JP2015519405A5 - - Google Patents

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Publication number
JP2015519405A5
JP2015519405A5 JP2015517489A JP2015517489A JP2015519405A5 JP 2015519405 A5 JP2015519405 A5 JP 2015519405A5 JP 2015517489 A JP2015517489 A JP 2015517489A JP 2015517489 A JP2015517489 A JP 2015517489A JP 2015519405 A5 JP2015519405 A5 JP 2015519405A5
Authority
JP
Japan
Prior art keywords
vaginal suppository
ester
estradiol
vaginal
solubilizer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015517489A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015519405A (ja
JP6397402B2 (ja
Filing date
Publication date
Priority claimed from US13/684,002 external-priority patent/US8633178B2/en
Priority claimed from PCT/US2013/023309 external-priority patent/WO2013112947A1/en
Priority claimed from US13/843,428 external-priority patent/US9301920B2/en
Application filed filed Critical
Priority claimed from PCT/US2013/046443 external-priority patent/WO2013192249A1/en
Publication of JP2015519405A publication Critical patent/JP2015519405A/ja
Publication of JP2015519405A5 publication Critical patent/JP2015519405A5/ja
Application granted granted Critical
Publication of JP6397402B2 publication Critical patent/JP6397402B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015517489A 2012-06-18 2013-06-18 膣内挿入用可溶性エストラジオールカプセル Expired - Fee Related JP6397402B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201261661302P 2012-06-18 2012-06-18
US61/661,302 2012-06-18
US201261662265P 2012-06-20 2012-06-20
US61/662,265 2012-06-20
US13/684,002 US8633178B2 (en) 2011-11-23 2012-11-21 Natural combination hormone replacement formulations and therapies
US13/684,002 2012-11-21
US201261745313P 2012-12-21 2012-12-21
US61/745,313 2012-12-21
PCT/US2013/023309 WO2013112947A1 (en) 2012-01-26 2013-01-25 Transdermal hormone replacement therapies
USPCT/US2013/023309 2013-01-25
US13/843,428 US9301920B2 (en) 2012-06-18 2013-03-15 Natural combination hormone replacement formulations and therapies
US13/843,428 2013-03-15
PCT/US2013/046443 WO2013192249A1 (en) 2012-06-18 2013-06-18 Soluble estradiol capsule for vaginal insertion

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018162966A Division JP6682127B2 (ja) 2012-06-18 2018-08-31 膣内挿入用可溶性エストラジオールカプセル

Publications (3)

Publication Number Publication Date
JP2015519405A JP2015519405A (ja) 2015-07-09
JP2015519405A5 true JP2015519405A5 (enExample) 2016-04-07
JP6397402B2 JP6397402B2 (ja) 2018-09-26

Family

ID=49769313

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2015517489A Expired - Fee Related JP6397402B2 (ja) 2012-06-18 2013-06-18 膣内挿入用可溶性エストラジオールカプセル
JP2018162966A Expired - Fee Related JP6682127B2 (ja) 2012-06-18 2018-08-31 膣内挿入用可溶性エストラジオールカプセル
JP2020030544A Pending JP2020100642A (ja) 2012-06-18 2020-02-26 膣内挿入用可溶性エストラジオールカプセル

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2018162966A Expired - Fee Related JP6682127B2 (ja) 2012-06-18 2018-08-31 膣内挿入用可溶性エストラジオールカプセル
JP2020030544A Pending JP2020100642A (ja) 2012-06-18 2020-02-26 膣内挿入用可溶性エストラジオールカプセル

Country Status (13)

