CN104394862A - 色满化合物 - Google Patents

色满化合物 Download PDF

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Publication number
CN104394862A
CN104394862A CN201380028374.8A CN201380028374A CN104394862A CN 104394862 A CN104394862 A CN 104394862A CN 201380028374 A CN201380028374 A CN 201380028374A CN 104394862 A CN104394862 A CN 104394862A
Authority
CN
China
Prior art keywords
chromene
compound
mixture
oxazole
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380028374.8A
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English (en)
Chinese (zh)
Inventor
宗像亮介
井上诚
富永博章
山崎真五
椎名康裕
三水清宽
滨口寿雄
洪林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CoMentis Inc
Original Assignee
CoMentis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CoMentis Inc filed Critical CoMentis Inc
Publication of CN104394862A publication Critical patent/CN104394862A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201380028374.8A 2012-05-30 2013-05-29 色满化合物 Pending CN104394862A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261653321P 2012-05-30 2012-05-30
US61/653,321 2012-05-30
US201361782038P 2013-03-14 2013-03-14
US61/782,038 2013-03-14
PCT/US2013/043016 WO2013181202A2 (en) 2012-05-30 2013-05-29 Chromane compounds

Publications (1)

Publication Number Publication Date
CN104394862A true CN104394862A (zh) 2015-03-04

Family

ID=49674034

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380028374.8A Pending CN104394862A (zh) 2012-05-30 2013-05-29 色满化合物

Country Status (15)

Country Link
US (2) US8975415B2 (enExample)
EP (1) EP2854797A4 (enExample)
JP (1) JP2015518048A (enExample)
KR (1) KR20150023536A (enExample)
CN (1) CN104394862A (enExample)
AR (1) AR091203A1 (enExample)
AU (1) AU2013267555A1 (enExample)
BR (1) BR112014029597A2 (enExample)
CA (1) CA2873678A1 (enExample)
EA (1) EA026380B1 (enExample)
HK (1) HK1208817A1 (enExample)
MX (1) MX2014014066A (enExample)
SG (1) SG11201407796YA (enExample)
TW (1) TW201408672A (enExample)
WO (1) WO2013181202A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110713483A (zh) * 2019-11-18 2020-01-21 上海医药工业研究院 艾拉普林中间体及艾拉普林的制备方法
CN110724135A (zh) * 2019-11-18 2020-01-24 上海医药工业研究院 一种艾拉普林中间体及其制备方法
CN110790753A (zh) * 2019-11-18 2020-02-14 上海医药工业研究院 艾拉普林对甲苯磺酸盐、其制备方法和应用
CN110818694A (zh) * 2019-11-18 2020-02-21 上海医药工业研究院 艾拉普林中间体及其应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150023536A (ko) 2012-05-30 2015-03-05 코멘티스, 인코포레이티드 크로만 화합물
WO2016055858A1 (en) * 2014-10-07 2016-04-14 Astrazeneca Ab Compounds and their use as bace inhibitors

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WO2010013302A1 (ja) * 2008-07-28 2010-02-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 スピロアミノジヒドロチアジン誘導体
WO2011072064A1 (en) * 2009-12-08 2011-06-16 Array Biopharma Inc. S piro [chroman - 4, 4 ' - imidazol] ones as beta - secretase inhibitors
CN102105475A (zh) * 2008-07-28 2011-06-22 卫材R&D管理有限公司 螺氨基二氢噻嗪衍生物
WO2011106414A1 (en) * 2010-02-24 2011-09-01 Dillard Lawrence W Inhibitors of beta-secretase
WO2011115928A1 (en) * 2010-03-15 2011-09-22 Amgen Inc. Amino -dihydrooxazine and amino - dihydrothiazine spiro compounds as beta - secretase modulators and their medical use
WO2011115938A1 (en) * 2010-03-15 2011-09-22 Amgen Inc. Spiro-tetracyclic ring compounds as beta - secretase modulators
CN102209721A (zh) * 2008-09-11 2011-10-05 安姆根有限公司 作为β-分泌酶调节剂的螺四环化合物及其使用方法
WO2011123674A1 (en) * 2010-03-31 2011-10-06 Array Biopharma Inc. Compounds for treating neurodegenerative diseases
CN102348698A (zh) * 2009-03-13 2012-02-08 生命医药公司 β-分泌酶的抑制剂
CN102421760A (zh) * 2009-05-08 2012-04-18 霍夫曼-拉罗奇有限公司 用作bace2抑制剂的二氢嘧啶酮
EP2324032B1 (en) * 2008-08-19 2014-10-01 Vitae Pharmaceuticals, Inc. Inhibitors of beta-secretase

