CN104411687A - 一种用于制备索非那新或其盐的方法 - Google Patents

一种用于制备索非那新或其盐的方法 Download PDF

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Publication number
CN104411687A
CN104411687A CN201280074426.0A CN201280074426A CN104411687A CN 104411687 A CN104411687 A CN 104411687A CN 201280074426 A CN201280074426 A CN 201280074426A CN 104411687 A CN104411687 A CN 104411687A
Authority
CN
China
Prior art keywords
solifenacin
impurity
formula
compound
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280074426.0A
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English (en)
Chinese (zh)
Inventor
T·V·科夫提斯
R·R·索尼
B·B·博达
R·C·古迪卡
V·S·帕特尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmathen SA
Original Assignee
Pharmathen SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmathen SA filed Critical Pharmathen SA
Publication of CN104411687A publication Critical patent/CN104411687A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201280074426.0A 2012-07-02 2012-07-02 一种用于制备索非那新或其盐的方法 Pending CN104411687A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2012/002769 WO2014005601A1 (en) 2012-07-02 2012-07-02 A process for the preparation of solifenacin or a salt thereof

Publications (1)

Publication Number Publication Date
CN104411687A true CN104411687A (zh) 2015-03-11

Family

ID=46750264

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280074426.0A Pending CN104411687A (zh) 2012-07-02 2012-07-02 一种用于制备索非那新或其盐的方法

Country Status (4)

Country Link
EP (1) EP2867210A1 (https=)
JP (1) JP2015521635A (https=)
CN (1) CN104411687A (https=)
WO (1) WO2014005601A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105566315A (zh) * 2016-01-20 2016-05-11 成都华宇制药有限公司 一种索利那新的后处理及制备琥珀酸索利那新的方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104133011A (zh) * 2014-07-01 2014-11-05 北京万全德众医药生物技术有限公司 液相色谱法分离分析琥珀酸索利那新中间体及其有关物质
CN105348278B (zh) * 2014-11-14 2017-11-17 天津市医药集团技术发展有限公司 一种琥珀酸索利那新杂质的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1934109A (zh) * 2004-03-25 2007-03-21 安斯泰来制药株式会社 用于固体制剂的索非那新或其盐的组合物
EP2088148A2 (en) * 2008-02-08 2009-08-12 Dipharma Francis S.r.l. "Process for the preparation of solifenacin"
WO2010103529A1 (en) * 2009-03-09 2010-09-16 Megafine Pharma(P) Ltd. A new method for the preparation of solifenacin and new intermediate thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO2005012I1 (no) * 1994-12-28 2005-06-06 Debio Rech Pharma Sa Triptorelin og farmasoytisk akseptable salter derav
AUPP405098A0 (en) * 1998-06-12 1998-07-02 Access Pharmaceuticals Australia Pty Limited Novel methods of preparation of vitamin b12 derivatives suitable for conjugation to pharmaceuticals
ME01059B (me) * 2003-12-23 2012-10-20 Janssen Sciences Ireland Uc Proces za pripremanje (3r,3as,6ar)-heksahidrofuro [2,3-b] furan-3-il (1s,2r)-3-[[(4-aminofenil) sulfonil] (izobutil) amino]-1-benzil-2- hidroksipropilkarbamata
JPWO2005087231A1 (ja) * 2004-03-16 2008-01-24 アステラス製薬株式会社 ソリフェナシン含有組成物
CA2630846A1 (en) 2005-12-21 2007-07-05 Teva Pharmaceutical Industries Ltd. Intermediates for preparing solifenacin
CZ300699B6 (cs) * 2006-06-21 2009-07-22 Zentiva, A. S. Zpusob prípravy solifenacinu
CN101711248A (zh) * 2007-03-30 2010-05-19 医药化学公司 一种改进的素非那新合成工艺

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1934109A (zh) * 2004-03-25 2007-03-21 安斯泰来制药株式会社 用于固体制剂的索非那新或其盐的组合物
EP2088148A2 (en) * 2008-02-08 2009-08-12 Dipharma Francis S.r.l. "Process for the preparation of solifenacin"
WO2010103529A1 (en) * 2009-03-09 2010-09-16 Megafine Pharma(P) Ltd. A new method for the preparation of solifenacin and new intermediate thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张华山等: "《分子探针与检测试剂》", 31 July 2007 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105566315A (zh) * 2016-01-20 2016-05-11 成都华宇制药有限公司 一种索利那新的后处理及制备琥珀酸索利那新的方法
CN105566315B (zh) * 2016-01-20 2017-07-18 成都华宇制药有限公司 一种索利那新的后处理及制备琥珀酸索利那新的方法

Also Published As

Publication number Publication date
WO2014005601A1 (en) 2014-01-09
EP2867210A1 (en) 2015-05-06
JP2015521635A (ja) 2015-07-30

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Application publication date: 20150311