JP2015519339A5 - - Google Patents
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- JP2015519339A5 JP2015519339A5 JP2015511804A JP2015511804A JP2015519339A5 JP 2015519339 A5 JP2015519339 A5 JP 2015519339A5 JP 2015511804 A JP2015511804 A JP 2015511804A JP 2015511804 A JP2015511804 A JP 2015511804A JP 2015519339 A5 JP2015519339 A5 JP 2015519339A5
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- protein
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- cancer
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| JP5149620B2 (ja) | 2004-07-23 | 2013-02-20 | エンドサイト，インコーポレイテッド | ２価リンカーおよびその結合体 |
| NZ580132A (en) | 2007-03-14 | 2012-11-30 | Endocyte Inc | Binding ligand linked drug delivery conjugates of tubulysins to vitamins |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| CN104383553A (zh) | 2007-06-25 | 2015-03-04 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| JP2015536323A (ja) | 2012-10-16 | 2015-12-21 | エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． | 非天然アミノ酸を含む薬物送達結合体および使用方法 |
| ES2759503T3 (es) | 2013-05-02 | 2020-05-11 | Glykos Finland Oy | Conjugados de una glicoproteína o un glicano con una carga útil tóxica |
| AU2014337555C1 (en) | 2013-10-15 | 2021-01-28 | Seagen Inc. | PEGylated drug-linkers for improved Ligand-Drug Conjugate pharmacokinetics |
| EA201692530A1 (ru) | 2014-06-13 | 2017-07-31 | Новартис Аг | Цитотоксические пептиды и их конъюгаты |
| CN107743494B (zh) | 2015-06-02 | 2022-04-29 | 诺和诺德股份有限公司 | 具有极性重组延伸体的胰岛素 |
| MX381031B (es) * | 2015-08-11 | 2025-03-12 | Coherent Biopharma | Ltd | Conjugados fármaco-multiligando y usos de los mismos. |
| GB2542391A (en) | 2015-09-17 | 2017-03-22 | Annexin Pharmaceuticals Ab | Process of manufacture |
| EP3355931B1 (en) | 2015-10-01 | 2024-06-26 | Novo Nordisk A/S | Protein conjugates |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| TWI852735B (zh) | 2015-12-04 | 2024-08-11 | 美商思進公司 | 四級胺化妥布賴森(tubulysin)化合物之結合物 |
| KR102626498B1 (ko) | 2016-03-25 | 2024-01-19 | 씨젠 인크. | 페길화된 약물-링커 및 그의 중간체의 제조를 위한 공정 |
| WO2018136455A1 (en) * | 2017-01-17 | 2018-07-26 | The Texas A&M University System | Endolysosomal targeting conjugates for improved delivery of cargo molecules to the endolysosomal compartment of target cells |
| US11730822B2 (en) | 2017-03-24 | 2023-08-22 | Seagen Inc. | Process for the preparation of glucuronide drug-linkers and intermediates thereof |
| MA49339A (fr) | 2017-04-05 | 2020-02-12 | Novo Nordisk As | Conjugués insuline-fc à extension oligomère |
| CN118027137A (zh) | 2018-12-21 | 2024-05-14 | 里珍纳龙药品有限公司 | 微管溶素及蛋白质-微管溶素偶联物 |
| WO2020247151A1 (en) * | 2019-06-05 | 2020-12-10 | Boston Scientific Scimed, Inc. | Click chemistry capturable platinum-based antineoplastic agents |
| EP4366780A1 (en) * | 2021-07-09 | 2024-05-15 | Bright Peak Therapeutics AG | Synthetic il-7 and il-7 immunocytokines |
| WO2023281482A1 (en) * | 2021-07-09 | 2023-01-12 | Bright Peak Therapeutics Ag | Cd20-targeted il-2 and its uses |
| CN116407640B (zh) * | 2023-03-03 | 2025-10-31 | 河南真实生物科技有限公司 | 包含阿兹夫定和化疗试剂的抗肿瘤药物组合物 |
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| EP1001968B1 (en) | 1997-06-13 | 2004-12-22 | Gryphon Therapeutics, Inc. | Solid phase native chemical ligation of unprotected or n-terminal cysteine protected peptides in aqueous solution |
| US6017876A (en) | 1997-08-15 | 2000-01-25 | Amgen Inc. | Chemical modification of granulocyte-colony stimulating factor (G-CSF) bioactivity |
| US5900404A (en) | 1997-08-15 | 1999-05-04 | Amgen Inc. | Chemical modification of proteins to improve biocompatibility and bioactivity |
| US6787154B2 (en) | 1998-10-20 | 2004-09-07 | Salvatore Albani | Artificial antigen presenting cells |
| WO2002042427A2 (en) | 2000-10-25 | 2002-05-30 | Surromed, Inc. | Mass tags for quantitative analysis |
| WO2002087497A2 (en) * | 2001-04-26 | 2002-11-07 | Board Of Regents, The University Of Texas System | Therapeutic agent/ligand conjugate compositions, their methods of synthesis and use |
| US20030215877A1 (en) | 2002-04-04 | 2003-11-20 | California Institute Of Technology | Directed protein docking algorithm |
| GB0209896D0 (en) * | 2002-04-30 | 2002-06-05 | Molmed Spa | Conjugate |
| EP1534269B1 (en) | 2002-07-19 | 2013-10-30 | The General Hospital Corporation | Oxime conjugates and methods for their formation and use |
| US20110002978A1 (en) * | 2003-06-17 | 2011-01-06 | Harrison Roger G | Enzyme prodrug cancer therapy selectively targeted to tumor cells or tumor vasculature and methods of production and use thereof |
| US20070123465A1 (en) | 2004-06-18 | 2007-05-31 | Ipf Pharmaceuticals Gmbh | Oligomeric peptides and their use for the treatment of hiv infections |
| WO2007112362A2 (en) | 2006-03-24 | 2007-10-04 | The Regents Of The University Of California | Construction of a multivalent scfv through alkyne-azide 1,3-dipolar cycloaddition |
| WO2009158668A1 (en) * | 2008-06-26 | 2009-12-30 | Prolynx Llc | Prodrugs and drug-macromolecule conjugates having controlled drug release rates |
| EP2350112A4 (en) * | 2008-10-03 | 2013-01-16 | Advanced Proteome Therapeutics Inc | Site specific N-termin protein modifications and conjugate formation |
| CA2764029C (en) | 2009-06-03 | 2019-10-29 | Mosamedix B.V. | Method for enhancing phagocytosis of phosphatidylserine-exposing cells |
| WO2011103409A1 (en) * | 2010-02-18 | 2011-08-25 | Advanced Proteome Therapeutics Inc. | Site-specific modification of proteins through chemical modification enabling protein conjugates, protein dimer formation, and stapled peptides |
| WO2011140392A1 (en) * | 2010-05-05 | 2011-11-10 | Prolynx Llc | Controlled drug release from solid supports |
| WO2011153250A2 (en) * | 2010-06-01 | 2011-12-08 | Advanced Proteome Therapeutics Inc. | Crosslinking of proteins and other entities via conjugates of alpha-haloacetophenones, benzyl halides, quinones, and their derivatives |
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- 2013-05-13 EP EP13787738.7A patent/EP2850201A4/en not_active Withdrawn
- 2013-05-13 CA CA2873112A patent/CA2873112A1/en not_active Abandoned
- 2013-05-13 WO PCT/US2013/040823 patent/WO2013170272A2/en not_active Ceased
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