BRPI0511005A - peptìdeos oligoméricos e seu uso para o tratamento de infecções por hiv - Google Patents
peptìdeos oligoméricos e seu uso para o tratamento de infecções por hivInfo
- Publication number
- BRPI0511005A BRPI0511005A BRPI0511005-0A BRPI0511005A BRPI0511005A BR PI0511005 A BRPI0511005 A BR PI0511005A BR PI0511005 A BRPI0511005 A BR PI0511005A BR PI0511005 A BRPI0511005 A BR PI0511005A
- Authority
- BR
- Brazil
- Prior art keywords
- amino acid
- phenylalanine
- cysteine
- alanine
- acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PEPTìDEOS OLIGOMéRICOS E SEU USO PARA O TRATAMENTO DE INFECçõES POR HIV. A invenção refere-se a peptídeos oligoméricos com atividade biológica contra infecção por HIV, tendo a seqüência de aminoácidos (Z~ 1~-LE-X~ 1~-I P-X~ 2~-X~ 3~-X~ 4~-P-X~ 5~-X~ 6~-X~ 7~-X~ 8~-X~ 9~-X~ 10~-K-X~ 11~-X~ 12~-X~ 13~-X~ 14~-X~ 15~-Z~ 2~)~ n~ onde n indica o número de cadeias peptídicas monoméricas, com o que n é 2, 3 ou 4; X~ 1~ é uma usina, alanina ou ácido aspártico; X~ 2~ é uma cisteina, metionina ou isoleucina; X~3~ é uma serina, cisteina, usina ou glicina; X~ 4~ é uma isoleucina, alanina, fenilalanina ou cisteina; X~ 5~ é uma prolina, D-prolina ou uma L-ou D-prolina substituida; X~ 6~ é uma cisteína ou ácido glutâmico; X~ 7~ é um aminoácido com cadeia lateral hidrofóbica ou aromática ou cisteína; X~ 8~ é um aminoácido com uma cadeia lateral hidrofóbica ou aromática ou cisteína; X~ 9~ é um aminoácido com uma cadeia lateral aromática; X~ 10~ é uma glicina, alanina ou asparagina; X~ 11~ é uma prolina, ácido aspártico, ácido octaidroindolil-2-carboxílico ou ácido D-,2,3,4-tetraisoquinolina-3-carboxílico; X~ 12~ é uma fenilalanina, alanina, glicina, ácido glutâmico ou ácido D-1,2,3,4-tetraisoquinolina-3-carboxílico; X~ 13~ é um aminoácido com uma cadeia lateral hidrofóbica ou aromática; X~ 14~ é um aminoácido com uma cadeia lateral hidrofóbica ou aromática; X~ 15~ é uma fenilalanina ou deleção; Z~ 1~ é NH~ 2~ ou uma seqüência de 1 a 10 resíduos de aminoácidos; Z~2~ é COOH ou uma seqüência de 1 a 10 resíduos de aminoácidos; e os peptídeos oligoméricos que são fragmentos dos mesmos e/ou derivados, especialmente os derivados amidados, alquilados, acuados, sulfatados, "peguilados", fosforilados e/ou glicosilados, e mutantes dos mesmos; e desde que (a) caso X~ 12~ seja alanina, glicina, ácido glutâmico, ou ácido 0-1,2,3,4-tetraisoquinolina-3-carboxílico, então X~ 13~, X~ 14~ e X~ 15~ são fenilalanina, valina ou fenilalanina, respectivamente; e/ou (b) caso X~ 12~ seja fenilalanina, então X~ 13~, X~ 14~ e X~ 15~ são valina, fenilalanina e uma deleção, respectivamente; e (c) há no máximo três resíduos de cisteína em um peptídeo; e (d) o peptídeo oligomérico não tem a seqüência (LEAIPCSIPPEFLFGKPFVF)~ 2~ (VIR-576); e (e) as cadeias peptídicas monoméricas não são ligadas por ligações peptídicas entre o terminal N de uma cadeia peptídica e o terminal C de outra cadeia peptídica.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58038404P | 2004-06-18 | 2004-06-18 | |
EP04014304 | 2004-06-18 | ||
US67586105P | 2005-04-29 | 2005-04-29 | |
PCT/EP2005/052833 WO2005123771A2 (en) | 2004-06-18 | 2005-06-17 | Oligomeric peptides and their use for the treatment of hiv infections |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0511005A true BRPI0511005A (pt) | 2007-11-20 |
Family
ID=34925397
