979-12-26 | 1981-07-25 | Kowa Co | Easily absorbable enzyme preparation |
| IT1264322B (it) | 1992-07-30 | 1996-09-23 | Lanfranco Callegaro | Esteri di gellano autoreticolato, procedimento di preparazione e loro applicazioni farmaceutiche e biomedico-sanitarie |
| CA2106609A1 (en) * | 1992-09-28 | 1994-03-29 | Irene Yeatman Aldridge | Proteases to inhibit and remove biofilm |
| US5902600A (en) | 1992-12-21 | 1999-05-11 | Healthpoint, Ltd. | Hydrogel polymer wound dressing |
| US6395529B1 (en) | 1998-11-10 | 2002-05-28 | Novozymes Biotech, Inc. | Polypeptides having lactonohydrolase activity and nucleic acids encoding same |
| US6548556B2 (en) | 2000-12-27 | 2003-04-15 | Healthpoint, Ltd. | Stable enzymatic wound debrider |
| US6399092B1 (en) | 2000-12-27 | 2002-06-04 | Healthpoint, Ltd. | Anhydrous, hydrophilic absorbent wound dressing (tube) with antimicrobials or other pharmaceutically active agents |
| US20030026794A1 (en) * | 2001-07-31 | 2003-02-06 | Howard Fein | Selective enzyme treatment of skin conditions |
| US6479060B1 (en) | 2001-09-04 | 2002-11-12 | Healthpoint, Ltd. | Elegant hydrogenated castor oil ointments |
| US20030198631A1 (en) | 2002-04-18 | 2003-10-23 | Healthpoint, Ltd. | Thermolysin enzymatic wound debrider |
| MX282672B (es) | 2002-10-10 | 2011-01-10 | Diversa Corp | Proteasas, acidos nucleicos que los codifican, y metodos de hacer y usar los mismos. |
| US20050079594A1 (en) | 2002-10-31 | 2005-04-14 | Karine Marion | Method of removing a biofilm |
| US8821862B2 (en) | 2002-12-20 | 2014-09-02 | Kane Biotech Inc. | Soluble β-N-acetylglucosaminidase based antibiofilm compositions and uses thereof |
| NZ540731A (en) | 2002-12-20 | 2008-04-30 | Univ New Jersey Med | Compositions and methods for enzymatic detachment of bacterial and fungal biofilms |
| US20100221237A1 (en) | 2003-03-26 | 2010-09-02 | Biosynexus Incorporated | Enzyme disruption of bacterial biofilms |
| US7785584B2 (en) | 2003-08-13 | 2010-08-31 | Healthpoint, Ltd. | Ointment wound spray |
| KR20060127857A (ko) * | 2003-10-29 | 2006-12-13 | 알투스 파마슈티컬스 인코포레이티드 | 혈장 콜레시스토키닌(ｃｃｋ) 농도 조절 및 통증 치료를위한 비-췌장 프로테아제 |
| GB0326194D0 (en) | 2003-11-10 | 2003-12-17 | Univ Kent Canterbury | Proteins involved in signal transduction |
| WO2005115357A2 (en) | 2004-05-14 | 2005-12-08 | Hans-Dietrich Polaschegg | Taurolidine formulations and delivery |
| EP1666075A1 (en) | 2004-10-04 | 2006-06-07 | Switch Biotech Aktiengesellschaft | Wound dressing compositions, especially for delivery of protease inhibitors |
| IL165334A0 (en) | 2004-11-22 | 2006-01-15 | Mediwound Ltd | Debriding composition from bromelain and methods of producing same |
| WO2007047205A2 (en) * | 2005-10-11 | 2007-04-26 | Amano Enzyme Usa Co., Ltd. | Enzyme inhibitors of pai-1 |
| WO2008021987A2 (en) | 2006-08-10 | 2008-02-21 | Jon Barron | Proteolytic enzyme formulations |
| AT504159A1 (de) | 2006-08-16 | 2008-03-15 | Marlyn Nutraceuticals Inc | Verwendung von proteasen |
| BRPI0809096A2 (pt) | 2007-03-23 | 2014-09-09 | Danisco Us Inc Genecor Division | Produção aumentada de amilase através da adição n-terminal à proteína amilase madura |
