JP2015518716A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015518716A5 JP2015518716A5 JP2015513076A JP2015513076A JP2015518716A5 JP 2015518716 A5 JP2015518716 A5 JP 2015518716A5 JP 2015513076 A JP2015513076 A JP 2015513076A JP 2015513076 A JP2015513076 A JP 2015513076A JP 2015518716 A5 JP2015518716 A5 JP 2015518716A5
- Authority
- JP
- Japan
- Prior art keywords
- lentiviral vector
- promoter
- seq
- sequence
- hla
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013598 vector Substances 0.000 claims 22
- 239000002245 particle Substances 0.000 claims 7
- 108700019146 Transgenes Proteins 0.000 claims 4
- 102000043129 MHC class I family Human genes 0.000 claims 3
- 108091054437 MHC class I family Proteins 0.000 claims 3
- 239000003623 enhancer Substances 0.000 claims 3
- 230000002163 immunogen Effects 0.000 claims 3
- 238000004806 packaging method and process Methods 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 2
- 102100028970 HLA class I histocompatibility antigen, alpha chain E Human genes 0.000 claims 1
- 102100028966 HLA class I histocompatibility antigen, alpha chain F Human genes 0.000 claims 1
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims 1
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims 1
- 108010091938 HLA-B7 Antigen Proteins 0.000 claims 1
- 108010016121 HLA-C*05 antigen Proteins 0.000 claims 1
- 101000986085 Homo sapiens HLA class I histocompatibility antigen, alpha chain E Proteins 0.000 claims 1
- 101000986080 Homo sapiens HLA class I histocompatibility antigen, alpha chain F Proteins 0.000 claims 1
- 241000725303 Human immunodeficiency virus Species 0.000 claims 1
- 241000713666 Lentivirus Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 101710192141 Protein Nef Proteins 0.000 claims 1
- 108020005202 Viral DNA Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000013600 plasmid vector Substances 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305566.7A EP2666477A1 (en) | 2012-05-23 | 2012-05-23 | Lentiviral vectors containing an MHC class I promoter |
| EP12305566.7 | 2012-05-23 | ||
| PCT/EP2013/059041 WO2013174630A1 (en) | 2012-05-23 | 2013-04-30 | Lentiviral vectors containing an mhc class i promoter |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015518716A JP2015518716A (ja) | 2015-07-06 |
| JP2015518716A5 true JP2015518716A5 (enExample) | 2015-12-10 |
| JP5938143B2 JP5938143B2 (ja) | 2016-06-22 |
Family
ID=48289150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015513076A Active JP5938143B2 (ja) | 2012-05-23 | 2013-04-30 | Ｍｈｃクラスｉプロモーターを含有するレンチウイルスベクター |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8951535B2 (enExample) |
| EP (2) | EP2666477A1 (enExample) |
| JP (1) | JP5938143B2 (enExample) |
| KR (1) | KR101774929B1 (enExample) |
| CN (1) | CN104736167B (enExample) |
| AU (1) | AU2013265586B2 (enExample) |
| BR (1) | BR112014028944B1 (enExample) |
| CA (1) | CA2873473C (enExample) |
| ES (1) | ES2498277T3 (enExample) |
| IL (1) | IL235705A (enExample) |
| IN (1) | IN2014DN10123A (enExample) |
| NZ (1) | NZ702345A (enExample) |
| PL (1) | PL2678032T3 (enExample) |
| PT (1) | PT2678032E (enExample) |
| SG (1) | SG11201407732SA (enExample) |
| WO (1) | WO2013174630A1 (enExample) |
| ZA (1) | ZA201408652B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016520316A (ja) * | 2013-06-03 | 2016-07-14 | テラベクティ | ＭＨＣクラスＩ、ＭＨＣクラスＩＩまたはβ２ミクログロブリン上流プロモーター配列を含有するレンチウイルスベクター |
| EP3276006A1 (en) * | 2016-07-27 | 2018-01-31 | Theravectys | Lentiviral vectors for expression of hepatitis b virus (hbv) antigens |
| KR20220005208A (ko) | 2020-07-06 | 2022-01-13 | 주식회사 지씨셀 | 면역원성이 감소된 신규한 이식용 세포 |
| CN114107393A (zh) | 2021-04-07 | 2022-03-01 | 上海劲威生物科技有限公司 | 一种治疗乙型肝炎的慢病毒载体、慢病毒颗粒及其制备方法和应用 |
| KR20240073177A (ko) * | 2022-11-10 | 2024-05-24 | 전남대학교산학협력단 | 다중에피토프 펩타이드를 포함하는 신경교종 예방 또는 치료용 약제학적 조성물 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19720152A1 (de) * | 1997-05-02 | 1998-11-05 | Max Delbrueck Centrum | Retrovirales Vektorsystem zur Optimierung des Gentransfers und der Genexpression in primären humanen T-Lymphozyten |
| FR2777909B1 (fr) | 1998-04-24 | 2002-08-02 | Pasteur Institut | Utilisation de sequences d'adn de structure triplex pour le tranfert de sequences de nucleotides dans des cellules, vecteurs recombinants contenant ces sequences triplex |
| EP1092779B1 (en) * | 1999-10-11 | 2009-11-25 | Institut Pasteur | Lentiviral vectors for the preparation of immunotherapeutical compositions |