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0511005-0A BRPI0511005A (pt) | 2004-06-18 | 2005-06-17 | peptìdeos oligoméricos e seu uso para o tratamento de infecções por hiv |
Country Status (13)
Country | Link |
---|---|
US (1) | US20070123465A1 (pt) |
EP (1) | EP1756160B1 (pt) |
JP (1) | JP4782782B2 (pt) |
CN (1) | CN100577686C (pt) |
AP (1) | AP2081A (pt) |
AU (1) | AU2005254736B2 (pt) |
BR (1) | BRPI0511005A (pt) |
CA (1) | CA2569807A1 (pt) |
EA (1) | EA011037B1 (pt) |
MX (1) | MXPA06014393A (pt) |
NO (1) | NO20070296L (pt) |
WO (1) | WO2005123771A2 (pt) |
ZA (1) | ZA200705769B (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007056083A2 (en) * | 2005-11-02 | 2007-05-18 | Ambrx, Inc. | Biosynthetic polypeptide fusion inhibitors |
US9212205B2 (en) * | 2007-07-26 | 2015-12-15 | University Of Rochester | Nucleic acid binding compounds and methods of use |
CN101993485B (zh) * | 2009-08-20 | 2013-04-17 | 重庆富进生物医药有限公司 | 促胰岛素分泌肽类似物同源二聚体及其用途 |
GR1007010B (el) * | 2009-10-08 | 2010-10-07 | Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), | Ινσουλινοειδη πεπτιδια |
EP2536287A4 (en) * | 2010-02-18 | 2015-10-07 | Advanced Proteome Therapeutics Inc | SPECIFIC SITE SIZE OF PROTEINS USING CHEMICAL MODIFICATION TO PROMOTE PROTEIN CONJUGATE FORMATION, PROTEIN DIMER FORMATION, AND AGRAFTED PEPTIDES |
WO2011110049A1 (zh) * | 2010-03-12 | 2011-09-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 抗hiv的融合多肽及其用途 |
WO2011127624A1 (zh) * | 2010-04-13 | 2011-10-20 | 中国人民解放军军事医学科学院毒物药物研究所 | 抗hiv肽 |
CN102180951B (zh) * | 2011-05-03 | 2012-09-26 | 中国医学科学院病原生物学研究所 | 胆固醇修饰的抗hiv多肽药物及其用途 |
JP6290187B2 (ja) | 2012-05-11 | 2018-03-07 | クランツ,アレクサンダー | 癌の処置のためのタンパク質の部位特異的標識及び標的送達 |
PL3007717T3 (pl) * | 2013-06-12 | 2018-12-31 | Pharis Biotec Gmbh | Peptydy o antagonistycznej aktywności w stosunku do naturalnego CXCR4 |
WO2018048806A1 (en) * | 2016-09-06 | 2018-03-15 | Mainline Biosciences | Cxcr4 antagonists and methods of use |
WO2018087146A1 (de) * | 2016-11-09 | 2018-05-17 | Pharis Biotec Gmbh | Protransduzin-c - ein enhancer des gentransfers |
WO2021060439A1 (ja) * | 2019-09-26 | 2021-04-01 | 日油株式会社 | ペプチドリンカーを有するヘテロ二官能性単分散ポリエチレングリコール |
WO2022202785A1 (ja) * | 2021-03-22 | 2022-09-29 | 美智子 甲賀 | ポリペプチド並びにそれを含む細胞融合剤及びがん治療用医薬組成物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1959013B1 (de) * | 1999-11-08 | 2014-04-23 | IPF Pharmaceuticals GmbH | Humanes zirkulierendes Virus inhibierendes Peptid (VIRIP) und seine Verwendung |
EP1572743B1 (en) * | 2002-12-19 | 2011-08-10 | IPF Pharmaceuticals GmbH | Peptides and their use for the treatment of hiv infections |
-
2005
- 2005-06-17 CA CA002569807A patent/CA2569807A1/en not_active Abandoned
- 2005-06-17 EA EA200700062A patent/EA011037B1/ru not_active IP Right Cessation
- 2005-06-17 WO PCT/EP2005/052833 patent/WO2005123771A2/en active Application Filing
- 2005-06-17 CN CN200580019909A patent/CN100577686C/zh not_active Expired - Fee Related
- 2005-06-17 US US11/629,883 patent/US20070123465A1/en not_active Abandoned
- 2005-06-17 BR BRPI0511005-0A patent/BRPI0511005A/pt not_active IP Right Cessation
- 2005-06-17 AU AU2005254736A patent/AU2005254736B2/en not_active Ceased
- 2005-06-17 EP EP05752836.6A patent/EP1756160B1/en not_active Not-in-force
- 2005-06-17 JP JP2007515966A patent/JP4782782B2/ja not_active Expired - Fee Related
- 2005-06-17 ZA ZA200705769A patent/ZA200705769B/xx unknown
- 2005-06-17 MX MXPA06014393A patent/MXPA06014393A/es active IP Right Grant
