BRPI0511005A - peptìdeos oligoméricos e seu uso para o tratamento de infecções por hiv - Google Patents
peptìdeos oligoméricos e seu uso para o tratamento de infecções por hivInfo
- Publication number
- BRPI0511005A BRPI0511005A BRPI0511005-0A BRPI0511005A BRPI0511005A BR PI0511005 A BRPI0511005 A BR PI0511005A BR PI0511005 A BRPI0511005 A BR PI0511005A BR PI0511005 A BRPI0511005 A BR PI0511005A
- Authority
- BR
- Brazil
- Prior art keywords
- amino acid
- phenylalanine
- cysteine
- alanine
- acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PEPTìDEOS OLIGOMéRICOS E SEU USO PARA O TRATAMENTO DE INFECçõES POR HIV. A invenção refere-se a peptídeos oligoméricos com atividade biológica contra infecção por HIV, tendo a seqüência de aminoácidos (Z~ 1~-LE-X~ 1~-I P-X~ 2~-X~ 3~-X~ 4~-P-X~ 5~-X~ 6~-X~ 7~-X~ 8~-X~ 9~-X~ 10~-K-X~ 11~-X~ 12~-X~ 13~-X~ 14~-X~ 15~-Z~ 2~)~ n~ onde n indica o número de cadeias peptídicas monoméricas, com o que n é 2, 3 ou 4; X~ 1~ é uma usina, alanina ou ácido aspártico; X~ 2~ é uma cisteina, metionina ou isoleucina; X~3~ é uma serina, cisteina, usina ou glicina; X~ 4~ é uma isoleucina, alanina, fenilalanina ou cisteina; X~ 5~ é uma prolina, D-prolina ou uma L-ou D-prolina substituida; X~ 6~ é uma cisteína ou ácido glutâmico; X~ 7~ é um aminoácido com cadeia lateral hidrofóbica ou aromática ou cisteína; X~ 8~ é um aminoácido com uma cadeia lateral hidrofóbica ou aromática ou cisteína; X~ 9~ é um aminoácido com uma cadeia lateral aromática; X~ 10~ é uma glicina, alanina ou asparagina; X~ 11~ é uma prolina, ácido aspártico, ácido octaidroindolil-2-carboxílico ou ácido D-,2,3,4-tetraisoquinolina-3-carboxílico; X~ 12~ é uma fenilalanina, alanina, glicina, ácido glutâmico ou ácido D-1,2,3,4-tetraisoquinolina-3-carboxílico; X~ 13~ é um aminoácido com uma cadeia lateral hidrofóbica ou aromática; X~ 14~ é um aminoácido com uma cadeia lateral hidrofóbica ou aromática; X~ 15~ é uma fenilalanina ou deleção; Z~ 1~ é NH~ 2~ ou uma seqüência de 1 a 10 resíduos de aminoácidos; Z~2~ é COOH ou uma seqüência de 1 a 10 resíduos de aminoácidos; e os peptídeos oligoméricos que são fragmentos dos mesmos e/ou derivados, especialmente os derivados amidados, alquilados, acuados, sulfatados, "peguilados", fosforilados e/ou glicosilados, e mutantes dos mesmos; e desde que (a) caso X~ 12~ seja alanina, glicina, ácido glutâmico, ou ácido 0-1,2,3,4-tetraisoquinolina-3-carboxílico, então X~ 13~, X~ 14~ e X~ 15~ são fenilalanina, valina ou fenilalanina, respectivamente; e/ou (b) caso X~ 12~ seja fenilalanina, então X~ 13~, X~ 14~ e X~ 15~ são valina, fenilalanina e uma deleção, respectivamente; e (c) há no máximo três resíduos de cisteína em um peptídeo; e (d) o peptídeo oligomérico não tem a seqüência (LEAIPCSIPPEFLFGKPFVF)~ 2~ (VIR-576); e (e) as cadeias peptídicas monoméricas não são ligadas por ligações peptídicas entre o terminal N de uma cadeia peptídica e o terminal C de outra cadeia peptídica.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58038404P | 2004-06-18 | 2004-06-18 | |
| EP04014304 | 2004-06-18 | ||
| US67586105P | 2005-04-29 | 2005-04-29 | |
| PCT/EP2005/052833 WO2005123771A2 (en) | 2004-06-18 | 2005-06-17 | Oligomeric peptides and their use for the treatment of hiv infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0511005A true BRPI0511005A (pt) | 2007-11-20 |
Family
ID=34925397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0511005-0A BRPI0511005A (pt) | 2004-06-18 | 2005-06-17 | peptìdeos oligoméricos e seu uso para o tratamento de infecções por hiv |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20070123465A1 (pt) |
| EP (1) | EP1756160B1 (pt) |
| JP (1) | JP4782782B2 (pt) |
| CN (1) | CN100577686C (pt) |
| AP (1) | AP2081A (pt) |
| AU (1) | AU2005254736B2 (pt) |
| BR (1) | BRPI0511005A (pt) |
| CA (1) | CA2569807A1 (pt) |
| EA (1) | EA011037B1 (pt) |
| MX (1) | MXPA06014393A (pt) |
| NO (1) | NO20070296L (pt) |
| WO (1) | WO2005123771A2 (pt) |
| ZA (1) | ZA200705769B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090088365A1 (en) * | 2005-11-02 | 2009-04-02 | Roberto Mariani | Biosynthetic Polypeptide Fusion Inhibitors |
| WO2009015384A1 (en) * | 2007-07-26 | 2009-01-29 | University Of Rochester | Nucleic acid binding compounds and methods of use |
| CN101993485B (zh) * | 2009-08-20 | 2013-04-17 | 重庆富进生物医药有限公司 | 促胰岛素分泌肽类似物同源二聚体及其用途 |
| GR1007010B (el) * | 2009-10-08 | 2010-10-07 | Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), | Ινσουλινοειδη πεπτιδια |
| CA2790343A1 (en) * | 2010-02-18 | 2011-08-25 | Advanced Proteome Therapeutics Inc. | Site-specific modification of proteins through chemical modification enabling protein conjugates, protein dimer formation, and stapled peptides |
| WO2011110049A1 (zh) * | 2010-03-12 | 2011-09-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 抗hiv的融合多肽及其用途 |
| WO2011127624A1 (zh) * | 2010-04-13 | 2011-10-20 | 中国人民解放军军事医学科学院毒物药物研究所 | 抗hiv肽 |
| CN102180951B (zh) * | 2011-05-03 | 2012-09-26 | 中国医学科学院病原生物学研究所 | 胆固醇修饰的抗hiv多肽药物及其用途 |
| JP6290187B2 (ja) | 2012-05-11 | 2018-03-07 | クランツ，アレクサンダー | 癌の処置のためのタンパク質の部位特異的標識及び標的送達 |
| DK3007717T3 (da) * | 2013-06-12 | 2019-01-02 | Pharis Biotec Gmbh | Peptider med antagonistiske aktiviteter mod naturlig cxcr4 |
| EP3509612A4 (en) * | 2016-09-06 | 2021-07-21 | Mainline Biosciences | CXCR4 ANTAGONISTS AND METHOD OF USE |
| JP2019535703A (ja) * | 2016-11-09 | 2019-12-12 | ファリス バイオテック ゲーエムベーハー | プロトランスデューシン−ｃ：遺伝子導入活性化因子 |
| WO2021060439A1 (ja) * | 2019-09-26 | 2021-04-01 | 日油株式会社 | ペプチドリンカーを有するヘテロ二官能性単分散ポリエチレングリコール |
| WO2022202785A1 (ja) * | 2021-03-22 | 2022-09-29 | 美智子 甲賀 | ポリペプチド並びにそれを含む細胞融合剤及びがん治療用医薬組成物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1959013B1 (de) * | 1999-11-08 | 2014-04-23 | IPF Pharmaceuticals GmbH | Humanes zirkulierendes Virus inhibierendes Peptid (VIRIP) und seine Verwendung |
| EP1572743B1 (en) * | 2002-12-19 | 2011-08-10 | IPF Pharmaceuticals GmbH | Peptides and their use for the treatment of hiv infections |
-
2005
- 2005-06-17 EP EP05752836.6A patent/EP1756160B1/en not_active Not-in-force
- 2005-06-17 WO PCT/EP2005/052833 patent/WO2005123771A2/en active Application Filing
- 2005-06-17 EA EA200700062A patent/EA011037B1/ru not_active IP Right Cessation
- 2005-06-17 JP JP2007515966A patent/JP4782782B2/ja not_active Expired - Fee Related
- 2005-06-17 CN CN200580019909A patent/CN100577686C/zh not_active Expired - Fee Related
- 2005-06-17 BR BRPI0511005-0A patent/BRPI0511005A/pt not_active IP Right Cessation
- 2005-06-17 AU AU2005254736A patent/AU2005254736B2/en not_active Ceased
- 2005-06-17 AP AP2007003877A patent/AP2081A/en active
- 2005-06-17 ZA ZA200705769A patent/ZA200705769B/xx unknown
- 2005-06-17 US US11/629,883 patent/US20070123465A1/en not_active Abandoned
- 2005-06-17 MX MXPA06014393A patent/MXPA06014393A/es active IP Right Grant
- 2005-06-17 CA CA002569807A patent/CA2569807A1/en not_active Abandoned
-
2007
- 2007-01-16 NO NO20070296A patent/NO20070296L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005254736B2 (en) | 2011-08-18 |
| AP2007003877A0 (en) | 2007-02-28 |
| CN100577686C (zh) | 2010-01-06 |
| NO20070296L (no) | 2007-02-27 |
| WO2005123771A3 (en) | 2006-02-09 |
| US20070123465A1 (en) | 2007-05-31 |
| EP1756160B1 (en) | 2013-08-14 |
| JP4782782B2 (ja) | 2011-09-28 |
| AU2005254736A1 (en) | 2005-12-29 |
| JP2008505854A (ja) | 2008-02-28 |
| EA011037B1 (ru) | 2008-12-30 |
| WO2005123771A2 (en) | 2005-12-29 |
| CA2569807A1 (en) | 2005-12-29 |
| EP1756160A2 (en) | 2007-02-28 |
| EA200700062A1 (ru) | 2007-04-27 |
| ZA200705769B (en) | 2008-09-25 |
| AP2081A (en) | 2010-01-04 |
| MXPA06014393A (es) | 2007-07-04 |
| CN1968964A (zh) | 2007-05-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 12A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |