JP2015522246A5 - - Google Patents
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- JP2015522246A5 JP2015522246A5 JP2015503288A JP2015503288A JP2015522246A5 JP 2015522246 A5 JP2015522246 A5 JP 2015522246A5 JP 2015503288 A JP2015503288 A JP 2015503288A JP 2015503288 A JP2015503288 A JP 2015503288A JP 2015522246 A5 JP2015522246 A5 JP 2015522246A5
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- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- antibody
- cdr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616394P | 2012-03-27 | 2012-03-27 | |
| US61/616,394 | 2012-03-27 | ||
| US201261707411P | 2012-09-28 | 2012-09-28 | |
| US61/707,411 | 2012-09-28 | ||
| PCT/US2013/031178 WO2013148232A1 (en) | 2012-03-27 | 2013-03-14 | Methods of prognosing, diagnosing and treating idiopathic pulmonary fibrosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522246A JP2015522246A (ja) | 2015-08-06 |
| JP2015522246A5 true JP2015522246A5 (https=) | 2016-05-12 |
| JP6404208B2 JP6404208B2 (ja) | 2018-10-10 |
Family
ID=49261043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503288A Active JP6404208B2 (ja) | 2012-03-27 | 2013-03-14 | 特発性肺線維症の予後予測、診断および処置の方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20160230226A1 (https=) |
| EP (2) | EP3725892A1 (https=) |
| JP (1) | JP6404208B2 (https=) |
| KR (1) | KR102197524B1 (https=) |
| CN (2) | CN107099581B (https=) |
| AR (1) | AR090339A1 (https=) |
| AU (2) | AU2013240344A1 (https=) |
| BR (1) | BR112014023348A2 (https=) |
| CA (1) | CA2864884A1 (https=) |
| HK (1) | HK1206796A1 (https=) |
| IL (1) | IL256396A (https=) |
| MX (2) | MX370486B (https=) |
| NZ (1) | NZ628458A (https=) |
| RU (1) | RU2014139546A (https=) |
| SG (2) | SG11201405830VA (https=) |
| WO (1) | WO2013148232A1 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10236078B2 (en) | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
| US8669057B2 (en) | 2009-05-07 | 2014-03-11 | Veracyte, Inc. | Methods and compositions for diagnosis of thyroid conditions |
| WO2013035799A1 (ja) | 2011-09-06 | 2013-03-14 | 株式会社シノテスト | ペリオスチンの特定領域に結合する抗体及びこれを用いたペリオスチンの測定方法 |
| US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| JP6799201B2 (ja) | 2013-07-31 | 2020-12-16 | アヴァリン ファーマ インク. | エアロゾルチロシンキナーゼ阻害剤の化合物、及びその使用 |
| SG11201603127WA (en) * | 2013-10-23 | 2016-05-30 | Genentech Inc | Methods of diagnosing and treating eosinophilic disorders |
| JP6312054B2 (ja) * | 2013-11-06 | 2018-04-18 | 学校法人日本大学 | 間質性肺炎のバイオマーカー |
| EP3068409A4 (en) * | 2013-11-14 | 2017-08-23 | Proterris, Inc. | Treatment or prevention of pulmonary conditions with carbon monoxide |
| CA2934662C (en) | 2013-12-20 | 2024-02-20 | President And Fellows Of Harvard College | Low shear microfluidic devices and methods of use and manufacturing thereof |
| WO2015120257A2 (en) * | 2014-02-06 | 2015-08-13 | The Brigham And Women's Hospital, Inc. | Uses of gli1 in detecting tissue fibrosis |
| TW201618795A (zh) | 2014-04-15 | 2016-06-01 | 波泰里斯股份有限公司 | 用以改良器官功能及延長器官移植物壽命之系統及方法 |
