JP2015504924A5 - - Google Patents
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- Publication number
- JP2015504924A5 JP2015504924A5 JP2014554892A JP2014554892A JP2015504924A5 JP 2015504924 A5 JP2015504924 A5 JP 2015504924A5 JP 2014554892 A JP2014554892 A JP 2014554892A JP 2014554892 A JP2014554892 A JP 2014554892A JP 2015504924 A5 JP2015504924 A5 JP 2015504924A5
- Authority
- JP
- Japan
- Prior art keywords
- progesterone
- drug substance
- transdermal pharmaceutical
- transdermal
- estrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 36
- 229960003387 progesterone Drugs 0.000 claims 18
- 239000000186 progesterone Substances 0.000 claims 18
- 239000008186 active pharmaceutical agent Substances 0.000 claims 14
- 229940088679 drug related substance Drugs 0.000 claims 14
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- 239000000825 pharmaceutical preparation Substances 0.000 claims 11
- 229940011871 estrogen Drugs 0.000 claims 8
- 239000000262 estrogen Substances 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 6
- 230000007812 deficiency Effects 0.000 claims 6
- 229960005309 estradiol Drugs 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- 206010030247 Oestrogen deficiency Diseases 0.000 claims 4
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 claims 4
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims 3
- -1 diglyceride Chemical compound 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 229930182833 estradiol Natural products 0.000 claims 2
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261590927P | 2012-01-26 | 2012-01-26 | |
| US61/590,927 | 2012-01-26 | ||
| US201261661302P | 2012-06-18 | 2012-06-18 | |
| US61/661,302 | 2012-06-18 | ||
| US201261662265P | 2012-06-20 | 2012-06-20 | |
| US61/662,265 | 2012-06-20 | ||
| US13/684,002 US8633178B2 (en) | 2011-11-23 | 2012-11-21 | Natural combination hormone replacement formulations and therapies |
| US13/684,002 | 2012-11-21 | ||
| PCT/US2013/023309 WO2013112947A1 (en) | 2012-01-26 | 2013-01-25 | Transdermal hormone replacement therapies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015504924A JP2015504924A (ja) | 2015-02-16 |
| JP2015504924A5 true JP2015504924A5 (enExample) | 2016-03-10 |
| JP6342334B2 JP6342334B2 (ja) | 2018-06-13 |
Family
ID=48873981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014554892A Expired - Fee Related JP6342334B2 (ja) | 2012-01-26 | 2013-01-25 | 経皮ホルモン補充療法 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP2806742B1 (enExample) |
| JP (1) | JP6342334B2 (enExample) |
| AU (1) | AU2013211876B2 (enExample) |
| BR (1) | BR112014018439A8 (enExample) |
| CA (1) | CA2861346C (enExample) |
| MX (1) | MX367596B (enExample) |
| WO (1) | WO2013112947A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| RS62297B1 (sr) | 2011-11-23 | 2021-09-30 | Therapeuticsmd Inc | Prirodne kombinovane hormonske supstitucione formulacije i terapije |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| WO2015073177A1 (en) * | 2013-10-10 | 2015-05-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositons and methods |
| BR112016009008B8 (pt) * | 2013-10-22 | 2023-01-31 | Therapeuticsmd Inc | Uso de estradiol e/ou hemi-hidrato de estradiol e de um agente solubilizante compreendendo um óleo de cadeia média para a preparação de um pessário para o tratamento de atrofia vulvovaginal e pessário que compreende estradiol |
| JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． | 天然の併用ホルモン補充療法剤及び療法 |
| US10098894B2 (en) | 2014-07-29 | 2018-10-16 | Therapeuticsmd, Inc. | Transdermal cream |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| JPWO2022102709A1 (enExample) * | 2020-11-12 | 2022-05-19 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5145682A (en) * | 1986-05-30 | 1992-09-08 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit for postmenopausal syndrome treatment and process for administration |
| CN1021196C (zh) * | 1986-12-29 | 1993-06-16 | 新泽西州州立大学(鲁杰斯) | 透皮雌激素/孕激素药剂单元、系统及方法 |
| US4788062A (en) * | 1987-02-26 | 1988-11-29 | Alza Corporation | Transdermal administration of progesterone, estradiol esters, and mixtures thereof |
| US4973468A (en) * | 1989-03-22 | 1990-11-27 | Cygnus Research Corporation | Skin permeation enhancer compositions |
| JP2910857B2 (ja) * | 1989-04-04 | 1999-06-23 | ニチバン株式会社 | プロスタグランジンｅ１経皮吸収製剤 |
| US5543150A (en) * | 1993-09-15 | 1996-08-06 | Columbia Laboratories, Inc. | Method of progesterone delivery and affect thereof |
| DE19548332A1 (de) * | 1995-12-22 | 1997-07-10 | Rotta Res Bv | Hormonpflaster |
| IL127189A0 (en) * | 1996-05-22 | 1999-09-22 | Diversified Pharmaceuticals In | Compositions methods and devices for the transdermal delivery of drugs |
| DE19700913C2 (de) * | 1997-01-14 | 2001-01-04 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System zur Abgabe von Hormonen |
| US7374779B2 (en) * | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
| US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| KR100452972B1 (ko) * | 2000-05-16 | 2004-10-14 | 주식회사 삼양사 | 경피투여용 하이드로젤 조성물 |
| US20030171343A1 (en) * | 2000-05-31 | 2003-09-11 | Yoshiko Furukawa | Percutaneous absorption type steroid preparation for external use |
| US20070111975A1 (en) * | 2004-10-07 | 2007-05-17 | Duramed Pharmaceuticals, Inc. | Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens |
-
2013
- 2013-01-25 AU AU2013211876A patent/AU2013211876B2/en not_active Ceased
- 2013-01-25 BR BR112014018439A patent/BR112014018439A8/pt not_active Application Discontinuation
- 2013-01-25 JP JP2014554892A patent/JP6342334B2/ja not_active Expired - Fee Related
- 2013-01-25 WO PCT/US2013/023309 patent/WO2013112947A1/en not_active Ceased
- 2013-01-25 EP EP13741053.6A patent/EP2806742B1/en active Active
- 2013-01-25 MX MX2014009093A patent/MX367596B/es active IP Right Grant
- 2013-01-25 CA CA2861346A patent/CA2861346C/en active Active
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