JP2015518048A - クロマン化合物 - Google Patents

クロマン化合物 Download PDF

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Publication number
JP2015518048A
JP2015518048A JP2015515133A JP2015515133A JP2015518048A JP 2015518048 A JP2015518048 A JP 2015518048A JP 2015515133 A JP2015515133 A JP 2015515133A JP 2015515133 A JP2015515133 A JP 2015515133A JP 2015518048 A JP2015518048 A JP 2015518048A
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Japan
Prior art keywords
mmol
mixture
chromene
compound
oxetane
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JP2015515133A
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Japanese (ja)
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JP2015518048A5 (enExample
Inventor
亮介 宗像
亮介 宗像
井上　誠
誠 井上
博章 冨永
博章 冨永
真五 山崎
真五 山崎
康裕 椎名
康裕 椎名
清寛 三水
清寛 三水
壽雄 濱口
壽雄 濱口
ホーン，リン
Original Assignee
コメンティス， インコーポレイテッド
コメンティス， インコーポレイテッド
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Application filed by コメンティス， インコーポレイテッド, コメンティス， インコーポレイテッド filed Critical コメンティス， インコーポレイテッド
Publication of JP2015518048A publication Critical patent/JP2015518048A/ja
Publication of JP2015518048A5 publication Critical patent/JP2015518048A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
JP2015515133A 2012-05-30 2013-05-29 クロマン化合物 Pending JP2015518048A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261653321P 2012-05-30 2012-05-30
US61/653,321 2012-05-30
US201361782038P 2013-03-14 2013-03-14
US61/782,038 2013-03-14
PCT/US2013/043016 WO2013181202A2 (en) 2012-05-30 2013-05-29 Chromane compounds

Publications (2)

Publication Number Publication Date
JP2015518048A true JP2015518048A (ja) 2015-06-25
JP2015518048A5 JP2015518048A5 (enExample) 2016-07-14

Family

ID=49674034

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015515133A Pending JP2015518048A (ja) 2012-05-30 2013-05-29 クロマン化合物

Country Status (15)

Country Link
US (2) US8975415B2 (enExample)
EP (1) EP2854797A4 (enExample)
JP (1) JP2015518048A (enExample)
KR (1) KR20150023536A (enExample)
CN (1) CN104394862A (enExample)
AR (1) AR091203A1 (enExample)
AU (1) AU2013267555A1 (enExample)
BR (1) BR112014029597A2 (enExample)
CA (1) CA2873678A1 (enExample)
EA (1) EA026380B1 (enExample)
HK (1) HK1208817A1 (enExample)
MX (1) MX2014014066A (enExample)
SG (1) SG11201407796YA (enExample)
TW (1) TW201408672A (enExample)
WO (1) WO2013181202A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013181202A2 (en) 2012-05-30 2013-12-05 Astellas Pharma Inc. Chromane compounds
UY36347A (es) * 2014-10-07 2016-04-01 Astrazeneca Ab Compuestos y su uso como inhibidores de bace
CN110818694B (zh) * 2019-11-18 2023-04-21 上海医药工业研究院有限公司 艾拉普林中间体及其应用
CN110724135B (zh) * 2019-11-18 2023-04-28 上海医药工业研究院有限公司 一种艾拉普林中间体及其制备方法
CN110790753B (zh) * 2019-11-18 2023-04-07 上海医药工业研究院 艾拉普林对甲苯磺酸盐、其制备方法和应用
CN110713483B (zh) * 2019-11-18 2023-04-07 上海医药工业研究院 艾拉普林中间体及艾拉普林的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011072064A1 (en) * 2009-12-08 2011-06-16 Array Biopharma Inc. S piro [chroman - 4, 4 ' - imidazol] ones as beta - secretase inhibitors
US20110218192A1 (en) * 2008-08-19 2011-09-08 Vitae Pharmaceuticals, Inc. Inhibitors Of Beta-Secretase
JP2011529443A (ja) * 2008-07-28 2011-12-08 エーザイ・アール・アンド・ディー・マネジメント株式会社 スピロアミノジヒドロチアジン誘導体
JP2012502112A (ja) * 2008-09-11 2012-01-26 アムジエン・インコーポレーテツド ベータ−セクレターゼ調節物質としてのスピロ四環式化合物および使用法
US20120065195A1 (en) * 2010-03-31 2012-03-15 Clark Christopher T Compounds for treating neurodegenerative diseases

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EP1196609A2 (en) 1999-06-28 2002-04-17 Oklahoma Medical Research Foundation Catalytically active recombinant memapsin and methods of use thereof
US20040121947A1 (en) 2000-12-28 2004-06-24 Oklahoma Medical Research Foundation Compounds which inhibit beta-secretase activity and methods of use thereof
EP1448218A4 (en) 2001-10-23 2009-01-14 Oklahoma Med Res Found BETA SECRETASE INHIBITORS AND METHODS OF USE
US7700603B2 (en) 2003-12-15 2010-04-20 Schering Corporation Heterocyclic aspartyl protease inhibitors
CA2548388A1 (en) 2003-12-15 2005-06-30 Schering Corporation Heterocyclic aspartyl protease inhibitors
WO2007100536A1 (en) 2006-02-24 2007-09-07 Wyeth DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE
WO2010013302A1 (ja) * 2008-07-28 2010-02-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 スピロアミノジヒドロチアジン誘導体
WO2010013794A1 (en) 2008-07-28 2010-02-04 Eisai R&D Management Co., Ltd. Spiroaminodihydrothiazine derivatives
PT2406240E (pt) * 2009-03-13 2016-02-24 Boehringer Ingelheim Int Inibidores de beta-secretase
US8461160B2 (en) 2009-05-08 2013-06-11 Hoffmann-La Roche, Inc. Dihydropyrimidinones
CN102812005B (zh) * 2010-02-24 2014-12-10 生命医药公司 β-分泌酶抑制剂
ES2450568T3 (es) * 2010-03-15 2014-03-25 Amgen Inc. Compuestos espiero de amino-dihidrooxazina y amino-dihidrotiazina como moduladores de beta-secretasa y su uso médico
CA2791281A1 (en) * 2010-03-15 2011-09-22 Amgen Inc. Spiro-tetracyclic ring compounds as beta-secretase modulators
WO2011130741A1 (en) 2010-04-16 2011-10-20 Array Biopharma Inc. Compounds for treating neurodegenerative diseases
UY33627A (es) 2010-09-24 2013-04-30 Array Biopharma Inc Compuestos para tratar enfermedades neurodegenerativas
TW201300380A (zh) 2010-10-19 2013-01-01 Comentis Inc 抑制β－分泌酶活性之噁二唑化合物及其使用方法
US20120157448A1 (en) 2010-11-22 2012-06-21 Adam Cook Compounds for treating neurodegenerative diseases
EP2643325A1 (en) 2010-11-23 2013-10-02 Amgen Inc. Spiro-amino-imidazolone and spiro-amino-dihydro-pyrimidinone compounds as beta-secretase modulators and methods of use
US8415483B2 (en) 2010-12-22 2013-04-09 Astrazeneca Ab Compounds and their use as BACE inhibitors
US9346827B2 (en) 2011-02-07 2016-05-24 Amgen Inc. 5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use
WO2012112462A1 (en) 2011-02-15 2012-08-23 Amgen Inc. Spiro-amino-imidazo-fused heterocyclic compounds as beta-secretase modulators and methods of use
US9079919B2 (en) 2011-05-27 2015-07-14 Hoffmann-La Roche Inc. Spiro-[1,3]-oxazines and spiro-[1,4]-oxazepines as BACE1 and/or BACE2 inhibitors
WO2013044092A1 (en) 2011-09-21 2013-03-28 Amgen Inc. Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
EP2780321B1 (en) 2011-10-10 2015-12-30 Astrazeneca AB Mono-fluoro beta-secretase inhibitors
WO2013181202A2 (en) 2012-05-30 2013-12-05 Astellas Pharma Inc. Chromane compounds
EP2669286A1 (en) 2012-05-31 2013-12-04 Ares Trading S.A. Spiro tetrahydro-benzothiophen derivatives useful for the treatment of neurodegenerative diseases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011529443A (ja) * 2008-07-28 2011-12-08 エーザイ・アール・アンド・ディー・マネジメント株式会社 スピロアミノジヒドロチアジン誘導体
US20110218192A1 (en) * 2008-08-19 2011-09-08 Vitae Pharmaceuticals, Inc. Inhibitors Of Beta-Secretase
JP2012502112A (ja) * 2008-09-11 2012-01-26 アムジエン・インコーポレーテツド ベータ−セクレターゼ調節物質としてのスピロ四環式化合物および使用法
WO2011072064A1 (en) * 2009-12-08 2011-06-16 Array Biopharma Inc. S piro [chroman - 4, 4 ' - imidazol] ones as beta - secretase inhibitors
US20120065195A1 (en) * 2010-03-31 2012-03-15 Clark Christopher T Compounds for treating neurodegenerative diseases

Also Published As

Publication number Publication date
TW201408672A (zh) 2014-03-01
AR091203A1 (es) 2015-01-21
US20140179695A1 (en) 2014-06-26
CA2873678A1 (en) 2013-12-05
HK1208817A1 (en) 2016-03-18
EP2854797A2 (en) 2015-04-08
WO2013181202A2 (en) 2013-12-05
KR20150023536A (ko) 2015-03-05
MX2014014066A (es) 2015-03-19
WO2013181202A3 (en) 2014-01-30
EA026380B1 (ru) 2017-04-28
SG11201407796YA (en) 2014-12-30
CN104394862A (zh) 2015-03-04
AU2013267555A1 (en) 2014-12-04
EA201492271A1 (ru) 2015-10-30
US20150225386A1 (en) 2015-08-13
US8975415B2 (en) 2015-03-10
US9242973B2 (en) 2016-01-26
EP2854797A4 (en) 2016-01-13
BR112014029597A2 (pt) 2017-11-07

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