JP2015521635A - ソリフェナシン又はその塩の調製方法 - Google Patents

ソリフェナシン又はその塩の調製方法 Download PDF

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Publication number
JP2015521635A
JP2015521635A JP2015518855A JP2015518855A JP2015521635A JP 2015521635 A JP2015521635 A JP 2015521635A JP 2015518855 A JP2015518855 A JP 2015518855A JP 2015518855 A JP2015518855 A JP 2015518855A JP 2015521635 A JP2015521635 A JP 2015521635A
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Japan
Prior art keywords
solifenacin
formula
compound
salt
impurity
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Pending
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JP2015518855A
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English (en)
Japanese (ja)
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JP2015521635A5 (enExample
Inventor
テオチャリス ヴィー． コフティス，
テオチャリス ヴィー． コフティス，
ロヒト ラヴィカント ソニ，
ロヒト ラヴィカント ソニ，
バラト ベシャールバーイー ボダ，
バラト ベシャールバーイー ボダ，
ラビンドラ シャルダッタ ゴーティカー，
ラビンドラ シャルダッタ ゴーティカー，
ヴィマル スディールバーイー パテル，
ヴィマル スディールバーイー パテル，
Original Assignee
ファーマシェン エス．エー．
ファーマシェン エス．エー．
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Publication of JP2015521635A publication Critical patent/JP2015521635A/ja
Publication of JP2015521635A5 publication Critical patent/JP2015521635A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015518855A 2012-07-02 2012-07-02 ソリフェナシン又はその塩の調製方法 Pending JP2015521635A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2012/002769 WO2014005601A1 (en) 2012-07-02 2012-07-02 A process for the preparation of solifenacin or a salt thereof

Publications (2)

Publication Number Publication Date
JP2015521635A true JP2015521635A (ja) 2015-07-30
JP2015521635A5 JP2015521635A5 (enExample) 2015-09-10

Family

ID=46750264

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015518855A Pending JP2015521635A (ja) 2012-07-02 2012-07-02 ソリフェナシン又はその塩の調製方法

Country Status (4)

Country Link
EP (1) EP2867210A1 (enExample)
JP (1) JP2015521635A (enExample)
CN (1) CN104411687A (enExample)
WO (1) WO2014005601A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104133011A (zh) * 2014-07-01 2014-11-05 北京万全德众医药生物技术有限公司 液相色谱法分离分析琥珀酸索利那新中间体及其有关物质
CN105348278B (zh) * 2014-11-14 2017-11-17 天津市医药集团技术发展有限公司 一种琥珀酸索利那新杂质的制备方法
CN105566315B (zh) * 2016-01-20 2017-07-18 成都华宇制药有限公司 一种索利那新的后处理及制备琥珀酸索利那新的方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3014457B2 (ja) * 1994-12-28 2000-02-28 山之内製薬株式会社 新規キヌクリジン誘導体及びその医薬組成物
JP2002518405A (ja) * 1998-06-12 2002-06-25 バイオテック・オーストラリア・ピーティーワイ・リミテッド ビタミンｂ１２誘導体及びそれらの製造方法
JP2007520468A (ja) * 2003-12-23 2007-07-26 テイボテク・フアーマシユーチカルズ・リミテツド （３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法
WO2007147374A2 (en) * 2006-06-21 2007-12-27 Zentiva A.S. Process for the preparation of solifenacin
EP2088148A2 (en) * 2008-02-08 2009-08-12 Dipharma Francis S.r.l. "Process for the preparation of solifenacin"
JP2010523539A (ja) * 2007-03-30 2010-07-15 メディチェム ソシエダ アノニマ ソリフェナシンの改良された合成法
WO2010103529A1 (en) * 2009-03-09 2010-09-16 Megafine Pharma(P) Ltd. A new method for the preparation of solifenacin and new intermediate thereof
JP2011084579A (ja) * 2004-04-28 2011-04-28 Astellas Pharma Inc ソリフェナシン又はその塩の製造法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1934109B (zh) * 2004-03-25 2010-06-23 安斯泰来制药株式会社 用于固体制剂的索非那新或其盐的组合物
EP1879867A2 (en) 2005-12-21 2008-01-23 Teva Pharmaceutical Industries Ltd Intermediates for preparing solifenacin

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3014457B2 (ja) * 1994-12-28 2000-02-28 山之内製薬株式会社 新規キヌクリジン誘導体及びその医薬組成物
JP2002518405A (ja) * 1998-06-12 2002-06-25 バイオテック・オーストラリア・ピーティーワイ・リミテッド ビタミンｂ１２誘導体及びそれらの製造方法
JP2007520468A (ja) * 2003-12-23 2007-07-26 テイボテク・フアーマシユーチカルズ・リミテツド （３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法
JP2011084579A (ja) * 2004-04-28 2011-04-28 Astellas Pharma Inc ソリフェナシン又はその塩の製造法
WO2007147374A2 (en) * 2006-06-21 2007-12-27 Zentiva A.S. Process for the preparation of solifenacin
JP2010523539A (ja) * 2007-03-30 2010-07-15 メディチェム ソシエダ アノニマ ソリフェナシンの改良された合成法
EP2088148A2 (en) * 2008-02-08 2009-08-12 Dipharma Francis S.r.l. "Process for the preparation of solifenacin"
WO2010103529A1 (en) * 2009-03-09 2010-09-16 Megafine Pharma(P) Ltd. A new method for the preparation of solifenacin and new intermediate thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6016006367; ＫＵＲＩＴＡ，　Ｋ．　ｅｔ　ａｌ．: 'Ｄｉｐｈｔｈａｌｉｍｉｄｏ　Ｃａｒｂｏｎａｔｅ：　Ａ　Ｎｅｗ　Ｒｅａｇｅｎｔ　ｆｏｒ　Ａｃｔｉｖｅ　Ｅｓｔｅｒ　Ｓｙｎｔｈｅｓｉｓ' Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．　４７，　Ｎｏ．　２３, 1982, ｐｐ．　４５８４-４５８６ *
JPN6016006368; ＳＥＧＮＥＡＮＵ，　Ａ．　ｅｔ　ａｌ．: 'ＵＴＩＬＩＺＡＲＥＡ　Ｎ，　Ｎ'-　ＤＩＦＴＡＬＩＭＩＤＩＬＣＡＲＢＯＮＡＴＵＬＵＩ　ＩＮ　ＳＩＮＴＥＺＥ　ＤＥ　ＣＡＲＢＯＮＡＴＩ　ＯＲＧＡＮＩＣＩ　ＮＥＳＩＭＥＴＲＩＣＩ　ＣＵ　ＡＰＬＩＣＡＴＩ' ＲＥＶＩＳＴＡ　ＤＥ　ＣＨＩＭＩＥ Ｖｏｌ．　５９，　Ｎｏ．　５, 2008, ｐｐ．５７５-５７７ *

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Publication number Publication date
EP2867210A1 (en) 2015-05-06
CN104411687A (zh) 2015-03-11
WO2014005601A1 (en) 2014-01-09

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