| WO2015164716A1 (en) * | 2014-04-25 | 2015-10-29 | Brown University | Methods for the diagnosis and treatment of pulmonary fibrosis in subjects with hermansky pudlak syndrome |
| WO2015191841A1 (en) * | 2014-06-12 | 2015-12-17 | Yale University | Novel methods of treating or preventing fibrotic lung diseases |
| EP2957634A1 (en) | 2014-06-20 | 2015-12-23 | Consejo Superior De Investigaciones Científicas | Compounds for prevention and/or treatment of fibrotic diseases |
| US12297505B2 (en) | 2014-07-14 | 2025-05-13 | Veracyte, Inc. | Algorithms for disease diagnostics |
| EP3215170A4 (en) | 2014-11-05 | 2018-04-25 | Veracyte, Inc. | Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data |
| CN104792998B (zh) * | 2015-03-09 | 2016-06-08 | 中国人民解放军第四军医大学 | Loxl2抗原用于制备甲状腺癌预示、侵袭、转移试剂盒的应用 |
| CN111718413A (zh) * | 2015-06-26 | 2020-09-29 | 上海市肿瘤研究所 | Cthrc1在肝硬化诊断和治疗中的应用 |
| WO2017044752A1 (en) * | 2015-09-10 | 2017-03-16 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Anti-fibrotic effect of cd70 |
| EP3368512B1 (en) * | 2015-10-27 | 2023-12-06 | Taipei Medical University | Indoline derivatives for treatment and/or prevention of fibrosis diseases |
| CN105400870B (zh) * | 2015-11-11 | 2018-09-25 | 南方医科大学 | CD1c在菌阴肺结核诊断中的应用 |
| US20190144547A1 (en) * | 2015-11-23 | 2019-05-16 | Merck Patent Gmbh | Anti-alpha-v integrin antibody for the treatment of fibrosis and/or fibrotic disorders |
| BR112018010337A2 (pt) * | 2015-11-23 | 2018-12-04 | Merck Patent Gmbh | anticorpo anti-alfa-v integrina para o tratamento de fibrose e/ou transtornos fibróticos |
| US20190275032A1 (en) * | 2016-05-27 | 2019-09-12 | Boehringer Ingelheim International Gmbh | Use of ecm biomarkers for determining the treatment onset with nintedanib and pirfenidone |
| CN106319058B (zh) * | 2016-08-31 | 2019-09-10 | 汪道文 | 一种检测特发性肺纤维化致病基因的dna文库及其应用 |
| CN109689892A (zh) * | 2016-09-07 | 2019-04-26 | 威拉赛特公司 | 用于检测寻常型间质性肺炎的方法和系统 |
| US11397178B2 (en) | 2016-10-28 | 2022-07-26 | Cedars-Sinai Medical Center | Method of predicting progression of idiopathic pulmonary fibrosis and monitoring of therapeutic efficacy |
| WO2018160925A1 (en) * | 2017-03-02 | 2018-09-07 | President And Fellows Of Harvard College | Methods and systems for predicting treatment responses in subjects |
| IT201700026858A1 (it) * | 2017-03-10 | 2018-09-10 | Univ Degli Studi Padova | Uso di inibitori delle serin proteasi, in particolare di serpinb3 |
| US20190127456A1 (en) * | 2017-10-31 | 2019-05-02 | Fibrogen, Inc. | Methods of treating idiopathic pulmonary fibrosis |
| CN108931645A (zh) * | 2018-07-26 | 2018-12-04 | 北京大学第医院 | 一种hcv清除后肝纤维化评估系统及评估方法 |
| AU2019339260B2 (en) | 2018-09-10 | 2025-06-26 | Rein Therapeutics, Inc. | Modified peptide fragments of Cav-1 protein and the use thereof in the treatment of fibrosis |
| JP7440042B2 (ja) * | 2018-10-29 | 2024-02-28 | 国立大学法人 東京医科歯科大学 | 間質性肺炎患者の呼吸機能の低下リスクに関する情報を取得する方法及びその利用 |
| EP3908668A4 (en) * | 2019-01-11 | 2022-11-09 | University of Virginia Patent Foundation | COMPOSITIONS AND METHODS FOR PREDICTING THE DECREASE IN LUNG FUNCTION IN IDIOPATHIC LUNG FIBROSIS |