- 2005-06-17 AP AP2007003877A patent/AP2081A/en active
-
2007
- 2007-01-16 NO NO20070296A patent/NO20070296L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MXPA06014393A (es) | 2007-07-04 |
CA2569807A1 (en) | 2005-12-29 |
AU2005254736A1 (en) | 2005-12-29 |
JP2008505854A (ja) | 2008-02-28 |
AP2007003877A0 (en) | 2007-02-28 |
AU2005254736B2 (en) | 2011-08-18 |
WO2005123771A2 (en) | 2005-12-29 |
EA011037B1 (ru) | 2008-12-30 |
JP4782782B2 (ja) | 2011-09-28 |
CN1968964A (zh) | 2007-05-23 |
US20070123465A1 (en) | 2007-05-31 |
EP1756160B1 (en) | 2013-08-14 |
CN100577686C (zh) | 2010-01-06 |
WO2005123771A3 (en) | 2006-02-09 |
ZA200705769B (en) | 2008-09-25 |
EP1756160A2 (en) | 2007-02-28 |
AP2081A (en) | 2010-01-04 |
NO20070296L (no) | 2007-02-27 |
EA200700062A1 (ru) | 2007-04-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0511005A (pt) | peptìdeos oligoméricos e seu uso para o tratamento de infecções por hiv | |
ATE368053T1 (de) | Antimikrobielle peptide | |
ATE308558T1 (de) | Hiv-1- und hiv-2-peptide zur hemmung von mit membranfusionen in zusammenhang stehenden phänomenen, einschliesslich der übertragung von hiv | |
GB0126194D0 (en) | Pharmaco-dietary preparation having a nutrition-supplementing and nutrition-enhancing effect | |
ATE322503T1 (de) | Gefrierschutzprotein | |
ATE211391T1 (de) | Verwendung von hmg proteinen zur herstellung von arzneimitteln mit zytotoxischer wirkung | |
FR2766191B1 (fr) | Peptides anti-microbiens de crustaces | |
FR2803594B1 (fr) | Oligomeres de mimes contraints non peptidiques de dipeptides ou de tripeptides, et leurs utilisations | |
CY1109946T1 (el) | Τροποποιημενα πεπτιδια και η χρηση τους για τη θεραπεια αυτοανοσων νοσων | |
DE602004028266D1 (de) | Angiogene peptide und ihre verwendungen | |
ATE543513T1 (de) | Anti-coronavirus impfstoff | |
ATE355302T1 (de) | N-substituierte d-aminosäuren enthaltende peptide,zur prävention der beta-strang assoziation | |
ATE362769T1 (de) | Lineare kationische peptide mit fungizider wirksamkeit | |
ATE411812T1 (de) | Peptide zur behandlung von infektionen mit dem herpes-virus | |
ATE519782T1 (de) | Peptide und ihre verwendung zur behandlung von hiv infektionen | |
WO2003097677A3 (fr) | Nouvelles compostions peptidiques et leur utilisation notamment dans la preparation de compositions pharmaceutiques actives contre le virus de l'hepatite c | |
NZ570708A (en) | Peptides of regulatory or accessory proteins of HIV, compositions and the utilization thereof | |
SE9700301D0 (sv) | New compound | |
PT975742E (pt) | Aminopeptidase derivada de bacillus licheniformis e processo para a preparacao de proteinas do tipo natural | |
GB2441941A (en) | An isolated recombinant vaccinia virus complement control protein (HRVCP) polypeptide | |
WO2004013167A3 (en) | Purified polypeptides from enterococcus faecalis | |
WO1998056810A3 (de) | Humanes protein lus-i, seine herstellung und verwendung | |
CY1115911T1 (el) | Τροποποιημενα πολυπεπτιδια περιοχης kunitz και η χρηση τους στην μειωση της ισχαιμιας ή της εκκινησης μιας συστημικης φλεγμονωδους ανταποκρισης που σχετιζεται με μια χειρουργικη επεμβαση | |
WO2004058812A3 (en) | Ribose-phosphate pyrophosphokinase polypeptides and structures | |
WO2004058811A3 (en) | Crystal structures of yhhf polypeptides |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 12A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |