BRPI0511005A - peptìdeos oligoméricos e seu uso para o tratamento de infecções por hiv - Google Patents

peptìdeos oligoméricos e seu uso para o tratamento de infecções por hiv

Info

Publication number
BRPI0511005A
BRPI0511005A BRPI0511005-0A BRPI0511005A BRPI0511005A BR PI0511005 A BRPI0511005 A BR PI0511005A BR PI0511005 A BRPI0511005 A BR PI0511005A BR PI0511005 A BRPI0511005 A BR PI0511005A
Authority
BR
Brazil
Prior art keywords
amino acid
phenylalanine
cysteine
alanine
acid
Prior art date
Application number
BRPI0511005-0A
Other languages
English (en)
Inventor
Knut Adermann
Frank Kirchhoff
Jan Muench
Axel Schulz
Wolf-Georg Forssmann
Original Assignee
Ipf Pharmaceuticals Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipf Pharmaceuticals Gmbh filed Critical Ipf Pharmaceuticals Gmbh
Publication of BRPI0511005A publication Critical patent/BRPI0511005A/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121Serpins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PEPTìDEOS OLIGOMéRICOS E SEU USO PARA O TRATAMENTO DE INFECçõES POR HIV. A invenção refere-se a peptídeos oligoméricos com atividade biológica contra infecção por HIV, tendo a seqüência de aminoácidos (Z~ 1~-LE-X~ 1~-I P-X~ 2~-X~ 3~-X~ 4~-P-X~ 5~-X~ 6~-X~ 7~-X~ 8~-X~ 9~-X~ 10~-K-X~ 11~-X~ 12~-X~ 13~-X~ 14~-X~ 15~-Z~ 2~)~ n~ onde n indica o número de cadeias peptídicas monoméricas, com o que n é 2, 3 ou 4; X~ 1~ é uma usina, alanina ou ácido aspártico; X~ 2~ é uma cisteina, metionina ou isoleucina; X~3~ é uma serina, cisteina, usina ou glicina; X~ 4~ é uma isoleucina, alanina, fenilalanina ou cisteina; X~ 5~ é uma prolina, D-prolina ou uma L-ou D-prolina substituida; X~ 6~ é uma cisteína ou ácido glutâmico; X~ 7~ é um aminoácido com cadeia lateral hidrofóbica ou aromática ou cisteína; X~ 8~ é um aminoácido com uma cadeia lateral hidrofóbica ou aromática ou cisteína; X~ 9~ é um aminoácido com uma cadeia lateral aromática; X~ 10~ é uma glicina, alanina ou asparagina; X~ 11~ é uma prolina, ácido aspártico, ácido octaidroindolil-2-carboxílico ou ácido D-,2,3,4-tetraisoquinolina-3-carboxílico; X~ 12~ é uma fenilalanina, alanina, glicina, ácido glutâmico ou ácido D-1,2,3,4-tetraisoquinolina-3-carboxílico; X~ 13~ é um aminoácido com uma cadeia lateral hidrofóbica ou aromática; X~ 14~ é um aminoácido com uma cadeia lateral hidrofóbica ou aromática; X~ 15~ é uma fenilalanina ou deleção; Z~ 1~ é NH~ 2~ ou uma seqüência de 1 a 10 resíduos de aminoácidos; Z~2~ é COOH ou uma seqüência de 1 a 10 resíduos de aminoácidos; e os peptídeos oligoméricos que são fragmentos dos mesmos e/ou derivados, especialmente os derivados amidados, alquilados, acuados, sulfatados, "peguilados", fosforilados e/ou glicosilados, e mutantes dos mesmos; e desde que (a) caso X~ 12~ seja alanina, glicina, ácido glutâmico, ou ácido 0-1,2,3,4-tetraisoquinolina-3-carboxílico, então X~ 13~, X~ 14~ e X~ 15~ são fenilalanina, valina ou fenilalanina, respectivamente; e/ou (b) caso X~ 12~ seja fenilalanina, então X~ 13~, X~ 14~ e X~ 15~ são valina, fenilalanina e uma deleção, respectivamente; e (c) há no máximo três resíduos de cisteína em um peptídeo; e (d) o peptídeo oligomérico não tem a seqüência (LEAIPCSIPPEFLFGKPFVF)~ 2~ (VIR-576); e (e) as cadeias peptídicas monoméricas não são ligadas por ligações peptídicas entre o terminal N de uma cadeia peptídica e o terminal C de outra cadeia peptídica.
BRPI0511005-0A 2004-06-18 2005-06-17 peptìdeos oligoméricos e seu uso para o tratamento de infecções por hiv BRPI0511005A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58038404P 2004-06-18 2004-06-18
EP04014304 2004-06-18
US67586105P 2005-04-29 2005-04-29
PCT/EP2005/052833 WO2005123771A2 (en) 2004-06-18 2005-06-17 Oligomeric peptides and their use for the treatment of hiv infections

Publications (1)

Publication Number Publication Date
BRPI0511005A true BRPI0511005A (pt) 2007-11-20

Family

ID=34925397

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511005-0A BRPI0511005A (pt) 2004-06-18 2005-06-17 peptìdeos oligoméricos e seu uso para o tratamento de infecções por hiv

Country Status (13)

Country Link
US (1) US20070123465A1 (pt)
EP (1) EP1756160B1 (pt)
JP (1) JP4782782B2 (pt)
CN (1) CN100577686C (pt)
AP (1) AP2081A (pt)
AU (1) AU2005254736B2 (pt)
BR (1) BRPI0511005A (pt)
CA (1) CA2569807A1 (pt)
EA (1) EA011037B1 (pt)
MX (1) MXPA06014393A (pt)
NO (1) NO20070296L (pt)
WO (1) WO2005123771A2 (pt)
ZA (1) ZA200705769B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007056083A2 (en) * 2005-11-02 2007-05-18 Ambrx, Inc. Biosynthetic polypeptide fusion inhibitors
US9212205B2 (en) * 2007-07-26 2015-12-15 University Of Rochester Nucleic acid binding compounds and methods of use
CN101993485B (zh) * 2009-08-20 2013-04-17 重庆富进生物医药有限公司 促胰岛素分泌肽类似物同源二聚体及其用途
GR1007010B (el) * 2009-10-08 2010-10-07 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), Ινσουλινοειδη πεπτιδια
EP2536287A4 (en) * 2010-02-18 2015-10-07 Advanced Proteome Therapeutics Inc SPECIFIC SITE SIZE OF PROTEINS USING CHEMICAL MODIFICATION TO PROMOTE PROTEIN CONJUGATE FORMATION, PROTEIN DIMER FORMATION, AND AGRAFTED PEPTIDES
WO2011110049A1 (zh) * 2010-03-12 2011-09-15 中国人民解放军军事医学科学院毒物药物研究所 抗hiv的融合多肽及其用途
WO2011127624A1 (zh) * 2010-04-13 2011-10-20 中国人民解放军军事医学科学院毒物药物研究所 抗hiv肽
CN102180951B (zh) * 2011-05-03 2012-09-26 中国医学科学院病原生物学研究所 胆固醇修饰的抗hiv多肽药物及其用途
JP6290187B2 (ja) 2012-05-11 2018-03-07 クランツ,アレクサンダー 癌の処置のためのタンパク質の部位特異的標識及び標的送達
PL3007717T3 (pl) * 2013-06-12 2018-12-31 Pharis Biotec Gmbh Peptydy o antagonistycznej aktywności w stosunku do naturalnego CXCR4
WO2018048806A1 (en) * 2016-09-06 2018-03-15 Mainline Biosciences Cxcr4 antagonists and methods of use
WO2018087146A1 (de) * 2016-11-09 2018-05-17 Pharis Biotec Gmbh Protransduzin-c - ein enhancer des gentransfers
WO2021060439A1 (ja) * 2019-09-26 2021-04-01 日油株式会社 ペプチドリンカーを有するヘテロ二官能性単分散ポリエチレングリコール
WO2022202785A1 (ja) * 2021-03-22 2022-09-29 美智子 甲賀 ポリペプチド並びにそれを含む細胞融合剤及びがん治療用医薬組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1959013B1 (de) * 1999-11-08 2014-04-23 IPF Pharmaceuticals GmbH Humanes zirkulierendes Virus inhibierendes Peptid (VIRIP) und seine Verwendung
EP1572743B1 (en) * 2002-12-19 2011-08-10 IPF Pharmaceuticals GmbH Peptides and their use for the treatment of hiv infections

Also Published As

Publication number Publication date
MXPA06014393A (es) 2007-07-04
CA2569807A1 (en) 2005-12-29
AU2005254736A1 (en) 2005-12-29
JP2008505854A (ja) 2008-02-28
AP2007003877A0 (en) 2007-02-28
AU2005254736B2 (en) 2011-08-18
WO2005123771A2 (en) 2005-12-29
EA011037B1 (ru) 2008-12-30
JP4782782B2 (ja) 2011-09-28
CN1968964A (zh) 2007-05-23
US20070123465A1 (en) 2007-05-31
EP1756160B1 (en) 2013-08-14
CN100577686C (zh) 2010-01-06
WO2005123771A3 (en) 2006-02-09
ZA200705769B (en) 2008-09-25
EP1756160A2 (en) 2007-02-28
AP2081A (en) 2010-01-04
NO20070296L (no) 2007-02-27
EA200700062A1 (ru) 2007-04-27

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 12A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]