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US20040121947A1 (en) 2000-12-28 2004-06-24 Oklahoma Medical Research Foundation Compounds which inhibit beta-secretase activity and methods of use thereof
AU2002359301B2 (en) 2001-10-23 2008-07-03 Comentis, Inc. Beta-secretase inhibitors and methods of use
EP2153832B1 (en) 2003-12-15 2016-03-09 Merck Sharp & Dohme Corp. Heterocyclic aspartyl protease inhibitors
US7700603B2 (en) 2003-12-15 2010-04-20 Schering Corporation Heterocyclic aspartyl protease inhibitors
WO2007100536A1 (en) 2006-02-24 2007-09-07 Wyeth DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE
JP5444240B2 (ja) * 2008-07-28 2014-03-19 エーザイ・アール・アンド・ディー・マネジメント株式会社 スピロアミノジヒドロチアジン誘導体
WO2011130741A1 (en) 2010-04-16 2011-10-20 Array Biopharma Inc. Compounds for treating neurodegenerative diseases
AR083169A1 (es) 2010-09-24 2013-02-06 Array Biopharma Inc Compuestos para tratar enfermedades neurodegenerativas
TW201300380A (zh) 2010-10-19 2013-01-01 Comentis Inc 抑制β－分泌酶活性之噁二唑化合物及其使用方法
TW201307357A (zh) 2010-11-22 2013-02-16 Array Biopharma Inc 治療神經退化性疾病之化合物
US8957083B2 (en) 2010-11-23 2015-02-17 Amgen Inc. Spiro-amino-imidazolone and spiro-amino-dihydro-pyrimidinone compounds as beta-secretase modulators and methods of use
US8415483B2 (en) 2010-12-22 2013-04-09 Astrazeneca Ab Compounds and their use as BACE inhibitors
EP2673279A1 (en) 2011-02-07 2013-12-18 Amgen Inc. 5-amino-oxazepine and 5-amino-thiazepane compounds as beta-secretase antagonists and methods of use
US8962859B2 (en) 2011-02-15 2015-02-24 Amgen Inc. Spiro-amino-imidazo-fused heterocyclic compounds as beta-secretase modulators and methods of use
US9079919B2 (en) 2011-05-27 2015-07-14 Hoffmann-La Roche Inc. Spiro-[1,3]-oxazines and spiro-[1,4]-oxazepines as BACE1 and/or BACE2 inhibitors
EP2758406A1 (en) 2011-09-21 2014-07-30 Amgen Inc. Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
US9650336B2 (en) 2011-10-10 2017-05-16 Astrazeneca Ab Mono-fluoro beta-secretase inhibitors
KR20150023536A (ko) 2012-05-30 2015-03-05 코멘티스, 인코포레이티드 크로만 화합물
EP2669286A1 (en) 2012-05-31 2013-12-04 Ares Trading S.A. Spiro tetrahydro-benzothiophen derivatives useful for the treatment of neurodegenerative diseases

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010013302A1 (ja) * 2008-07-28 2010-02-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 スピロアミノジヒドロチアジン誘導体
CN102105475A (zh) * 2008-07-28 2011-06-22 卫材R&D管理有限公司 螺氨基二氢噻嗪衍生物
EP2324032B1 (en) * 2008-08-19 2014-10-01 Vitae Pharmaceuticals, Inc. Inhibitors of beta-secretase
CN102209721A (zh) * 2008-09-11 2011-10-05 安姆根有限公司 作为β-分泌酶调节剂的螺四环化合物及其使用方法
CN102348698A (zh) * 2009-03-13 2012-02-08 生命医药公司 β-分泌酶的抑制剂
CN102421760A (zh) * 2009-05-08 2012-04-18 霍夫曼-拉罗奇有限公司 用作bace2抑制剂的二氢嘧啶酮
WO2011072064A1 (en) * 2009-12-08 2011-06-16 Array Biopharma Inc. S piro [chroman - 4, 4 ' - imidazol] ones as beta - secretase inhibitors
WO2011106414A1 (en) * 2010-02-24 2011-09-01 Dillard Lawrence W Inhibitors of beta-secretase
WO2011115928A1 (en) * 2010-03-15 2011-09-22 Amgen Inc. Amino -dihydrooxazine and amino - dihydrothiazine spiro compounds as beta - secretase modulators and their medical use
WO2011115938A1 (en) * 2010-03-15 2011-09-22 Amgen Inc. Spiro-tetracyclic ring compounds as beta - secretase modulators
WO2011123674A1 (en) * 2010-03-31 2011-10-06 Array Biopharma Inc. Compounds for treating neurodegenerative diseases

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110713483A (zh) * 2019-11-18 2020-01-21 上海医药工业研究院 艾拉普林中间体及艾拉普林的制备方法
CN110724135A (zh) * 2019-11-18 2020-01-24 上海医药工业研究院 一种艾拉普林中间体及其制备方法
CN110790753A (zh) * 2019-11-18 2020-02-14 上海医药工业研究院 艾拉普林对甲苯磺酸盐、其制备方法和应用
CN110818694A (zh) * 2019-11-18 2020-02-21 上海医药工业研究院 艾拉普林中间体及其应用
CN110790753B (zh) * 2019-11-18 2023-04-07 上海医药工业研究院 艾拉普林对甲苯磺酸盐、其制备方法和应用
CN110713483B (zh) * 2019-11-18 2023-04-07 上海医药工业研究院 艾拉普林中间体及艾拉普林的制备方法
CN110818694B (zh) * 2019-11-18 2023-04-21 上海医药工业研究院有限公司 艾拉普林中间体及其应用
CN110724135B (zh) * 2019-11-18 2023-04-28 上海医药工业研究院有限公司 一种艾拉普林中间体及其制备方法

Also Published As

Publication number Publication date
TW201408672A (zh) 2014-03-01
US9242973B2 (en) 2016-01-26
EA026380B1 (ru) 2017-04-28
AU2013267555A1 (en) 2014-12-04
US8975415B2 (en) 2015-03-10
MX2014014066A (es) 2015-03-19
EP2854797A2 (en) 2015-04-08
HK1208817A1 (en) 2016-03-18
JP2015518048A (ja) 2015-06-25
SG11201407796YA (en) 2014-12-30
WO2013181202A3 (en) 2014-01-30
US20140179695A1 (en) 2014-06-26
WO2013181202A2 (en) 2013-12-05
KR20150023536A (ko) 2015-03-05
BR112014029597A2 (pt) 2017-11-07
AR091203A1 (es) 2015-01-21
CA2873678A1 (en) 2013-12-05
EA201492271A1 (ru) 2015-10-30
US20150225386A1 (en) 2015-08-13
EP2854797A4 (en) 2016-01-13

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Application publication date: 20150304