JP2015522656A5 - - Google Patents
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- Publication number
- JP2015522656A5 JP2015522656A5 JP2015524218A JP2015524218A JP2015522656A5 JP 2015522656 A5 JP2015522656 A5 JP 2015522656A5 JP 2015524218 A JP2015524218 A JP 2015524218A JP 2015524218 A JP2015524218 A JP 2015524218A JP 2015522656 A5 JP2015522656 A5 JP 2015522656A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- group
- formula
- stereochemistry
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 23
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 12
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 125000000676 alkoxyimino group Chemical group 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000004663 dialkyl amino group Chemical group 0.000 claims 3
- 125000003147 glycosyl group Chemical group 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 208000012657 Atopic disease Diseases 0.000 claims 2
- -1 C 6 amide Chemical class 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000732 arylene group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 201000009961 allergic asthma Diseases 0.000 claims 1
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000004431 deuterium atom Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000026037 malignant tumor of neck Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000004999 nitroaryl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ601473 | 2012-07-26 | ||
| NZ60147312 | 2012-07-26 | ||
| PCT/NZ2013/000133 WO2014017928A1 (en) | 2012-07-26 | 2013-07-26 | Organic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522656A JP2015522656A (ja) | 2015-08-06 |
| JP2015522656A5 true JP2015522656A5 (enExample) | 2016-08-25 |
| JP6528029B2 JP6528029B2 (ja) | 2019-06-12 |
Family
ID=49997620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524218A Expired - Fee Related JP6528029B2 (ja) | 2012-07-26 | 2013-07-26 | 有機化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9586985B2 (enExample) |
| EP (1) | EP2877481B1 (enExample) |
| JP (1) | JP6528029B2 (enExample) |
| KR (1) | KR102162619B1 (enExample) |
| CN (1) | CN104736550B (enExample) |
| AU (1) | AU2013293646B2 (enExample) |
| CA (1) | CA2880191C (enExample) |
| IN (1) | IN2015KN00492A (enExample) |
| WO (1) | WO2014017928A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9764037B2 (en) | 2012-12-06 | 2017-09-19 | Victoria Link Limited | Conjugate compounds |
| WO2014200363A1 (en) * | 2013-06-10 | 2014-12-18 | Victoria Link Limited | Sphingoglycolipid analogues |
| US10046046B2 (en) | 2014-06-05 | 2018-08-14 | Victoria Link Limited | Amino sphingoglycolipid analogues |
| JP6453033B2 (ja) * | 2014-10-22 | 2019-01-16 | 国立大学法人北海道大学 | 糖スフィンゴシン及びスフィンゴ塩基の製造方法 |
| US9394312B1 (en) * | 2015-06-14 | 2016-07-19 | Mark Quang Nguyen | Ibrutinib prodrugs, pharmaceutical compositions thereof, and methods of use |
| EP3374028B1 (en) | 2015-11-13 | 2021-05-26 | La Jolla Institute for Allergy and Immunology | Sphingamide compounds and methods for binding inkt cells |
| WO2017163808A1 (ja) * | 2016-03-22 | 2017-09-28 | 学校法人慶應義塾 | 化合物又はその塩、ナチュラルキラーｔ細胞活性化剤、及び医薬組成物 |
| WO2019122050A1 (en) | 2017-12-22 | 2019-06-27 | Isa Pharmaceuticals B.V. | Methods of immunization |
| US12036286B2 (en) | 2021-03-18 | 2024-07-16 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4410913B2 (ja) * | 2000-06-12 | 2010-02-10 | 壽製薬株式会社 | 新規糖脂質誘導体の製造方法 |
| AU2003225891A1 (en) * | 2003-03-20 | 2004-11-19 | Brigham Young University | 6"-amino-6"-deoxygalactosylceramides |
| JP3824319B2 (ja) * | 2004-02-19 | 2006-09-20 | 株式会社紀文フードケミファ | 抗ウイルス作用組成物 |
| US20060024691A1 (en) * | 2004-03-25 | 2006-02-02 | Buck Institute For Age Research | Novel pathways in the etiology of cancer |
| KR20120116511A (ko) * | 2004-08-27 | 2012-10-22 | 알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티 | 면역 및 자가면역의 조절제로서의 세라마이드 유도체 |
| JP5090928B2 (ja) * | 2004-12-28 | 2012-12-05 | ザ ロックフェラー ユニバーシティ | Ｎｋｔ細胞に対する抗原としての糖脂質及びその類似体 |
| US7923013B2 (en) * | 2004-12-28 | 2011-04-12 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NKT cells |
| US20090117089A1 (en) * | 2005-09-19 | 2009-05-07 | The Rockefeller University | Glycolipids and analogues thereof as antigens for nk t cells |
| WO2008047174A1 (en) * | 2006-10-18 | 2008-04-24 | Centre National De La Recherche Scientifique | Alpha-galactosylceramide analogs, their methods of manufacture, intermediate compounds useful in these methods, and pharmaceutical compositions containing them |
| US20080133801A1 (en) * | 2006-12-04 | 2008-06-05 | Aten International Co., Ltd. | Keyboard-video-mouse switch system for switching between computers having a plurality of video sources each and switching method thereof |
| CN104478092B (zh) | 2007-04-12 | 2016-06-01 | 诺维信生物股份有限公司 | 废水处理 |
| EP2058011A1 (en) * | 2007-11-07 | 2009-05-13 | Wittycell | Nkt cell activating gycolipids covalently bound antigens and/or drug |
| CN102215864A (zh) * | 2008-10-08 | 2011-10-12 | 威蒂赛尔公司 | 用于抗流感的疫苗组合物 |
-
2013
- 2013-07-26 US US14/417,487 patent/US9586985B2/en not_active Expired - Fee Related
- 2013-07-26 IN IN492KON2015 patent/IN2015KN00492A/en unknown
- 2013-07-26 JP JP2015524218A patent/JP6528029B2/ja not_active Expired - Fee Related
- 2013-07-26 WO PCT/NZ2013/000133 patent/WO2014017928A1/en not_active Ceased
- 2013-07-26 CN CN201380050112.1A patent/CN104736550B/zh not_active Expired - Fee Related
- 2013-07-26 EP EP13823249.1A patent/EP2877481B1/en active Active
- 2013-07-26 CA CA2880191A patent/CA2880191C/en active Active
- 2013-07-26 KR KR1020157004813A patent/KR102162619B1/ko not_active Expired - Fee Related
- 2013-07-26 AU AU2013293646A patent/AU2013293646B2/en not_active Ceased
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