| JP2023536159A (ja) * | 2020-07-31 | 2023-08-23 | ジェネンテック, インコーポレイテッド | 炎症性呼吸器疾患の増悪を治療するための方法 |
| US20250076312A1 (en) | 2021-02-25 | 2025-03-06 | Lung Therapeutics, Llc | Biomarkers for the treatment of interstitial lung disease |
| CA3221735A1 (en) * | 2021-06-18 | 2022-12-22 | F. Hoffmann-La Roche Ag | Bispecific anti-ccl2 antibodies |
| ES2957479B2 (es) * | 2022-06-07 | 2025-07-28 | Baigene S L | Metodo de obtencion de datos utiles para la prediccion del riesgo de un sujeto de sufrir fibrosis |
| IL317083A (en) | 2022-06-17 | 2025-01-01 | Apogee Biologics Inc | Antibodies that bind interleukin 13 and methods of use |
| CN115925920B (zh) * | 2022-08-04 | 2023-07-25 | 瑞因细胞工程科技(广州)有限公司 | 一种基因增强型免疫细胞治疗肝硬化的方法 |
| AU2023380152A1 (en) * | 2022-11-14 | 2025-05-22 | Alentis Therapeutics Ag | Biomarkers for fibrosis treatment using anti-claudin-1 antibodies |
| CN117747093B (zh) * | 2024-02-20 | 2024-06-07 | 神州医疗科技股份有限公司 | 一种特发性肺纤维化诊断模型的构建方法及诊断系统 |
| CN118583834B (zh) * | 2024-07-30 | 2024-11-22 | 上海交通大学医学院附属仁济医院 | 一种慢性肝纤维化性疾病的诊断系统 |
| CN119162300A (zh) * | 2024-09-12 | 2024-12-20 | 中国人民解放军陆军军医大学第一附属医院 | 用于预测肺纤维化程度及预后情况的标志物、模型及应用 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4018653A (en) | 1971-10-29 | 1977-04-19 | U.S. Packaging Corporation | Instrument for the detection of Neisseria gonorrhoeae without culture |
| US4016043A (en) | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
| US4424279A (en) | 1982-08-12 | 1984-01-03 | Quidel | Rapid plunger immunoassay method and apparatus |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| EP1690934A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| ATE300615T1 (de) | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| ES2341666T3 (es) | 1991-12-02 | 2010-06-24 | Medimmune Limited | Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos. |
| ATE182651T1 (de) | 1992-06-09 | 1999-08-15 | Hoppe Ag | Riegel und türschloss |
| CA2219361C (en) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
| DE19544393A1 (de) | 1995-11-15 | 1997-05-22 | Hoechst Schering Agrevo Gmbh | Synergistische herbizide Mischungen |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| EP1500329B1 (en) | 1996-12-03 | 2012-03-21 | Amgen Fremont Inc. | Human antibodies that specifically bind human TNF alpha |
| AR045614A1 (es) * | 2003-09-10 | 2005-11-02 | Hoffmann La Roche | Anticuerpos contra el recepctor de la interleuquina- 1 y los usos de los mismos |
| SG10201404273QA (en) | 2003-12-23 | 2014-10-30 | Genentech Inc | Novel anti-il 13 antibodies and uses thereof |
| US20080044420A1 (en) | 2005-05-11 | 2008-02-21 | Heavner George A | Anti-IL-13 antibodies, compositions, methods and uses |
| AU2006296399B2 (en) | 2005-09-30 | 2011-01-20 | Medimmune Limited | Interleukin-13 antibody composition |
| RU2421464C2 (ru) | 2005-10-21 | 2011-06-20 | Новартис Аг | Человеческие антитела к il-13 и их терапевтическое применение |
| CA2641318C (en) * | 2006-01-13 | 2017-06-20 | Indiana University Research & Technology Corporation | Molecules for the treatment of lung disease involving an autoimmune reaction to connective tissue found in the lung |