| JP2008290966A (ja) | 2007-05-24 | 2008-12-04 | Michiharu Sasaki | 養毛剤 |
| KR101690631B1 (ko) | 2007-11-27 | 2017-01-09 | 알지파마 아이피알 에이에스 | 바이오필름 퇴치에 있어서의 알기네이트 올리고머의 용도 |
| AT506095A1 (de) * | 2007-12-03 | 2009-06-15 | Volopharm Gmbh | Verwendung von proteasen |
| US8309081B2 (en) | 2008-11-18 | 2012-11-13 | Scarguard Labs, Llc. | Composition and method for treatment of bruising |
| JP2010126710A (ja) | 2008-12-01 | 2010-06-10 | Kao Corp | バイオフィルム除去剤組成物 |
| WO2010079209A2 (en) * | 2009-01-08 | 2010-07-15 | Golub Alexandr A | Compositions for treating wounds and skin conditions |
| GB0905451D0 (en) * | 2009-03-31 | 2009-05-13 | Novabiotics Ltd | Biofilms |
| WO2011063394A2 (en) * | 2009-11-23 | 2011-05-26 | Olmstead Stephen F | Compositions and methods comprising serratia peptidase for inhibition and treatment of biofilms related to certain conditions |
| CN102711808B (zh) | 2009-12-08 | 2015-08-19 | 史密夫和内修整形外科股份公司 | 具有增强的酶活性的酶学伤口清创组合物 |
| AU2012253379A1 (en) | 2011-05-12 | 2013-11-21 | Healthpoint, Ltd. | Wound debridement compositions containing seaprose and methods of wound treatment using same |
| WO2013096337A1 (en) | 2011-12-20 | 2013-06-27 | Kci Licensing, Inc. | Composition for enzymatic debridement |
| MX2014013745A (es) | 2012-05-11 | 2016-05-05 | Smith & Nephew Inc | Uso de seaprose para eliminar la pelicula biologica bacteriana. |
| CN109260465A (zh) | 2012-11-14 | 2019-01-25 | 史密夫和内修公司 | 稳定的嗜热菌蛋白酶水凝胶 |
| RU2015137174A (ru) | 2013-03-15 | 2017-04-24 | Смит энд Невью, Инк. | Растворимая образующая гель плёнка и способ очистки раны |
| CA2907175C (en) * | 2013-03-15 | 2022-11-08 | M. Alphabet 3, L.L.C. | Methods and compositions for enhancing oxygen levels in tissues |
| JP6987039B2 (ja) | 2015-08-24 | 2021-12-22 | スミス アンド ネフュー インコーポレイテッド | 抗菌剤と組み合わせた中極性油の細菌性バイオフィルムに対する相乗的抗菌活性 |
-
2013
- 2013-05-10 MX MX2014013745A patent/MX2014013745A/es unknown
- 2013-05-10 RU RU2014145270A patent/RU2014145270A/ru not_active Application Discontinuation
- 2013-05-10 AU AU2013259360A patent/AU2013259360B2/en not_active Ceased
- 2013-05-10 KR KR20147034713A patent/KR20150013280A/ko not_active Withdrawn
- 2013-05-10 CA CA 2872530 patent/CA2872530A1/en not_active Abandoned
- 2013-05-10 NZ NZ701623A patent/NZ701623A/en not_active IP Right Cessation
- 2013-05-10 IN IN9412DEN2014 patent/IN2014DN09412A/en unknown
- 2013-05-10 WO PCT/US2013/040514 patent/WO2013170128A1/en not_active Ceased
- 2013-05-10 EP EP13724135.2A patent/EP2849777B1/en not_active Not-in-force
- 2013-05-10 JP JP2015511734A patent/JP2015523330A/ja not_active Withdrawn
- 2013-05-10 BR BR112014027995A patent/BR112014027995A2/pt not_active IP Right Cessation
- 2013-05-10 CN CN201380036705.2A patent/CN104602700A/zh active Pending
- 2013-05-10 US US14/399,124 patent/US11096992B2/en active Active
-
2014
- 2014-11-10 IL IL235617A patent/IL235617A0/en unknown
- 2014-11-11 CO CO14248773A patent/CO7250444A2/es unknown
- 2014-11-11 CL CL2014003059A patent/CL2014003059A1/es unknown
-
2018
- 2018-01-12 JP JP2018003062A patent/JP2018083830A/ja active Pending
-
2019
- 2019-03-19 JP JP2019050562A patent/JP7118022B2/ja active Active
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