| HK1050210B (en) | 1999-10-12 | 2007-08-24 | Institut Pasteur | Lentiviral triplex dna, and vectors and recombinant cells containing lentiviral triplex dna |
| FR2870126B1 (fr) | 2004-05-17 | 2009-07-17 | Pasteur Institut | Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin |
| US8222029B2 (en) | 2005-05-16 | 2012-07-17 | Institut Pasteur | Lentiviral vector-based vaccine |
| WO2009019612A2 (en) | 2007-08-03 | 2009-02-12 | Institut Pasteur | Lentiviral gene transfer vectors and their medicinal applications |
-
2012
- 2012-05-23 EP EP12305566.7A patent/EP2666477A1/en not_active Ceased
-
2013
- 2013-04-30 CA CA2873473A patent/CA2873473C/en active Active
- 2013-04-30 KR KR1020147033419A patent/KR101774929B1/ko active Active
- 2013-04-30 CN CN201380026705.4A patent/CN104736167B/zh active Active
- 2013-04-30 IN IN10123DEN2014 patent/IN2014DN10123A/en unknown
- 2013-04-30 PL PL13720364T patent/PL2678032T3/pl unknown
- 2013-04-30 US US13/873,922 patent/US8951535B2/en active Active
- 2013-04-30 SG SG11201407732SA patent/SG11201407732SA/en unknown
- 2013-04-30 JP JP2015513076A patent/JP5938143B2/ja active Active
- 2013-04-30 PT PT137203642T patent/PT2678032E/pt unknown
- 2013-04-30 BR BR112014028944-1A patent/BR112014028944B1/pt active IP Right Grant
- 2013-04-30 AU AU2013265586A patent/AU2013265586B2/en active Active
- 2013-04-30 ES ES13720364.2T patent/ES2498277T3/es active Active
- 2013-04-30 NZ NZ702345A patent/NZ702345A/en unknown
- 2013-04-30 EP EP13720364.2A patent/EP2678032B1/en active Active
- 2013-04-30 WO PCT/EP2013/059041 patent/WO2013174630A1/en not_active Ceased
-
2014
- 2014-11-13 IL IL235705A patent/IL235705A/en active IP Right Grant
- 2014-11-25 ZA ZA2014/08652A patent/ZA201408652B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Morris et al. | Simian adenoviruses as vaccine vectors | |
| Lasaro et al. | New insights on adenovirus as vaccine vectors | |
| Tatsis et al. | Adenoviruses as vaccine vectors | |
| Afkhami et al. | Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogens | |
| Fausther-Bovendo et al. | Pre-existing immunity against Ad vectors: humoral, cellular, and innate response, what's important? | |
| Capone et al. | Development of chimpanzee adenoviruses as vaccine vectors: challenges and successes emerging from clinical trials | |
| DK2770061T3 (en) | NON-INTEGRATING LENTIVIRUS VECTORS | |
| Otten et al. | Enhanced potency of plasmid DNA microparticle human immunodeficiency virus vaccines in rhesus macaques by using a priming-boosting regimen with recombinant proteins | |
| Lundstrom | Alphavirus-based vaccines | |
| Tubulekas et al. | Alphavirus expression vectors and their use as recombinant vaccines: a minireview | |
| RU2015135890A (ru) | Композиция вакцины | |
| JP2014503206A5 (enExample) | ||
| JP2015518716A5 (enExample) | ||
| JP2015096070A5 (enExample) | ||
| JP2009544318A5 (enExample) | ||
| Sun et al. | Mucosal priming with a replicating-vaccinia virus-based vaccine elicits protective immunity to simian immunodeficiency virus challenge in rhesus monkeys | |
| Schell et al. | Significant protection against high-dose simian immunodeficiency virus challenge conferred by a new prime-boost vaccine regimen | |
| Chapman et al. | Heterologous prime-boost vaccination with DNA and MVA vaccines, expressing HIV-1 subtype C mosaic Gag virus-like particles, is highly immunogenic in mice | |
| JP2019508044A5 (enExample) | ||
| Schöne et al. | Immunodominance of adenovirus-derived CD8+ T cell epitopes interferes with the induction of transgene-specific immunity in adenovirus-based immunization | |
| Kawada et al. | Long-term control of simian immunodeficiency virus replication with central memory CD4+ T-cell preservation after nonsterile protection by a cytotoxic T-lymphocyte-based vaccine | |
| Bonaldo et al. | Recombinant yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 gag induces SIV-specific CD8+ T-cell responses in rhesus macaques | |
| Schoenly et al. | Human immunodeficiency virus type 1 vaccine development: recent advances in the cytotoxic T-lymphocyte platform “spotty business” | |
| Bruce et al. | Replication-deficient recombinant adenoviruses expressing the human immunodeficiency virus Env antigen can induce both humoral and CTL immune responses in mice | |
| Wen et al. | The novel replication-defective vaccinia virus (Tiantan strain)–based hepatitis C virus vaccine induces robust immunity in macaques |