ECSP20010477A - Composición tópica semisólida conteniendo un agente antimicrobiano y pirfenidona para el tratamiento de daños crónicos de la piel - Google Patents
Composición tópica semisólida conteniendo un agente antimicrobiano y pirfenidona para el tratamiento de daños crónicos de la pielInfo
- Publication number
- ECSP20010477A ECSP20010477A ECSENADI202010477A ECDI202010477A ECSP20010477A EC SP20010477 A ECSP20010477 A EC SP20010477A EC SENADI202010477 A ECSENADI202010477 A EC SENADI202010477A EC DI202010477 A ECDI202010477 A EC DI202010477A EC SP20010477 A ECSP20010477 A EC SP20010477A
- Authority
- EC
- Ecuador
- Prior art keywords
- treatment
- chronic skin
- pyrphenidone
- semi
- composition containing
- Prior art date
Links
- 230000001684 chronic effect Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000004599 antimicrobial Substances 0.000 title abstract 2
- 239000007787 solid Substances 0.000 title 1
- 230000000699 topical effect Effects 0.000 title 1
- 208000008960 Diabetic foot Diseases 0.000 abstract 2
- 206010050502 Neuropathic ulcer Diseases 0.000 abstract 2
- 208000025865 Ulcer Diseases 0.000 abstract 2
- 230000006378 damage Effects 0.000 abstract 2
- 231100000397 ulcer Toxicity 0.000 abstract 2
- 230000002792 vascular Effects 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000002421 anti-septic effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- PFRGXCVKLLPLIP-UHFFFAOYSA-N diallyl disulfide Chemical class C=CCSSCC=C PFRGXCVKLLPLIP-UHFFFAOYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 abstract 1
- 230000037380 skin damage Effects 0.000 abstract 1
- 206010040882 skin lesion Diseases 0.000 abstract 1
- 231100000444 skin lesion Toxicity 0.000 abstract 1
- 229940042129 topical gel Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención proporciona composiciones de gel tópicas farmacéuticas para el tratamiento de daños crónicos de la piel, específicamente para los daños causados por úlceras neuropáticas y preferentemente para el tratamiento del pie diabético y en el tratamiento de úlceras vasculares, en donde dichas composiciones comprenden una combinación de Dialil Óxido de Disulfuro Modificado (ODD-M) (como agente antiséptico/antibiótico) y 5-metil-1-fenil-2(1H)-piridona. Además, la invención describe métodos de tratamiento, aplicaciones y/o usos farmacéuticos en la preparación de medicamentos para eliminar, reducir o prevenir lesiones crónicas de la piel y los daños causados por úlceras neuropáticas y particularmente en el tratamiento del pie diabético y en el tratamiento de úlceras vasculares.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2017010486A MX366086B (es) | 2017-08-15 | 2017-08-15 | Composicion topica semisolida conteniendo un agente antimicrobiano y pirfenidona para el tratamiento de daños cronicos de la piel. |
| PCT/MX2018/000071 WO2019035705A2 (es) | 2017-08-15 | 2018-08-10 | Composición tópica semisólida conteniendo un agente antimicrobiano y pirfenidona para el tratamiento de daños crónicos de la piel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP20010477A true ECSP20010477A (es) | 2020-04-22 |
Family
ID=64605095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI202010477A ECSP20010477A (es) | 2017-08-15 | 2020-02-12 | Composición tópica semisólida conteniendo un agente antimicrobiano y pirfenidona para el tratamiento de daños crónicos de la piel |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11576905B2 (es) |
| EP (1) | EP3714872A2 (es) |
| JP (2) | JP2020531455A (es) |
| KR (1) | KR102746175B1 (es) |
| CN (1) | CN111246840A (es) |
| AR (1) | AR112474A1 (es) |
| AU (1) | AU2018317188B2 (es) |
| BR (1) | BR112020003001A2 (es) |
| CA (1) | CA3072855A1 (es) |
| EC (1) | ECSP20010477A (es) |
| MX (1) | MX366086B (es) |
| PH (1) | PH12020500324A1 (es) |
| RU (1) | RU2020110783A (es) |
| SG (1) | SG11202002214QA (es) |
| WO (1) | WO2019035705A2 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007009796A (es) | 2007-08-14 | 2009-02-25 | Cell Therapy And Technology S | Gel conteniendo pirfenidona. |
| MX2011007675A (es) | 2011-07-19 | 2012-07-11 | Cell Therapy And Technology S A De C V | Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas. |
| MX346763B (es) | 2012-03-28 | 2017-03-31 | Cell Therapy And Tech S A De C V | Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné. |
| MX356551B (es) | 2012-08-23 | 2018-06-04 | Grupo Medifarma S A De C V Star | Composición antiséptica, antiseborreica y exfoliante para eliminar o prevenir el acné. |