| TWI395754B (zh) * | 2006-04-24 | 2013-05-11 | Amgen Inc | 人類化之c-kit抗體 |
| KR20090074787A (ko) * | 2006-10-05 | 2009-07-07 | 센토코 오르토 바이오테크 인코포레이티드 | 섬유증 치료용 ccr2 길항제 |
| WO2008083695A1 (de) | 2006-12-20 | 2008-07-17 | Patent-Treuhand-Gesellschaft für elektrische Glühlampen mbH | Vorrichtung und verfahren zur messung der intensität des lichtes einer ersten gruppe von lichtquellen einer beleuchtungseinheit |
| BRPI0810561A2 (pt) * | 2007-04-23 | 2019-09-24 | Wyeth Corp | métodos e composições para tratar e monitorar tratamento de desordens associadas à il-13. |
| EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| US7892760B2 (en) * | 2007-11-19 | 2011-02-22 | Celera Corporation | Lung cancer markers, and uses thereof |
| EP2631302A3 (en) * | 2008-03-31 | 2014-01-08 | Genentech, Inc. | Compositions and methods for treating and diagnosing asthma |
| WO2010028274A1 (en) * | 2008-09-05 | 2010-03-11 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Marker panels for idiopathic pulmonary fibrosis diagnosis and evaluation |
| AU2008364461A1 (en) * | 2008-11-26 | 2010-06-03 | Domantis Limited | Ligands that bind IL-13 |
| WO2010141469A2 (en) * | 2009-06-01 | 2010-12-09 | Case Western Reserve University | Protein biomarkers and therapeutic targets for autoimmune and alloimmune diseases |
| TWI732259B (zh) * | 2010-12-16 | 2021-07-01 | 美商建南德克公司 | 關於th2抑制作用之診斷及治療 |
-
2013
- 2013-03-14 EP EP20153153.0A patent/EP3725892A1/en not_active Withdrawn
- 2013-03-14 NZ NZ628458A patent/NZ628458A/en not_active IP Right Cessation
- 2013-03-14 MX MX2014011503A patent/MX370486B/es active IP Right Grant
- 2013-03-14 AU AU2013240344A patent/AU2013240344A1/en not_active Abandoned
- 2013-03-14 CA CA2864884A patent/CA2864884A1/en not_active Abandoned
- 2013-03-14 CN CN201611178102.8A patent/CN107099581B/zh active Active
- 2013-03-14 HK HK15107420.8A patent/HK1206796A1/xx unknown
- 2013-03-14 KR KR1020147029554A patent/KR102197524B1/ko not_active Expired - Fee Related
- 2013-03-14 RU RU2014139546A patent/RU2014139546A/ru not_active Application Discontinuation
- 2013-03-14 SG SG11201405830VA patent/SG11201405830VA/en unknown
- 2013-03-14 AR ARP130100827A patent/AR090339A1/es unknown
- 2013-03-14 CN CN201380027564.8A patent/CN104334744A/zh active Pending
- 2013-03-14 EP EP13768451.0A patent/EP2831280B1/en active Active
- 2013-03-14 SG SG10201702842SA patent/SG10201702842SA/en unknown
- 2013-03-14 BR BR112014023348-9A patent/BR112014023348A2/pt not_active IP Right Cessation
- 2013-03-14 WO PCT/US2013/031178 patent/WO2013148232A1/en not_active Ceased
- 2013-03-14 JP JP2015503288A patent/JP6404208B2/ja active Active
-
2014
- 2014-09-23 US US14/493,649 patent/US20160230226A1/en not_active Abandoned
- 2014-09-25 MX MX2019015159A patent/MX2019015159A/es unknown
-
2017
- 2017-12-18 IL IL256396A patent/IL256396A/en unknown
-
2018
- 2018-03-16 US US15/924,114 patent/US20190062836A1/en not_active Abandoned
- 2018-10-16 AU AU2018250393A patent/AU2018250393A1/en not_active Abandoned
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