JP2015521635A5 - - Google Patents
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- Publication number
- JP2015521635A5 JP2015521635A5 JP2015518855A JP2015518855A JP2015521635A5 JP 2015521635 A5 JP2015521635 A5 JP 2015521635A5 JP 2015518855 A JP2015518855 A JP 2015518855A JP 2015518855 A JP2015518855 A JP 2015518855A JP 2015521635 A5 JP2015521635 A5 JP 2015521635A5
- Authority
- JP
- Japan
- Prior art keywords
- solifenacin
- compound
- formula
- salt
- impurity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 11
- FBOUYBDGKBSUES-VXKWHMMOSA-N solifenacin Chemical compound C1([C@H]2C3=CC=CC=C3CCN2C(O[C@@H]2C3CCN(CC3)C2)=O)=CC=CC=C1 FBOUYBDGKBSUES-VXKWHMMOSA-N 0.000 claims 11
- 229960003855 solifenacin Drugs 0.000 claims 10
- 239000012535 impurity Substances 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 8
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 238000004128 high performance liquid chromatography Methods 0.000 claims 5
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 239000012458 free base Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000012454 non-polar solvent Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000003880 polar aprotic solvent Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- QPONJQKOPGKHTE-IBGZPJMESA-N (2,5-dioxopyrrolidin-1-yl) (1s)-1-phenyl-3,4-dihydro-1h-isoquinoline-2-carboxylate Chemical compound N1([C@H](C2=CC=CC=C2CC1)C=1C=CC=CC=1)C(=O)ON1C(=O)CCC1=O QPONJQKOPGKHTE-IBGZPJMESA-N 0.000 claims 1
- FDJKLIVKKYFLSA-UHFFFAOYSA-N 1-oxido-1-azoniabicyclo[2.2.2]octane Chemical compound C1CC2CC[N+]1([O-])CC2 FDJKLIVKKYFLSA-UHFFFAOYSA-N 0.000 claims 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- CAQGZNDDACGLPT-KYJUHHDHSA-N bis[(1s)-1-phenyl-3,4-dihydro-1h-isoquinolin-2-yl]methanone Chemical compound C1([C@H]2C3=CC=CC=C3CCN2C(=O)N2[C@H](C3=CC=CC=C3CC2)C=2C=CC=CC=2)=CC=CC=C1 CAQGZNDDACGLPT-KYJUHHDHSA-N 0.000 claims 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 claims 1
- 150000007522 mineralic acids Chemical group 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 235000006408 oxalic acid Nutrition 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2012/002769 WO2014005601A1 (en) | 2012-07-02 | 2012-07-02 | A process for the preparation of solifenacin or a salt thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015521635A JP2015521635A (ja) | 2015-07-30 |
| JP2015521635A5 true JP2015521635A5 (https=) | 2015-09-10 |
Family
ID=46750264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015518855A Pending JP2015521635A (ja) | 2012-07-02 | 2012-07-02 | ソリフェナシン又はその塩の調製方法 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP2867210A1 (https=) |
| JP (1) | JP2015521635A (https=) |
| CN (1) | CN104411687A (https=) |
| WO (1) | WO2014005601A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104133011A (zh) * | 2014-07-01 | 2014-11-05 | 北京万全德众医药生物技术有限公司 | 液相色谱法分离分析琥珀酸索利那新中间体及其有关物质 |
| CN105348278B (zh) * | 2014-11-14 | 2017-11-17 | 天津市医药集团技术发展有限公司 | 一种琥珀酸索利那新杂质的制备方法 |
| CN105566315B (zh) * | 2016-01-20 | 2017-07-18 | 成都华宇制药有限公司 | 一种索利那新的后处理及制备琥珀酸索利那新的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2005012I1 (no) | 1994-12-28 | 2005-06-06 | Debio Rech Pharma Sa | Triptorelin og farmasoytisk akseptable salter derav |
| AUPP405098A0 (en) * | 1998-06-12 | 1998-07-02 | Access Pharmaceuticals Australia Pty Limited | Novel methods of preparation of vitamin b12 derivatives suitable for conjugation to pharmaceuticals |
| JP4818124B2 (ja) * | 2003-12-23 | 2011-11-16 | テイボテク・フアーマシユーチカルズ・リミテツド | （３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法 |
| JPWO2005087231A1 (ja) * | 2004-03-16 | 2008-01-24 | アステラス製薬株式会社 | ソリフェナシン含有組成物 |
| ZA200608614B (en) * | 2004-03-25 | 2008-06-25 | Astellas Pharma Inc | Composition for solid pharmaceutical preparation of solifenacin or salt thereof |
| EP1879867A2 (en) | 2005-12-21 | 2008-01-23 | Teva Pharmaceutical Industries Ltd | Intermediates for preparing solifenacin |
| CZ300699B6 (cs) * | 2006-06-21 | 2009-07-22 | Zentiva, A. S. | Zpusob prípravy solifenacinu |
| JP2010523539A (ja) * | 2007-03-30 | 2010-07-15 | メディチェム ソシエダ アノニマ | ソリフェナシンの改良された合成法 |
| ITMI20080195A1 (it) * | 2008-02-08 | 2009-08-09 | Dipharma Francis Srl | Procedimento per la preparazione di solifenacin |
| US8283470B2 (en) | 2009-03-09 | 2012-10-09 | Megafine Pharma(P) Ltd. | Method for the preparation of solifenacin and intermediate thereof |
-
2012
- 2012-07-02 WO PCT/EP2012/002769 patent/WO2014005601A1/en not_active Ceased
- 2012-07-02 EP EP12750992.5A patent/EP2867210A1/en not_active Withdrawn
- 2012-07-02 JP JP2015518855A patent/JP2015521635A/ja active Pending
- 2012-07-02 CN CN201280074426.0A patent/CN104411687A/zh active Pending
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