| MX366086B (es) | 2017-08-15 | 2019-06-27 | Cell Therapy And Tech S A De C V | Composicion topica semisolida conteniendo un agente antimicrobiano y pirfenidona para el tratamiento de daños cronicos de la piel. |
| WO2021022033A1 (en) * | 2019-07-30 | 2021-02-04 | Leung Kai P | Layered composite for scar treatment and prevention |
| RU2753638C2 (ru) * | 2020-01-24 | 2021-08-18 | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НОВАСКИН" (ООО "Новаскин") | Гелевая композиция для обработки кожных покровов |
| CN116887810A (zh) * | 2020-12-16 | 2023-10-13 | 希普拉有限公司 | 吡非尼酮的局部组合物 |
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| US4052509A (en) | 1972-12-18 | 1977-10-04 | Affiliated Medical Research, Inc. | Method for reducing serum uric acid levels |
| US3839346A (en) | 1972-12-18 | 1974-10-01 | Affiliated Med Res | N-substituted pyridone and general method for preparing pyridones |
| ES421598A1 (es) | 1972-12-18 | 1977-01-01 | Affiliated Med Res | Un procedimiento para la sintesis de piridonas. |
| CA1049411A (en) | 1972-12-18 | 1979-02-27 | Affiliated Medical Research | N-substituted pyridone and general method for preparing pyridones |
| US4105782A (en) | 1975-03-07 | 1978-08-08 | Yu Ruey J | Treatment of acne and dandruff |
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| MX2011007675A (es) | 2011-07-19 | 2012-07-11 | Cell Therapy And Technology S A De C V | Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas. |
| MX346763B (es) | 2012-03-28 | 2017-03-31 | Cell Therapy And Tech S A De C V | Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné. |
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| MX356551B (es) | 2012-08-23 | 2018-06-04 | Grupo Medifarma S A De C V Star | Composición antiséptica, antiseborreica y exfoliante para eliminar o prevenir el acné. |
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| WO2017104725A1 (ja) | 2015-12-16 | 2017-06-22 | 第一三共株式会社 | 創傷治療剤 |
| MX364040B (es) | 2016-11-11 | 2019-04-11 | Cell Therapy And Tech S A De C V | Uso farmacéutico de una composición que contiene pirfenidona de liberación prolongada (pfd-lp) para la reversión y tratamiento de la esteatohepatitis humana (nafld/nash). |
| MX366086B (es) | 2017-08-15 | 2019-06-27 | Cell Therapy And Tech S A De C V | Composicion topica semisolida conteniendo un agente antimicrobiano y pirfenidona para el tratamiento de daños cronicos de la piel. |
| MX368750B (es) | 2018-08-31 | 2019-10-15 | Cell Therapy And Tech S A De C V | Composiciones farmaceuticas semisolidas de base oleosa conteniendo pirfenidona para su aplicacion en la reparacion tisular. |
-
2017
- 2017-08-15 MX MX2017010486A patent/MX366086B/es active IP Right Grant
-
2018
- 2018-08-10 WO PCT/MX2018/000071 patent/WO2019035705A2/es not_active Ceased
- 2018-08-10 BR BR112020003001-5A patent/BR112020003001A2/pt not_active IP Right Cessation
- 2018-08-10 KR KR1020207007458A patent/KR102746175B1/ko active Active
- 2018-08-10 CN CN201880066604.2A patent/CN111246840A/zh active Pending
- 2018-08-10 RU RU2020110783A patent/RU2020110783A/ru unknown
- 2018-08-10 AU AU2018317188A patent/AU2018317188B2/en active Active
- 2018-08-10 EP EP18839550.3A patent/EP3714872A2/en active Pending
- 2018-08-10 SG SG11202002214QA patent/SG11202002214QA/en unknown
- 2018-08-10 US US16/638,621 patent/US11576905B2/en active Active
- 2018-08-10 JP JP2020508593A patent/JP2020531455A/ja active Pending
- 2018-08-10 CA CA3072855A patent/CA3072855A1/en active Pending
- 2018-08-15 AR ARP180102342 patent/AR112474A1/es unknown
-
2020
- 2020-02-12 EC ECSENADI202010477A patent/ECSP20010477A/es unknown
- 2020-02-13 PH PH12020500324A patent/PH12020500324A1/en unknown
-
2023
- 2023-04-13 JP JP2023065867A patent/JP2023080289A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR102746175B1 (ko) | 2024-12-26 |
| CA3072855A1 (en) | 2019-02-21 |
| BR112020003001A2 (pt) | 2020-08-11 |
| US11576905B2 (en) | 2023-02-14 |
| AR112474A1 (es) | 2019-10-30 |
| SG11202002214QA (en) | 2020-04-29 |
| MX366086B (es) | 2019-06-27 |
| AU2018317188B2 (en) | 2024-08-29 |
| WO2019035705A3 (es) | 2019-05-09 |
| WO2019035705A2 (es) | 2019-02-21 |
| JP2020531455A (ja) | 2020-11-05 |
| EP3714872A2 (en) | 2020-09-30 |
| RU2020110783A3 (es) | 2021-12-08 |
| RU2020110783A (ru) | 2021-09-16 |
| PH12020500324A1 (en) | 2020-09-28 |
| KR20200091379A (ko) | 2020-07-30 |
| AU2018317188A1 (en) | 2020-04-02 |
| JP2023080289A (ja) | 2023-06-08 |
| MX2017010486A (es) | 2018-09-21 |
| US20200253944A1 (en) | 2020-08-13 |
| CN111246840A (zh) | 2020-06-05 |
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