JP2015521201A - 呼吸制御障害または呼吸制御疾患の処置用の新規化合物および組成物 - Google Patents

呼吸制御障害または呼吸制御疾患の処置用の新規化合物および組成物 Download PDF

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JP2015521201A
JP2015521201A JP2015515140A JP2015515140A JP2015521201A JP 2015521201 A JP2015521201 A JP 2015521201A JP 2015515140 A JP2015515140 A JP 2015515140A JP 2015515140 A JP2015515140 A JP 2015515140A JP 2015521201 A JP2015521201 A JP 2015521201A
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propylamino
bis
hydroxylamine
triazin
methyl
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JP2015515140A
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JP2015521201A5 (enExample
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ジェイムズ シー． マニオン
ジェイムズ シー． マニオン
スコット エル． ダックス
スコット エル． ダックス
ダンカン ユアン マッキンタイアー
ダンカン ユアン マッキンタイアー
フランシス ジョン ゴールダー
フランシス ジョン ゴールダー
ジェイムズ フランシス マクラウド
ジェイムズ フランシス マクラウド
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ガリオン ファーマシューティカルズ インコーポレイテッド
ガリオン ファーマシューティカルズ インコーポレイテッド
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Application filed by ガリオン ファーマシューティカルズ インコーポレイテッド, ガリオン ファーマシューティカルズ インコーポレイテッド filed Critical ガリオン ファーマシューティカルズ インコーポレイテッド
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Publication of JP2015521201A5 publication Critical patent/JP2015521201A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015515140A 2012-05-29 2013-05-29 呼吸制御障害または呼吸制御疾患の処置用の新規化合物および組成物 Pending JP2015521201A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/482,837 US20120295911A1 (en) 2010-11-29 2012-05-29 Novel Compounds and Compositions for Treatment of Breathing Control Disorders or Diseases
US13/482,837 2012-05-29
PCT/US2013/043052 WO2013181217A2 (en) 2012-05-29 2013-05-29 Novel compounds and compositions for treatment of breathing control disorders or diseases

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JP2015521201A true JP2015521201A (ja) 2015-07-27
JP2015521201A5 JP2015521201A5 (enExample) 2016-07-14

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JP2015515140A Pending JP2015521201A (ja) 2012-05-29 2013-05-29 呼吸制御障害または呼吸制御疾患の処置用の新規化合物および組成物

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EP (1) EP2855438A4 (enExample)
JP (1) JP2015521201A (enExample)
KR (1) KR20150020616A (enExample)
CN (1) CN104602694A (enExample)
AU (1) AU2013267570A1 (enExample)
BR (1) BR112014029703A2 (enExample)
CA (1) CA2875012A1 (enExample)
HK (1) HK1209118A1 (enExample)
SG (1) SG11201407964YA (enExample)
WO (1) WO2013181217A2 (enExample)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2024516730A (ja) * 2021-05-04 2024-04-16 エナラーレ セラピューティクス インコーポレイテッド 大導電性カリウムチャネル調節剤、その組成物、その製造方法、及びその使用方法

Families Citing this family (4)

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CN104926816A (zh) * 2014-03-19 2015-09-23 江苏先声药物研究有限公司 一种托法替布类似物及其制备方法与应用
FR3076751B1 (fr) * 2018-01-18 2020-10-23 Lebronze Alloys Electrode de soudage pour toles en aluminium ou acier et procede d'obtention de l'electrode
KR20240167901A (ko) * 2022-04-01 2024-11-28 에날레어 테라퓨틱스 인크. 호흡 자극제 비강 제형
EP4543455A4 (en) * 2022-06-24 2026-06-03 Enalare Therapeutics Inc METHODS OF TREATMENT FOR NEUROLOGICAL VENTILATORY FAILURE

Citations (2)

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US5661148A (en) * 1989-09-19 1997-08-26 Teijin Limited Pyrrolo[2,3-d]pyrimidine derivatives, process for producing the same and pharmaceutical preparation comprising the same as active ingredient
JP5907986B2 (ja) * 2010-11-29 2016-04-26 ガリオン ファーマシューティカルズ インコーポレイテッド 呼吸制御障害または呼吸制御疾患の処置用の呼吸刺激薬としての化合物

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US4269832A (en) * 1978-04-12 1981-05-26 American Cyanamid Company Method of treating arthritic disease
DE3401675A1 (de) * 1984-01-19 1985-07-25 Bayer Ag, 5090 Leverkusen Neue polyamine und ein verfahren zu ihrer herstellung
US7169785B2 (en) * 2001-09-21 2007-01-30 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
CN101885707B (zh) * 2009-05-15 2012-08-29 中国科学院化学研究所 三嗪类衍生物及其制备方法与作为杀虫剂的用途
US20120295911A1 (en) * 2010-11-29 2012-11-22 Galleon Pharmaceuticals, Inc. Novel Compounds and Compositions for Treatment of Breathing Control Disorders or Diseases
BR112015011213A2 (pt) * 2012-11-15 2017-08-29 Galleon Pharmaceuticals Inc Composto, composição farmacêutica, método de prevenção ou tratamento de um distúrbio ou doença de controle respiratório em um indivíduo, método de prevenção de desestabilização ou de estabilização do ritmo respiratório em um indivíduo, método de preparação de o,n-dimetil-n-[4-(n-propilamina)-6-(prop-2-inilamina)-[1,3,5]triazin-2-il]-hidroxilamina, e composição.

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US5661148A (en) * 1989-09-19 1997-08-26 Teijin Limited Pyrrolo[2,3-d]pyrimidine derivatives, process for producing the same and pharmaceutical preparation comprising the same as active ingredient
JP5907986B2 (ja) * 2010-11-29 2016-04-26 ガリオン ファーマシューティカルズ インコーポレイテッド 呼吸制御障害または呼吸制御疾患の処置用の呼吸刺激薬としての化合物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024516730A (ja) * 2021-05-04 2024-04-16 エナラーレ セラピューティクス インコーポレイテッド 大導電性カリウムチャネル調節剤、その組成物、その製造方法、及びその使用方法

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BR112014029703A2 (pt) 2017-06-27
EP2855438A2 (en) 2015-04-08
EP2855438A4 (en) 2016-02-24
SG11201407964YA (en) 2014-12-30
CN104602694A (zh) 2015-05-06
WO2013181217A3 (en) 2014-02-06
AU2013267570A1 (en) 2014-12-18
WO2013181217A2 (en) 2013-12-05
HK1209118A1 (en) 2016-03-24
CA2875012A1 (en) 2013-12-05
KR20150020616A (ko) 2015-02-26

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