CN104736167B - 含有mhc i型启动子的慢病毒载体 - Google Patents

含有mhc i型启动子的慢病毒载体 Download PDF

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CN104736167B
CN104736167B CN201380026705.4A CN201380026705A CN104736167B CN 104736167 B CN104736167 B CN 104736167B CN 201380026705 A CN201380026705 A CN 201380026705A CN 104736167 B CN104736167 B CN 104736167B
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CN104736167A (zh
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E·萨莉
C·伯奇
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Theravectys SA
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    • C12N2740/10011—Retroviridae
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201380026705.4A 2012-05-23 2013-04-30 含有mhc i型启动子的慢病毒载体 Active CN104736167B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12305566.7A EP2666477A1 (en) 2012-05-23 2012-05-23 Lentiviral vectors containing an MHC class I promoter
EP12305566.7 2012-05-23
PCT/EP2013/059041 WO2013174630A1 (en) 2012-05-23 2013-04-30 Lentiviral vectors containing an mhc class i promoter

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CN104736167A CN104736167A (zh) 2015-06-24
CN104736167B true CN104736167B (zh) 2018-07-27

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US (1) US8951535B2 (enExample)
EP (2) EP2666477A1 (enExample)
JP (1) JP5938143B2 (enExample)
KR (1) KR101774929B1 (enExample)
CN (1) CN104736167B (enExample)
AU (1) AU2013265586B2 (enExample)
BR (1) BR112014028944B1 (enExample)
CA (1) CA2873473C (enExample)
ES (1) ES2498277T3 (enExample)
IL (1) IL235705A (enExample)
IN (1) IN2014DN10123A (enExample)
NZ (1) NZ702345A (enExample)
PL (1) PL2678032T3 (enExample)
PT (1) PT2678032E (enExample)
SG (1) SG11201407732SA (enExample)
WO (1) WO2013174630A1 (enExample)
ZA (1) ZA201408652B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014195159A1 (en) 2013-06-03 2014-12-11 Theravectys Lentiviral vectors containing an mhc class i, mhc class ii, or beta-2 microglobulin upstream promoter sequence
EP3276006A1 (en) * 2016-07-27 2018-01-31 Theravectys Lentiviral vectors for expression of hepatitis b virus (hbv) antigens
KR102932097B1 (ko) 2020-07-06 2026-02-27 주식회사 지씨셀 면역원성이 감소된 신규한 이식용 세포
CN114107393A (zh) 2021-04-07 2022-03-01 上海劲威生物科技有限公司 一种治疗乙型肝炎的慢病毒载体、慢病毒颗粒及其制备方法和应用
KR102913951B1 (ko) * 2022-11-10 2026-01-20 전남대학교 산학협력단 다중에피토프 펩타이드를 포함하는 신경교종 예방 또는 치료용 약제학적 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19720152A1 (de) * 1997-05-02 1998-11-05 Max Delbrueck Centrum Retrovirales Vektorsystem zur Optimierung des Gentransfers und der Genexpression in primären humanen T-Lymphozyten

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2777909B1 (fr) 1998-04-24 2002-08-02 Pasteur Institut Utilisation de sequences d'adn de structure triplex pour le tranfert de sequences de nucleotides dans des cellules, vecteurs recombinants contenant ces sequences triplex
ES2337429T3 (es) 1999-10-11 2010-04-23 Institut Pasteur Vectores lentivirales para la preparacion de composiciones inmunoterapeuticas.
HK1050210B (en) 1999-10-12 2007-08-24 Institut Pasteur Lentiviral triplex dna, and vectors and recombinant cells containing lentiviral triplex dna
FR2870126B1 (fr) 2004-05-17 2009-07-17 Pasteur Institut Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin
US8222029B2 (en) 2005-05-16 2012-07-17 Institut Pasteur Lentiviral vector-based vaccine
ES2708856T3 (es) 2007-08-03 2019-04-11 Pasteur Institut Vectores de transferencia de gen lentivírico y sus aplicaciones medicinales

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19720152A1 (de) * 1997-05-02 1998-11-05 Max Delbrueck Centrum Retrovirales Vektorsystem zur Optimierung des Gentransfers und der Genexpression in primären humanen T-Lymphozyten

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Adenovirus Type 12 ElA Down Regulates Expression of a Transgene under Control of a Major Histocompatibility Complex Class I Promoter: Evidence for Transcriptional Control;INGEBORG MEIJER等;《JOURNAL OF VIROLOGY》;19890930;第63卷(第9期);第4039-4042页 *
Establishment and Characterization of Conditionally Immortalized Stromal Cell Lines from a Temperature-Sensitive T-Ag Transgenic Mouse;DOMINIK FEUERBACH等;《JOURNAL OF BONE AND MINERAL RESEARCH》;19971231;第12卷(第2期);正文第180页第20-28行, *
Human papillomavirus type 16 (HPV 16) E7 and major histocompatibility complex (MHC) class I and II expression in human keratinocytes in culture;A. Hoos等;《Arch Virol》;19961231;第141卷;第449-458页 *
Interferons Increase Transcription of a Major Histocompatibility Class I Gene via a 5" Interferon Consensus Sequence;KENJI SUGITA等;《MOLECULAR AND CELLULAR BIOLOGY》;19870731;第7卷(第7期);第2626-2630页 *
Lentiviral vectors for cancer immunotherapy:transforming infectious particles into therapeutics;K Breckpot等;《Gene Therapy》;20070322;第14卷;摘要 *
Negative regulation of the major histocompatibility complex class I promoter in embryonal carcinoma cells;JAMES R. FLANAGAN等;《Developmental Biology》;19910430;第88卷;第3145-3149页 *

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JP2015518716A (ja) 2015-07-06
CA2873473C (en) 2019-05-07
CN104736167A (zh) 2015-06-24
BR112014028944B1 (pt) 2020-11-10
KR20150014472A (ko) 2015-02-06
EP2666477A1 (en) 2013-11-27
HK1211837A1 (en) 2016-06-03
JP5938143B2 (ja) 2016-06-22
US20140120132A1 (en) 2014-05-01
EP2678032B1 (en) 2014-06-18
AU2013265586B2 (en) 2015-09-03
IN2014DN10123A (enExample) 2015-08-21
PT2678032E (pt) 2014-09-09
WO2013174630A1 (en) 2013-11-28
EP2678032A1 (en) 2014-01-01
IL235705A0 (en) 2015-01-29
AU2013265586A1 (en) 2014-12-11
IL235705A (en) 2016-10-31
US8951535B2 (en) 2015-02-10
PL2678032T3 (pl) 2014-11-28
NZ702345A (en) 2016-03-31
BR112014028944A2 (pt) 2015-09-29
CA2873473A1 (en) 2013-11-28
KR101774929B1 (ko) 2017-09-19
ES2498277T3 (es) 2014-09-24
SG11201407732SA (en) 2014-12-30
ZA201408652B (en) 2016-09-28

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