Country Link
EP (2) EP3909586A1 (enExample)
JP (3) JP6397402B2 (enExample)
AU (3) AU2013277234B2 (enExample)
BR (1) BR112014031914B1 (enExample)
CA (1) CA2876968C (enExample)
ES (1) ES2869250T3 (enExample)
HR (1) HRP20210861T1 (enExample)
HU (1) HUE055275T2 (enExample)
IL (1) IL236359B (enExample)
MX (2) MX393195B (enExample)
PL (1) PL2861073T3 (enExample)
RU (2) RU2740059C2 (enExample)
WO (1) WO2013192249A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
RS62297B1 (sr) 2011-11-23 2021-09-30 Therapeuticsmd Inc Prirodne kombinovane hormonske supstitucione formulacije i terapije
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
JP2017516768A (ja) 2014-05-22 2017-06-22 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． 天然の併用ホルモン補充療法剤及び療法
US10098894B2 (en) 2014-07-29 2018-10-16 Therapeuticsmd, Inc. Transdermal cream
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
JP2018538290A (ja) * 2015-12-07 2018-12-27 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． 膣挿入エストラジオール医薬組成物および方法
WO2017105512A1 (en) * 2015-12-18 2017-06-22 Proinvet Innovations S.A. Formulations and methods for controlling the reproductive cycle and ovulation
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US9931349B2 (en) 2016-04-01 2018-04-03 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US20220378697A1 (en) * 2019-10-31 2022-12-01 R.P. Scherer Technologies, Llc Suppository capsule

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IT1090703B (it) * 1976-12-03 1985-06-26 Scherer Ltd R P Perfezionamento nelle composizioni utili quali veicolo per farmaci
US4384096A (en) * 1979-08-27 1983-05-17 The Dow Chemical Company Liquid emulsion polymers useful as pH responsive thickeners for aqueous systems
FR2668945B1 (fr) * 1990-11-12 1993-02-19 Theramex Nouveau procede de cristallisation des substances organiques et les composes ainsi obtenus.
GB9405304D0 (en) * 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
FR2728464B1 (fr) * 1994-12-22 1997-04-30 Innothera Lab Sa Forme galenique unitaire, son procede d'obtention et ses utilisations
FR2739558B1 (fr) * 1995-10-05 1997-11-28 Innothera Lab Sa Forme galenique unitaire pour hormonotherapie locale de la secheresse vaginale
GB9608719D0 (en) 1996-04-26 1996-07-03 Scherer Ltd R P Pharmaceutical compositions
US6018033A (en) 1997-05-13 2000-01-25 Purdue Research Foundation Hydrophilic, hydrophobic, and thermoreversible saccharide gels and forms, and methods for producing same
NZ330726A (en) * 1998-06-18 2000-10-27 Dec Res Intra-vaginal delivery unit or composition containing a cyclodextrin which improves absorbtion of 17-beta oestradiol or oestradiol benzoate
US6294192B1 (en) * 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US7374779B2 (en) * 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US20030083286A1 (en) * 2001-08-22 2003-05-01 Ching-Leou Teng Bioadhesive compositions and methods for enhanced intestinal drug absorption
US20050042268A1 (en) * 2003-07-16 2005-02-24 Chaim Aschkenasy Pharmaceutical composition and method for transdermal drug delivery
US20060134188A1 (en) * 2004-12-20 2006-06-22 Hans-Peter Podhaisky Transdermal pharmaceutical preparation with a progesterone A-specific ligand (PRASL) as active ingredient
US20070036843A1 (en) * 2005-01-28 2007-02-15 Collegium Pharmaceutical, Inc. Non-ionic non-aqueous vehicles for topical and oral administration of carrier-complexed active agents
EP1971325A2 (en) * 2005-12-27 2008-09-24 Duramed Pharmaceuticals, Inc. Conjugated estrogen compositions, applicators, kits, and methods of making and use thereof
WO2007103294A2 (en) * 2006-03-07 2007-09-13 Novavax, Inc. Nanoemulsions of poorly soluble pharmaceutical active ingredients and methods of making the same
FR2900052B1 (fr) * 2006-04-19 2011-02-18 Galderma Sa Composition comprenant au moins une phase aqueuse et au moins une phase grasse comprenant de l'ivermectine
US20070287789A1 (en) * 2006-06-07 2007-12-13 Stephen Ray Jones Bleed-resistant colored microparticles
CN101474167A (zh) * 2009-01-23 2009-07-08 西安德天药业股份有限公司 雌二醇阴道用胶囊的制备方法
US9301920B2 (en) * 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
RS62297B1 (sr) * 2011-11-23 2021-09-30 Therapeuticsmd Inc Prirodne kombinovane hormonske supstitucione formulacije i terapije

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